CL2017003351A1 - Anticuerpo anti receptor de transferrina humana que pasan a través de la barrera hematoencefálica. - Google Patents

Anticuerpo anti receptor de transferrina humana que pasan a través de la barrera hematoencefálica.

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Publication number
CL2017003351A1
CL2017003351A1 CL2017003351A CL2017003351A CL2017003351A1 CL 2017003351 A1 CL2017003351 A1 CL 2017003351A1 CL 2017003351 A CL2017003351 A CL 2017003351A CL 2017003351 A CL2017003351 A CL 2017003351A CL 2017003351 A1 CL2017003351 A1 CL 2017003351A1
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CL
Chile
Prior art keywords
blood
passes
brain barrier
receptor antibody
transferrin receptor
Prior art date
Application number
CL2017003351A
Other languages
English (en)
Inventor
Hiroyuki Sonoda
Kenichi Takahashi
Original Assignee
Japan Chem Res
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Application filed by Japan Chem Res filed Critical Japan Chem Res
Publication of CL2017003351A1 publication Critical patent/CL2017003351A1/es

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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2881—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
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Abstract

<p>SE DIVULGAN MEDIOS PARA CONVERTIR COMPUESTOS QUE TIENEN ACTIVIDAD FISIOLÓGICA O FARMACOLÓGICA Y QUE NO PUEDEN PASAR A TRAVÉS DE LA BARRERA HEMATOENCEFÁLICA EN UNA FORMA QUE LES PERMITA PASAR A TRAVÉS DE LA BARRERA HEMATOENCEFÁLICA, Y LOS COMPUESTOS CONVERTIDOS MEDIANTE ELLOS. EL MEDIO ES UN ANTICUERPO ANTI-RECEPTOR DE TRANSFERRINA HUMANA Y LOS COMPUESTOS CONVERTIDOS SON CONJUGADOS MOLECULARES ENTRE PROTEÍNA FISIOLÓGICAMENTE ACTIVA O COMPUESTOS FARMACOLÓGICAMENTE ACTIVOS DE BAJO PESO MOLECULAR Y UN ANTICUERPO ANTI-RECEPTOR DE TRANSFERRINA HUMANA.</p>
CL2017003351A 2015-06-24 2017-12-22 Anticuerpo anti receptor de transferrina humana que pasan a través de la barrera hematoencefálica. CL2017003351A1 (es)

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CL2018003680A CL2018003680A1 (es) 2015-06-24 2018-12-18 Anticuerpo del receptor de transferencia anti-humano que permea la barrera hematoencefálica. (divisional solicitud 201703351)

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US12252533B2 (en) 2015-06-24 2025-03-18 Hoffmann-La Roche Inc. Anti-transferrin receptor antibodies with tailored affinity
US11603411B2 (en) 2015-10-02 2023-03-14 Hoffmann-La Roche Inc. Bispecific anti-human CD20/human transferrin receptor antibodies and methods of use
US12030952B2 (en) 2015-10-02 2024-07-09 Hoffmann-La Roche Inc. Bispecific anti-human CD20/human transferrin receptor antibodies and methods of use

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