CL2017002050A1 - Uso de plinabulina en combinación con inhibidores de punto de control inmunitario - Google Patents

Uso de plinabulina en combinación con inhibidores de punto de control inmunitario

Info

Publication number
CL2017002050A1
CL2017002050A1 CL2017002050A CL2017002050A CL2017002050A1 CL 2017002050 A1 CL2017002050 A1 CL 2017002050A1 CL 2017002050 A CL2017002050 A CL 2017002050A CL 2017002050 A CL2017002050 A CL 2017002050A CL 2017002050 A1 CL2017002050 A1 CL 2017002050A1
Authority
CL
Chile
Prior art keywords
plinabulin
control point
point inhibitors
combination
immune control
Prior art date
Application number
CL2017002050A
Other languages
English (en)
Inventor
Lan Huang
Gloria Tsi-Yie Lee
Original Assignee
Beyondspring Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beyondspring Pharmaceuticals Inc filed Critical Beyondspring Pharmaceuticals Inc
Publication of CL2017002050A1 publication Critical patent/CL2017002050A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

<p>SE DESCRIBEN EN LA PRESENTE COMPOSICIONES QUE COMPRENDEN PLINABULINA Y UNO O MÁS INHIBIDORES DE PUNTO DE CONTROL INMUNITARIO PARA TRATAR CÁNCER. ALGUNAS MODALIDADES SE REFIEREN A MÉTODOS PARA TRATAR CÁNCER AL CO-ADMINISTRAR PLINABULINA Y UNO O MÁS INHIBIDORES DE PUNTO DE CONTROL INMUNITARIO A UN SUJETO EN NECESIDAD DEL MISMO.</p>
CL2017002050A 2015-02-12 2017-08-10 Uso de plinabulina en combinación con inhibidores de punto de control inmunitario CL2017002050A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562115468P 2015-02-12 2015-02-12
US201562255259P 2015-11-13 2015-11-13

Publications (1)

Publication Number Publication Date
CL2017002050A1 true CL2017002050A1 (es) 2018-04-13

Family

ID=56615698

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017002050A CL2017002050A1 (es) 2015-02-12 2017-08-10 Uso de plinabulina en combinación con inhibidores de punto de control inmunitario

Country Status (16)

Country Link
US (1) US20180028531A1 (es)
EP (1) EP3256130A4 (es)
JP (4) JP7243021B2 (es)
KR (2) KR20240110996A (es)
CN (2) CN107427510A (es)
AU (3) AU2016219204B2 (es)
CA (1) CA2975729A1 (es)
CL (1) CL2017002050A1 (es)
HK (1) HK1247816A1 (es)
IL (2) IL286282B2 (es)
MX (2) MX394865B (es)
MY (1) MY193968A (es)
NZ (1) NZ734256A (es)
RU (1) RU2723021C2 (es)
SG (1) SG11201706281YA (es)
WO (1) WO2016130839A1 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5551683B2 (ja) 2009-03-30 2014-07-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 リポソーム組成物
US10441654B2 (en) 2014-01-24 2019-10-15 Children's Hospital Of Eastern Ontario Research Institute Inc. SMC combination therapy for the treatment of cancer
AU2016229294B2 (en) 2015-03-06 2021-11-04 Beyondspring Pharmaceuticals, Inc. Method of treating cancer associated with a RAS mutation
HK1249051A1 (zh) 2015-03-06 2018-10-26 BeyondSpring Pharmaceuticals Inc. 治疗脑肿瘤的方法
AU2016275574B2 (en) * 2015-06-11 2019-07-11 Bionomics Limited Pharmaceutical combination and uses thereof
US10155748B2 (en) 2015-07-13 2018-12-18 Beyondspring Pharmaceuticals, Inc. Plinabulin compositions
CA3013467A1 (en) 2016-02-08 2017-08-17 Beyondspring Pharmaceuticals, Inc. Compositions containing tucaresol or its analogs
EP3449921B1 (en) 2016-04-28 2023-05-31 Eisai R&D Management Co., Ltd. Eribulin for inhibiting tumor growth
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
RU2760348C2 (ru) 2016-06-06 2021-11-24 Бейондспринг Фармасьютикалс, Инк. Способ уменьшения нейтропении
US11382953B2 (en) 2016-08-26 2022-07-12 Tetsuji Okuno Microvascular blood flow decreasing agent and use thereof
CN110072552A (zh) * 2016-10-14 2019-07-30 默沙东公司 用于治疗尿路上皮癌的pd-1拮抗剂和艾立布林的组合
WO2018129381A1 (en) 2017-01-06 2018-07-12 Beyondspring Pharmaceuticals, Inc. Tubulin binding compounds and therapeutic use thereof
WO2018144764A1 (en) 2017-02-01 2018-08-09 Beyondspring Pharmaceuticals, Inc. Method of reducing neutropenia
KR102659907B1 (ko) * 2017-03-13 2024-04-24 비욘드스프링 파마수티컬스, 인코포레이티드. 플리나불린 조성물 및 그의 용도
BR112020001188A2 (pt) * 2017-07-26 2020-07-28 Chong Kun Dang Pharmaceutical Corp. composição para prevenir ou tratar câncer que compreende um agente de disrupção vascular e inibidor de ponto de verificação imunológico
US12109215B2 (en) 2017-09-08 2024-10-08 University Health Network Combination therapies for inhibition of polo-like kinase 4
CN109498627B (zh) * 2017-09-15 2021-06-04 深圳华大海洋科技有限公司 一种治疗肿瘤的药物组合物及其应用
SG11202006985TA (en) 2018-01-24 2020-08-28 Beyondspring Pharmaceuticals Inc Composition and method for reducing thrombocytopenia via the administration of plinabulin
KR102790127B1 (ko) * 2018-06-01 2025-04-03 비욘드스프링 파마수티컬스, 인코포레이티드. Egfr 돌연변이와 관련된 암을 치료하는 조성물 및 방법
CN108524442B (zh) * 2018-06-05 2022-01-28 深圳海王医药科技研究院有限公司 一种抗肿瘤药物的注射剂及其制备方法
JP2021534183A (ja) * 2018-08-16 2021-12-09 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド 免疫応答を刺激するための方法及び組成物
US20210369787A1 (en) * 2018-11-01 2021-12-02 North Carolina State University Adipocyte mediated delivery of anticancer therapeutics
CN110265095A (zh) * 2019-05-22 2019-09-20 首都医科大学附属北京佑安医院 用于hcc复发及rfs的预测模型和诺模图的构建方法及应用
US12036204B2 (en) 2019-07-26 2024-07-16 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
CN112778155B (zh) * 2019-11-11 2023-08-11 大连万春布林医药有限公司 妥卡雷琐衍生物及其用途
CN113891714A (zh) * 2020-05-04 2022-01-04 大连万春布林医药有限公司 增强低免疫原性癌症中癌细胞杀伤的三联疗法
WO2022133492A1 (en) * 2020-12-18 2022-06-23 Beyondspring Pharmaceuticals, Inc. Compositions and methods for generating anti-tumor immune response
US20240197723A1 (en) 2021-04-09 2024-06-20 Beyondspring Pharmaceuticals, Inc. Therapeutic compositions and methods for treating tumors
CN113456643B (zh) * 2021-08-11 2022-04-01 遵义医科大学 一种含普那布林的药物组合及其应用
CN117860672A (zh) 2022-10-11 2024-04-12 大连万春布林医药有限公司 一种普那布林胶束组合物及其制备方法
JP2026509292A (ja) * 2023-03-10 2026-03-17 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド 腫瘍学的併用療法及びその使用方法
WO2025006507A1 (en) * 2023-06-27 2025-01-02 Beyondspring Pharmaceuticals, Inc. Oncology combination therapy and methods of use

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0313363A (pt) * 2002-08-02 2005-08-09 Nereus Pharmaceuticals Inc Deidrofenilahistinas e seus análogos, e sua sìntese
BRPI0506655A (pt) * 2004-02-04 2007-05-08 Nereus Pharmaceuticals Inc dehidrofenilahistinas e seus análogos, e sìntese de dehidrofenilahistinas e seus análogos
CN103059138B (zh) * 2005-05-09 2015-10-28 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
US8569262B2 (en) * 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
KR20100100949A (ko) * 2008-01-08 2010-09-15 브리스톨-마이어스 스큅 컴퍼니 증식성 질환의 치료를 위한 튜불린 조정제와 항-ｃｔｌａ４ 항체의 조합물
JP2012505920A (ja) * 2008-10-17 2012-03-08 エグゼリクシス， インコーポレイテッド スフィンゴシン１リン酸塩受容体拮抗薬
MX342709B (es) * 2009-09-15 2016-10-10 Cerulean Pharma Inc Tratamiento contra el cancer.
EP2571577A1 (en) * 2010-05-17 2013-03-27 Bristol-Myers Squibb Company Improved immunotherapeutic dosing regimens and combinations thereof
WO2012035436A1 (en) * 2010-09-15 2012-03-22 Tokyo University Of Pharmacy And Life Sciences Plinabulin prodrug analogs and therapeutic uses thereof
WO2013090552A1 (en) * 2011-12-13 2013-06-20 Yale University Compositions and methods for reducing ctl exhaustion
EP3981791A1 (en) * 2012-08-30 2022-04-13 Amgen Inc. A method for treating melanoma using a herpes simplex virus and an immune checkpoint inhibitor
CA2889182A1 (en) * 2012-10-26 2014-05-01 The University Of Chicago Synergistic combination of immunologic inhibitors for the treatment of cancer
AU2014218976B2 (en) * 2013-02-20 2018-11-15 Novartis Ag Treatment of cancer using humanized anti-EGFRvIII chimeric antigen receptor
EP2958571B1 (en) * 2013-02-21 2024-04-10 Michele Maio Dna hypomethylating agents for cancer therapy
US10260038B2 (en) * 2013-05-10 2019-04-16 Whitehead Institute For Biomedical Research Protein modification of living cells using sortase
CA2909052A1 (en) * 2013-06-03 2014-12-11 Novartis Ag Combinations of an anti-pd-l1 antibody and a mek inhibitor and/or a braf inhibitor
ES2902665T3 (es) * 2013-10-11 2022-03-29 Beyondspring Inc Tratamiento del cáncer con combinación de plinabulina y taxano
CA3013467A1 (en) * 2016-02-08 2017-08-17 Beyondspring Pharmaceuticals, Inc. Compositions containing tucaresol or its analogs

Also Published As

Publication number Publication date
RU2017127966A3 (es) 2019-06-20
IL286282A (en) 2021-10-31
KR20240110996A (ko) 2024-07-16
MX2017010338A (es) 2017-12-20
IL253784A0 (en) 2017-09-28
MX2022007472A (es) 2022-06-29
AU2024200672B2 (en) 2026-03-05
US20180028531A1 (en) 2018-02-01
IL286282B1 (en) 2023-06-01
HK1247816A1 (zh) 2018-10-05
JP2021050247A (ja) 2021-04-01
JP2024174070A (ja) 2024-12-13
JP2018508572A (ja) 2018-03-29
NZ734256A (en) 2019-02-22
AU2016219204A1 (en) 2017-08-24
MX394865B (es) 2025-03-24
JP2022190005A (ja) 2022-12-22
NZ750444A (en) 2021-03-26
KR20170117113A (ko) 2017-10-20
EP3256130A4 (en) 2018-08-01
CA2975729A1 (en) 2016-08-18
AU2024200672A1 (en) 2024-02-22
IL286282B2 (en) 2023-10-01
AU2021202416A1 (en) 2021-05-20
RU2723021C2 (ru) 2020-06-08
JP7243021B2 (ja) 2023-03-22
JP7157181B2 (ja) 2022-10-19
BR112017016902A2 (pt) 2018-03-27
AU2021202416B2 (en) 2024-02-15
WO2016130839A1 (en) 2016-08-18
CN117100753A (zh) 2023-11-24
CN107427510A (zh) 2017-12-01
AU2016219204B2 (en) 2021-01-21
MY193968A (en) 2022-11-03
IL253784B (en) 2021-09-30
EP3256130A1 (en) 2017-12-20
JP7564172B2 (ja) 2024-10-08
RU2017127966A (ru) 2019-03-12
SG11201706281YA (en) 2017-09-28

Similar Documents

Publication Publication Date Title
CL2017002050A1 (es) Uso de plinabulina en combinación con inhibidores de punto de control inmunitario
ZA202502076B (en) Chimeric neurotoxins
PH12020550781A1 (en) Anti-jagged1 antibodies and methods of use
CL2016001609A1 (es) Composiciones farmacéuticas que comprenden azd9291.
MX2022010805A (es) Metodo para reducir la neutropenia.
PH12017500877A1 (en) ANTI-CD79b ANTIBODIES AND METHODS OF USE
CL2016002772A1 (es) Composiciones de insulina de rápida acción
MX374788B (es) Anticuerpos anti-tim3 y metodos de uso.
BR112016017112A2 (pt) Composições de apilimod e métodos de uso das mesmas
MX2016014247A (es) Conjugados de anticuerpo-farmaco anti-proteina tirosina quinasa 7 (anti-ptk7).
MX2021013837A (es) Enfoque de inmunoterapias de combinacion para el tratamiento del cancer.
MX2017012380A (es) Derivados de maitansinoide, conjugados de los mismos, y metodos de uso.
BR112017000456A2 (pt) composições antivirais tópicas e métodos de uso das mesmas
MX2018000715A (es) Metodos para tratar cancer usando apilimod.
MX2017006015A (es) Composiciones para usar en el tratamiento de cancer renal.
TR201901062T4 (tr) Modifiye meningokokal fhbp polipeptidleri.
BR112017009792A2 (pt) anticorpos anti-pdgf-b e métodos de uso
BR112017009265A2 (pt) apilimode para uso no tratamento do câncer colorretal
CL2016002223A1 (es) Microorganismo recombinante que expresa análogos de avermectina y uso de los mismos.
AU358035S (en) Valve
AU356694S (en) Remote control
MX2017012553A (es) Compuestos espirociclicos.
BR112017011685A2 (pt) composições compreendendo 15-hepe e métodos de tratamento ou prevenção da fibrose usando as mesmas
MX379126B (es) Formulación de factor viii.
PH12016501838A1 (en) Compounds and their methods of use