DK3523310T3 - Krystallinske polymorfer af en muscarinacetylcholinreceptoragonist - Google Patents

Krystallinske polymorfer af en muscarinacetylcholinreceptoragonist Download PDF

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Publication number
DK3523310T3
DK3523310T3 DK17788131.5T DK17788131T DK3523310T3 DK 3523310 T3 DK3523310 T3 DK 3523310T3 DK 17788131 T DK17788131 T DK 17788131T DK 3523310 T3 DK3523310 T3 DK 3523310T3
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Prior art keywords
muscarinacetylcholine
receptor agonist
crystalline polymorphs
polymorphs
crystalline
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DK17788131.5T
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English (en)
Inventor
Abraham Fisher
Nira Bar-Ner
Manfred Windisch
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Nsc Therapeutics Gmbh
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
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  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
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  • Addiction (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
DK17788131.5T 2016-10-05 2017-10-05 Krystallinske polymorfer af en muscarinacetylcholinreceptoragonist DK3523310T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16192494 2016-10-05
PCT/EP2017/075373 WO2018065529A1 (en) 2016-10-05 2017-10-05 Crystalline polymorphs of a muscarinic acetylcholine receptor agonist

Publications (1)

Publication Number Publication Date
DK3523310T3 true DK3523310T3 (da) 2022-08-08

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DK17788131.5T DK3523310T3 (da) 2016-10-05 2017-10-05 Krystallinske polymorfer af en muscarinacetylcholinreceptoragonist

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US (3) US11008342B2 (da)
EP (1) EP3523310B1 (da)
JP (3) JP7163280B2 (da)
KR (1) KR102710640B1 (da)
CN (1) CN109790180A (da)
AU (1) AU2017341088B2 (da)
CA (1) CA3036134A1 (da)
CL (1) CL2019000532A1 (da)
CO (1) CO2019003003A2 (da)
CY (1) CY1125464T1 (da)
DK (1) DK3523310T3 (da)
EA (1) EA201990376A1 (da)
ES (1) ES2924432T3 (da)
HR (1) HRP20220962T1 (da)
HU (1) HUE059720T2 (da)
IL (2) IL265747B2 (da)
LT (1) LT3523310T (da)
MA (1) MA46464B1 (da)
MD (1) MD3523310T2 (da)
MX (1) MX383581B (da)
PE (2) PE20191003A1 (da)
PH (1) PH12019550048B1 (da)
PL (1) PL3523310T3 (da)
PT (1) PT3523310T (da)
RS (1) RS63438B1 (da)
SG (1) SG11201901612TA (da)
SI (1) SI3523310T1 (da)
SM (1) SMT202200331T1 (da)
WO (1) WO2018065529A1 (da)
ZA (1) ZA201901695B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3523310T3 (pl) * 2016-10-05 2022-08-29 Nsc Therapeutics Gmbh Krystaliczne polimorfy agonisty receptora muskarynowego acetylocholiny
WO2019180224A1 (en) * 2018-03-22 2019-09-26 Nsc Therapeutics Gmbh Compounds and methods for use in the treatment of microglia-mediated disorders
WO2022098700A1 (en) * 2020-11-03 2022-05-12 Cassava Sciences, Inc. Inhibiting an immune response mediated by one or more of tlr2, rage, ccr5, cxcr4 and cd4

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855290A (en) 1985-05-10 1989-08-08 State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research Derivatives of quinuclidine
US5534520A (en) 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US6797558B2 (en) 2001-04-24 2004-09-28 Micron Technology, Inc. Methods of forming a capacitor with substantially selective deposite of polysilicon on a substantially crystalline capacitor dielectric layer
EP1395257A1 (en) * 2001-06-12 2004-03-10 Elan Pharmaceuticals, Inc. Macrocycles useful in the treatment of alzheimer's disease
JP4584706B2 (ja) 2002-05-03 2010-11-24 イスラエル インスティチュート フォー バイオロジカル リサーチ 中枢及び末梢神経系障害を治療するための方法及び組成物、並びにそれらに有用な新規の化合物
EP2488177B1 (en) * 2008-10-31 2016-10-12 Pain Therapeutics, Inc. Filamin a binding anti-inflammatory and analgesic
PL3523310T3 (pl) 2016-10-05 2022-08-29 Nsc Therapeutics Gmbh Krystaliczne polimorfy agonisty receptora muskarynowego acetylocholiny
WO2019180224A1 (en) 2018-03-22 2019-09-26 Nsc Therapeutics Gmbh Compounds and methods for use in the treatment of microglia-mediated disorders

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US20240083914A1 (en) 2024-03-14
HUE059720T2 (hu) 2022-12-28
PH12019550048B1 (en) 2023-12-06
JP2024056724A (ja) 2024-04-23
IL265747B1 (en) 2023-08-01
MA46464B1 (fr) 2022-10-31
CN109790180A (zh) 2019-05-21
ZA201901695B (en) 2021-08-25
KR20190056398A (ko) 2019-05-24
ES2924432T3 (es) 2022-10-06
US11866449B2 (en) 2024-01-09
EA201990376A1 (ru) 2019-11-29
CL2019000532A1 (es) 2019-07-12
IL304126A (en) 2023-09-01
WO2018065529A1 (en) 2018-04-12
US20200040007A1 (en) 2020-02-06
CY1125464T1 (el) 2025-05-09
IL265747A (en) 2019-06-30
BR112019005450A2 (pt) 2019-06-18
AU2017341088A1 (en) 2019-04-04
KR102710640B1 (ko) 2024-09-27
MX2019003748A (es) 2019-08-12
US20210238195A1 (en) 2021-08-05
JP2019529389A (ja) 2019-10-17
PH12019550048A1 (en) 2019-07-24
MA46464A (fr) 2021-05-26
NZ751538A (en) 2024-10-25
SMT202200331T1 (it) 2022-09-14
MX383581B (es) 2025-03-14
MD3523310T2 (ro) 2022-10-31
JP2022119840A (ja) 2022-08-17
SG11201901612TA (en) 2019-03-28
US11008342B2 (en) 2021-05-18
IL265747B2 (en) 2023-12-01
PE20250745A1 (es) 2025-03-13
CO2019003003A2 (es) 2019-04-12
PL3523310T3 (pl) 2022-08-29
EP3523310A1 (en) 2019-08-14
EP3523310B1 (en) 2022-05-18
AU2017341088B2 (en) 2021-06-24
SI3523310T1 (sl) 2022-10-28
RS63438B1 (sr) 2022-08-31
LT3523310T (lt) 2022-08-25
CA3036134A1 (en) 2018-04-12
HRP20220962T1 (hr) 2022-10-28
JP7163280B2 (ja) 2022-10-31
PT3523310T (pt) 2022-08-04
PE20191003A1 (es) 2019-07-15

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