MX2017007338A - Péptidos cíclicos derivados de cd44v6 para el tratamiento de enfermedades relacionadas con cánceres y angiogénesis. - Google Patents

Péptidos cíclicos derivados de cd44v6 para el tratamiento de enfermedades relacionadas con cánceres y angiogénesis.

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Publication number
MX2017007338A
MX2017007338A MX2017007338A MX2017007338A MX2017007338A MX 2017007338 A MX2017007338 A MX 2017007338A MX 2017007338 A MX2017007338 A MX 2017007338A MX 2017007338 A MX2017007338 A MX 2017007338A MX 2017007338 A MX2017007338 A MX 2017007338A
Authority
MX
Mexico
Prior art keywords
related diseases
cd44v6
cyclic peptides
treating cancers
angiogenesis related
Prior art date
Application number
MX2017007338A
Other languages
English (en)
Other versions
MX391474B (es
Inventor
Lindner Thomas
Haberkorn Uwe
Mier Walter
Matzke-Ogi Alexandra
Orian-Rousseau Véronique
Original Assignee
Amcure Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52425505&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017007338(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amcure Gmbh filed Critical Amcure Gmbh
Publication of MX2017007338A publication Critical patent/MX2017007338A/es
Publication of MX391474B publication Critical patent/MX391474B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70585—CD44
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)

Abstract

La presente invención se refiere a compuestos, composiciones farmacéuticas y métodos para el tratamiento de diferentes formas de enfermedades relacionadas con el cáncer y angiogénesis usando péptidos cíclicos.
MX2017007338A 2014-12-05 2015-12-07 Péptidos cíclicos derivados de cd44v6 para el tratamiento de enfermedades relacionadas con cánceres y angiogénesis MX391474B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1421647.7A GB201421647D0 (en) 2014-12-05 2014-12-05 CD44v6-derived cyclic peptides for treating cancers and angiogenesis related diseases
PCT/EP2015/078892 WO2016087680A1 (en) 2014-12-05 2015-12-07 Cd44v6-derived cyclic peptides for treating cancers and angiogenesis related diseases

Publications (2)

Publication Number Publication Date
MX2017007338A true MX2017007338A (es) 2018-04-11
MX391474B MX391474B (es) 2025-03-21

Family

ID=52425505

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017007338A MX391474B (es) 2014-12-05 2015-12-07 Péptidos cíclicos derivados de cd44v6 para el tratamiento de enfermedades relacionadas con cánceres y angiogénesis

Country Status (17)

Country Link
US (2) US10703796B2 (es)
EP (1) EP3227322B1 (es)
JP (2) JP2018506508A (es)
KR (1) KR20170086124A (es)
CN (1) CN107207578B (es)
AU (1) AU2015356997B2 (es)
BR (1) BR112017011543A2 (es)
CA (1) CA2968333A1 (es)
CL (1) CL2017001310A1 (es)
CO (1) CO2017005566A2 (es)
EA (1) EA035767B1 (es)
GB (1) GB201421647D0 (es)
IL (1) IL252626B (es)
MX (1) MX391474B (es)
PH (1) PH12017500853B1 (es)
SG (1) SG11201703825UA (es)
WO (1) WO2016087680A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10441654B2 (en) 2014-01-24 2019-10-15 Children's Hospital Of Eastern Ontario Research Institute Inc. SMC combination therapy for the treatment of cancer
SI3102605T1 (sl) 2014-02-04 2019-04-30 Pfizer Inc. Kombinacija PD-1 antagonista in VEGFR inhibitorja za zdravljenje raka
BR112017018234A2 (pt) 2015-02-26 2018-04-17 Merck Patent Gmbh inibidores de pd-1 / pd-l1 para o tratamento de câncer
RU2766890C2 (ru) 2015-06-16 2022-03-16 Мерк Патент Гмбх Комбинированные способы лечения антагонистами pd-l1
WO2018065938A1 (en) 2016-10-06 2018-04-12 Pfizer Inc. Dosing regimen of avelumab for the treatment of cancer
US20190388407A1 (en) * 2017-02-12 2019-12-26 Aiviva Biopharma, Inc. Multikinase inhibitors of vegf and tfg beta and uses thereof
CA3109703C (en) 2018-08-15 2023-10-17 Aiviva Biopharma, Inc. Multi-kinase inhibitors of vegf and tgf beta and uses thereof
CN111053771A (zh) * 2018-10-16 2020-04-24 正大天晴药业集团股份有限公司 用于治疗食道鳞状细胞癌的喹啉类化合物或其药学上可接受的盐

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU656230B2 (en) * 1991-10-11 1995-01-27 F. Hoffmann-La Roche Ag Cyclic vasoactive peptides
US5696229A (en) 1995-03-16 1997-12-09 The University Of Virginia Patent Foundation Polypeptide with laminin cell adhesion and morphogenesis activity
DE19540515C1 (de) 1995-10-31 1997-02-06 Boehringer Ingelheim Int Tumortherapie durch adoptiven Transfer CD44v-spezifischer zytotoxischer T-Lymphozyten
AUPP616498A0 (en) * 1998-09-25 1998-10-15 University Of Queensland, The Synthesis of cyclic peptides
GB9901710D0 (en) 1999-01-26 1999-03-17 Prolifix Ltd Peptide inhibitors
EP1258255A1 (en) 2001-05-18 2002-11-20 Boehringer Ingelheim International GmbH Conjugates of an antibody to CD44 and a maytansinoid
JP2003089700A (ja) 2001-09-18 2003-03-28 Life Science Management:Kk ペプチド
EP1391213A1 (en) 2002-08-21 2004-02-25 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents
EP1417974A1 (en) 2002-11-08 2004-05-12 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and radiotherapy
US20070032415A1 (en) * 2002-12-05 2007-02-08 Macina Roberto A Compositions, splice variants and methods relating to breast specific genes and proteins
US20040121971A1 (en) * 2002-12-20 2004-06-24 Gang Chen Therapeutic use of tumor necrosis factor-alpha mutein
WO2005065709A2 (de) 2003-12-24 2005-07-21 Boehringer Ingelheim International Gmbh Gefriergetrocknete formulierung von antikörperkonjugaten
ATE468350T1 (de) * 2004-10-14 2010-06-15 Karlsruher Inst Technologie Peptidische verbindungen und deren ableitungen für die behandllung von menschlichen krankheiten durch hemmung der signalübertragung über wachstumfaktoren
CN103351425B (zh) 2006-04-10 2016-01-20 健泰科生物技术公司 散乱蛋白pdz调节剂
WO2010072228A1 (en) * 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
EP2218457B1 (en) 2009-02-16 2011-09-07 Karlsruher Institut für Technologie CD44v6 peptides as inhibitors of bacterial infections
US20120045393A1 (en) 2009-03-17 2012-02-23 Linder Karen E Lhrh-ii peptide analogs
EP2266593A1 (en) 2009-06-24 2010-12-29 Karlsruher Institut für Technologie Use of CD44v6 in the treatment of ophthalmic diseases
EP2467491A4 (en) 2009-08-21 2014-04-02 Sinai School Medicine METHOD OF USE OF CD44 FUSION PROTEINS FOR CANCER TREATMENT
US20120258998A1 (en) 2011-04-05 2012-10-11 Patrick Tan Fusion genes in gastrointestinal cancer
GB201220901D0 (en) * 2012-11-21 2013-01-02 Kit Karlsrusher Inst Fuer Technologie Und Inst Fuer Toxikologie Und Genetik And Amcure Gmbh CD44v6-derived peptides for treating pancreatic cancer
GB201220899D0 (en) * 2012-11-21 2013-01-02 Kit Karlsrusher Inst Fuer Technologie Und Inst Fuer Toxikologie Und Genetik And Amcure Gmbh CD44v6-derived pegylated peptides
GB201220889D0 (en) * 2012-11-21 2013-01-02 Kit Karlsrusher Inst Fuer Technologie Und Inst Fuer Toxikologie Und Genetik And Amcure Gmbh CD44v6-derived peptides for treating metastasizing cancers
CN105188734B (zh) * 2013-04-23 2019-03-01 阿佩普蒂科研究和开发有限责任公司 含有式x1-gqretpegaeakpwy-x2的环肽的冻干物

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EP3227322A1 (en) 2017-10-11
AU2015356997B2 (en) 2020-06-25
CA2968333A1 (en) 2016-06-09
IL252626A0 (en) 2017-07-31
IL252626B (en) 2022-01-01
PH12017500853B1 (en) 2023-01-11
EA035767B1 (ru) 2020-08-07
JP2018506508A (ja) 2018-03-08
BR112017011543A2 (pt) 2018-07-10
US10703796B2 (en) 2020-07-07
US20170320930A1 (en) 2017-11-09
MX391474B (es) 2025-03-21
JP6952843B2 (ja) 2021-10-27
CN107207578B (zh) 2021-10-22
SG11201703825UA (en) 2017-07-28
AU2015356997A1 (en) 2017-06-29
US20200283503A1 (en) 2020-09-10
GB201421647D0 (en) 2015-01-21
WO2016087680A1 (en) 2016-06-09
KR20170086124A (ko) 2017-07-25
CL2017001310A1 (es) 2018-02-02
CO2017005566A2 (es) 2017-08-31
CN107207578A (zh) 2017-09-26
EP3227322B1 (en) 2024-04-10
PH12017500853A1 (en) 2017-11-06
EA201791249A1 (ru) 2017-11-30
JP2020183441A (ja) 2020-11-12

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