CL2020001335A1 - Métodos de tratamiento de la insuficiencia cardiaca con fracción de eyección reducida con dapagliflozina - Google Patents
Métodos de tratamiento de la insuficiencia cardiaca con fracción de eyección reducida con dapagliflozinaInfo
- Publication number
- CL2020001335A1 CL2020001335A1 CL2020001335A CL2020001335A CL2020001335A1 CL 2020001335 A1 CL2020001335 A1 CL 2020001335A1 CL 2020001335 A CL2020001335 A CL 2020001335A CL 2020001335 A CL2020001335 A CL 2020001335A CL 2020001335 A1 CL2020001335 A1 CL 2020001335A1
- Authority
- CL
- Chile
- Prior art keywords
- heart failure
- dapagliflozin
- methods
- ejection fraction
- reduced ejection
- Prior art date
Links
- JVHXJTBJCFBINQ-ADAARDCZSA-N Dapagliflozin Chemical compound C1=CC(OCC)=CC=C1CC1=CC([C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC=C1Cl JVHXJTBJCFBINQ-ADAARDCZSA-N 0.000 title abstract 3
- 229960003834 dapagliflozin Drugs 0.000 title abstract 3
- 208000038002 heart failure with reduced ejection fraction Diseases 0.000 title 1
- 206010019280 Heart failures Diseases 0.000 abstract 7
- 229940123518 Sodium/glucose cotransporter 2 inhibitor Drugs 0.000 abstract 2
- 230000034994 death Effects 0.000 abstract 2
- 231100000517 death Toxicity 0.000 abstract 2
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 2
- 208000024891 symptom Diseases 0.000 abstract 2
- 230000003862 health status Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente divulgación se refiere a métodos de tratamiento de pacientes con insuficiencia cardiaca con fracción de eyección reducida (HFrEF), con y sin diabetes de tipo 2, con un inhibidor de SGLT2 tal como dapagliflozina. Los métodos desvelados en el presente documento reducen el riesgo de un resultado combinado de un primer episodio de empeoramiento de insuficiencia cardiaca (hospitalización por insuficiencia cardiaca o una visita de urgencias por insuficiencia cardiaca) o muerte por causas cardiovasculares. También puede reducirse cada uno de los tres componentes de este resultado combinado, así como el número total de hospitalizaciones por insuficiencia cardiaca y muertes por causas cardiovasculares. Los inhibidores de SGLT2, tales como dapagliflozina, también pueden reducir un empeoramiento de los síntomas de insuficiencia cardiaca. Los métodos desvelados en el presente documento también pueden mejorar los síntomas de insuficiencia cardiaca, el estado de salud y la calidad de vida.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962893849P | 2019-08-30 | 2019-08-30 | |
| US201962930673P | 2019-11-05 | 2019-11-05 | |
| US201962946625P | 2019-12-11 | 2019-12-11 | |
| US202062960756P | 2020-01-14 | 2020-01-14 | |
| US202062969181P | 2020-02-03 | 2020-02-03 | |
| US202062985407P | 2020-03-05 | 2020-03-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2020001335A1 true CL2020001335A1 (es) | 2021-07-09 |
Family
ID=69784449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2020001335A CL2020001335A1 (es) | 2019-08-30 | 2020-05-20 | Métodos de tratamiento de la insuficiencia cardiaca con fracción de eyección reducida con dapagliflozina |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US10973836B2 (es) |
| EP (1) | EP4021507A1 (es) |
| JP (4) | JP7756487B2 (es) |
| KR (3) | KR102359799B1 (es) |
| CN (1) | CN112752582A (es) |
| AU (4) | AU2020202887B2 (es) |
| BR (1) | BR112020008705A2 (es) |
| CA (1) | CA3079175A1 (es) |
| CL (1) | CL2020001335A1 (es) |
| CR (1) | CR20200224A (es) |
| IL (1) | IL274020A (es) |
| JO (1) | JOP20200098A1 (es) |
| MX (2) | MX2020005388A (es) |
| PE (1) | PE20211267A1 (es) |
| PH (1) | PH12020551141A1 (es) |
| SG (1) | SG11202003971RA (es) |
| TW (3) | TW202504616A (es) |
| WO (1) | WO2021037400A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA53175A (fr) | 2018-07-19 | 2021-05-26 | Astrazeneca Ab | Méthodes de traitement de hfpef au moyen de dapagliflozine et compositions comprenant celle-ci |
| PE20211267A1 (es) * | 2019-08-30 | 2021-07-19 | Astrazeneca Ab | Metodos de tratamiento de la insuficiencia cardiaca con fraccion de eyeccion reducida con dapagliflozina |
| CA3180674A1 (en) * | 2020-04-22 | 2021-10-28 | Bayer Aktiengesellschaft | Combination of finerenone and a sglt2 inhibitor for the treatment and/or prevention of cardiovascular and/or renal diseases |
| WO2022144465A1 (en) * | 2021-01-04 | 2022-07-07 | Charité-Universitätsmedizin Berlin | Sotagliflozin for improving left atrial function |
| US20250108065A1 (en) | 2022-01-26 | 2025-04-03 | Astrazeneca Ab | Methods of treating prediabetes or reducing the risk of developing type 2 diabetes with dapagliflozin |
| JP7396579B2 (ja) * | 2022-01-31 | 2023-12-12 | 壽製薬株式会社 | 左室駆出率が保たれた心不全に対する医薬組成物 |
| WO2023175573A1 (en) * | 2022-03-17 | 2023-09-21 | Zydus Lifesciences Limited | Pharmaceutical compositions comprising a β-blocker and an sglt2 inhibitor |
| WO2023192848A1 (en) * | 2022-03-28 | 2023-10-05 | University Of Maryland, Baltimore | Methods and compositions for the treatment of stroke |
| AU2023331475A1 (en) * | 2022-09-01 | 2025-04-17 | Astrazeneca Ab | Combination of sglt2 inhibitors and mineralcorticoid receptor modulators for use in treatment of cardiorenal diseases |
| CN120390636A (zh) * | 2022-12-20 | 2025-07-29 | 斯法姆公司 | 包含钠-葡萄糖协同转运蛋白2抑制剂和血管紧张素ⅱ受体阻滞剂的口服药物制剂 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12000002657B1 (en) | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
| US6515117B2 (en) | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| AR059489A1 (es) | 2006-02-15 | 2008-04-09 | Boehringer Ingelheim Vetmed | Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion |
| TW200904405A (en) * | 2007-03-22 | 2009-02-01 | Bristol Myers Squibb Co | Pharmaceutical formulations containing an SGLT2 inhibitor |
| TW200904454A (en) * | 2007-03-22 | 2009-02-01 | Bristol Myers Squibb Co | Methods for treating obesity employing an SGLT2 inhibitor and compositions thereof |
| JP2011506363A (ja) | 2007-12-11 | 2011-03-03 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | 心不全の処置および／または予防用のオキサゾリジノン類 |
| CA2812016A1 (en) * | 2013-04-05 | 2014-10-05 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| EP3160948B1 (en) | 2014-06-30 | 2018-10-24 | Astrazeneca AB | Benzoxazinone amides as mineralocorticoid receptor modulators |
| CN106714840A (zh) * | 2014-09-25 | 2017-05-24 | 阿斯利康(瑞典)有限公司 | 用于治疗肝病的ω‑3脂肪酸和SGLT‑2抑制剂的组合 |
| BR112018016001A2 (en) * | 2016-03-16 | 2018-12-18 | Boehringer Ingelheim International Gmbh | pharmaceutical composition, treatment methods and uses thereof |
| WO2018043463A1 (ja) * | 2016-08-30 | 2018-03-08 | 国立大学法人新潟大学 | 老化細胞除去薬 |
| WO2018142422A1 (en) | 2017-02-02 | 2018-08-09 | Indoco Remedies Limited | Process for the preparation of dapagliflozin |
| KR101943382B1 (ko) | 2017-09-19 | 2019-01-29 | 오토텔릭바이오 주식회사 | Sglt-2 저해제 및 안지오텐신 수용체 차단제를 포함하는 의약 조성물 |
| MA53175A (fr) | 2018-07-19 | 2021-05-26 | Astrazeneca Ab | Méthodes de traitement de hfpef au moyen de dapagliflozine et compositions comprenant celle-ci |
| PE20211267A1 (es) | 2019-08-30 | 2021-07-19 | Astrazeneca Ab | Metodos de tratamiento de la insuficiencia cardiaca con fraccion de eyeccion reducida con dapagliflozina |
| US12409186B2 (en) * | 2020-07-27 | 2025-09-09 | Astrazeneca Ab | Methods of treating chronic kidney disease with dapagliflozin |
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2020
- 2020-03-09 PE PE2020000563A patent/PE20211267A1/es unknown
- 2020-03-09 CR CR20200224A patent/CR20200224A/es unknown
- 2020-03-09 KR KR1020207012588A patent/KR102359799B1/ko active Active
- 2020-03-09 KR KR1020247038499A patent/KR20240166611A/ko active Pending
- 2020-03-09 CA CA3079175A patent/CA3079175A1/en active Pending
- 2020-03-09 WO PCT/EP2020/056211 patent/WO2021037400A1/en not_active Ceased
- 2020-03-09 KR KR1020217014553A patent/KR20220044234A/ko not_active Ceased
- 2020-03-09 JP JP2020524303A patent/JP7756487B2/ja active Active
- 2020-03-09 US US16/812,745 patent/US10973836B2/en active Active
- 2020-03-09 CN CN202080000531.4A patent/CN112752582A/zh active Pending
- 2020-03-09 SG SG11202003971RA patent/SG11202003971RA/en unknown
- 2020-03-09 EP EP20710490.2A patent/EP4021507A1/en active Pending
- 2020-03-09 JO JOP/2020/0098A patent/JOP20200098A1/ar unknown
- 2020-03-09 MX MX2020005388A patent/MX2020005388A/es unknown
- 2020-03-09 BR BR112020008705A patent/BR112020008705A2/pt not_active Application Discontinuation
- 2020-03-09 AU AU2020202887A patent/AU2020202887B2/en active Active
- 2020-04-19 IL IL274020A patent/IL274020A/en unknown
- 2020-04-30 TW TW113137483A patent/TW202504616A/zh unknown
- 2020-04-30 TW TW109114687A patent/TWI786398B/zh active
- 2020-04-30 TW TW111145734A patent/TWI859649B/zh active
- 2020-05-01 PH PH12020551141A patent/PH12020551141A1/en unknown
- 2020-05-20 CL CL2020001335A patent/CL2020001335A1/es unknown
- 2020-07-13 MX MX2022008018A patent/MX2022008018A/es unknown
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2021
- 2021-02-25 US US17/184,746 patent/US11903955B2/en active Active
- 2021-08-10 AU AU2021215150A patent/AU2021215150B2/en active Active
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2022
- 2022-12-06 JP JP2022194700A patent/JP7494277B2/ja active Active
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2023
- 2023-07-31 AU AU2023210548A patent/AU2023210548B2/en active Active
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2024
- 2024-01-11 US US18/410,094 patent/US20240216404A1/en active Pending
- 2024-05-22 JP JP2024083232A patent/JP2024119842A/ja active Pending
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2025
- 2025-04-04 JP JP2025062458A patent/JP2025108488A/ja active Pending
- 2025-06-17 AU AU2025204486A patent/AU2025204486A1/en active Pending
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