CL2020002011A1 - Método para producir células asesinas naturales (nk) y composición para el tratamiento de cáncer - Google Patents

Método para producir células asesinas naturales (nk) y composición para el tratamiento de cáncer

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Publication number
CL2020002011A1
CL2020002011A1 CL2020002011A CL2020002011A CL2020002011A1 CL 2020002011 A1 CL2020002011 A1 CL 2020002011A1 CL 2020002011 A CL2020002011 A CL 2020002011A CL 2020002011 A CL2020002011 A CL 2020002011A CL 2020002011 A1 CL2020002011 A1 CL 2020002011A1
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CL
Chile
Prior art keywords
cells
natural killer
composition
cancer treatment
producing natural
Prior art date
Application number
CL2020002011A
Other languages
English (en)
Inventor
Sang Woo Park
Yong Man Kim
Jae Seob Jung
Yong-Hee Rhee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020190001983A external-priority patent/KR102765799B1/ko
Priority claimed from KR1020190001981A external-priority patent/KR102732845B1/ko
Application filed filed Critical
Publication of CL2020002011A1 publication Critical patent/CL2020002011A1/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/50—Colon
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Abstract

Se describe un método para producir células asesinas naturales (NK). El método comprende aislar células mononucleares de sangre periférica (PBMCs) de una muestra de sangre; aislar al menos una de las células CD56+ y/o células CD3-/CD56+ de las PBMCs; y cocultivar la al menos una de las células CD56+ y/o células CD3-/CD56+ con una combinación de células alimentadoras en presencia de una citocina. También se describe una composición para tratar el cáncer. La composición comprende las células asesinas naturales CD56+ producidas por el método de la presente invención y una citocina.
CL2020002011A 2018-02-01 2020-07-31 Método para producir células asesinas naturales (nk) y composición para el tratamiento de cáncer CL2020002011A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20180012938 2018-02-01
KR20180012942 2018-02-01
KR1020190001983A KR102765799B1 (ko) 2018-02-01 2019-01-07 Cd56+ 자연살해세포를 포함하는 항암용 조성물
KR1020190001981A KR102732845B1 (ko) 2018-02-01 2019-01-07 자연살해세포의 생산방법

Publications (1)

Publication Number Publication Date
CL2020002011A1 true CL2020002011A1 (es) 2021-02-12

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ID=68465207

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Application Number Title Priority Date Filing Date
CL2020002011A CL2020002011A1 (es) 2018-02-01 2020-07-31 Método para producir células asesinas naturales (nk) y composición para el tratamiento de cáncer

Country Status (15)

Country Link
US (4) US10590385B2 (es)
EP (1) EP3746095A4 (es)
JP (3) JP7268039B2 (es)
CN (2) CN115710576A (es)
AU (2) AU2019215034C1 (es)
BR (1) BR112020015512A2 (es)
CA (1) CA3089853A1 (es)
CL (1) CL2020002011A1 (es)
IL (1) IL276365B2 (es)
MX (2) MX386373B (es)
MY (2) MY199514A (es)
NZ (1) NZ766453A (es)
PH (1) PH12020551151A1 (es)
SA (1) SA520412566B1 (es)
SG (1) SG11202007221QA (es)

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CN115710576A (zh) 2018-02-01 2023-02-24 Nkmax有限公司 产生天然杀伤细胞的方法和用于治疗癌症的组合物
EP4048296A4 (en) * 2019-11-29 2024-01-24 Nkmax Co., Ltd. Method of producing natural killer cells and compositions thereof
CN113913384A (zh) * 2020-07-09 2022-01-11 杭州优凯瑞医药科技有限公司 一种制备靶点特异性nk细胞的方法及其应用
CN112626029B (zh) * 2020-12-22 2022-12-20 深圳市赛欧细胞技术有限公司 一种转基因修饰的Daudi细胞及其制备方法、应用
KR20220160479A (ko) * 2021-05-27 2022-12-06 (주)에스엠티바이오 신경내분비종양의 치료용 자연살해세포
WO2024036226A1 (en) * 2022-08-10 2024-02-15 Nkmax Co., Ltd. Method of treating autism with expanded natural killer cells
CN117122612B (zh) * 2023-07-07 2024-08-27 河络新图生物科技(上海)有限公司 外周血单个核细胞在制备治疗/预防阿尔茨海默病的药物中的用途
CN116904397B (zh) * 2023-09-04 2023-12-26 山东德升细胞治疗工程技术有限公司 Nk细胞的细胞外囊泡的制备及应用
KR20260105563A (ko) * 2024-12-27 2026-07-07 동아대학교 산학협력단 종양 감작 자연살해세포 및 이의 제조 방법

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