CL2019000532A1 - Polimorfos cristalinos de un agonista del receptor de acetilcolina muscarínico. - Google Patents
Polimorfos cristalinos de un agonista del receptor de acetilcolina muscarínico.Info
- Publication number
- CL2019000532A1 CL2019000532A1 CL2019000532A CL2019000532A CL2019000532A1 CL 2019000532 A1 CL2019000532 A1 CL 2019000532A1 CL 2019000532 A CL2019000532 A CL 2019000532A CL 2019000532 A CL2019000532 A CL 2019000532A CL 2019000532 A1 CL2019000532 A1 CL 2019000532A1
- Authority
- CL
- Chile
- Prior art keywords
- receptor agonist
- acetylcholine receptor
- muscarinic acetylcholine
- crystalline polymorphs
- crystalline
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
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- Immunology (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Abstract
SE PROPORCIONAN FORMAS CRISTALINAS NOVEDOSAS DE UN COMPUESTO ESPIRO QUE ACTÚA COMO UN AQONISTA DEL RECEPTOR MUSCARINICO DE ACETILCOLINA. EN PARTICULAR, SE DESCRIBEN POLIMORFOS CRISTALINOS AISLADOS DE (S)-2-ETIL-8-METIL-1 -TIA-4,8-DIAZAESPIRO[4.5)DECSNO-3-ONA QUE TIENEN PROPIEDADES FAVORABLES EN LA PREPARACIÓN FARMACÉUTICA. TAMBIÉN SE PROPORCIONAN MNIÉTOCLNS PARA PREPARAR DICHOS POLIMORFOS CRISTALINOS Y PARA CONVERTIRLOS ENTRE SÍ, ASÍ COMO MÉTODOS PARA PREPARAR MEDICAMENTOS QUE CONTIENEN LOS MISMOS QUE SON ADECUADOS PARA USARSE EN EL TRATAMIENTO DE ENFERMEDADES Y TRASTORNOS QUE RESPONDEN ALA MODULACIÓN DEL RECEPTOR MUSCARINICO DE ACETILCOLINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16192494 | 2016-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2019000532A1 true CL2019000532A1 (es) | 2019-07-12 |
Family
ID=57083221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2019000532A CL2019000532A1 (es) | 2016-10-05 | 2019-02-28 | Polimorfos cristalinos de un agonista del receptor de acetilcolina muscarínico. |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US11008342B2 (es) |
| EP (1) | EP3523310B1 (es) |
| JP (3) | JP7163280B2 (es) |
| KR (1) | KR102710640B1 (es) |
| CN (1) | CN109790180A (es) |
| AU (1) | AU2017341088B2 (es) |
| CA (1) | CA3036134A1 (es) |
| CL (1) | CL2019000532A1 (es) |
| CO (1) | CO2019003003A2 (es) |
| CY (1) | CY1125464T1 (es) |
| DK (1) | DK3523310T3 (es) |
| EA (1) | EA201990376A1 (es) |
| ES (1) | ES2924432T3 (es) |
| HR (1) | HRP20220962T1 (es) |
| HU (1) | HUE059720T2 (es) |
| IL (2) | IL265747B2 (es) |
| LT (1) | LT3523310T (es) |
| MA (1) | MA46464B1 (es) |
| MD (1) | MD3523310T2 (es) |
| MX (1) | MX383581B (es) |
| PE (2) | PE20191003A1 (es) |
| PH (1) | PH12019550048B1 (es) |
| PL (1) | PL3523310T3 (es) |
| PT (1) | PT3523310T (es) |
| RS (1) | RS63438B1 (es) |
| SG (1) | SG11201901612TA (es) |
| SI (1) | SI3523310T1 (es) |
| SM (1) | SMT202200331T1 (es) |
| WO (1) | WO2018065529A1 (es) |
| ZA (1) | ZA201901695B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3523310T1 (sl) | 2016-10-05 | 2022-10-28 | Nsc Therapeutics Gmbh | Kristalinični polimorfi agonista muskarinskega acetilholinskega receptorja |
| US12201619B2 (en) | 2018-03-22 | 2025-01-21 | Nsc Therapeutics Gmbh | Compounds and methods for use in the treatment of microglia-mediated disorders |
| EP4240355A4 (en) * | 2020-11-03 | 2024-10-09 | Cassava Sciences, Inc. | INHIBITION OF AN IMMUNE RESPONSE INDUCED BY ONE OR MORE COMPONENTS AMONG TLR2, RAGE, CCR5, CXCR4 AND CD4 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855290A (en) | 1985-05-10 | 1989-08-08 | State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research | Derivatives of quinuclidine |
| US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
| US6797558B2 (en) | 2001-04-24 | 2004-09-28 | Micron Technology, Inc. | Methods of forming a capacitor with substantially selective deposite of polysilicon on a substantially crystalline capacitor dielectric layer |
| WO2002100399A1 (en) * | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| US7439251B2 (en) | 2002-05-03 | 2008-10-21 | Israel Institute For Biological Research | Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor |
| WO2010051497A1 (en) * | 2008-10-31 | 2010-05-06 | Pain Therapeutics, Inc. | Filamin a binding anti-inflammatory and analgesic |
| SI3523310T1 (sl) * | 2016-10-05 | 2022-10-28 | Nsc Therapeutics Gmbh | Kristalinični polimorfi agonista muskarinskega acetilholinskega receptorja |
| US12201619B2 (en) | 2018-03-22 | 2025-01-21 | Nsc Therapeutics Gmbh | Compounds and methods for use in the treatment of microglia-mediated disorders |
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2017
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