CL2018000151A1 - Procesos mejorados para la preparación de compuestos de 1-aril-5-alquil pirazol (divisional de solicitud 201402825) - Google Patents

Procesos mejorados para la preparación de compuestos de 1-aril-5-alquil pirazol (divisional de solicitud 201402825)

Info

Publication number
CL2018000151A1
CL2018000151A1 CL2018000151A CL2018000151A CL2018000151A1 CL 2018000151 A1 CL2018000151 A1 CL 2018000151A1 CL 2018000151 A CL2018000151 A CL 2018000151A CL 2018000151 A CL2018000151 A CL 2018000151A CL 2018000151 A1 CL2018000151 A1 CL 2018000151A1
Authority
CL
Chile
Prior art keywords
preparation
aryl
pyrazole compounds
improved processes
alkyl pyrazole
Prior art date
Application number
CL2018000151A
Other languages
English (en)
Inventor
Michel Mulhauser
Charles Meng
Hyoung Ik Lee
Hir De Falloios Loic Patrick Le
Zinxi Zhan
Jean Robert Labrosse
Original Assignee
Merial Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48237288&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2018000151(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merial Ltd filed Critical Merial Ltd
Publication of CL2018000151A1 publication Critical patent/CL2018000151A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

<p>PROCESO MEJORADO PARA LA PREPARACIÓN DE COMPUESTOS DE 1-ARIL PIRAZOL DE FÓRMULA (1) Y (IB), QUE ESTÁN SUSTITUIDOS EN LA POSICIÓN 5 DEL ANILLO PIRAZOL CON UN GRUPO FUNCIONAL UNIDO A CARBONO. EL PROCESO DESCRITO ES EFICAZ Y CON CAPACIDAD DE ESCALADO Y NO UTILIZA REACTIVOS DE HALURO DE SULFENILO PELIGROSOS.</p>
CL2018000151A 2012-04-20 2018-01-18 Procesos mejorados para la preparación de compuestos de 1-aril-5-alquil pirazol (divisional de solicitud 201402825) CL2018000151A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261635969P 2012-04-20 2012-04-20

Publications (1)

Publication Number Publication Date
CL2018000151A1 true CL2018000151A1 (es) 2018-05-18

Family

ID=48237288

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2014002825A CL2014002825A1 (es) 2012-04-20 2014-10-20 Procesos para la preparación de un compuesto de 1-aril-5-alquil pirazol
CL2018000151A CL2018000151A1 (es) 2012-04-20 2018-01-18 Procesos mejorados para la preparación de compuestos de 1-aril-5-alquil pirazol (divisional de solicitud 201402825)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2014002825A CL2014002825A1 (es) 2012-04-20 2014-10-20 Procesos para la preparación de un compuesto de 1-aril-5-alquil pirazol

Country Status (23)

Country Link
US (2) US8937185B2 (es)
EP (2) EP2852577B1 (es)
JP (2) JP6197192B2 (es)
KR (2) KR102099547B1 (es)
CN (2) CN110452174A (es)
AR (2) AR090773A1 (es)
AU (2) AU2013248984B2 (es)
BR (1) BR112014026052A8 (es)
CA (2) CA3045419A1 (es)
CL (2) CL2014002825A1 (es)
CO (1) CO7141468A2 (es)
EA (2) EA025905B9 (es)
ES (1) ES2626167T3 (es)
IL (3) IL235108A (es)
MX (1) MX344802B (es)
MY (2) MY177999A (es)
NZ (2) NZ709054A (es)
PH (1) PH12014502346A1 (es)
SG (2) SG11201406734TA (es)
TW (1) TWI579274B (es)
UA (1) UA116629C2 (es)
WO (1) WO2013159094A2 (es)
ZA (1) ZA201407603B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110997654B (zh) 2017-07-28 2023-08-15 诺华股份有限公司 吲哚衍生物及其用途
ES2985747T3 (es) 2017-09-13 2024-11-07 Novartis Ag Derivados de difenilo y usos de los mismos
CN115124471B (zh) * 2021-03-24 2024-02-13 中国工程物理研究院化工材料研究所 一类具有高能和低熔点特性的吡唑环类炸药及其合成方法
CN115353490A (zh) * 2022-09-26 2022-11-18 安徽美诺华药物化学有限公司 一种氟虫腈的纯化工艺

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2716453B1 (fr) 1994-02-22 1996-03-29 Rhone Poulenc Agrochimie Procédé de sulfinylation de composés hétérocycliques.
US3402308A (en) 1965-01-19 1968-09-17 Superior Electric Co Rotary actuated linear motor
US3609158A (en) 1969-03-17 1971-09-28 Dow Chemical Co Certain substituted (pyridyl)-oxy acetic acid derivatives
US3742046A (en) 1970-08-05 1973-06-26 Chemagro Corp {60 -(dichlorovinylthio)-acetophenone
IN140318B (es) 1974-12-27 1976-10-16 Dow Chemical Co
US4127575A (en) 1976-10-20 1978-11-28 The Dow Chemical Company Preparation of chloro substituted pyridines
GB2136427B (en) 1983-03-09 1986-07-09 May & Baker Ltd Herbicidal n-pyridylpyrazole derivatives
DE3402308A1 (de) 1984-01-24 1985-08-01 Bayer Ag, 5090 Leverkusen Herbizide mittel auf basis von pyrazolderivaten
DE3602728A1 (de) 1985-05-17 1986-11-20 Bayer Ag, 51373 Leverkusen Schaedlingsbekaempfungsmittel auf basis von pyrazolderivaten
DE3520330A1 (de) 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen 5-amino-1-pyridyl-pyrazole
DE3617977A1 (de) 1985-12-05 1987-06-11 Bayer Ag 5-dichloracetamido-4-nitro-1-aryl-pyrazole
GB8531485D0 (en) 1985-12-20 1986-02-05 May & Baker Ltd Compositions of matter
GB8713768D0 (en) 1987-06-12 1987-07-15 May & Baker Ltd Compositions of matter
US5232940A (en) 1985-12-20 1993-08-03 Hatton Leslie R Derivatives of N-phenylpyrazoles
US6372774B1 (en) 1985-12-20 2002-04-16 Rhone-Poulenc Agriculture Ltd. Derivatives of N-phenylpyrazoles
US5547974A (en) 1985-12-20 1996-08-20 Rhone-Poulenc Agriculture Ltd. Derivatives of N-phenylpyrazoles
DE3600287A1 (de) 1986-01-08 1987-07-16 Bayer Ag 1-arylpyrazole
DE3628892A1 (de) * 1986-08-26 1988-03-10 Bayer Ag Substituierte 1-aryl-3-tert.-butyl-pyrazole
SE8802173D0 (sv) 1988-06-10 1988-06-10 Astra Ab Pyrimidine derivatives
GB8816915D0 (en) 1988-07-15 1988-08-17 May & Baker Ltd New compositions of matter
CA2004776C (fr) 1988-12-13 2000-04-25 Claude Wakselman Procede de preparation de perfluoroalkylthioethers
US4918085A (en) 1989-03-02 1990-04-17 Rhone-Poulenc Ag Company Pesticidal 3-cyano-5-alkoxy-1-arylpyrazoles, compositions and use
DE4003371A1 (de) 1990-02-05 1991-08-08 Richard Herbst Verfahren zum entformen eines formteils sowie vorrichtung zur durchfuehrung des verfahrens
CA2036147A1 (en) 1990-06-29 1991-12-30 Hiroki Tomioka A 1-pyridylimidazole derivative and its production and use
NO179282C (no) 1991-01-18 1996-09-11 Rhone Poulenc Agrochimie Nye 1-(2-pyridyl)pyrazolforbindelser til kontroll av skadeinsekter
US5246255A (en) 1991-06-24 1993-09-21 Forbes Christopher B Repair flange
GB9120641D0 (en) 1991-09-27 1991-11-06 Ici Plc Heterocyclic compounds
DE4343832A1 (de) * 1993-12-22 1995-06-29 Bayer Ag Substituierte 1-Arylpyrazole
US5817688A (en) 1995-12-19 1998-10-06 Rhone-Poulenc Inc. Pesticidal 1-arylpyrazole derivatives
US5922885A (en) 1995-12-19 1999-07-13 Rhone-Poulenc Inc. Pesticidal 1-arylpyrazole derivatives
ATE236883T1 (de) 1995-12-19 2003-04-15 Bayer Cropscience Sa Neue 1-aryl pyrazol derivate und ihre verwendung als schädlingsbekämpfungsmittel
US6316477B1 (en) * 1996-01-30 2001-11-13 Takeda Chemical Industries, Ltd. Arylpyrazole insecticides
US6010710A (en) 1996-03-29 2000-01-04 Merial Direct pour-on skin solution for antiparasitic use in cattle and sheep
IE80657B1 (en) 1996-03-29 1998-11-04 Merial Sas Insecticidal combination to control mammal fleas in particular fleas on cats and dogs
US5885607A (en) 1996-03-29 1999-03-23 Rhone Merieux N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs
US6069157A (en) 1997-11-25 2000-05-30 Pfizer Inc. Parasiticidal compounds
GB9625045D0 (en) 1996-11-30 1997-01-22 Pfizer Ltd Parasiticidal compounds
DE19650197A1 (de) 1996-12-04 1998-06-10 Bayer Ag 3-Thiocarbamoylpyrazol-Derivate
US6350771B1 (en) * 1996-12-24 2002-02-26 Rhone-Poulenc, Inc. Pesticidal 1-arylpyrazoles
DE19824487A1 (de) 1998-06-02 1999-12-09 Bayer Ag Substituierte 3-Thiocarbamoylpyrazole
HRP20020438B1 (en) * 1999-10-22 2011-01-31 BASF Agro B.V. Process for preparing 4-trifluoromethylsulphinylpyrazole derivative
CN1939909A (zh) 1999-12-02 2007-04-04 阿温提斯作物科学股份有限公司 控制动物中的节肢动物
MXPA03000906A (es) * 2000-07-31 2005-02-24 Hoffmann La Roche Derivados de piperazina.
AU2002236830A1 (en) 2001-01-26 2002-08-06 Chugai Seiyaku Kabushiki Kaisha Methods for the treatment of diseases using malonyl-coa decarbox ylase inhibitors
US20040220170A1 (en) 2003-05-01 2004-11-04 Atkinson Robert N. Pyrazole-amides and sulfonamides as sodium channel modulators
BRPI0414081A (pt) * 2003-09-04 2006-10-24 Bayer Cropscience Sa pesticidas
JP4868603B2 (ja) * 2004-06-26 2012-02-01 メリアル リミテッド 殺虫剤としての１−アリールピラゾール誘導体
EP2465851A1 (en) * 2006-07-05 2012-06-20 Aventis Agriculture 1-Aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof
DE602008005582D1 (de) * 2007-05-10 2011-04-28 Glaxo Group Ltd Pyrazolderivate als p2x7-modulatoren
FR2925493B1 (fr) 2007-12-19 2011-09-30 Vetoquinol Procede de preparation du fipronil et d'analogues de celui-ci.
ES2500643T3 (es) * 2009-04-03 2014-09-30 Verastem, Inc. Compuestos de purina sustituidos con pirimidina como inhibidores de las cinasas

Also Published As

Publication number Publication date
IL235108A (en) 2017-03-30
EA201500483A1 (ru) 2015-08-31
EA201401159A1 (ru) 2015-03-31
EA025905B9 (ru) 2017-04-28
WO2013159094A3 (en) 2014-05-22
PH12014502346B1 (en) 2014-12-22
PH12014502346A1 (en) 2014-12-22
MX2014012647A (es) 2014-11-25
JP2017203034A (ja) 2017-11-16
NZ701406A (en) 2015-06-26
KR102027755B1 (ko) 2019-10-02
EP3184510B1 (en) 2019-06-12
CL2014002825A1 (es) 2015-01-30
SG11201406734TA (en) 2014-11-27
TWI579274B (zh) 2017-04-21
UA116629C2 (uk) 2018-04-25
US20150073153A1 (en) 2015-03-12
CA2870909C (en) 2020-11-24
ZA201407603B (en) 2015-11-25
CN104334534A (zh) 2015-02-04
AU2016269435B2 (en) 2018-07-19
AR116733A2 (es) 2021-06-09
KR102099547B1 (ko) 2020-04-09
CA2870909A1 (en) 2013-10-24
WO2013159094A2 (en) 2013-10-24
MX344802B (es) 2017-01-09
JP6494700B2 (ja) 2019-04-03
ES2626167T3 (es) 2017-07-24
EA025905B1 (ru) 2017-02-28
AU2013248984B2 (en) 2016-12-15
MY177999A (en) 2020-09-29
IL250684A0 (en) 2017-04-30
EA028539B1 (ru) 2017-11-30
CA3045419A1 (en) 2013-10-24
CN104334534B (zh) 2020-01-10
JP6197192B2 (ja) 2017-09-20
IL250684B (en) 2018-03-29
EP3184510A1 (en) 2017-06-28
US20130281710A1 (en) 2013-10-24
MY166795A (en) 2018-07-23
US8937185B2 (en) 2015-01-20
SG10201610736YA (en) 2017-02-27
BR112014026052A2 (pt) 2017-06-27
JP2015518486A (ja) 2015-07-02
IL249668A0 (en) 2017-02-28
TW201348210A (zh) 2013-12-01
AU2016269435A1 (en) 2016-12-22
CN110452174A (zh) 2019-11-15
NZ709054A (en) 2016-06-24
AU2013248984A1 (en) 2014-11-13
CO7141468A2 (es) 2014-12-12
AR090773A1 (es) 2014-12-03
BR112014026052A8 (pt) 2019-04-02
EA028539B9 (ru) 2018-01-31
EP2852577A2 (en) 2015-04-01
US9273007B2 (en) 2016-03-01
EP2852577B1 (en) 2017-03-01
KR20190058709A (ko) 2019-05-29
KR20150000902A (ko) 2015-01-05

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