CL2017000104A1 - Compuestos novedosos de pirimidina sustituidos. - Google Patents

Compuestos novedosos de pirimidina sustituidos.

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Publication number
CL2017000104A1
CL2017000104A1 CL2017000104A CL2017000104A CL2017000104A1 CL 2017000104 A1 CL2017000104 A1 CL 2017000104A1 CL 2017000104 A CL2017000104 A CL 2017000104A CL 2017000104 A CL2017000104 A CL 2017000104A CL 2017000104 A1 CL2017000104 A1 CL 2017000104A1
Authority
CL
Chile
Prior art keywords
pyrimidine compounds
novel substituted
substituted pyrimidine
medications
novedous
Prior art date
Application number
CL2017000104A
Other languages
English (en)
Inventor
Antonio Nardi
Florian Jakob
Ingo Konetzki
Tobias Craan
Christian Hesslinger
Robin Doodeman
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of CL2017000104A1 publication Critical patent/CL2017000104A1/es

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

<p>COMPUESTOS NOVEDOSOS DE PIRIMIDINA SUSTITUIDOS DE FÓRMULA GENERAL (I)</p> <p>* Incluir figura de estructrura hoja resumen (pag 290)</p> <p>EN LOS CUALES LOS GRUPOS QUÍMICOS, SUSTITUYENTES, VARIABLES E ÍNDICES SON TAL COMO SE LOS DEFINE EN LA DESCRIPCIÓN, Y A SU USO COMO MEDICAMENTOS, EN PARTICULAR COMO MEDICAMENTOS PARA EL TRATAMIENTO DE CONDICIONES Y ENFERMEDADES QUE SE PUEDEN TRATAR POR INHIBICIÓN DE LA ENZIMA PDE4.</p>
CL2017000104A 2014-07-16 2017-01-13 Compuestos novedosos de pirimidina sustituidos. CL2017000104A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14002452 2014-07-16

Publications (1)

Publication Number Publication Date
CL2017000104A1 true CL2017000104A1 (es) 2017-08-04

Family

ID=51210213

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017000104A CL2017000104A1 (es) 2014-07-16 2017-01-13 Compuestos novedosos de pirimidina sustituidos.

Country Status (18)

Country Link
US (2) US9540349B2 (es)
EP (2) EP3527561A1 (es)
JP (1) JP6738795B2 (es)
KR (1) KR20170029614A (es)
CN (1) CN107074812B (es)
AR (1) AR101196A1 (es)
AU (1) AU2015291478B2 (es)
BR (1) BR112017000821A2 (es)
CA (1) CA2955070A1 (es)
CL (1) CL2017000104A1 (es)
CO (1) CO2017001528A2 (es)
EA (1) EA201790207A8 (es)
EC (1) ECSP17010238A (es)
IL (1) IL250022B (es)
MX (1) MX2017000524A (es)
PE (1) PE20170120A1 (es)
TW (1) TW201609707A (es)
WO (1) WO2016008593A1 (es)

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AR101198A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Pirimidinas 2,5-sustituidas como inhibidores de pde4b
AR101196A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Compuestos de pirimidina sustituidos
AR101197A1 (es) * 2014-07-16 2016-11-30 Gruenenthal Gmbh Pirimidinas 2,5-sustituidas
AR107099A1 (es) * 2015-12-22 2018-03-21 Gruenenthal Gmbh Compuestos espiro-[indolin heterocicloalcano] como inhibidores de la fosfodiesterasa
AR107004A1 (es) * 2015-12-22 2018-03-07 Gruenenthal Gmbh Compuestos de indolina sustituidas como inhibidores fosfodiesterasa
WO2018036470A1 (zh) * 2016-08-22 2018-03-01 南京明德新药研发股份有限公司 作为pde4抑制剂的并环类化合物
CN108570052A (zh) * 2017-03-13 2018-09-25 中国科学院上海药物研究所 五元杂环并吡嗪化合物、制备方法、中间体、组合和应用
WO2018234353A1 (en) 2017-06-20 2018-12-27 Grünenthal GmbH NOVEL SUBSTITUTED INDOLE AND INDAZOLE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASE
WO2018234354A1 (en) 2017-06-20 2018-12-27 Grünenthal GmbH NOVEL SUBSTITUTED 3-INDOLE AND 3-INDAZOLE COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS
CN110407741B (zh) * 2018-04-26 2023-03-21 启元生物(杭州)有限公司 一种抗炎化合物及其制备和应用
EP4532496A1 (en) * 2022-06-03 2025-04-09 Domain Therapeutics Novel par-2 inhibitors

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