CL2017001883A1 - Compuestos antisenescentes y usos de los mismos - Google Patents

Compuestos antisenescentes y usos de los mismos

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Publication number
CL2017001883A1
CL2017001883A1 CL2017001883A CL2017001883A CL2017001883A1 CL 2017001883 A1 CL2017001883 A1 CL 2017001883A1 CL 2017001883 A CL2017001883 A CL 2017001883A CL 2017001883 A CL2017001883 A CL 2017001883A CL 2017001883 A1 CL2017001883 A1 CL 2017001883A1
Authority
CL
Chile
Prior art keywords
antisenescent
compounds
treatment
amino acid
amino acids
Prior art date
Application number
CL2017001883A
Other languages
English (en)
Inventor
Keizer Peterus Leonardus Josephus De
Original Assignee
Univ Erasmus Med Ct Rotterdam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Erasmus Med Ct Rotterdam filed Critical Univ Erasmus Med Ct Rotterdam
Publication of CL2017001883A1 publication Critical patent/CL2017001883A1/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)

Abstract

<p>LA INVENCIÓN SE REFIERE A UN PÉPTIDO QUE COMPRENDE LA SECUENCIA DE AMINOÁCIDOS LTLRKEPASEIAQSILEAYSQNGWANRRSGGKPR, EN LA QUE LOS AMINOÁCIDO EN DICHA SECUENCIA DE AMINOÁCIDOS SON RESIDUOS DE D-AMINOÁCIDO, Y A MÉTODOS PARA EL USO DE ESTE PÉPTIDO EN EL TRATAMIENTO DE TRASTORNOS RELACIONADOS CON LA EDAD.</p>
CL2017001883A 2015-01-23 2017-07-21 Compuestos antisenescentes y usos de los mismos CL2017001883A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2014183 2015-01-23
EP15193041 2015-11-04

Publications (1)

Publication Number Publication Date
CL2017001883A1 true CL2017001883A1 (es) 2018-02-02

Family

ID=55642804

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017001883A CL2017001883A1 (es) 2015-01-23 2017-07-21 Compuestos antisenescentes y usos de los mismos

Country Status (13)

Country Link
US (1) US11723947B2 (es)
EP (2) EP3247375B1 (es)
JP (1) JP6707549B2 (es)
CN (1) CN107531768A (es)
AU (1) AU2016209737A1 (es)
BR (1) BR112017015833A2 (es)
CA (1) CA2974623A1 (es)
CL (1) CL2017001883A1 (es)
MX (1) MX2017009595A (es)
PE (1) PE20180128A1 (es)
RU (1) RU2017128116A (es)
SG (1) SG11201706029VA (es)
WO (1) WO2016118014A2 (es)

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CA3087881A1 (en) 2017-01-17 2018-07-26 Michael David FORREST Therapeutic inhibitors of the reverse mode of atp synthase
CA3099077A1 (en) 2017-07-13 2019-01-17 Michael David FORREST Therapeutic modulators of the reverse mode of atp synthase
US20200255489A1 (en) * 2017-10-02 2020-08-13 Eternans Ltd Novel Senolytic Peptides
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WO2020201444A1 (en) * 2019-04-02 2020-10-08 Eternans Ltd Repurposing small molecules for senescence-related diseases and disorders
CN111346101B (zh) * 2019-04-16 2023-01-24 中山大学 Tamatinib在制备治疗胶质瘤的药物中的用途
ES3049051T3 (en) 2019-07-22 2025-12-12 Oneskin Inc Polypeptides having anti-senescent effects and uses thereof
CN114981298B (zh) 2019-12-12 2024-08-20 听治疗有限责任公司 用于预防和治疗听力损失的组合物和方法
CN113144192A (zh) * 2020-01-22 2021-07-23 中国科学院上海营养与健康研究所 Mapk/erk通路抑制剂在拮抗皮肤老化与辐射性皮肤早衰中的应用
US12653862B2 (en) * 2020-02-21 2026-06-16 Cleara Biotech B.v. Anti-senescence compounds and uses thereof
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CN115466321B (zh) * 2022-09-23 2024-03-22 南方医科大学珠江医院 FOXO3a-DRI肽段、其药物组合物及应用
CN116832049A (zh) * 2023-04-18 2023-10-03 复旦大学附属中山医院 一种清除衰老细胞的核酸药物、药物组合物及其制备方法和应用
EP4613274A1 (en) 2024-03-06 2025-09-10 Freie Universität Berlin Senolytic compounds
CN119587553A (zh) * 2024-12-02 2025-03-11 衢州市复大生物医药创新研究院 一种小分子化合物r406在制备防治帕金森病的产品中的应用

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RU2017128116A3 (es) 2019-08-21
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PE20180128A1 (es) 2018-01-18
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US11723947B2 (en) 2023-08-15
EP3247375A2 (en) 2017-11-29
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