CL2020000086A1 - Derivado de anillo fusionado que tiene una actividad inhibidora de monoacilglicerol aciltransferasa 2 (mgat-2). - Google Patents

Derivado de anillo fusionado que tiene una actividad inhibidora de monoacilglicerol aciltransferasa 2 (mgat-2).

Info

Publication number
CL2020000086A1
CL2020000086A1 CL2020000086A CL2020000086A CL2020000086A1 CL 2020000086 A1 CL2020000086 A1 CL 2020000086A1 CL 2020000086 A CL2020000086 A CL 2020000086A CL 2020000086 A CL2020000086 A CL 2020000086A CL 2020000086 A1 CL2020000086 A1 CL 2020000086A1
Authority
CL
Chile
Prior art keywords
mgat
inhibitory activity
fused ring
ring derivative
monoacylglycerol acyltransferase
Prior art date
Application number
CL2020000086A
Other languages
English (en)
Inventor
Kouhei Nodu
yusuke Tateno
Kengo Masuda
Yuji Nishiura
Yoshikazu Sasaki
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of CL2020000086A1 publication Critical patent/CL2020000086A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

LA PRESENTE INVENCIÓN PROPORCIONA UN COMPUESTO REPRESENTADO POR LA FÓRMULA (I). (EN LA FÓRMULA (I), (2) ES, POR EJEMPLO, (3); R1 ES UN ÁTOMO DE HIDRÓGENO; R2A Y R2B HAN SIDO UNIDOS ENTRE SÍ PARA FORMAR UN ANILLO B, QUE ES (5); R3A ES UN ÁTOMO DE HIDRÓGENO; R3B ES UN ÁTOMO DE HIDRÓGENO; R4A ES CARBOXI, ETC.; Y R4B ES, POR EJEMPLO, UN ALQUILO OPCIONALMENTE SUSTITUIDO POR CUALQUIERA DEL GRUPO SUSTITUYENTE a).
CL2020000086A 2017-07-14 2020-01-10 Derivado de anillo fusionado que tiene una actividad inhibidora de monoacilglicerol aciltransferasa 2 (mgat-2). CL2020000086A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2017137678 2017-07-14

Publications (1)

Publication Number Publication Date
CL2020000086A1 true CL2020000086A1 (es) 2020-06-12

Family

ID=65001726

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020000086A CL2020000086A1 (es) 2017-07-14 2020-01-10 Derivado de anillo fusionado que tiene una actividad inhibidora de monoacilglicerol aciltransferasa 2 (mgat-2).

Country Status (23)

Country Link
US (3) US11198695B2 (es)
EP (2) EP4043463B1 (es)
JP (3) JP7224086B2 (es)
KR (1) KR102612176B1 (es)
CN (2) CN113501821B (es)
AU (1) AU2018298733B2 (es)
BR (1) BR112020000401A2 (es)
CA (1) CA3069799A1 (es)
CL (1) CL2020000086A1 (es)
DK (1) DK3653625T3 (es)
ES (1) ES2974287T3 (es)
FI (1) FI3653625T3 (es)
HR (1) HRP20240295T1 (es)
HU (1) HUE065838T2 (es)
LT (1) LT3653625T (es)
MX (1) MX394836B (es)
PL (1) PL3653625T3 (es)
PT (1) PT3653625T (es)
RU (1) RU2770437C2 (es)
SA (1) SA520411017B1 (es)
SI (1) SI3653625T1 (es)
TW (1) TWI782056B (es)
WO (2) WO2019013312A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI782056B (zh) * 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 具有ｍｇａｔ２抑制活性的縮合環衍生物
CA3126334A1 (en) * 2019-01-11 2020-07-16 Shionogi & Co., Ltd. Dihydropyrazolopyrazinone derivative having mgat2 inhibitory activity
JP7068743B2 (ja) * 2019-01-11 2022-05-17 塩野義製薬株式会社 Ｍｇａｔ２阻害活性を有する縮合環誘導体を含有する医薬組成物
CN119841865A (zh) 2020-02-07 2025-04-18 加舒布鲁姆生物公司 杂环glp-1激动剂
JP2022016394A (ja) * 2020-07-10 2022-01-21 塩野義製薬株式会社 Ｍｇａｔ２阻害活性を有するジヒドロピラゾロピラジノン誘導体を含有する医薬組成物
EP4211139A4 (en) 2020-09-10 2024-12-18 Gasherbrum Bio, Inc. HETEROCYCLIC GLP-1 AGONISTS
CN114685502A (zh) * 2020-12-25 2022-07-01 由理生物医药（上海）有限公司 作为kras-g12c抑制剂的螺环类化合物
WO2023038039A1 (ja) 2021-09-08 2023-03-16 塩野義製薬株式会社 抗肥満作用の関与する疾患の予防及び治療用医薬
AU2023218370B2 (en) * 2022-02-09 2024-11-28 Quanta Therapeutics, Inc. Kras modulators and uses thereof
IL317601A (en) 2022-05-25 2025-02-01 Quanta Therapeutics Inc Pyrimidine-based modulators and their uses
AU2023296166A1 (en) 2022-06-13 2024-11-28 Shionogi & Co., Ltd. Crystal of dihydropyridinone derivative or solvate thereof
AU2024222719A1 (en) 2023-02-16 2025-08-21 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
WO2024192424A1 (en) 2023-03-15 2024-09-19 Quanta Therapeutics, Inc. Kras modulators and uses thereof
WO2025127097A1 (ja) * 2023-12-13 2025-06-19 塩野義製薬株式会社 脂肪性肝疾患の治療用医薬
JP2024100975A (ja) * 2024-01-31 2024-07-26 塩野義製薬株式会社 ジヒドロピリジノン誘導体を含有する医薬組成物
WO2026008045A1 (zh) * 2024-07-04 2026-01-08 苏州信诺维医药科技股份有限公司 一种含有炔基的螺环化合物及其用途

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1747949A (zh) 2002-12-20 2006-03-15 法马西亚公司 无环吡唑化合物
US8232282B2 (en) 2006-09-28 2012-07-31 Dainippon Sumitomo Pharma Co., Ltd. Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same
AU2007342368A1 (en) 2007-01-04 2008-07-17 Merck & Co., Inc. Bicyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
US8389533B2 (en) 2008-04-07 2013-03-05 Amgen Inc. Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors
US20110275647A1 (en) * 2009-02-23 2011-11-10 Msd K.K. Pyrimidin-4-(3h)-one derivatives
KR20100097077A (ko) * 2009-02-25 2010-09-02 주식회사 중외제약 Ｈｓｐ90에 대한 억제 효능을 갖는 피리디논 유도체
SG181857A1 (en) * 2009-12-23 2012-07-30 Takeda Pharmaceutical Fused heteroaromatic pyrrolidinones as syk inhibitors
JP2014051434A (ja) 2010-12-28 2014-03-20 Dainippon Sumitomo Pharma Co Ltd 二環性ピリミジン誘導体
JP5853033B2 (ja) * 2011-03-01 2016-02-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ β−セクレターゼ（ＢＡＣＥ）の阻害剤として有用な６，７−ジヒドロ−ピラゾロ［１，５−ａ］ピラジン−４−イルアミン誘導体
WO2012124744A1 (ja) 2011-03-14 2012-09-20 大正製薬株式会社 含窒素縮合複素環化合物
PT2573073E (pt) * 2011-09-26 2015-02-05 Sanofi Sa Derivados de pirazoloquinolinona, sua preparação e sua utilização terapêutica
CN103012397B (zh) 2011-09-26 2017-03-01 赛诺菲 吡唑并喹啉酮衍生物、其制备方法及其治疗用途
JP6042060B2 (ja) 2011-09-26 2016-12-14 サノフイ ピラゾロキノリノン誘導体、その調製および治療上の使用
US8791091B2 (en) * 2011-12-02 2014-07-29 Bristol-Myers Squibb Company Aryl dihydropyridinone and piperidinone MGAT2 inhibitors
US9073856B2 (en) 2012-01-23 2015-07-07 Eli Lilly And Company Phenyl methanesulfonamide derivatives useful as MGAT-2 inhibitors
JP5852269B2 (ja) 2012-01-31 2016-02-03 イーライ リリー アンド カンパニー Ｍｏｇａｔ−２阻害剤として有用な新規モルホリニル誘導体
AR089771A1 (es) 2012-01-31 2014-09-17 Lilly Co Eli Derivados de bencil sulfonamida utiles como inhibidores de mogat-2
US9394297B2 (en) * 2012-02-28 2016-07-19 Amgen Inc. Amides as pim inhibitors
EP2855483B1 (en) 2012-05-24 2017-10-25 Novartis AG Pyrrolopyrrolidinone compounds
JP2014005245A (ja) 2012-06-26 2014-01-16 Dainippon Sumitomo Pharma Co Ltd 二環性ピリミジン誘導体を含有する医薬組成物
JP2014009165A (ja) 2012-06-27 2014-01-20 Dainippon Sumitomo Pharma Co Ltd 二環性ピリミジン化合物
EP2903985A1 (en) * 2012-10-03 2015-08-12 Advinus Therapeutics Limited Spirocyclic compounds, compositions and medicinal applications thereof
MX2015005739A (es) 2012-11-06 2015-09-16 Lilly Co Eli Compuestos novedosos de bencil sulfonamida utiles como inhibidores de mogat-2.
WO2014133134A1 (ja) 2013-02-28 2014-09-04 味の素株式会社 新規テトラヒドロピリドピリミジノン誘導体
TWI629275B (zh) * 2013-03-13 2018-07-11 賽諾菲公司 Ｎ－（４－（氮雜吲唑－６－基）－苯基）－磺醯胺及其作為醫藥之用途
CA2907532A1 (en) * 2013-03-25 2014-10-02 Sanofi Pyrazolonaphthyridinone derivatives as metap2 inhibitors (methionine aminopeptidase type-2)
CN104109160B (zh) 2013-04-17 2017-12-15 上海翰森生物医药科技有限公司 吡咯并n杂环类化合物及其制备方法和医药用途
SG11201509070YA (en) 2013-05-29 2015-12-30 Bristol Myers Squibb Co Dihydropyridinone mgat2 inhibitors
AR098414A1 (es) * 2013-11-14 2016-05-26 Bristol Myers Squibb Co PIPERAZINAS DE PIRAZOLO SUSTITUIDO COMO INHIBIDORES DE CASEÍNA QUINASA 1 d/e
WO2015112465A1 (en) 2014-01-24 2015-07-30 Merck Sharp & Dohme Corp. Isoquinoline derivatives as mgat2 inhibitors
EP3097095A1 (en) * 2014-01-24 2016-11-30 AbbVie Inc. Furo-3-carboxamide derivatives and methods of use
JP6513075B2 (ja) 2014-02-27 2019-05-15 国立大学法人 東京大学 オートタキシン阻害活性を有する縮合ピラゾール誘導体
JP2017078024A (ja) 2014-02-28 2017-04-27 味の素株式会社 新規テトラヒドロピリドピリミジノン誘導体
SMT201900256T1 (it) 2014-03-07 2019-07-11 Bristol Myers Squibb Co Inibitori dell'mgat2 diidropiridinonici sostituiti con tetrazolone
SG11201607392SA (en) * 2014-03-07 2016-10-28 Bristol Myers Squibb Co Dihydropyridinone mgat2 inhibitors for use in the treatment of metabolic disorders
EP3129376B1 (en) 2014-03-27 2018-12-26 Janssen Pharmaceutica NV Substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine derivatives and 5,6,7,8-tetrahydro-4h-pyrazolo[1,5-a][1,4]diazepine derivatives as ros1 inhibitors
WO2015191681A2 (en) 2014-06-11 2015-12-17 Bristol-Myers Squibb Company Substituted pyridinones as mgat2 inhibitors
JP2017171579A (ja) 2014-08-11 2017-09-28 味の素株式会社 新規テトラヒドロピリドピリミジノン誘導体
WO2016044120A1 (en) 2014-09-19 2016-03-24 Merck Sharp & Dohme Corp. Diazine-fused amidine compounds as bace inhibitors, compositions, and their use
CN107205993B (zh) * 2014-12-06 2021-03-09 细胞内治疗公司 有机化合物
WO2016106009A1 (en) * 2014-12-22 2016-06-30 Eli Lilly And Company Erk inhibitors
JP2018052818A (ja) 2015-01-28 2018-04-05 武田薬品工業株式会社 スルホンアミド化合物
JP2016164154A (ja) * 2015-02-26 2016-09-08 塩野義製薬株式会社 オートタキシン阻害活性を有する７位無置換縮合ピラゾール誘導体
WO2017069224A1 (ja) * 2015-10-22 2017-04-27 塩野義製薬株式会社 Ｍｇａｔ２阻害活性を有するスピロ環誘導体
TWI782056B (zh) * 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 具有ｍｇａｔ２抑制活性的縮合環衍生物

Also Published As

Publication number Publication date
US12454533B2 (en) 2025-10-28
KR102612176B1 (ko) 2023-12-08
JP7493635B2 (ja) 2024-05-31
RU2020106727A (ru) 2021-08-16
ES2974287T3 (es) 2024-06-26
JP7060298B1 (ja) 2022-04-26
JP2023055851A (ja) 2023-04-18
KR20200029549A (ko) 2020-03-18
PT3653625T (pt) 2024-03-27
FI3653625T3 (fi) 2024-03-12
EP4043463C0 (en) 2025-11-26
BR112020000401A2 (pt) 2020-07-14
TWI782056B (zh) 2022-11-01
TW201908313A (zh) 2019-03-01
US12024519B2 (en) 2024-07-02
SI3653625T1 (sl) 2024-04-30
EP3653625B1 (en) 2024-02-07
JP2022068347A (ja) 2022-05-09
US20220073518A1 (en) 2022-03-10
SA520411017B1 (ar) 2022-08-14
PL3653625T3 (pl) 2024-05-20
RU2020106727A3 (es) 2021-09-29
JPWO2019013311A1 (ja) 2020-05-07
AU2018298733A1 (en) 2020-02-06
RU2770437C2 (ru) 2022-04-18
EP4043463A1 (en) 2022-08-17
AU2018298733B2 (en) 2022-03-31
HRP20240295T1 (hr) 2024-05-10
EP3653625A4 (en) 2021-02-24
CN111094288A (zh) 2020-05-01
EP3653625A1 (en) 2020-05-20
CN111094288B (zh) 2022-12-23
US20200291025A1 (en) 2020-09-17
DK3653625T3 (da) 2024-03-04
HUE065838T2 (hu) 2024-06-28
CN113501821B (zh) 2024-04-09
WO2019013312A1 (ja) 2019-01-17
CA3069799A1 (en) 2019-01-17
US11198695B2 (en) 2021-12-14
CN113501821A (zh) 2021-10-15
EP4043463B1 (en) 2025-11-26
US20240309002A1 (en) 2024-09-19
WO2019013311A1 (ja) 2019-01-17
MX394836B (es) 2025-03-24
LT3653625T (lt) 2024-03-25
JP7224086B2 (ja) 2023-02-17

Similar Documents

Publication Publication Date Title
CL2020000086A1 (es) Derivado de anillo fusionado que tiene una actividad inhibidora de monoacilglicerol aciltransferasa 2 (mgat-2).
CL2017001967A1 (es) Composición agroquímica
CR20170530A (es) Derivados de piridona policíclica sustituída y profármaco de los mismos.
MX2019001640A (es) Composiciones farmaceuticas que contienen derivados de piridona policiclicos sustituidos y profarmacos de los mismos.
CL2018001618A1 (es) Un medicamento que comprende a) compuestos heterociclicos nitrogenados fusionados, moduladores de cen y cpe, y b) un compuestyo o anticuerpo con actividad antiinfluenza; y su uso para la influenza.
AR111346A1 (es) Compuesto peptídico con acción activante sobre receptores gip
CR20160328A (es) Compuestos derivados y composiciones de n-azaspirocicloalcano n-heteroaril sustituido para inhibir la actividad de shp2
CL2018001181A1 (es) Inhibidores de ret
DOP2015000261A (es) Compuesto peptídico como activador de los receptores del glp-1 y del gip
ECSP18003372A (es) Compuestos tricíclicos y su uso como inhibidores de la fosfodiesterasa
MX381970B (es) Derivado de sulfonamida y composición farmacéutica que contiene el mismo.
MY189144A (en) Substituted polycyclic pyridone derivatives and prodrugs thereof
MX2021007141A (es) Sintesis de gamma-carbolinas fusionadas con heterociclo sustituido.
BR112018002461A2 (pt) compostos para dispositivos opticamente ativos
MX2021007245A (es) Microorganismos para la produccion de putrescina u ornitina y procedimiento para la produccion de putrescina u ornitina usando los mismos.
ECSP20084442A (es) Tiofenocarboxamidas sustituidas y análogos de las mismas
BR112018075736A2 (pt) composto de amida alfa e beta insaturado derivado de benzotriazol usado como inibidor de tgf-betar1
UY35976A (es) Composiciones herbicidas estables
CR20130158A (es) Derivados de 1,4-oxazepina
MX390507B (es) Compuestos de amida y su uso.
CO2021007442A2 (es) Compuesto de 1,3,4-oxadiazolona y fármaco
MX2021008050A (es) Derivado de dihidropirazolopirazinona que tiene actividad inhibidora de monoacilglicerol aciltransferasa 2 (mgat2).
BR112018011437A2 (pt) processo para a preparação de lisdexanfetamina
AR108369A1 (es) Derivado de benzodiazepina con actividad sobre el sistema nervioso central y vascular
BR112015017493A2 (pt) processos para produção de derivados de magnolol