CU20140124A7 - FORMULATION OF DELAYED RELEASE DRUG - Google Patents
FORMULATION OF DELAYED RELEASE DRUGInfo
- Publication number
- CU20140124A7 CU20140124A7 CU2014000124A CU20140124A CU20140124A7 CU 20140124 A7 CU20140124 A7 CU 20140124A7 CU 2014000124 A CU2014000124 A CU 2014000124A CU 20140124 A CU20140124 A CU 20140124A CU 20140124 A7 CU20140124 A7 CU 20140124A7
- Authority
- CU
- Cuba
- Prior art keywords
- polymeric material
- drug
- delayed release
- core
- inner layer
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 5
- 229940079593 drug Drugs 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 4
- 230000003111 delayed effect Effects 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title abstract 3
- 239000000463 material Substances 0.000 abstract 5
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 230000000112 colonic effect Effects 0.000 abstract 2
- 239000012530 fluid Substances 0.000 abstract 2
- 229920000831 ionic polymer Polymers 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000006172 buffering agent Substances 0.000 abstract 1
- 210000001072 colon Anatomy 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 230000009246 food effect Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
La liberación retardada de un fármaco al colon se logra de una formulación de liberación retardada que comprende un núcleo y un recubrimiento para el núcleo. El núcleo comprende un fármaco y un recubrimiento que comprende una capa interior y una capa exterior. La capa exterior comprende una mezcla de un primer material polimérico que es susceptible a ataques por parte de la bacteria colónica, y un segundo material polimérico que tiene un umbral de pH a aproximadamente pH 5 o más alto. La capa interior comprende un tercer material polimérico que es soluble en el fluido intestinal o en el fluido gastrointestinal, tal tercer material polimérico se selecciona de ácido policarboxílico al menos parcialmente neutralizado y un polímero no iónico. En modalidades en donde el tercer material polimérico es un polímero no iónico, la capa interior comprende al menos un agente amortiguador y una base. Las ventajas de las formulaciones de acuerdo con la presente invención incluyen la liberación acelerada del fármaco cuando se expone a condiciones colónicas y la reducción o eliminación del efecto de los alimentos y/o alcohol en la liberación del fármaco después de la administración.Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and a coating comprising an inner layer and an outer layer. The outer layer comprises a mixture of a first polymeric material that is susceptible to attacks by the colonic bacteria, and a second polymeric material that has a pH threshold at about pH 5 or higher. The inner layer comprises a third polymeric material that is soluble in the intestinal fluid or in the gastrointestinal fluid, such a third polymeric material is selected from at least partially neutralized polycarboxylic acid and a non-ionic polymer. In embodiments where the third polymeric material is a non-ionic polymer, the inner layer comprises at least one buffering agent and a base. Advantages of the formulations according to the present invention include accelerated drug release when exposed to colonic conditions and the reduction or elimination of the effect of food and / or alcohol on drug release after administration.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261640217P | 2012-04-30 | 2012-04-30 | |
| EP12166110.2A EP2659881B1 (en) | 2012-04-30 | 2012-04-30 | A delayed release drug formulation |
| PCT/EP2013/058921 WO2013164315A1 (en) | 2012-04-30 | 2013-04-29 | A delayed release drug formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20140124A7 true CU20140124A7 (en) | 2015-02-26 |
| CU24302B1 CU24302B1 (en) | 2017-12-08 |
Family
ID=53365656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CUP2014000124A CU24302B1 (en) | 2012-04-30 | 2013-04-29 | FORMULATION OF DELAYED RELEASE DRUG |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU24302B1 (en) |
-
2013
- 2013-04-29 CU CUP2014000124A patent/CU24302B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CU24302B1 (en) | 2017-12-08 |
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