CL2019000397A1 - Proceso para preparar el compuesto n-((s)-1-(3-(3-cloro -4-cianofenil)-1h-pirazol-1-il)-5-(1-hidroxi-etil)-1h-pirazol-3-carboxamida de la formula (1a).(divisional solicitud 201702491) - Google Patents
Proceso para preparar el compuesto n-((s)-1-(3-(3-cloro -4-cianofenil)-1h-pirazol-1-il)-5-(1-hidroxi-etil)-1h-pirazol-3-carboxamida de la formula (1a).(divisional solicitud 201702491)Info
- Publication number
- CL2019000397A1 CL2019000397A1 CL2019000397A CL2019000397A CL2019000397A1 CL 2019000397 A1 CL2019000397 A1 CL 2019000397A1 CL 2019000397 A CL2019000397 A CL 2019000397A CL 2019000397 A CL2019000397 A CL 2019000397A CL 2019000397 A1 CL2019000397 A1 CL 2019000397A1
- Authority
- CL
- Chile
- Prior art keywords
- cyanophenyl
- chloro
- pyrazol
- carboxamide
- pyrazole
- Prior art date
Links
- -1 (s) -1- (3- (3-chloro -4-cyanophenyl) -1h-pyrazol-1-yl) -5- (1-hydroxy-ethyl) -1h-pyrazole- 3-carboxamide Chemical compound 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical class C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PROCESO PARA PREPARAR EL COMPUESTO N-((S)-1-(3-(3-CLORO-4-CIANOFENIL).1H-PIRAZOL-1-IL)-PROPAN-2-IL)-5-(1-HIDROXIETIL)-1H-PIRAZOL-3-CARBOXAMIDA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20150111 | 2015-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2019000397A1 true CL2019000397A1 (es) | 2019-05-10 |
Family
ID=55802393
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017002491A CL2017002491A1 (es) | 2015-04-09 | 2017-10-03 | Proceso para la preparación de antagonistas del receptor andrógeno e intermediarios de los mismos |
| CL2019000397A CL2019000397A1 (es) | 2015-04-09 | 2019-02-14 | Proceso para preparar el compuesto n-((s)-1-(3-(3-cloro -4-cianofenil)-1h-pirazol-1-il)-5-(1-hidroxi-etil)-1h-pirazol-3-carboxamida de la formula (1a).(divisional solicitud 201702491) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017002491A CL2017002491A1 (es) | 2015-04-09 | 2017-10-03 | Proceso para la preparación de antagonistas del receptor andrógeno e intermediarios de los mismos |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US10189789B2 (es) |
| EP (1) | EP3280710B1 (es) |
| JP (1) | JP6707560B2 (es) |
| KR (1) | KR102628078B1 (es) |
| CN (1) | CN107428695B (es) |
| AU (1) | AU2016245278B2 (es) |
| BR (1) | BR112017021636B1 (es) |
| CA (1) | CA2980965C (es) |
| CL (2) | CL2017002491A1 (es) |
| CO (1) | CO2017010052A2 (es) |
| CY (1) | CY1123105T1 (es) |
| DK (1) | DK3280710T3 (es) |
| ES (1) | ES2800828T3 (es) |
| HR (1) | HRP20200707T1 (es) |
| HU (1) | HUE049144T2 (es) |
| IL (1) | IL254629B (es) |
| LT (1) | LT3280710T (es) |
| MX (1) | MX378231B (es) |
| MY (1) | MY185488A (es) |
| PE (1) | PE20171738A1 (es) |
| PL (1) | PL3280710T3 (es) |
| PT (1) | PT3280710T (es) |
| RS (1) | RS60184B1 (es) |
| RU (1) | RU2719590C2 (es) |
| SG (1) | SG11201707959VA (es) |
| SI (1) | SI3280710T1 (es) |
| UA (1) | UA120777C2 (es) |
| WO (1) | WO2016162604A1 (es) |
| ZA (1) | ZA201706671B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020006387A (es) * | 2017-12-19 | 2020-09-03 | Boehringer Ingelheim Vetmedica Gmbh | Sintesis del cocristal 1:1:1 de 1-ciano-2-(4-ciclopropil-bencil)-4 -(beta-d-glucopiranos-1-il)-benceno, l-prolina y agua. |
| US11236070B2 (en) | 2019-05-16 | 2022-02-01 | Novartis Ag | Chemical process |
| AU2020300043B2 (en) | 2019-07-02 | 2025-03-20 | Orion Corporation | Pharmaceutical composition of darolutamide |
| CN110590668A (zh) * | 2019-07-17 | 2019-12-20 | 江苏君若医药有限公司 | N-[(1s)-2-[3-(3-氯-4-氰基苯基)-1h-吡唑-1-基]-1-甲基乙基]-5-(1-羟基乙基)- 1h-吡唑-3-甲酰胺的制备方法 |
| CN110483534B (zh) * | 2019-07-23 | 2021-05-18 | 上海药明康德新药开发有限公司 | 一种(2,4,5,7-四氢吡喃并[3,4-c]吡唑-7-基)甲醇的制备方法 |
| CN111116477B (zh) * | 2019-12-27 | 2021-04-20 | 武汉九州钰民医药科技有限公司 | 多拉米胺的合成工艺 |
| CN111116476A (zh) * | 2019-12-27 | 2020-05-08 | 武汉九州钰民医药科技有限公司 | 制备抗肿瘤药物多拉米胺的方法 |
| BR112022022978A2 (pt) | 2020-05-11 | 2022-12-20 | Orion Corp | Método para a preparação de antagonistas de receptores de androgênio e seus intermediários |
| CN113527208A (zh) * | 2021-08-31 | 2021-10-22 | 江西金丰药业有限公司 | 一步法制备2-氯-4-（1h-吡唑-3-基）苯甲腈的方法 |
| CN113861115A (zh) * | 2021-09-10 | 2021-12-31 | 浙江师范大学 | 一种吡唑酰胺类衍生物及合成方法和应用 |
| TW202521513A (zh) | 2023-08-17 | 2025-06-01 | 芬蘭商奧利安公司 | 雄性素受體拮抗劑及其中間物之製備方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR078793A1 (es) * | 2009-10-27 | 2011-12-07 | Orion Corp | Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros |
| JP5964407B2 (ja) * | 2011-04-21 | 2016-08-03 | オリオン コーポレーション | アンドロゲン受容体調節カルボキシアミド |
| WO2012154679A1 (en) * | 2011-05-06 | 2012-11-15 | Zafgen Corporation | Tricyclic pyrazole sulfonamide compounds and methods of making and using same |
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2016
- 2016-04-08 MY MYPI2017703709A patent/MY185488A/en unknown
- 2016-04-08 ES ES16717672T patent/ES2800828T3/es active Active
- 2016-04-08 HR HRP20200707TT patent/HRP20200707T1/hr unknown
- 2016-04-08 PL PL16717672T patent/PL3280710T3/pl unknown
- 2016-04-08 SG SG11201707959VA patent/SG11201707959VA/en unknown
- 2016-04-08 CN CN201680018881.7A patent/CN107428695B/zh active Active
- 2016-04-08 US US15/564,878 patent/US10189789B2/en active Active
- 2016-04-08 SI SI201630674T patent/SI3280710T1/sl unknown
- 2016-04-08 AU AU2016245278A patent/AU2016245278B2/en active Active
- 2016-04-08 MX MX2017012910A patent/MX378231B/es unknown
- 2016-04-08 UA UAA201710897A patent/UA120777C2/uk unknown
- 2016-04-08 BR BR112017021636-1A patent/BR112017021636B1/pt active IP Right Grant
- 2016-04-08 PT PT167176726T patent/PT3280710T/pt unknown
- 2016-04-08 WO PCT/FI2016/050220 patent/WO2016162604A1/en not_active Ceased
- 2016-04-08 KR KR1020177032529A patent/KR102628078B1/ko active Active
- 2016-04-08 LT LTEP16717672.6T patent/LT3280710T/lt unknown
- 2016-04-08 HU HUE16717672A patent/HUE049144T2/hu unknown
- 2016-04-08 PE PE2017001969A patent/PE20171738A1/es unknown
- 2016-04-08 RU RU2017134662A patent/RU2719590C2/ru not_active Application Discontinuation
- 2016-04-08 RS RS20200496A patent/RS60184B1/sr unknown
- 2016-04-08 JP JP2017552929A patent/JP6707560B2/ja active Active
- 2016-04-08 DK DK16717672.6T patent/DK3280710T3/da active
- 2016-04-08 EP EP16717672.6A patent/EP3280710B1/en active Active
- 2016-04-08 CA CA2980965A patent/CA2980965C/en active Active
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2017
- 2017-09-24 IL IL254629A patent/IL254629B/en active IP Right Grant
- 2017-10-03 CO CONC2017/0010052A patent/CO2017010052A2/es unknown
- 2017-10-03 CL CL2017002491A patent/CL2017002491A1/es unknown
- 2017-10-04 ZA ZA2017/06671A patent/ZA201706671B/en unknown
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2019
- 2019-02-14 CL CL2019000397A patent/CL2019000397A1/es unknown
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2020
- 2020-05-25 CY CY20201100495T patent/CY1123105T1/el unknown
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