CL2018003492A1 - Hepatitis b agentes antivirales. - Google Patents

Hepatitis b agentes antivirales.

Info

Publication number
CL2018003492A1
CL2018003492A1 CL2018003492A CL2018003492A CL2018003492A1 CL 2018003492 A1 CL2018003492 A1 CL 2018003492A1 CL 2018003492 A CL2018003492 A CL 2018003492A CL 2018003492 A CL2018003492 A CL 2018003492A CL 2018003492 A1 CL2018003492 A1 CL 2018003492A1
Authority
CL
Chile
Prior art keywords
hepatitis
vhb
compounds
antiviral agents
virus
Prior art date
Application number
CL2018003492A
Other languages
English (en)
Inventor
Yao-Ling Qiu
Xuri Gao
Wei Li
Hui Cao
Meizhong Jin
Jorden Kass
Xiaowen Peng
Yat Sun Or
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of CL2018003492A1 publication Critical patent/CL2018003492A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA PRESENTE INVENCIÓN DESCRIBE COMPUESTOS DE FÓRMULA (I) DERIVADOS DE PIRIMIDINA, O SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS: QUE INHIBEN LA (S) PROTEÍNA (S) CODIFICADA (S) POR EL VIRUS DE LA HEPATITIS B (VHB) O INTERFIEREN CON LA FUNCIÓN DEL CICLO DE VIDA DEL VHB DEL VIRUS DE LA HEPATITIS B Y SON: TAMBIÉN ES ÚTIL COMO AGENTES ANTIVIRALES. LA PRESENTE INVENCIÓN SE REFIERE ADEMÁS A COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN LOS COMPUESTOS MENCIONADOS ANTERIORMENTE PARA ADMINISTRACIÓN A UN SUJETO QUE PADECE UNA INFECCIÓN POR VHB. LA INVENCIÓN TAMBIÉN SE REFIERE A MÉTODOS PARA TRATAR UNA INFECCIÓN POR VHB EN UN SUJETO ADMINISTRANDO UNA COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE LOS COMPUESTOS DE LA PRESENTE INVENCIÓN.
CL2018003492A 2016-06-10 2018-12-05 Hepatitis b agentes antivirales. CL2018003492A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662348419P 2016-06-10 2016-06-10
US201762443245P 2017-01-06 2017-01-06

Publications (1)

Publication Number Publication Date
CL2018003492A1 true CL2018003492A1 (es) 2019-04-05

Family

ID=60573663

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2018003492A CL2018003492A1 (es) 2016-06-10 2018-12-05 Hepatitis b agentes antivirales.

Country Status (15)

Country Link
US (3) US10189846B2 (es)
EP (1) EP3468561A4 (es)
JP (1) JP2019521972A (es)
KR (1) KR20190027814A (es)
CN (1) CN109843296A (es)
AU (1) AU2017277664A1 (es)
BR (1) BR112018075465A2 (es)
CA (1) CA3028228A1 (es)
CL (1) CL2018003492A1 (es)
CO (1) CO2019000069A2 (es)
IL (1) IL263535A (es)
MX (1) MX2018015315A (es)
PH (1) PH12018550201A1 (es)
SG (1) SG11201810834WA (es)
WO (1) WO2017214395A1 (es)

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