CL2017000484A1 - Compuestos de azetidiniloxifenilpirrolidina - Google Patents

Compuestos de azetidiniloxifenilpirrolidina

Info

Publication number
CL2017000484A1
CL2017000484A1 CL2017000484A CL2017000484A CL2017000484A1 CL 2017000484 A1 CL2017000484 A1 CL 2017000484A1 CL 2017000484 A CL2017000484 A CL 2017000484A CL 2017000484 A CL2017000484 A CL 2017000484A CL 2017000484 A1 CL2017000484 A1 CL 2017000484A1
Authority
CL
Chile
Prior art keywords
compounds
formula
azetidinyloxyphenylpyrrolidine compounds
azetidinyloxyphenylpyrrolidine
azetidinyloxyphenylpirrolidine
Prior art date
Application number
CL2017000484A
Other languages
English (en)
Inventor
Gary G Deng
Danwen Huang
Cynthia Darshini Jesudason
Joshua O Odingo
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54140711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017000484(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CL2017000484A1 publication Critical patent/CL2017000484A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

<p>LA INVENCIÓN PROPORCIONA DETERMINADOS COMPUESTOS DE AZETIDINILOXIFENILPIRROLIDINA, PARTICULARMENTE COMPUESTOS DE LA FORMULA I, Y COMPOSICIONES FARMACÉUTICAMENTE DE ESTOS. LA INVENCIÓN PROPORCIONA ADEMÁS MÉTODOS PARA USAR UN COMPUESTO DE LA FORMULA I PARA TRATAR LA VEJIGA HIPERACTIVA.</p>
CL2017000484A 2014-09-12 2017-03-01 Compuestos de azetidiniloxifenilpirrolidina CL2017000484A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462049485P 2014-09-12 2014-09-12

Publications (1)

Publication Number Publication Date
CL2017000484A1 true CL2017000484A1 (es) 2017-11-10

Family

ID=54140711

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017000484A CL2017000484A1 (es) 2014-09-12 2017-03-01 Compuestos de azetidiniloxifenilpirrolidina

Country Status (34)

Country Link
US (2) US10781202B2 (es)
EP (1) EP3191466B1 (es)
JP (1) JP6285610B2 (es)
KR (1) KR101857931B1 (es)
CN (1) CN106795137B (es)
AP (1) AP2017009778A0 (es)
AR (1) AR101696A1 (es)
AU (1) AU2015315533B2 (es)
BR (1) BR112017002852A2 (es)
CA (1) CA2955634A1 (es)
CL (1) CL2017000484A1 (es)
CO (1) CO2017001389A2 (es)
CR (1) CR20170050A (es)
DK (1) DK3191466T3 (es)
EA (1) EA030034B1 (es)
EC (1) ECSP17014972A (es)
ES (1) ES2770047T3 (es)
HR (1) HRP20200119T1 (es)
HU (1) HUE047551T2 (es)
IL (1) IL250378A0 (es)
LT (1) LT3191466T (es)
MX (1) MX2017003138A (es)
NZ (1) NZ729087A (es)
PE (1) PE20170328A1 (es)
PH (1) PH12017500459A1 (es)
PL (1) PL3191466T3 (es)
PT (1) PT3191466T (es)
RS (1) RS59845B1 (es)
SG (1) SG11201701225YA (es)
SI (1) SI3191466T1 (es)
TN (1) TN2017000047A1 (es)
TW (1) TW201625591A (es)
WO (1) WO2016040083A1 (es)
ZA (1) ZA201700555B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA029052B1 (ru) 2013-03-14 2018-02-28 Бёрингер Ингельхайм Интернациональ Гмбх Замещенные (бензилцианометил)амиды 2-азабицикло[2.2.1]гептан-3-карбоновых кислот в качестве ингибиторов катепсина с
HUE047208T2 (hu) 2014-09-12 2020-04-28 Boehringer Ingelheim Int A katepszin-C spirociklikus inhibitorai
CA3123995C (en) * 2018-12-18 2023-05-23 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company Phenylpyrrolidine compound and use thereof
CN111333625B (zh) * 2018-12-18 2022-10-18 武汉人福创新药物研发中心有限公司 苯基吡咯烷类化合物及其用途
CN111333637B (zh) * 2018-12-18 2022-07-29 武汉人福创新药物研发中心有限公司 苯基吡咯烷类衍生物及其制备方法
WO2021036953A1 (zh) * 2019-08-23 2021-03-04 湖北生物医药产业技术研究院有限公司 苯基吡咯烷类化合物
JP2024517583A (ja) 2021-04-29 2024-04-23 ▲蘇▼州盛迪▲亞▼生物医▲薬▼有限公司 イソキノリノン系化合物及びその用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258833B1 (en) * 1999-12-23 2001-07-10 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
CZ20031903A3 (cs) * 2001-01-31 2004-07-14 Pfizer Products Inc. Amidové deriváty thiazolyl-, oxazolyl-, pyrrolyl- a imidazolyl karboxylových kyselin užitečné jako inhibitory isozymů PDE4
CA2623657A1 (en) 2005-09-29 2007-04-12 Bayer Healthcare Ag Pde inhibitors and combinations thereof for the treatment of urological disorders
TW201206440A (en) 2010-04-28 2012-02-16 Astellas Pharma Inc Prophylactic or therapeutic agent for diseases associated with pains in urinary organs
JO3264B1 (ar) * 2013-03-13 2018-09-16 Lilly Co Eli مركبات ازيتيدينيل أوكسي فينيل بيروليدين
WO2016033776A1 (en) * 2014-09-04 2016-03-10 Eli Lilly And Company Crystalline (2s) -3- [ (3s, 4s) -3- [ (1r) -1-hydroxyethyl] -4- (4-methoxy-3- { [1- (5-methylpyridin-2-yl) azetidin-3-yl] oxy} phenyl) -3-methylpyrrolidin-1-yl] -3-oxopropane-1, 2-diol

Also Published As

Publication number Publication date
IL250378A0 (en) 2017-03-30
KR20170040803A (ko) 2017-04-13
PT3191466T (pt) 2020-02-17
TN2017000047A1 (en) 2018-07-04
CR20170050A (es) 2017-04-25
AU2015315533A1 (en) 2017-02-23
JP6285610B2 (ja) 2018-02-28
ECSP17014972A (es) 2018-03-31
RS59845B1 (sr) 2020-02-28
PH12017500459A1 (en) 2017-07-31
AU2015315533B2 (en) 2018-03-15
HRP20200119T1 (hr) 2020-04-03
EP3191466A1 (en) 2017-07-19
EP3191466B1 (en) 2019-12-04
US20200002318A1 (en) 2020-01-02
ZA201700555B (en) 2018-12-19
MX2017003138A (es) 2017-05-23
EA030034B1 (ru) 2018-06-29
US20170240532A1 (en) 2017-08-24
SI3191466T1 (sl) 2020-02-28
PL3191466T3 (pl) 2020-05-18
WO2016040083A1 (en) 2016-03-17
TW201625591A (zh) 2016-07-16
LT3191466T (lt) 2020-02-25
AP2017009778A0 (en) 2017-03-31
HUE047551T2 (hu) 2020-04-28
SG11201701225YA (en) 2017-03-30
DK3191466T3 (da) 2020-01-20
CO2017001389A2 (es) 2017-05-10
PE20170328A1 (es) 2017-04-19
CN106795137A (zh) 2017-05-31
NZ729087A (en) 2018-07-27
EA201790156A1 (ru) 2017-06-30
US10781202B2 (en) 2020-09-22
CA2955634A1 (en) 2016-03-17
AR101696A1 (es) 2017-01-04
CN106795137B (zh) 2020-08-25
KR101857931B1 (ko) 2018-05-14
JP2017527587A (ja) 2017-09-21
BR112017002852A2 (pt) 2017-12-26
ES2770047T3 (es) 2020-06-30

Similar Documents

Publication Publication Date Title
EA201792205A1 (ru) Гетероциклические соединения как ингибиторы lsd1
EA201692203A1 (ru) Соединения, ингибирующие tank-связывающую киназу
EA201692193A1 (ru) Способы получения ингибитора jak1 и его новых форм
MX2018006148A (es) Inhibidores de cxcr2.
EA201792021A1 (ru) Ингибитор jak
EA201691799A1 (ru) Бициклические соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
EA201891910A1 (ru) Гетероарильные ингибиторы pad4
EA201692219A1 (ru) Способы получения противовирусных соединений
MX377277B (es) Derivados de fenoximetilo.
EA201492223A1 (ru) Новые диазаспироциклоалканы и азаспироциклоалканы
PH12018500408A1 (en) Bicyclic compounds as atx inhibitors
EA201790395A1 (ru) Производные аминотриазина, подходящие для применения в качестве соединений-ингибиторов tank-связывающей киназы
TW201613853A (en) Synthesis of polycyclic-carbamoylpyridone compounds
EA201591634A1 (ru) Дигидропиридопиримидиновые соединения
PH12017502051A1 (en) TBK/IKKe INHIBITOR COMPOUNDS AND USES THEREOF
UY37017A (es) Inhibidores aza-bencimidazol de pad4
EA201690764A1 (ru) Ингибитор грелин-o-ацилтрансферазы
CO2017001389A2 (es) Compuestos de azetidiniloxifenilpirrolidina
UY36204A (es) Derivados de insoindolina.
MA41803A (fr) Dérivés amino-indazoles utilisés comme inhibiteurs des canaux sodiques
EA201790983A1 (ru) Синтез копанлисиба и его дигидрохлорида
MX387796B (es) Compuestos de aminocarbonilcarbamato.
EA201790982A1 (ru) Синтез копанлисиба и его дигидрохлорида
EA201691632A1 (ru) Пиразины в качестве модуляторов gpr6
EA201591915A1 (ru) Соединения феноксиэтил дигидро-1h-изохинолина