CL2020001817A1 - Moduladores del receptor c5a - Google Patents

Moduladores del receptor c5a

Info

Publication number
CL2020001817A1
CL2020001817A1 CL2020001817A CL2020001817A CL2020001817A1 CL 2020001817 A1 CL2020001817 A1 CL 2020001817A1 CL 2020001817 A CL2020001817 A CL 2020001817A CL 2020001817 A CL2020001817 A CL 2020001817A CL 2020001817 A1 CL2020001817 A1 CL 2020001817A1
Authority
CL
Chile
Prior art keywords
receptor modulators
formula
derivatives
compounds
pharmaceutically acceptable
Prior art date
Application number
CL2020001817A
Other languages
English (en)
Inventor
Sylvie Froidevaux
Francis Hubler
Mark Murphy
Dorte Renneberg
Simon Stamm
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of CL2020001817A1 publication Critical patent/CL2020001817A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Eye Examination Apparatus (AREA)
  • Oscillators With Electromechanical Resonators (AREA)

Abstract

La presente invención se refiere a derivados de fórmula (I), en donde el anillo A, X, Y, Z, RA, R1, R2, R3 y R4 son como se describe en la descripción, a su preparación, a sales farmacéuticamente aceptables de los mismos, y a su uso como agentes farmacéuticos, a composiciones farmacéuticas que contienen uno o más compuestos de fórmula (I), y especialmente a su uso como moduladores del receptor C5a.
CL2020001817A 2018-01-10 2020-07-08 Moduladores del receptor c5a CL2020001817A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP2018050598 2018-01-10

Publications (1)

Publication Number Publication Date
CL2020001817A1 true CL2020001817A1 (es) 2020-12-04

Family

ID=65012016

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2020001817A CL2020001817A1 (es) 2018-01-10 2020-07-08 Moduladores del receptor c5a

Country Status (30)

Country Link
US (2) US11608341B2 (es)
EP (1) EP3737684B1 (es)
JP (1) JP7014914B2 (es)
KR (1) KR102574564B1 (es)
CN (1) CN111566109B (es)
AR (1) AR114564A1 (es)
AU (1) AU2019207666B2 (es)
BR (1) BR112020013788A2 (es)
CA (1) CA3086310C (es)
CL (1) CL2020001817A1 (es)
DK (1) DK3737684T3 (es)
EA (1) EA202091641A1 (es)
ES (1) ES2933820T3 (es)
HR (1) HRP20221449T1 (es)
HU (1) HUE060515T2 (es)
IL (1) IL275868B2 (es)
LT (1) LT3737684T (es)
MA (1) MA51558B1 (es)
MX (1) MX2020007443A (es)
MY (1) MY198902A (es)
PH (1) PH12020500583B1 (es)
PL (1) PL3737684T3 (es)
PT (1) PT3737684T (es)
RS (1) RS63806B1 (es)
SG (1) SG11202006490YA (es)
SI (1) SI3737684T1 (es)
TW (2) TWI774905B (es)
UA (1) UA124694C2 (es)
WO (1) WO2019137927A1 (es)
ZA (1) ZA202004910B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3737684B1 (en) * 2018-01-10 2022-11-16 Idorsia Pharmaceuticals Ltd 2,4,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-5-one derivatives and related compounds as c5a receptor modulators for treating vasculitis and inflammatory diseases
US11685729B2 (en) 2018-01-19 2023-06-27 Idorsia Pharmaceuticals Ltd. C5a receptor modulators
CA3087886A1 (en) 2018-01-19 2019-07-25 Idorsia Pharmaceuticals Ltd C5a receptor modulators
HRP20240381T1 (hr) * 2019-07-09 2024-06-07 Idorsia Pharmaceuticals Ltd Farmaceutski pripravak koji sadrži spoj tetrahidropirazolopirimidinona
US11193891B2 (en) * 2019-12-20 2021-12-07 Robert Bosch Gmbh Receptors and spacers for a fluorescence-based lead ion chemosensor

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003218374A1 (en) 2002-03-28 2003-10-13 Neurogen Corporation Substituted tetrahydroisoquinolines as c5a receptor modulators
AU2003269850A1 (en) * 2002-10-08 2004-05-04 Novo Nordisk A/S Hemisuccinate salts of heterocyclic dpp-iv inhibitors
US7906528B2 (en) * 2004-10-05 2011-03-15 Novartis International Pharmaceutical Ltd. Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds
PT2585064T (pt) 2010-06-24 2017-08-08 Chemocentryx Inc Antagonistas do c5ar
US8846656B2 (en) 2011-07-22 2014-09-30 Novartis Ag Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators
TWI687220B (zh) * 2013-03-01 2020-03-11 美商英塞特控股公司 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途
JP6417419B2 (ja) 2013-09-04 2018-11-07 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 免疫調節剤として有用な化合物
HRP20181052T1 (hr) 2013-09-06 2018-09-07 Aurigene Discovery Technologies Limited Derivati 1,2,4-oksadiazola kao imunomodulatori
WO2015044900A1 (en) 2013-09-27 2015-04-02 Aurigene Discovery Technologies Limited Therapeutic immunomodulating compounds
CA2960436C (en) * 2014-09-16 2021-01-05 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
US9682940B2 (en) 2015-08-25 2017-06-20 Janssen Pharmaceutica Nv Indazole derivatives useful as CB-1 inverse agonists
EP3737684B1 (en) * 2018-01-10 2022-11-16 Idorsia Pharmaceuticals Ltd 2,4,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-5-one derivatives and related compounds as c5a receptor modulators for treating vasculitis and inflammatory diseases
CA3087886A1 (en) 2018-01-19 2019-07-25 Idorsia Pharmaceuticals Ltd C5a receptor modulators
US11685729B2 (en) 2018-01-19 2023-06-27 Idorsia Pharmaceuticals Ltd. C5a receptor modulators
HRP20240381T1 (hr) 2019-07-09 2024-06-07 Idorsia Pharmaceuticals Ltd Farmaceutski pripravak koji sadrži spoj tetrahidropirazolopirimidinona

Also Published As

Publication number Publication date
EA202091641A1 (ru) 2020-11-17
HUE060515T2 (hu) 2023-03-28
SG11202006490YA (en) 2020-08-28
IL275868A (en) 2020-08-31
ES2933820T3 (es) 2023-02-14
JP2021510373A (ja) 2021-04-22
SI3737684T1 (sl) 2023-01-31
PH12020500583B1 (en) 2024-02-21
PL3737684T3 (pl) 2023-02-27
AR114564A1 (es) 2020-09-23
US20230192708A1 (en) 2023-06-22
CA3086310C (en) 2023-09-19
MX2020007443A (es) 2020-09-14
EP3737684B1 (en) 2022-11-16
PT3737684T (pt) 2022-12-20
PH12020500583A1 (en) 2021-06-14
LT3737684T (lt) 2022-12-27
TW202244047A (zh) 2022-11-16
ZA202004910B (en) 2024-02-28
KR102574564B1 (ko) 2023-09-04
IL275868B2 (en) 2023-06-01
US11608341B2 (en) 2023-03-21
HRP20221449T1 (hr) 2023-01-20
KR20200106061A (ko) 2020-09-10
AU2019207666A1 (en) 2020-08-27
CN111566109A (zh) 2020-08-21
TWI839788B (zh) 2024-04-21
CN111566109B (zh) 2023-07-11
EP3737684A1 (en) 2020-11-18
JP7014914B2 (ja) 2022-02-01
MY198902A (en) 2023-10-02
DK3737684T3 (da) 2022-12-12
TW201930307A (zh) 2019-08-01
RS63806B1 (sr) 2023-01-31
WO2019137927A1 (en) 2019-07-18
UA124694C2 (uk) 2021-10-27
TWI774905B (zh) 2022-08-21
MA51558B1 (fr) 2022-12-30
CA3086310A1 (en) 2019-07-18
BR112020013788A2 (pt) 2020-12-01
US20200369672A1 (en) 2020-11-26
MA51558A (fr) 2021-04-14
AU2019207666B2 (en) 2023-12-21

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