CL2017001310A1 - Péptidos cíclicos derivados de cd44v6 para el tratamiento de enfermedades relacionadas con cánceres y angiogénesis - Google Patents

Péptidos cíclicos derivados de cd44v6 para el tratamiento de enfermedades relacionadas con cánceres y angiogénesis

Info

Publication number
CL2017001310A1
CL2017001310A1 CL2017001310A CL2017001310A CL2017001310A1 CL 2017001310 A1 CL2017001310 A1 CL 2017001310A1 CL 2017001310 A CL2017001310 A CL 2017001310A CL 2017001310 A CL2017001310 A CL 2017001310A CL 2017001310 A1 CL2017001310 A1 CL 2017001310A1
Authority
CL
Chile
Prior art keywords
angiogenesis
treatment
diseases related
cd44v6
cancers
Prior art date
Application number
CL2017001310A
Other languages
English (en)
Inventor
Thomas Lindner
Uwe Haberkorn
Walter Mier
Alexandra Matzke-Ogi
Veronique Orian-Rousseau
Original Assignee
Amcure Gmbh
Ruprecht Karls Univ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52425505&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017001310(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amcure Gmbh, Ruprecht Karls Univ filed Critical Amcure Gmbh
Publication of CL2017001310A1 publication Critical patent/CL2017001310A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70585—CD44
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)

Abstract

<p>LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS, COMPOSICIONES FARMACÉUTICAS Y MÉTODOS PARA EL TRATAMIENTO DE DIFERENTES FORMAS DE ENFERMEDADES RELACIONADAS CON EL CÁNCER Y ANGIOGÉNESIS USANDO PÉPTIDOS CÍCLICOS.</p>
CL2017001310A 2014-12-05 2017-05-23 Péptidos cíclicos derivados de cd44v6 para el tratamiento de enfermedades relacionadas con cánceres y angiogénesis CL2017001310A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1421647.7A GB201421647D0 (en) 2014-12-05 2014-12-05 CD44v6-derived cyclic peptides for treating cancers and angiogenesis related diseases

Publications (1)

Publication Number Publication Date
CL2017001310A1 true CL2017001310A1 (es) 2018-02-02

Family

ID=52425505

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017001310A CL2017001310A1 (es) 2014-12-05 2017-05-23 Péptidos cíclicos derivados de cd44v6 para el tratamiento de enfermedades relacionadas con cánceres y angiogénesis

Country Status (17)

Country Link
US (2) US10703796B2 (es)
EP (1) EP3227322B1 (es)
JP (2) JP2018506508A (es)
KR (1) KR20170086124A (es)
CN (1) CN107207578B (es)
AU (1) AU2015356997B2 (es)
BR (1) BR112017011543A2 (es)
CA (1) CA2968333A1 (es)
CL (1) CL2017001310A1 (es)
CO (1) CO2017005566A2 (es)
EA (1) EA035767B1 (es)
GB (1) GB201421647D0 (es)
IL (1) IL252626B (es)
MX (1) MX391474B (es)
PH (1) PH12017500853B1 (es)
SG (1) SG11201703825UA (es)
WO (1) WO2016087680A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015109391A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
US10570202B2 (en) 2014-02-04 2020-02-25 Pfizer Inc. Combination of a PD-1 antagonist and a VEGFR inhibitor for treating cancer
KR20170132171A (ko) 2015-02-26 2017-12-01 메르크 파텐트 게엠베하 암 치료를 위한 ｐｄ­１ ／ ｐｄ­ｌ１ 저해제
RU2766890C2 (ru) 2015-06-16 2022-03-16 Мерк Патент Гмбх Комбинированные способы лечения антагонистами pd-l1
BR112019006504A2 (pt) 2016-10-06 2019-06-25 Pfizer Inc. regime de dosagem de avelumabe para o tratamento de câncer
US20190388407A1 (en) * 2017-02-12 2019-12-26 Aiviva Biopharma, Inc. Multikinase inhibitors of vegf and tfg beta and uses thereof
JP2021534153A (ja) 2018-08-15 2021-12-09 アイビバ バイオファーマ インコーポレイテッド Ｖｅｇｆおよびｔｇｆベータのマルチキナーゼ阻害剤およびその使用
CN111053771A (zh) * 2018-10-16 2020-04-24 正大天晴药业集团股份有限公司 用于治疗食道鳞状细胞癌的喹啉类化合物或其药学上可接受的盐

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU656230B2 (en) * 1991-10-11 1995-01-27 F. Hoffmann-La Roche Ag Cyclic vasoactive peptides
US5696229A (en) 1995-03-16 1997-12-09 The University Of Virginia Patent Foundation Polypeptide with laminin cell adhesion and morphogenesis activity
DE19540515C1 (de) 1995-10-31 1997-02-06 Boehringer Ingelheim Int Tumortherapie durch adoptiven Transfer CD44v-spezifischer zytotoxischer T-Lymphozyten
AUPP616498A0 (en) * 1998-09-25 1998-10-15 University Of Queensland, The Synthesis of cyclic peptides
GB9901710D0 (en) 1999-01-26 1999-03-17 Prolifix Ltd Peptide inhibitors
EP1258255A1 (en) 2001-05-18 2002-11-20 Boehringer Ingelheim International GmbH Conjugates of an antibody to CD44 and a maytansinoid
JP2003089700A (ja) 2001-09-18 2003-03-28 Life Science Management:Kk ペプチド
EP1391213A1 (en) 2002-08-21 2004-02-25 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents
EP1417974A1 (en) 2002-11-08 2004-05-12 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and radiotherapy
US20070032415A1 (en) * 2002-12-05 2007-02-08 Macina Roberto A Compositions, splice variants and methods relating to breast specific genes and proteins
US20040121971A1 (en) * 2002-12-20 2004-06-24 Gang Chen Therapeutic use of tumor necrosis factor-alpha mutein
WO2005065709A2 (de) 2003-12-24 2005-07-21 Boehringer Ingelheim International Gmbh Gefriergetrocknete formulierung von antikörperkonjugaten
EP1647556B1 (en) * 2004-10-14 2010-05-19 Karlsruher Institut für Technologie Peptidic compounds and derivatives thereof for the treatment of human diseases through inhibition of signaling via growth factors
EP2343551B1 (en) 2006-04-10 2014-05-28 Genentech, Inc. Dishevelled PDZ modulators
WO2010072228A1 (en) * 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
ATE523204T1 (de) 2009-02-16 2011-09-15 Karlsruher Inst Technologie Cd44v6-peptide als bakterielle infektionsinhibitoren
US20120045393A1 (en) 2009-03-17 2012-02-23 Linder Karen E Lhrh-ii peptide analogs
EP2266593A1 (en) 2009-06-24 2010-12-29 Karlsruher Institut für Technologie Use of CD44v6 in the treatment of ophthalmic diseases
WO2011022335A1 (en) 2009-08-21 2011-02-24 Mount Sinai School Of Medicine Of New York University Methods of using cd44 fusion proteins to treat cancer
US20120258998A1 (en) 2011-04-05 2012-10-11 Patrick Tan Fusion genes in gastrointestinal cancer
GB201220899D0 (en) * 2012-11-21 2013-01-02 Kit Karlsrusher Inst Fuer Technologie Und Inst Fuer Toxikologie Und Genetik And Amcure Gmbh CD44v6-derived pegylated peptides
GB201220889D0 (en) * 2012-11-21 2013-01-02 Kit Karlsrusher Inst Fuer Technologie Und Inst Fuer Toxikologie Und Genetik And Amcure Gmbh CD44v6-derived peptides for treating metastasizing cancers
GB201220901D0 (en) * 2012-11-21 2013-01-02 Kit Karlsrusher Inst Fuer Technologie Und Inst Fuer Toxikologie Und Genetik And Amcure Gmbh CD44v6-derived peptides for treating pancreatic cancer
AU2014257678A1 (en) * 2013-04-23 2015-10-15 Apeptico Forschung Und Entwicklung Gmbh Lyophilisate containing a cyclic peptide of formula X1-GQRETPEGAEAKPWY-X2

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EA035767B1 (ru) 2020-08-07
WO2016087680A1 (en) 2016-06-09
CN107207578A (zh) 2017-09-26
KR20170086124A (ko) 2017-07-25
US10703796B2 (en) 2020-07-07
JP2018506508A (ja) 2018-03-08
CN107207578B (zh) 2021-10-22
AU2015356997A1 (en) 2017-06-29
MX391474B (es) 2025-03-21
CO2017005566A2 (es) 2017-08-31
EA201791249A1 (ru) 2017-11-30
BR112017011543A2 (pt) 2018-07-10
EP3227322A1 (en) 2017-10-11
SG11201703825UA (en) 2017-07-28
CA2968333A1 (en) 2016-06-09
GB201421647D0 (en) 2015-01-21
PH12017500853A1 (en) 2017-11-06
IL252626B (en) 2022-01-01
JP6952843B2 (ja) 2021-10-27
AU2015356997B2 (en) 2020-06-25
EP3227322B1 (en) 2024-04-10
JP2020183441A (ja) 2020-11-12
PH12017500853B1 (en) 2023-01-11
US20170320930A1 (en) 2017-11-09
IL252626A0 (en) 2017-07-31
MX2017007338A (es) 2018-04-11
US20200283503A1 (en) 2020-09-10

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