CL2019000099A1 - Factor vii de coagulación de larga duración y métodos para producir el mismo. - Google Patents

Factor vii de coagulación de larga duración y métodos para producir el mismo.

Info

Publication number
CL2019000099A1
CL2019000099A1 CL2019000099A CL2019000099A CL2019000099A1 CL 2019000099 A1 CL2019000099 A1 CL 2019000099A1 CL 2019000099 A CL2019000099 A CL 2019000099A CL 2019000099 A CL2019000099 A CL 2019000099A CL 2019000099 A1 CL2019000099 A1 CL 2019000099A1
Authority
CL
Chile
Prior art keywords
methods
coagulation factor
produce
long
factor vii
Prior art date
Application number
CL2019000099A
Other languages
English (en)
Inventor
Oren Hershkovitz
Laura Moschcovich
Original Assignee
Opko Biologics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Opko Biologics Ltd filed Critical Opko Biologics Ltd
Publication of CL2019000099A1 publication Critical patent/CL2019000099A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE DESCRIBEN POLIPÉPTIDOS QUE COMPRENDEN AL MENOS UN PÉPTIDO CARBOXI-TERMINAL (CTP) DE GONADOTROPINA CORIÓNICA UNIDO AL TÉRMINO CARBOXI PERO NO AL TÉRMINO AMINO DE UN FACTOR DE COAGULACIÓN Y POLINUCLEÓTIDOS QUE CODIFICAN EL MISMO. TAMBIÉN SE DESCRIBEN COMPOSICIONES FARMACÉUTICAS Y FORMULACIONES FARMACÉUTICAS QUE COMPRENDEN LOS POLIPÉPTIDOS Y POLINUCLEÓTIDOS DE LA DESCRIPCIÓN Y LOS MÉTODOS DE USO Y PRODUCCIÓN DE LOS MISMOS.
CL2019000099A 2016-07-11 2019-01-11 Factor vii de coagulación de larga duración y métodos para producir el mismo. CL2019000099A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662360767P 2016-07-11 2016-07-11

Publications (1)

Publication Number Publication Date
CL2019000099A1 true CL2019000099A1 (es) 2019-04-12

Family

ID=59656113

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019000099A CL2019000099A1 (es) 2016-07-11 2019-01-11 Factor vii de coagulación de larga duración y métodos para producir el mismo.

Country Status (19)

Country Link
US (2) US11976106B2 (es)
EP (2) EP3481855B1 (es)
JP (1) JP7319187B2 (es)
KR (2) KR102894101B1 (es)
CN (2) CN109563145B (es)
AU (3) AU2017296352A1 (es)
BR (1) BR112019000610A2 (es)
CA (1) CA3030533A1 (es)
CL (1) CL2019000099A1 (es)
EA (1) EA201990255A1 (es)
ES (1) ES2963725T3 (es)
HU (1) HUE064463T2 (es)
IL (2) IL264208B2 (es)
MX (2) MX2019000554A (es)
MY (1) MY206271A (es)
PT (1) PT3481855T (es)
SG (2) SG11201900279UA (es)
TW (2) TW202444744A (es)
WO (1) WO2018011799A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY206271A (en) 2016-07-11 2024-12-06 Opko Biologics Ltd Long-acting coagulation factor vii and methods of producing same
CA3145913A1 (en) * 2019-07-29 2021-02-04 James Everett Dahlman Nanomaterials containing constrained lipids and uses thereof
IL294318A (en) 2020-01-09 2022-08-01 Guide Therapeutics Llc Nanomaterials
CA3260437A1 (en) 2022-07-20 2024-01-25 Beam Therapeutics Inc. NANOMATERIALS INCLUDING TRIOLS

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