CR20170050A - Compuestos de azetidiniloxifenilpirrolidina - Google Patents

Compuestos de azetidiniloxifenilpirrolidina

Info

Publication number
CR20170050A
CR20170050A CR20170050A CR20170050A CR20170050A CR 20170050 A CR20170050 A CR 20170050A CR 20170050 A CR20170050 A CR 20170050A CR 20170050 A CR20170050 A CR 20170050A CR 20170050 A CR20170050 A CR 20170050A
Authority
CR
Costa Rica
Prior art keywords
compounds
azetidinyloxyphenylpirrolidine
formula
treat
compound
Prior art date
Application number
CR20170050A
Other languages
English (en)
Inventor
Danwen Huang
Gary G Deng
Joshua O Odingo
Cynthia Darshini Jesudason
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54140711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20170050(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CR20170050A publication Critical patent/CR20170050A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención proporciona determinados compuestos de azetidiniloxifenilpirrolidina, particularmente compuestos de la fórmula I, y composiciones farmacéuticas de estos. La invención proporciona además métodos para usar un compuesto de la fórmula I para tratar la vejiga hiperactiva.
CR20170050A 2014-09-12 2015-09-03 Compuestos de azetidiniloxifenilpirrolidina CR20170050A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462049485P 2014-09-12 2014-09-12
PCT/US2015/048267 WO2016040083A1 (en) 2014-09-12 2015-09-03 Azetidinyloxyphenylpyrrolidine compounds

Publications (1)

Publication Number Publication Date
CR20170050A true CR20170050A (es) 2017-04-25

Family

ID=54140711

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20170050A CR20170050A (es) 2014-09-12 2015-09-03 Compuestos de azetidiniloxifenilpirrolidina

Country Status (34)

Country Link
US (2) US10781202B2 (es)
EP (1) EP3191466B1 (es)
JP (1) JP6285610B2 (es)
KR (1) KR101857931B1 (es)
CN (1) CN106795137B (es)
AP (1) AP2017009778A0 (es)
AR (1) AR101696A1 (es)
AU (1) AU2015315533B2 (es)
BR (1) BR112017002852A2 (es)
CA (1) CA2955634A1 (es)
CL (1) CL2017000484A1 (es)
CO (1) CO2017001389A2 (es)
CR (1) CR20170050A (es)
DK (1) DK3191466T3 (es)
EA (1) EA030034B1 (es)
EC (1) ECSP17014972A (es)
ES (1) ES2770047T3 (es)
HR (1) HRP20200119T1 (es)
HU (1) HUE047551T2 (es)
IL (1) IL250378A0 (es)
LT (1) LT3191466T (es)
MX (1) MX2017003138A (es)
NZ (1) NZ729087A (es)
PE (1) PE20170328A1 (es)
PH (1) PH12017500459A1 (es)
PL (1) PL3191466T3 (es)
PT (1) PT3191466T (es)
RS (1) RS59845B1 (es)
SG (1) SG11201701225YA (es)
SI (1) SI3191466T1 (es)
TN (1) TN2017000047A1 (es)
TW (1) TW201625591A (es)
WO (1) WO2016040083A1 (es)
ZA (1) ZA201700555B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP201706780B (en) 2013-03-14 2017-11-27 Boehringer Ingelheim Int Substituted 2-aza-bicyclo [2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c
UA118610C2 (uk) 2014-09-12 2019-02-11 Бьорінгер Інгельхайм Інтернаціональ Гмбх Спіроциклічні інгібітори катепсину c
CA3123995C (en) 2018-12-18 2023-05-23 Wuhan Humanwell Innovative Drug Research and Development Center Limited Company Phenylpyrrolidine compound and use thereof
CN111333625B (zh) * 2018-12-18 2022-10-18 武汉人福创新药物研发中心有限公司 苯基吡咯烷类化合物及其用途
CN111333637B (zh) * 2018-12-18 2022-07-29 武汉人福创新药物研发中心有限公司 苯基吡咯烷类衍生物及其制备方法
WO2021036953A1 (zh) * 2019-08-23 2021-03-04 湖北生物医药产业技术研究院有限公司 苯基吡咯烷类化合物
KR20240004495A (ko) 2021-04-29 2024-01-11 쑤저우 선카디아 바이오파마수티컬즈 컴퍼니 리미티드 이소퀴놀론 화합물과 이의 용도

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258833B1 (en) * 1999-12-23 2001-07-10 Icos Corporation Cyclic AMP-specific phosphodiesterase inhibitors
BR0116850A (pt) * 2001-01-31 2004-02-25 Pfizer Prod Inc Derivados de amida de ácido tiazolil-, oxazolil-, pirrolil- e imidazolil- úteis como inibidores de isoenzimas de pde4
JP2009509984A (ja) 2005-09-29 2009-03-12 バイエル・ヘルスケア・アクチェンゲゼルシャフト 泌尿器系障害の処置用のｐｄｅ阻害剤およびそれらの組合せ
TW201206440A (en) 2010-04-28 2012-02-16 Astellas Pharma Inc Prophylactic or therapeutic agent for diseases associated with pains in urinary organs
JO3264B1 (ar) * 2013-03-13 2018-09-16 Lilly Co Eli مركبات ازيتيدينيل أوكسي فينيل بيروليدين
WO2016033776A1 (en) * 2014-09-04 2016-03-10 Eli Lilly And Company Crystalline (2s) -3- [ (3s, 4s) -3- [ (1r) -1-hydroxyethyl] -4- (4-methoxy-3- { [1- (5-methylpyridin-2-yl) azetidin-3-yl] oxy} phenyl) -3-methylpyrrolidin-1-yl] -3-oxopropane-1, 2-diol

Also Published As

Publication number Publication date
AU2015315533B2 (en) 2018-03-15
AU2015315533A1 (en) 2017-02-23
HUE047551T2 (hu) 2020-04-28
CO2017001389A2 (es) 2017-05-10
PE20170328A1 (es) 2017-04-19
HRP20200119T1 (hr) 2020-04-03
ECSP17014972A (es) 2018-03-31
PH12017500459A1 (en) 2017-07-31
BR112017002852A2 (pt) 2017-12-26
EP3191466B1 (en) 2019-12-04
MX2017003138A (es) 2017-05-23
ES2770047T3 (es) 2020-06-30
CN106795137B (zh) 2020-08-25
CA2955634A1 (en) 2016-03-17
TW201625591A (zh) 2016-07-16
PT3191466T (pt) 2020-02-17
DK3191466T3 (da) 2020-01-20
PL3191466T3 (pl) 2020-05-18
CN106795137A (zh) 2017-05-31
SI3191466T1 (sl) 2020-02-28
IL250378A0 (en) 2017-03-30
US10781202B2 (en) 2020-09-22
AR101696A1 (es) 2017-01-04
US20170240532A1 (en) 2017-08-24
CL2017000484A1 (es) 2017-11-10
EA201790156A1 (ru) 2017-06-30
LT3191466T (lt) 2020-02-25
ZA201700555B (en) 2018-12-19
US20200002318A1 (en) 2020-01-02
AP2017009778A0 (en) 2017-03-31
JP2017527587A (ja) 2017-09-21
KR101857931B1 (ko) 2018-05-14
RS59845B1 (sr) 2020-02-28
WO2016040083A1 (en) 2016-03-17
KR20170040803A (ko) 2017-04-13
SG11201701225YA (en) 2017-03-30
NZ729087A (en) 2018-07-27
JP6285610B2 (ja) 2018-02-28
EA030034B1 (ru) 2018-06-29
TN2017000047A1 (en) 2018-07-04
EP3191466A1 (en) 2017-07-19

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