CL2017001989A1 - Delayed-release drug formulation. (divisional application 2795-2014) - Google Patents
Delayed-release drug formulation. (divisional application 2795-2014)Info
- Publication number
- CL2017001989A1 CL2017001989A1 CL2017001989A CL2017001989A CL2017001989A1 CL 2017001989 A1 CL2017001989 A1 CL 2017001989A1 CL 2017001989 A CL2017001989 A CL 2017001989A CL 2017001989 A CL2017001989 A CL 2017001989A CL 2017001989 A1 CL2017001989 A1 CL 2017001989A1
- Authority
- CL
- Chile
- Prior art keywords
- polymer material
- polymer
- drug
- core
- delayed
- Prior art date
Links
- 230000003111 delayed effect Effects 0.000 title abstract 3
- 239000013583 drug formulation Substances 0.000 title 1
- 239000002861 polymer material Substances 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 3
- 230000000112 colonic effect Effects 0.000 abstract 2
- 239000012530 fluid Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 210000001072 colon Anatomy 0.000 abstract 1
- 238000001647 drug administration Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 229920000831 ionic polymer Polymers 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
<p>LA LIBERACIÓN RETARDADA DE UN FÁRMACO AL COLON SE LOGRA DE UNA FORMULACIÓN DE LIBERACIÓN RETARDADA QUE COMPRENDE UN NÚCLEO Y UN RECUBRIMIENTO PARA EL NÚCLEO. EL NÚCLEO COMPRENDE UN FÁRMACO Y UN RECUBRIMIENTO QUE COMPRENDE UNA CAPA INTERIOR Y UNA CAPA EXTERIOR. LA CAPA EXTERIOR COMPRENDE UNA MEZCLA DE UN PRIMER MATERIAL POLIMÉRICO QUE ES SUSCEPTIBLE A ATAQUES POR PARTE DE LA BACTERIA COLÓNICA, Y UN SEGUNDO MATERIAL POLIMÉRICO QUE TIENE UN UMBRAL DE PH A APROXIMADAMENTE PH 5 O MÁS ALTO. LA CAPA INTERIOR COMPRENDE UN TERCER MATERIAL POLIMÉRICO QUE ES SOLUBLE EN EL FLUIDO INTESTINAL O EN EL FLUIDO GASTROINTESTINAL, TAL TERCER MATERIAL POLIMÉRICO SE SELECCIONA DE ÁCIDO POLICARBOXÍLICO AL MENOS PARCIALMENTE NEUTRALIZADO Y UN POLÍMERO NO IÓNICO. EN MODALIDADES EN DONDE EL TERCER MATERIAL POLIMÉRICO ES UN POLÍMERO NO IÓNICO, LA CAPA INTERIOR COMPRENDE AL MENOS UN AGENTE AMORTIGUADOR Y UNA BASE. LAS VENTAJAS DE LAS FORMULACIONES DE ACUERDO CON LA PRESENTE INVENCIÓN INCLUYEN LA LIBERACIÓN ACELERADA DEL FÁRMACO CUANDO SE EXPONE A CONDICIONES COLÓNICAS Y LA REDUCCIÓN O ELIMINACIÓN DEL EFECTO DE LOS ALIMENTOS Y/O ALCOHOL EN LA LIBERACIÓN DEL FÁRMACO DESPUÉS DE LA ADMINISTRACIÓN.</p><p> THE DELAYED RELEASE OF A DRUG TO THE COLON IS ACHIEVED BY A FORMATION OF DELAYED RELEASE THAT INCLUDES A CORE AND A COVER FOR THE CORE. THE CORE INCLUDES A DRUG AND COVERING THAT INCLUDES AN INNER LAYER AND AN OUTER LAYER. THE OUTER LAYER INCLUDES A MIXTURE OF A FIRST POLYMER MATERIAL THAT IS SUSCEPTIBLE TO ATTACKS BY THE COLONIC BACTERIA, AND A SECOND POLYMER MATERIAL THAT HAS A THRESHOLD OF PH TO APPROXIMATELY PH 5 OR HIGHER. THE INNER LAYER INCLUDES A THIRD POLYMER MATERIAL THAT IS SOLUBLE IN THE INTESTINAL FLUID OR IN THE GASTROINTESTINAL FLUID, SUCH THIRD POLYMER MATERIAL IS SELECTED FROM POLYCARBOXYLIC ACID AT LEAST PARTIALLY NEUTRALIZED AND A NON-POLYMER POLYMER. IN MODALITIES WHERE THE THIRD POLYMER MATERIAL IS A NON-IONIC POLYMER, THE INNER LAYER INCLUDES AT LEAST A SHOCK AGENT AND A BASE. THE ADVANTAGES OF THE FORMULATIONS IN ACCORDANCE WITH THE PRESENT INVENTION INCLUDE THE ACCELERATED RELEASE OF THE DRUG WHEN IT IS EXPOSED TO COLONIC CONDITIONS AND THE REDUCTION OR ELIMINATION OF THE EFFECT OF THE FOODS AND / OR ALCOHOL IN THE RELEASE OF THE DRUG ADMINISTRATION. >
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261640217P | 2012-04-30 | 2012-04-30 | |
| EP12166110.2A EP2659881B1 (en) | 2012-04-30 | 2012-04-30 | A delayed release drug formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2017001989A1 true CL2017001989A1 (en) | 2018-03-16 |
Family
ID=54196716
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017001989A CL2017001989A1 (en) | 2012-04-30 | 2017-08-03 | Delayed-release drug formulation. (divisional application 2795-2014) |
| CL2017001990A CL2017001990A1 (en) | 2012-04-30 | 2017-08-03 | Delayed-release drug formulation (divisional application 2796-2014) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017001990A CL2017001990A1 (en) | 2012-04-30 | 2017-08-03 | Delayed-release drug formulation (divisional application 2796-2014) |
Country Status (10)
| Country | Link |
|---|---|
| JP (2) | JP6700220B2 (en) |
| CL (2) | CL2017001989A1 (en) |
| CU (2) | CU24343B1 (en) |
| CY (1) | CY1121470T1 (en) |
| EC (2) | ECSP14028077A (en) |
| HK (1) | HK1244435B (en) |
| HR (3) | HRP20190470T1 (en) |
| IL (2) | IL235282A (en) |
| PH (3) | PH12017502369A1 (en) |
| ZA (1) | ZA201407675B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3662900A1 (en) * | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Colonic drug delivery formulation |
| EP3662902B1 (en) * | 2018-12-07 | 2024-07-31 | Tillotts Pharma AG | Colonic drug delivery formulation |
| ES3002632T3 (en) | 2018-12-07 | 2025-03-07 | Tillotts Pharma Ag | Delayed release drug formulation comprising an outerlayer with an enzymatically degradable polymer, its composition and its method of manufacturing |
| CN113493220A (en) * | 2020-04-02 | 2021-10-12 | 杨洋 | Hollow metal oxide microsphere, preparation method thereof and drug sustained-release application |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5422121A (en) * | 1990-11-14 | 1995-06-06 | Rohm Gmbh | Oral dosage unit form |
| PL2152250T3 (en) * | 2007-05-07 | 2020-06-15 | Evonik Röhm Gmbh | Solid dosage forms comprising an enteric coating with accelerated drug release |
| SI2659881T1 (en) * | 2012-04-30 | 2018-03-30 | Tillotts Pharma Ag | A delayed release drug formulation |
-
2013
- 2013-04-29 CU CUP2016000026A patent/CU24343B1/en unknown
- 2013-04-29 HR HRP20190470TT patent/HRP20190470T1/en unknown
- 2013-04-29 HR HRP20192210TT patent/HRP20192210T1/en unknown
- 2013-04-29 CU CUP2016000014A patent/CU24342B1/en unknown
-
2014
- 2014-10-22 IL IL235282A patent/IL235282A/en active IP Right Grant
- 2014-10-22 IL IL235283A patent/IL235283A/en active IP Right Grant
- 2014-10-22 ZA ZA2014/07675A patent/ZA201407675B/en unknown
- 2014-11-25 EC ECIEPI201428077A patent/ECSP14028077A/en unknown
- 2014-11-25 EC ECIEPI201428079A patent/ECSP14028079A/en unknown
-
2015
- 2015-03-19 HK HK18103919.2A patent/HK1244435B/en not_active IP Right Cessation
-
2017
- 2017-06-06 JP JP2017112044A patent/JP6700220B2/en not_active Expired - Fee Related
- 2017-06-06 JP JP2017112035A patent/JP6626470B2/en active Active
- 2017-08-03 CL CL2017001989A patent/CL2017001989A1/en unknown
- 2017-08-03 CL CL2017001990A patent/CL2017001990A1/en unknown
- 2017-12-20 PH PH12017502369A patent/PH12017502369A1/en unknown
-
2018
- 2018-02-12 PH PH12018500304A patent/PH12018500304B1/en unknown
- 2018-06-19 PH PH12018501311A patent/PH12018501311A1/en unknown
-
2019
- 2019-03-15 CY CY20191100312T patent/CY1121470T1/en unknown
- 2019-04-17 HR HRP20190727TT patent/HRP20190727T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL235283A (en) | 2017-09-28 |
| HRP20190727T1 (en) | 2019-06-14 |
| CY1121470T1 (en) | 2020-05-29 |
| JP6626470B2 (en) | 2019-12-25 |
| CU20160014A7 (en) | 2016-04-25 |
| CU24342B1 (en) | 2018-05-08 |
| JP6700220B2 (en) | 2020-05-27 |
| PH12018501311A1 (en) | 2020-09-14 |
| HK1202266A1 (en) | 2015-09-25 |
| PH12017502369A1 (en) | 2020-09-28 |
| PH12018500304A1 (en) | 2018-09-24 |
| ECSP14028079A (en) | 2015-12-31 |
| JP2017145268A (en) | 2017-08-24 |
| CU20160026A7 (en) | 2016-05-30 |
| ZA201407675B (en) | 2016-05-25 |
| HRP20192210T1 (en) | 2020-02-21 |
| CL2017001990A1 (en) | 2018-03-16 |
| HRP20190470T1 (en) | 2019-05-17 |
| HK1244435B (en) | 2019-10-25 |
| PH12018500304B1 (en) | 2018-09-24 |
| ECSP14028077A (en) | 2015-12-31 |
| CU24343B1 (en) | 2018-05-08 |
| JP2017145267A (en) | 2017-08-24 |
| HK1202267A1 (en) | 2015-09-25 |
| IL235282A (en) | 2017-09-28 |
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