CL2018000856A1 - Derivados de éter cíclico de pirazolo[1,5-a]pirimidin-3-carboxiamida. - Google Patents

Derivados de éter cíclico de pirazolo[1,5-a]pirimidin-3-carboxiamida.

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Publication number
CL2018000856A1
CL2018000856A1 CL2018000856A CL2018000856A CL2018000856A1 CL 2018000856 A1 CL2018000856 A1 CL 2018000856A1 CL 2018000856 A CL2018000856 A CL 2018000856A CL 2018000856 A CL2018000856 A CL 2018000856A CL 2018000856 A1 CL2018000856 A1 CL 2018000856A1
Authority
CL
Chile
Prior art keywords
carboxyamide
pyrazolo
pyrimidin
derivatives
cyclic ether
Prior art date
Application number
CL2018000856A
Other languages
English (en)
Inventor
Christoph Hoenke
Barbara Bertani
Marco Ferrara
Giacomo Fossati
Sara Frattini
Riccardo Giovannini
Scott Hobson
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2018000856A1 publication Critical patent/CL2018000856A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/20—Hypnotics; Sedatives
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

<p>La invención se refiere a derivados de éter espirocíclico de pirazolo[1,5-a]pirimidin-3-carboxiamida de la Fórmula general (I) que son inhibidores de la fosfodiesterasa 2, útiles en el tratamiento de enfermedades del sistema nervioso central y otras enfermedades. Además, la invención se refiere a procesos para preparar composiciones farmacéuticas, así como a procesos para la fabricación de compuestos de acuerdo con la invención.</p>
CL2018000856A 2015-10-13 2018-04-03 Derivados de éter cíclico de pirazolo[1,5-a]pirimidin-3-carboxiamida. CL2018000856A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15189600.8A EP3156405A1 (en) 2015-10-13 2015-10-13 Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide

Publications (1)

Publication Number Publication Date
CL2018000856A1 true CL2018000856A1 (es) 2018-07-27

Family

ID=54293164

Family Applications (1)

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CL2018000856A CL2018000856A1 (es) 2015-10-13 2018-04-03 Derivados de éter cíclico de pirazolo[1,5-a]pirimidin-3-carboxiamida.

Country Status (30)

Country Link
US (5) US10023575B2 (es)
EP (2) EP3156405A1 (es)
JP (1) JP6626965B2 (es)
KR (1) KR102611558B1 (es)
CN (2) CN108137602B (es)
AU (1) AU2016338602B2 (es)
BR (1) BR112018004347B1 (es)
CA (1) CA3001929C (es)
CL (1) CL2018000856A1 (es)
CO (1) CO2018003756A2 (es)
CY (1) CY1125323T1 (es)
DK (1) DK3362453T3 (es)
EA (1) EA035350B1 (es)
ES (1) ES2912223T3 (es)
HR (1) HRP20220595T1 (es)
IL (1) IL258070B (es)
LT (1) LT3362453T (es)
MA (1) MA42988B1 (es)
MX (1) MX376458B (es)
MY (1) MY195169A (es)
NZ (1) NZ740119A (es)
PE (2) PE20181447A1 (es)
PH (1) PH12018500796B1 (es)
PL (1) PL3362453T3 (es)
PT (1) PT3362453T (es)
RS (1) RS63218B1 (es)
SA (1) SA518391334B1 (es)
SI (1) SI3362453T1 (es)
UA (1) UA124576C2 (es)
WO (1) WO2017064082A1 (es)

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JP6626965B2 (ja) 2019-12-25
UA124576C2 (uk) 2021-10-13
IL258070A (en) 2018-05-31
MX376458B (es) 2025-03-07
LT3362453T (lt) 2022-05-25
US12351584B2 (en) 2025-07-08
US20180134720A1 (en) 2018-05-17
US20170101411A1 (en) 2017-04-13
PT3362453T (pt) 2022-05-04
ES2912223T3 (es) 2022-05-25
BR112018004347A2 (pt) 2018-10-09
EP3156405A1 (en) 2017-04-19
MA42988A (fr) 2021-04-07
CN108137602A (zh) 2018-06-08
KR20180063316A (ko) 2018-06-11
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US20200039991A1 (en) 2020-02-06
IL258070B (en) 2020-06-30
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US20210032259A1 (en) 2021-02-04
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PH12018500796B1 (en) 2022-10-26
EA201890922A1 (ru) 2018-11-30
US10875867B2 (en) 2020-12-29
SI3362453T1 (sl) 2022-06-30
MY195169A (en) 2023-01-11
AU2016338602A1 (en) 2018-03-15
MX2018004524A (es) 2018-06-27
PE20181447A1 (es) 2018-09-12
PL3362453T3 (pl) 2022-07-25
WO2017064082A1 (en) 2017-04-20
MA42988B1 (fr) 2022-04-29
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US11691977B2 (en) 2023-07-04
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EP3362453A1 (en) 2018-08-22
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US20230286993A1 (en) 2023-09-14
EA035350B1 (ru) 2020-05-29
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CO2018003756A2 (es) 2018-07-10
BR112018004347B1 (pt) 2023-12-05
JP2018534279A (ja) 2018-11-22
NZ740119A (en) 2022-02-25
US10479794B2 (en) 2019-11-19
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SA518391334B1 (ar) 2021-03-29
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