CL2018003682A1 - Composición farmacéutica oral, que comprende un agente farmacéuticamente activo, al menos un polímero catiónico bioadhesivo y al menos dos polímeros aniónicos. - Google Patents

Composición farmacéutica oral, que comprende un agente farmacéuticamente activo, al menos un polímero catiónico bioadhesivo y al menos dos polímeros aniónicos.

Info

Publication number
CL2018003682A1
CL2018003682A1 CL2018003682A CL2018003682A CL2018003682A1 CL 2018003682 A1 CL2018003682 A1 CL 2018003682A1 CL 2018003682 A CL2018003682 A CL 2018003682A CL 2018003682 A CL2018003682 A CL 2018003682A CL 2018003682 A1 CL2018003682 A1 CL 2018003682A1
Authority
CL
Chile
Prior art keywords
active agent
pharmaceutically active
cationic polymer
pharmaceutical composition
oral pharmaceutical
Prior art date
Application number
CL2018003682A
Other languages
English (en)
Inventor
Nathalie Delhom
Original Assignee
Virbac
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virbac filed Critical Virbac
Publication of CL2018003682A1 publication Critical patent/CL2018003682A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0233—Rickettsiales, e.g. Anaplasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA PRESENTE INVENCIÓN SE RELACIONA CON UNA COMPOSICIÓN ORAL SÓLIDA, QUE COMPRENDE UN AGENTE FARMACÉUTICAMENTE ACTIVO, COMO POR EJEMPLO, UN AGENTE INMUNOGÉNICO (POR EJEMPLO, UNA VACUNA), AL MENOS UN POLÍMERO CATIÓNICO BIOADHESIVO, QUE DE PREFERENCIA ES CHITOSÁN, Y AL MENOS DOS COMPUESTOS ANIÓNICOS, LOS CUALES PERMITEN LA ADMINISTRACIÓN Y ENTREGA ORAL DEL AGENTE FARMACÉUTICAMENTE ACTIVO ESENCIALMENTE INALTERADO A LA MUCOSA INTESTINAL; LA PRESENTE INVENCIÓN SE RELACIONA ADEMÁS CON UN PROCESO DE PREPARACIÓN DE DICHA COMPOSICIÓN ORAL SÓLIDA Y SU USO PARA VACUNAR O REFORZAR UN ANIMAL, QUE CONSISTE EN LA ADMINISTRACIÓN ORAL PARA ENTREGA INTESTINAL A DICHO ANIMAL.
CL2018003682A 2016-06-20 2018-12-19 Composición farmacéutica oral, que comprende un agente farmacéuticamente activo, al menos un polímero catiónico bioadhesivo y al menos dos polímeros aniónicos. CL2018003682A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16175308 2016-06-20

Publications (1)

Publication Number Publication Date
CL2018003682A1 true CL2018003682A1 (es) 2019-04-26

Family

ID=56148230

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2018003688A CL2018003688A1 (es) 2016-06-20 2018-12-19 Método y equipo de preparación de una composición de micropartículas
CL2018003682A CL2018003682A1 (es) 2016-06-20 2018-12-19 Composición farmacéutica oral, que comprende un agente farmacéuticamente activo, al menos un polímero catiónico bioadhesivo y al menos dos polímeros aniónicos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2018003688A CL2018003688A1 (es) 2016-06-20 2018-12-19 Método y equipo de preparación de una composición de micropartículas

Country Status (3)

Country Link
EP (2) EP3471705A1 (es)
CL (2) CL2018003688A1 (es)
WO (2) WO2017220615A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9597385B2 (en) 2012-04-23 2017-03-21 Allertein Therapeutics, Llc Nanoparticles for treatment of allergy
WO2019140318A1 (en) * 2018-01-11 2019-07-18 N-Fold Llc Nanoparticle systems
WO2019180047A1 (en) * 2018-03-19 2019-09-26 Algipharma As Use of alginate oligomers to enhance the translocation of micro/nanoparticles across mucus layers
CN111568881A (zh) * 2020-06-08 2020-08-25 广东悦生生物科技有限公司 一种核壳体缓释氨基酸补剂及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9799198A (en) * 1997-10-09 1999-05-03 Vanderbilt University Micro-particulate and nano-particulate polymeric delivery system
DE19923628C2 (de) * 1999-05-22 2002-03-07 Herbert Huettlin Verfahren und Vorrichtung zum Herstellen von partikelförmigen Teilchen
ITMI20031617A1 (it) 2003-08-06 2005-02-07 Fond Carlo E Dirce Callerio Onlus Microcapsule a doppio strato di polisaccaridi utilizzabili
WO2006003581A1 (en) 2004-06-29 2006-01-12 Koninklijke Philips Electronics N.V. System for manufacturing micro-spheres
WO2007067145A1 (en) * 2005-12-07 2007-06-14 Mip Technologies Ab Monodisperse molecularly imprinted polymer beads
US20110142914A1 (en) 2007-12-06 2011-06-16 Cytotech Labs, Llc Inhalable compositions having enhanced bioavailability
PL2105129T3 (pl) * 2008-03-24 2018-04-30 Intervet International B.V. Szczepionki w kapsułkach do szczepienia doustnego i wzmocnienia dla ryb i innych zwierząt
GB0814302D0 (en) 2008-08-05 2008-10-01 Coretherapix Slu Compounds and methods
IT1395524B1 (it) * 2009-09-02 2012-09-28 Fond Carlo E Dirce Callerio Onlus Metodo e apparato per la preparazione di micro-particelle di polisaccaridi
CN113750075A (zh) * 2013-12-06 2021-12-07 英特维特国际股份有限公司 用于经口递送生物活性剂的组合物

Also Published As

Publication number Publication date
EP3471705A1 (en) 2019-04-24
EP3471706B1 (en) 2023-12-20
CL2018003688A1 (es) 2019-04-26
WO2017220615A1 (en) 2017-12-28
WO2017220611A1 (en) 2017-12-28
EP3471706A1 (en) 2019-04-24

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