CL2017002199A1 - Vectores retrovirales a lentivirales - Google Patents

Vectores retrovirales a lentivirales

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Publication number
CL2017002199A1
CL2017002199A1 CL2017002199A CL2017002199A CL2017002199A1 CL 2017002199 A1 CL2017002199 A1 CL 2017002199A1 CL 2017002199 A CL2017002199 A CL 2017002199A CL 2017002199 A CL2017002199 A CL 2017002199A CL 2017002199 A1 CL2017002199 A1 CL 2017002199A1
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CL
Chile
Prior art keywords
transmembrane
cell activating
mitogenic
protein
domain
Prior art date
Application number
CL2017002199A
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English (en)
Inventor
Martin Pulé
Leila Mekkaoui
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Ucl Business Plc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52876362&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017002199(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ucl Business Plc filed Critical Ucl Business Plc
Publication of CL2017002199A1 publication Critical patent/CL2017002199A1/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C12N2740/10011—Retroviridae
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    • C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
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    • C12N2810/859—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian from immunoglobulins

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Abstract

<p>La presente invención proporciona un vector retroviral o lentiviral que tiene una envoltura viral que comprende: (i) una proteína transmembranal mitogénica activadora de células T que comprende un dominio mitogénico y un dominio transmembranal; y/o (ii) una proteína transmembranal basada en citocinas activadora de células T que comprende un dominio de citocina y un dominio transmembranal, en donde la proteína transmembranal mitogénica o basada en citocinas activadora de células T no forma parte de una glucoproteína de envoltura viral. Cuando células tales como células T o células asesinas naturales, se transducen por un vector viral, éstas se activan en forma simultánea por la proteína transmembranal mitogénica activadora de células T y/o la proteína transmembranal basada en citocinas activadora de células T.</p>
CL2017002199A 2015-03-02 2017-08-30 Vectores retrovirales a lentivirales CL2017002199A1 (es)

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GB201503500A GB201503500D0 (en) 2015-03-02 2015-03-02 Cell

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CL2017002199A1 true CL2017002199A1 (es) 2018-03-16

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US (3) US10954530B2 (es)
EP (2) EP3265570B2 (es)
JP (4) JP6695347B2 (es)
KR (1) KR20180002602A (es)
CN (1) CN107406860A (es)
AU (1) AU2016227474A1 (es)
BR (1) BR112017018251A2 (es)
CA (1) CA2977472A1 (es)
CL (1) CL2017002199A1 (es)
ES (1) ES2877398T5 (es)
GB (1) GB201503500D0 (es)
IL (1) IL253820B (es)
MX (1) MX2017010553A (es)
RU (1) RU2017133854A (es)
SG (1) SG11201706721PA (es)
WO (1) WO2016139463A1 (es)

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