CL2017000249A1 - Compuestos de 6,7-dihidropirazolo [1,5-a] pirazin-4(5h)-ona y su uso como moduladores alostéricos negativos de receptores mglu2r2 - Google Patents

Compuestos de 6,7-dihidropirazolo [1,5-a] pirazin-4(5h)-ona y su uso como moduladores alostéricos negativos de receptores mglu2r2

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Publication number
CL2017000249A1
CL2017000249A1 CL2017000249A CL2017000249A CL2017000249A1 CL 2017000249 A1 CL2017000249 A1 CL 2017000249A1 CL 2017000249 A CL2017000249 A CL 2017000249A CL 2017000249 A CL2017000249 A CL 2017000249A CL 2017000249 A1 CL2017000249 A1 CL 2017000249A1
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CL
Chile
Prior art keywords
compounds
mglu2r2
dihydropyrazolo
pyrazin
receptors
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CL2017000249A
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English (en)
Inventor
Gool Michiel Luc Maria Van
Óscar Delgado-González
Andrés Avelino Trabanco-Suárez
José Ignacio Andrés-Gil
Diego Sergio-Alvar; Alonso-De
María Luz Martín-Martín
Susana Conde-Ceide
Gary John Tresadern
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Janssen Pharmaceutica Nv
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CL2017000249A1 publication Critical patent/CL2017000249A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

<p>LA PRESENTE INVENCIÓN SE REFIERE A NOVEDOSOS DERIVADOS DE 6,7-DIHIDROPIRAZOLO [1, 5-A]PIRAZIN-4 (5H)-ONA COMO MODULADORES ALOSTÉRICOS NEGATIVOS (NAM) DEL RECEPTOR DE GLUCAMATO METABOTRÓPICOS SUBTIPO 2 (“mGluR2). LA INVENCIÓN TAMBIÉN ESTÁ DIRIGIDA A COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN DICHOS COMPUESTOS, A PROCESOS PARA PREPARAR DICHOS COMPUESTOS Y COMPOSICIONES Y AL USO DE DICHOS COMPUESTOS Y COMPOSICIONES PARA PREVENIR O TRATAR TRASTORNOS EN LOS QUE ESTÁ IMPLICADO EL SUBTIPO mGluR2 DE RECEPTORES METABOTRÓPICOS.</p>
CL2017000249A 2014-08-01 2017-01-31 Compuestos de 6,7-dihidropirazolo [1,5-a] pirazin-4(5h)-ona y su uso como moduladores alostéricos negativos de receptores mglu2r2 CL2017000249A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14179600 2014-08-01
EP14196083 2014-12-03

Publications (1)

Publication Number Publication Date
CL2017000249A1 true CL2017000249A1 (es) 2017-08-18

Family

ID=53765202

Family Applications (1)

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CL2017000249A CL2017000249A1 (es) 2014-08-01 2017-01-31 Compuestos de 6,7-dihidropirazolo [1,5-a] pirazin-4(5h)-ona y su uso como moduladores alostéricos negativos de receptores mglu2r2

Country Status (31)

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US (2) US10005785B2 (es)
EP (1) EP3174883B1 (es)
JP (1) JP6609306B2 (es)
KR (1) KR102531680B1 (es)
CN (1) CN107018662B (es)
AU (1) AU2015295313B2 (es)
BR (1) BR112017001861A2 (es)
CA (1) CA2954094C (es)
CL (1) CL2017000249A1 (es)
CY (1) CY1121123T1 (es)
DK (1) DK3174883T3 (es)
EA (1) EA033052B1 (es)
ES (1) ES2705425T3 (es)
HR (1) HRP20182114T1 (es)
HU (1) HUE041777T2 (es)
IL (1) IL250303A0 (es)
JO (1) JOP20150177B1 (es)
LT (1) LT3174883T (es)
ME (1) ME03341B (es)
MX (1) MX370182B (es)
NZ (1) NZ728025A (es)
PH (1) PH12017500170A1 (es)
PL (1) PL3174883T3 (es)
PT (1) PT3174883T (es)
RS (1) RS58215B1 (es)
SG (1) SG11201700637WA (es)
SI (1) SI3174883T1 (es)
SM (1) SMT201900013T1 (es)
TW (1) TWI688566B (es)
WO (1) WO2016016395A1 (es)
ZA (1) ZA201700758B (es)

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RS58215B1 (sr) 2019-03-29
US20170217971A1 (en) 2017-08-03
CN107018662A (zh) 2017-08-04
US10005785B2 (en) 2018-06-26
MX2017001454A (es) 2017-05-09
EP3174883B1 (en) 2018-10-24
NZ728025A (en) 2022-04-29
TW201625630A (zh) 2016-07-16
WO2016016395A1 (en) 2016-02-04
SI3174883T1 (sl) 2019-01-31
PL3174883T3 (pl) 2019-04-30
LT3174883T (lt) 2019-01-10
SG11201700637WA (en) 2017-02-27
IL250303A0 (en) 2017-03-30
CA2954094C (en) 2023-02-14
CN107018662B (zh) 2020-01-07
PH12017500170B1 (en) 2017-07-10
JP6609306B2 (ja) 2019-11-20
CA2954094A1 (en) 2016-02-04
ES2705425T3 (es) 2019-03-25
KR102531680B1 (ko) 2023-05-10
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