CL2020001817A1 - Moduladores del receptor c5a - Google Patents

Moduladores del receptor c5a

Info

Publication number
CL2020001817A1
CL2020001817A1 CL2020001817A CL2020001817A CL2020001817A1 CL 2020001817 A1 CL2020001817 A1 CL 2020001817A1 CL 2020001817 A CL2020001817 A CL 2020001817A CL 2020001817 A CL2020001817 A CL 2020001817A CL 2020001817 A1 CL2020001817 A1 CL 2020001817A1
Authority
CL
Chile
Prior art keywords
receptor modulators
formula
derivatives
compounds
pharmaceutically acceptable
Prior art date
Application number
CL2020001817A
Other languages
English (en)
Inventor
Sylvie Froidevaux
Francis Hubler
Mark Murphy
Dorte Renneberg
Simon Stamm
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of CL2020001817A1 publication Critical patent/CL2020001817A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Eye Examination Apparatus (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)

Abstract

La presente invención se refiere a derivados de fórmula (I), en donde el anillo A, X, Y, Z, RA, R1, R2, R3 y R4 son como se describe en la descripción, a su preparación, a sales farmacéuticamente aceptables de los mismos, y a su uso como agentes farmacéuticos, a composiciones farmacéuticas que contienen uno o más compuestos de fórmula (I), y especialmente a su uso como moduladores del receptor C5a.
CL2020001817A 2018-01-10 2020-07-08 Moduladores del receptor c5a CL2020001817A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2018050598 2018-01-10

Publications (1)

Publication Number Publication Date
CL2020001817A1 true CL2020001817A1 (es) 2020-12-04

Family

ID=65012016

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020001817A CL2020001817A1 (es) 2018-01-10 2020-07-08 Moduladores del receptor c5a

Country Status (29)

Country Link
US (2) US11608341B2 (es)
EP (1) EP3737684B1 (es)
JP (1) JP7014914B2 (es)
KR (1) KR102574564B1 (es)
CN (1) CN111566109B (es)
AR (1) AR114564A1 (es)
AU (1) AU2019207666B2 (es)
CA (1) CA3086310C (es)
CL (1) CL2020001817A1 (es)
DK (1) DK3737684T3 (es)
EA (1) EA202091641A1 (es)
ES (1) ES2933820T3 (es)
HR (1) HRP20221449T1 (es)
HU (1) HUE060515T2 (es)
IL (1) IL275868B2 (es)
LT (1) LT3737684T (es)
MA (1) MA51558B1 (es)
MX (1) MX2020007443A (es)
MY (1) MY198902A (es)
PH (1) PH12020500583B1 (es)
PL (1) PL3737684T3 (es)
PT (1) PT3737684T (es)
RS (1) RS63806B1 (es)
SG (1) SG11202006490YA (es)
SI (1) SI3737684T1 (es)
TW (2) TWI839788B (es)
UA (1) UA124694C2 (es)
WO (1) WO2019137927A1 (es)
ZA (1) ZA202004910B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12020500583B1 (en) * 2018-01-10 2024-02-21 Idorsia Pharmaceuticals Ltd 2,4,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-5-one derivatives and related compounds as c5a receptor modulators for treating vasculitis and inflammatory diseases
JP7281469B2 (ja) * 2018-01-19 2023-05-25 イドーシア ファーマシューティカルズ リミテッド Ｃ５ａ受容体調節剤
CN111683937A (zh) 2018-01-19 2020-09-18 爱杜西亚药品有限公司 C5a受体调节剂
CA3146386A1 (en) * 2019-07-09 2021-01-14 Idorsia Pharmaceuticals Ltd Pharmaceutical composition comprising a tetrahydropyrazolopyrimidinone compound
US11193891B2 (en) * 2019-12-20 2021-12-07 Robert Bosch Gmbh Receptors and spacers for a fluorescence-based lead ion chemosensor

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003082828A1 (en) * 2002-03-28 2003-10-09 Neurogen Corporation Substituted tetrahydroisoquinolines as c5a receptor modulators
AU2003269850A1 (en) * 2002-10-08 2004-05-04 Novo Nordisk A/S Hemisuccinate salts of heterocyclic dpp-iv inhibitors
US7906528B2 (en) * 2004-10-05 2011-03-15 Novartis International Pharmaceutical Ltd. Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds
HRP20171176T1 (hr) * 2010-06-24 2017-10-06 Chemocentryx, Inc. C5ar antagonisti
US8846656B2 (en) * 2011-07-22 2014-09-30 Novartis Ag Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators
TWI841376B (zh) * 2013-03-01 2024-05-01 美商英塞特控股公司 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途
ES2642074T3 (es) 2013-09-04 2017-11-15 Bristol-Myers Squibb Company Compuestos útiles como inmunomoduladores
CN105814028B (zh) 2013-09-06 2018-02-16 奥瑞基尼探索技术有限公司 作为免疫调节剂的1，2，4‑*二唑衍生物
WO2015044900A1 (en) 2013-09-27 2015-04-02 Aurigene Discovery Technologies Limited Therapeutic immunomodulating compounds
JP2017526730A (ja) * 2014-09-16 2017-09-14 ギリアード サイエンシーズ， インコーポレイテッド Ｔｏｌｌ様受容体モジュレーターの固体形態
WO2017034872A1 (en) * 2015-08-25 2017-03-02 Janssen Pharmaceutica Nv Indazole derivatives useful as cb-1 inverse agonists
PH12020500583B1 (en) * 2018-01-10 2024-02-21 Idorsia Pharmaceuticals Ltd 2,4,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-5-one derivatives and related compounds as c5a receptor modulators for treating vasculitis and inflammatory diseases
CN111683937A (zh) 2018-01-19 2020-09-18 爱杜西亚药品有限公司 C5a受体调节剂
JP7281469B2 (ja) 2018-01-19 2023-05-25 イドーシア ファーマシューティカルズ リミテッド Ｃ５ａ受容体調節剤
CA3146386A1 (en) 2019-07-09 2021-01-14 Idorsia Pharmaceuticals Ltd Pharmaceutical composition comprising a tetrahydropyrazolopyrimidinone compound

Also Published As

Publication number Publication date
SG11202006490YA (en) 2020-08-28
TWI774905B (zh) 2022-08-21
AU2019207666A1 (en) 2020-08-27
EA202091641A1 (ru) 2020-11-17
PT3737684T (pt) 2022-12-20
US20230192708A1 (en) 2023-06-22
JP2021510373A (ja) 2021-04-22
MA51558A (fr) 2021-04-14
IL275868A (en) 2020-08-31
MA51558B1 (fr) 2022-12-30
US20200369672A1 (en) 2020-11-26
MY198902A (en) 2023-10-02
TWI839788B (zh) 2024-04-21
KR102574564B1 (ko) 2023-09-04
WO2019137927A1 (en) 2019-07-18
MX2020007443A (es) 2020-09-14
RS63806B1 (sr) 2023-01-31
TW202244047A (zh) 2022-11-16
EP3737684A1 (en) 2020-11-18
CA3086310C (en) 2023-09-19
PH12020500583B1 (en) 2024-02-21
SI3737684T1 (sl) 2023-01-31
HRP20221449T1 (hr) 2023-01-20
JP7014914B2 (ja) 2022-02-01
TW201930307A (zh) 2019-08-01
CN111566109B (zh) 2023-07-11
AR114564A1 (es) 2020-09-23
AU2019207666B2 (en) 2023-12-21
CN111566109A (zh) 2020-08-21
DK3737684T3 (da) 2022-12-12
CA3086310A1 (en) 2019-07-18
UA124694C2 (uk) 2021-10-27
IL275868B2 (en) 2023-06-01
BR112020013788A2 (pt) 2020-12-01
HUE060515T2 (hu) 2023-03-28
ES2933820T3 (es) 2023-02-14
PH12020500583A1 (en) 2021-06-14
ZA202004910B (en) 2024-02-28
PL3737684T3 (pl) 2023-02-27
EP3737684B1 (en) 2022-11-16
KR20200106061A (ko) 2020-09-10
US11608341B2 (en) 2023-03-21
LT3737684T (lt) 2022-12-27

Similar Documents

Publication Publication Date Title
CL2019000169A1 (es) Derivados de piperidina.
MX2018011831A (es) Antagonistas solubles de receptor de c5aa(c5ar).
CL2022003646A1 (es) Derivados de amidopirimidona
CO2018007443A2 (es) Nuevos derivados de amonio, un proceso para su preparación y composiciones farmacéuticas que los contienen
CL2018001325A1 (es) Derivados de indol n-sustituidos como moduladores del receptor de pge2
UY32462A (es) Derivados de bifenilo novedosos para el tratamiento de infección por virus de hepatitis c 644
MX2019013639A (es) Derivados de indol n-sustituidos.
MX2018004207A (es) Nuevos compuestos de espiro[3h-indol-3,2â´-pirrolidin]-2(1h)-ona y derivados como inhibidores de mdm2-p53.
MX2022011354A (es) Compuestos de pirimidina fusionados como moduladores de kcc2.
MX2020011449A (es) Oxiesteroles y metodos de uso de los mismos.
MX2022001789A (es) Derivados de 2-hidroxicicloalcan-1-carbamoilo.
CO2020004977A2 (es) Compuestos bicíclicos para su uso como inhibidores de la ripi quinasa
UY36003A (es) Derivados de amida, procesos de preparación y composiciones, útiles en afecciones asociadas con el receptor sub-tipo 1 de orexina.
MX2021003945A (es) Compuestos de indolinona para uso como inhibidores de map4k1.
CL2019001991A1 (es) Moduladores del receptor de estrógeno.
PY2039849A (es) Derivados de 3,6-diamino-piridazin-3-ilo, composiciones farmacéuticas que los contienen y sus usos como agentes proapoptóticos
MX2020007443A (es) Derivados de 2,4,6,7-tetrahidro-pirazolo[4,3-d]pirimidin-5-ona y compuestos relacionados como moduladores del receptor c5a para el tratamiento de vasculitis y enfermedades inflamatorias.
CL2017002498A1 (es) Piridopirimidinonas y su uso como modulares del receptor nmda
CR20160084A (es) Derivados de amida como agonistas del receptor del ácido lisofosfatídico
CO2018001700A2 (es) Derivados de n-[1h-bencimidazol-2-il] metil-pirazin-2-il-carboxamida, composiciones y procedimientos de preparación de los mismos
CO2017008156A2 (es) Derivados de 1-(4-(4-(pirimidin-5-il)tiazol-5-il)piperazin-1-il)etan-1-ona y análogos de piridina de los mismos como moduladores del receptor cxcr3, composiciones que los comprenden y métodos de elaboración
CL2021003348A1 (es) Derivados de piridin–3–ilo.
CO2019004143A2 (es) Compuestos azaheterocíclicos fusionados y su uso como moduladores de los receptores ampa
MX2020004339A (es) Moduladores alostericos positivos del receptor m1 muscarinico.
UY38423A (es) Nuevos derivados amino-pirimidonil-piperidinilo, un proceso para su preparación y composiciones farmacéuticas que los contienen