MA50972A - Forme cristalline de n-[1-(5-cyano-pyridin-2-ylméthyl)-1h-pyrazol-3-yl]-2-[4-(1-trifluorométhyl-cyclopropyl)-phényl]-acétamide - Google Patents

Forme cristalline de n-[1-(5-cyano-pyridin-2-ylméthyl)-1h-pyrazol-3-yl]-2-[4-(1-trifluorométhyl-cyclopropyl)-phényl]-acétamide

Info

Publication number
MA50972A
MA50972A MA050972A MA50972A MA50972A MA 50972 A MA50972 A MA 50972A MA 050972 A MA050972 A MA 050972A MA 50972 A MA50972 A MA 50972A MA 50972 A MA50972 A MA 50972A
Authority
MA
Morocco
Prior art keywords
pyrazol
ylmethyl
pyridin
acetamide
cyclopropyl
Prior art date
Application number
MA050972A
Other languages
English (en)
Inventor
Bibia Heidmann
Raumer Markus Von
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of MA50972A publication Critical patent/MA50972A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA050972A 2017-07-05 2018-07-04 Forme cristalline de n-[1-(5-cyano-pyridin-2-ylméthyl)-1h-pyrazol-3-yl]-2-[4-(1-trifluorométhyl-cyclopropyl)-phényl]-acétamide MA50972A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2017066806 2017-07-05

Publications (1)

Publication Number Publication Date
MA50972A true MA50972A (fr) 2020-10-14

Family

ID=63079885

Family Applications (1)

Application Number Title Priority Date Filing Date
MA050972A MA50972A (fr) 2017-07-05 2018-07-04 Forme cristalline de n-[1-(5-cyano-pyridin-2-ylméthyl)-1h-pyrazol-3-yl]-2-[4-(1-trifluorométhyl-cyclopropyl)-phényl]-acétamide

Country Status (17)

Country Link
US (2) US11059803B2 (fr)
EP (1) EP3649117B1 (fr)
JP (2) JP2020525475A (fr)
KR (1) KR102645911B1 (fr)
CN (1) CN110831932A (fr)
AU (1) AU2018296423B2 (fr)
BR (1) BR112020000099A2 (fr)
CA (1) CA3067489A1 (fr)
CL (1) CL2020000002A1 (fr)
EA (1) EA202090193A1 (fr)
IL (1) IL271764B2 (fr)
MA (1) MA50972A (fr)
MY (1) MY206357A (fr)
PH (1) PH12020500040A1 (fr)
SG (1) SG11201912881SA (fr)
UA (1) UA126582C2 (fr)
WO (1) WO2019008034A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA49114A (fr) 2016-12-16 2020-03-25 Idorsia Pharmaceuticals Ltd Combinaison pharmaceutique comprenant un bloqueur de canal calcique de type t
EP3577099B1 (fr) 2017-02-06 2024-01-24 Idorsia Pharmaceuticals Ltd Un procédé nouveau pour la préparation des 1-aryl-1-trifluorométhylcyclopropanes
US11059803B2 (en) * 2017-07-05 2021-07-13 Idorsia Pharmaceuticals Ltd Crystalline form of N-[1-(5-cyano-pyridin-2- ylmethyl)-1H-pyrazol-3-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide
TW202128158A (zh) 2019-12-20 2021-08-01 瑞士商愛杜西亞製藥有限公司 包含n-[1-(5-氰基-吡啶-2-基甲基)-1h-吡唑-3-基]-2-[4-(1-三氟甲基-環丙基)-苯基]-乙醯胺之醫藥組合物
EP4389892A4 (fr) * 2021-08-17 2025-12-10 Korea Advanced Inst Sci & Tech Oligonucléotide antisens ciblant le gène cav3.1 et ses utilisations
WO2023240205A1 (fr) 2022-06-10 2023-12-14 Neurocrine Biosciences, Inc. Composés deutérés

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201816624T4 (tr) 2014-06-03 2018-11-21 Idorsia Pharmaceuticals Ltd Pirazol bileşikleri ve t tipi kalsiyum kanalı bloke edicileri olarak kullanımları.
PL3194374T3 (pl) 2014-09-15 2019-01-31 Idorsia Pharmaceuticals Ltd Związki triazolowe jako blokery kanału wapniowego typu t
MA49114A (fr) 2016-12-16 2020-03-25 Idorsia Pharmaceuticals Ltd Combinaison pharmaceutique comprenant un bloqueur de canal calcique de type t
EP3577099B1 (fr) 2017-02-06 2024-01-24 Idorsia Pharmaceuticals Ltd Un procédé nouveau pour la préparation des 1-aryl-1-trifluorométhylcyclopropanes
US11059803B2 (en) * 2017-07-05 2021-07-13 Idorsia Pharmaceuticals Ltd Crystalline form of N-[1-(5-cyano-pyridin-2- ylmethyl)-1H-pyrazol-3-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide

Also Published As

Publication number Publication date
AU2018296423B2 (en) 2022-07-28
EP3649117B1 (fr) 2024-10-09
MY206357A (en) 2024-12-12
AU2018296423A1 (en) 2020-02-20
IL271764A (en) 2020-02-27
US20200165221A1 (en) 2020-05-28
CN110831932A (zh) 2020-02-21
BR112020000099A2 (pt) 2020-07-07
CL2020000002A1 (es) 2020-07-31
IL271764B1 (en) 2023-06-01
US20210300894A1 (en) 2021-09-30
JP2020525475A (ja) 2020-08-27
PH12020500040A1 (en) 2020-10-12
EP3649117A1 (fr) 2020-05-13
JP2023123679A (ja) 2023-09-05
US11555025B2 (en) 2023-01-17
UA126582C2 (uk) 2022-11-02
SG11201912881SA (en) 2020-01-30
IL271764B2 (en) 2023-10-01
US11059803B2 (en) 2021-07-13
KR20200018698A (ko) 2020-02-19
KR102645911B1 (ko) 2024-03-08
EA202090193A1 (ru) 2020-06-03
CA3067489A1 (fr) 2019-01-10
WO2019008034A1 (fr) 2019-01-10

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