CL2020000002A1 - Forma cristalina de n-[1-(5-ciano-piridin-2-ilmetil)-1h-pirazol-3-il]-2-[4-(1-trifluorometil-ciclopropil)-fenil]-acetamida. - Google Patents
Forma cristalina de n-[1-(5-ciano-piridin-2-ilmetil)-1h-pirazol-3-il]-2-[4-(1-trifluorometil-ciclopropil)-fenil]-acetamida.Info
- Publication number
- CL2020000002A1 CL2020000002A1 CL2020000002A CL2020000002A CL2020000002A1 CL 2020000002 A1 CL2020000002 A1 CL 2020000002A1 CL 2020000002 A CL2020000002 A CL 2020000002A CL 2020000002 A CL2020000002 A CL 2020000002A CL 2020000002 A1 CL2020000002 A1 CL 2020000002A1
- Authority
- CL
- Chile
- Prior art keywords
- pyridin
- acetamide
- cyclopropyl
- trifluoromethyl
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A LAS FORMAS CRISTALINAS DE N-[1-(5-CIANO-PIRIDIN-2-ILMETIL)-1HPIRAZOL-3-IL]-2-[4-(1-TRIFLUOROMETIL-CICLOPROPIL)-FENIL]-ACETAMIDA, COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN DICHAS FORMAS CRISTALINAS Y SU USO COMO BLOQUEADORES DE CANALES DE CALCIO TIPO T EN EL TRATAMIENTO O PREVENCIÓN DE ENFERMEDADES O TRASTORNOS EN DONDE ESTÁN IMPLICADOS LOS CANALES DE CALCIO TIPO T.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2017066806 | 2017-07-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2020000002A1 true CL2020000002A1 (es) | 2020-07-31 |
Family
ID=63079885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2020000002A CL2020000002A1 (es) | 2017-07-05 | 2020-01-02 | Forma cristalina de n-[1-(5-ciano-piridin-2-ilmetil)-1h-pirazol-3-il]-2-[4-(1-trifluorometil-ciclopropil)-fenil]-acetamida. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11059803B2 (es) |
| EP (1) | EP3649117B1 (es) |
| JP (2) | JP2020525475A (es) |
| KR (1) | KR102645911B1 (es) |
| CN (1) | CN110831932A (es) |
| AU (1) | AU2018296423B2 (es) |
| BR (1) | BR112020000099A2 (es) |
| CA (1) | CA3067489A1 (es) |
| CL (1) | CL2020000002A1 (es) |
| EA (1) | EA202090193A1 (es) |
| IL (1) | IL271764B2 (es) |
| MA (1) | MA50972A (es) |
| MY (1) | MY206357A (es) |
| PH (1) | PH12020500040A1 (es) |
| SG (1) | SG11201912881SA (es) |
| UA (1) | UA126582C2 (es) |
| WO (1) | WO2019008034A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3554490T (lt) | 2016-12-16 | 2022-04-25 | Idorsia Pharmaceuticals Ltd | Farmacinis derinys, apimantis t tipo kalcio kanalo blokatorių |
| CA3050348A1 (en) | 2017-02-06 | 2018-08-09 | Idorsia Pharmaceuticals Ltd | A novel process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes |
| EA202090193A1 (ru) * | 2017-07-05 | 2020-06-03 | Идорсия Фармасьютиклз Лтд | Кристаллическая форма n-[1-(5-цианопиридин-2-илметил)-1h-пиразол-3-ил]-2-[4-(1-трифторметилциклопропил)фенил]ацетамида |
| TW202128158A (zh) | 2019-12-20 | 2021-08-01 | 瑞士商愛杜西亞製藥有限公司 | 包含n-[1-(5-氰基-吡啶-2-基甲基)-1h-吡唑-3-基]-2-[4-(1-三氟甲基-環丙基)-苯基]-乙醯胺之醫藥組合物 |
| WO2023022504A1 (ko) * | 2021-08-17 | 2023-02-23 | 한국과학기술원 | Cav3.1 유전자를 표적으로 하는 안티센스 올리고뉴클레오타이드 및 그의 용도 |
| WO2023240205A1 (en) | 2022-06-10 | 2023-12-14 | Neurocrine Biosciences, Inc. | Deuterated compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6195684B2 (ja) | 2014-06-03 | 2017-09-13 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ピラゾール化合物及びｔ型カルシウムチャンネルブロッカーとしてのそれらの使用 |
| CN107074822B (zh) | 2014-09-15 | 2020-01-03 | 爱杜西亚药品有限公司 | 作为t型钙通道阻断剂的三唑化合物 |
| LT3554490T (lt) | 2016-12-16 | 2022-04-25 | Idorsia Pharmaceuticals Ltd | Farmacinis derinys, apimantis t tipo kalcio kanalo blokatorių |
| CA3050348A1 (en) | 2017-02-06 | 2018-08-09 | Idorsia Pharmaceuticals Ltd | A novel process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes |
| EA202090193A1 (ru) * | 2017-07-05 | 2020-06-03 | Идорсия Фармасьютиклз Лтд | Кристаллическая форма n-[1-(5-цианопиридин-2-илметил)-1h-пиразол-3-ил]-2-[4-(1-трифторметилциклопропил)фенил]ацетамида |
-
2018
- 2018-07-04 EA EA202090193A patent/EA202090193A1/ru unknown
- 2018-07-04 SG SG11201912881SA patent/SG11201912881SA/en unknown
- 2018-07-04 WO PCT/EP2018/068087 patent/WO2019008034A1/en not_active Ceased
- 2018-07-04 UA UAA202000506A patent/UA126582C2/uk unknown
- 2018-07-04 MY MYPI2020000011A patent/MY206357A/en unknown
- 2018-07-04 IL IL271764A patent/IL271764B2/en unknown
- 2018-07-04 CN CN201880044771.7A patent/CN110831932A/zh active Pending
- 2018-07-04 US US16/628,618 patent/US11059803B2/en active Active
- 2018-07-04 EP EP18749304.4A patent/EP3649117B1/en active Active
- 2018-07-04 MA MA050972A patent/MA50972A/fr unknown
- 2018-07-04 JP JP2019572102A patent/JP2020525475A/ja active Pending
- 2018-07-04 AU AU2018296423A patent/AU2018296423B2/en not_active Ceased
- 2018-07-04 CA CA3067489A patent/CA3067489A1/en active Pending
- 2018-07-04 BR BR112020000099-0A patent/BR112020000099A2/pt active Search and Examination
- 2018-07-04 KR KR1020207002894A patent/KR102645911B1/ko active Active
-
2020
- 2020-01-02 CL CL2020000002A patent/CL2020000002A1/es unknown
- 2020-01-03 PH PH12020500040A patent/PH12020500040A1/en unknown
-
2021
- 2021-06-11 US US17/345,844 patent/US11555025B2/en active Active
-
2023
- 2023-06-26 JP JP2023104050A patent/JP2023123679A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112020000099A2 (pt) | 2020-07-07 |
| WO2019008034A1 (en) | 2019-01-10 |
| AU2018296423A1 (en) | 2020-02-20 |
| EA202090193A1 (ru) | 2020-06-03 |
| SG11201912881SA (en) | 2020-01-30 |
| IL271764B1 (en) | 2023-06-01 |
| MA50972A (fr) | 2020-10-14 |
| IL271764B2 (en) | 2023-10-01 |
| US11059803B2 (en) | 2021-07-13 |
| US20200165221A1 (en) | 2020-05-28 |
| JP2023123679A (ja) | 2023-09-05 |
| CN110831932A (zh) | 2020-02-21 |
| KR102645911B1 (ko) | 2024-03-08 |
| UA126582C2 (uk) | 2022-11-02 |
| AU2018296423B2 (en) | 2022-07-28 |
| CA3067489A1 (en) | 2019-01-10 |
| IL271764A (en) | 2020-02-27 |
| PH12020500040A1 (en) | 2020-10-12 |
| US11555025B2 (en) | 2023-01-17 |
| EP3649117A1 (en) | 2020-05-13 |
| JP2020525475A (ja) | 2020-08-27 |
| KR20200018698A (ko) | 2020-02-19 |
| MY206357A (en) | 2024-12-12 |
| EP3649117B1 (en) | 2024-10-09 |
| US20210300894A1 (en) | 2021-09-30 |
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