CL2018000587A1 - Adenovirus oncolítico que codifica una proteína b7 (divisional de sol. n° 2731-2017) - Google Patents

Adenovirus oncolítico que codifica una proteína b7 (divisional de sol. n° 2731-2017)

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Publication number
CL2018000587A1
CL2018000587A1 CL2018000587A CL2018000587A CL2018000587A1 CL 2018000587 A1 CL2018000587 A1 CL 2018000587A1 CL 2018000587 A CL2018000587 A CL 2018000587A CL 2018000587 A CL2018000587 A CL 2018000587A CL 2018000587 A1 CL2018000587 A1 CL 2018000587A1
Authority
CL
Chile
Prior art keywords
protein
oncolytic adenovirus
virus
divisional
adenovirus encoding
Prior art date
Application number
CL2018000587A
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English (en)
Inventor
Alice Claire Noel Bromley
Brian Robert Champion
Original Assignee
Psioxus Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1507419.8A external-priority patent/GB201507419D0/en
Priority claimed from GBGB1516936.0A external-priority patent/GB201516936D0/en
Priority claimed from GBGB1522013.0A external-priority patent/GB201522013D0/en
Application filed by Psioxus Therapeutics Ltd filed Critical Psioxus Therapeutics Ltd
Publication of CL2018000587A1 publication Critical patent/CL2018000587A1/es

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    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
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    • C12N2710/10371—Demonstrated in vivo effect

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Abstract

La presente invención se refiere a un adenovirus oncolítico de replicación competente con selectividad para células cancerosas, en donde el adenovirus comprende un transgen bajo el control de un promotor endógeno al virus, en donde el transgen comprende una secuencia de ADN que codifica una proteína B7 o un fragmento activo de la misma, composiciones que comprenden los mismos, métodos para generar el virus, y uso del virus y composiciones en el tratamiento, particularmente en el tratamiento de cáncer. (DIVISIONAL 2731-2017)
CL2018000587A 2015-04-30 2018-03-05 Adenovirus oncolítico que codifica una proteína b7 (divisional de sol. n° 2731-2017) CL2018000587A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1507419.8A GB201507419D0 (en) 2015-04-30 2015-04-30 Virus
GBGB1516936.0A GB201516936D0 (en) 2015-09-24 2015-09-24 Virus
GBGB1522013.0A GB201522013D0 (en) 2015-12-14 2015-12-14 Virus

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CL2018000587A1 true CL2018000587A1 (es) 2018-08-10

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CL2017002731A CL2017002731A1 (es) 2015-04-30 2017-10-26 Adenovirus oncolítico que codifica una proteína b7
CL2018000587A CL2018000587A1 (es) 2015-04-30 2018-03-05 Adenovirus oncolítico que codifica una proteína b7 (divisional de sol. n° 2731-2017)

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CL2017002731A CL2017002731A1 (es) 2015-04-30 2017-10-26 Adenovirus oncolítico que codifica una proteína b7

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US (6) US11000559B2 (es)
EP (2) EP3288573B1 (es)
JP (3) JP6931229B2 (es)
KR (4) KR20250134212A (es)
CN (2) CN108396015B (es)
AU (3) AU2016256582B2 (es)
BR (2) BR112017023171A2 (es)
CA (1) CA2984038C (es)
CL (2) CL2017002731A1 (es)
CO (1) CO2017010831A2 (es)
CY (1) CY1122833T1 (es)
DK (1) DK3288573T3 (es)
EA (1) EA037611B1 (es)
ES (1) ES2780366T3 (es)
HR (1) HRP20200439T1 (es)
HU (1) HUE048320T2 (es)
IL (3) IL284375B (es)
LT (1) LT3288573T (es)
MX (1) MX2017013684A (es)
MY (1) MY183703A (es)
PE (2) PE20180241A1 (es)
PH (1) PH12017501942A1 (es)
PL (1) PL3288573T3 (es)
PT (1) PT3288573T (es)
RS (1) RS60105B1 (es)
SA (2) SA517390260B1 (es)
SG (3) SG11201708604TA (es)
SI (1) SI3288573T1 (es)
SM (1) SMT202000222T1 (es)
WO (1) WO2016174200A1 (es)
ZA (1) ZA201801589B (es)

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