CL2020002051A1 - Formas de co-cristales de un análogo de novobiocina y prolina.- - Google Patents

Formas de co-cristales de un análogo de novobiocina y prolina.-

Info

Publication number
CL2020002051A1
CL2020002051A1 CL2020002051A CL2020002051A CL2020002051A1 CL 2020002051 A1 CL2020002051 A1 CL 2020002051A1 CL 2020002051 A CL2020002051 A CL 2020002051A CL 2020002051 A CL2020002051 A CL 2020002051A CL 2020002051 A1 CL2020002051 A1 CL 2020002051A1
Authority
CL
Chile
Prior art keywords
forms
novobiocin
crystals
proline
proline analog
Prior art date
Application number
CL2020002051A
Other languages
English (en)
Inventor
Xin Jiang
John Allen Walling
Melanie J Bevill
Christopher S Seadeek
Jared P Smit
Original Assignee
Reata Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reata Pharmaceuticals Inc filed Critical Reata Pharmaceuticals Inc
Publication of CL2020002051A1 publication Critical patent/CL2020002051A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se divulgan formas de co-cristales de N-(2-(5-(((2R,3R,4S,5R)-3,4-dihidroxi-5-metoxi-6,6-dimetiltetra-hidro-2H-piran-2-il)oxi)-3'-fluoro-[1,1'-bifenil]-2-il)etil)-acetamida y L-prolina o D-prolina, sus composiciones farmacéuticas, procesos de fabricación y métodos de uso para tratar trastornos neurodegenerativos tales como la neuropatía periférica diabética.
CL2020002051A 2018-02-07 2020-08-07 Formas de co-cristales de un análogo de novobiocina y prolina.- CL2020002051A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862627570P 2018-02-07 2018-02-07

Publications (1)

Publication Number Publication Date
CL2020002051A1 true CL2020002051A1 (es) 2021-02-19

Family

ID=65444361

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2020002051A CL2020002051A1 (es) 2018-02-07 2020-08-07 Formas de co-cristales de un análogo de novobiocina y prolina.-
CL2022003784A CL2022003784A1 (es) 2018-02-07 2022-12-27 Formas co-cristalinas de un análogo de novobiocina y prolina

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2022003784A CL2022003784A1 (es) 2018-02-07 2022-12-27 Formas co-cristalinas de un análogo de novobiocina y prolina

Country Status (19)

Country Link
US (3) US10717755B2 (es)
EP (1) EP3749675B1 (es)
JP (3) JP2021512910A (es)
KR (2) KR102718111B1 (es)
CN (2) CN118894894A (es)
AR (1) AR114245A1 (es)
AU (3) AU2019217821B2 (es)
BR (1) BR112020016205A2 (es)
CA (2) CA3226385A1 (es)
CL (2) CL2020002051A1 (es)
CO (1) CO2020009761A2 (es)
EA (1) EA202091885A1 (es)
IL (2) IL276583B2 (es)
MX (2) MX2020008326A (es)
MY (1) MY209803A (es)
PE (1) PE20211446A1 (es)
SG (1) SG11202007530XA (es)
TW (2) TWI868593B (es)
WO (1) WO2019156907A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL276583B2 (en) 2018-02-07 2025-03-01 Reata Pharmaceuticals Inc Crystal structures of proline and a novobiocin analog
CN119264211A (zh) 2018-08-27 2025-01-07 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
CN115181146B (zh) * 2021-04-02 2024-06-04 浙江普洛家园药业有限公司 一种新生霉素的提取工艺

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013006651A2 (pt) * 2010-09-23 2017-07-18 Nuformix Ltd composição e cocristal de aprepitante l-prolina
TWI542596B (zh) * 2011-05-09 2016-07-21 健生藥品公司 （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體
CN108640910A (zh) * 2011-11-25 2018-10-12 诺弗米克斯技术有限公司 阿瑞吡坦l-脯氨酸溶剂化物-组合物和共晶体
EP2602249B1 (en) * 2011-12-06 2015-08-12 F.I.S. Fabbrica Italiana Sintetici S.p.A. Synthesis of rosuvastatin by means of co-crystals
WO2013119985A1 (en) * 2012-02-09 2013-08-15 University Of Kansas C-terminal hsp90 inhibitors
ES2671478T3 (es) * 2012-08-31 2018-06-06 Novartis Ag Derivados de 2'-etinil nucleósidos para el tratamiento de infecciones virales
TW201512201A (zh) * 2013-03-14 2015-04-01 Forum Pharmaceuticals Inc 化合物的多晶型及鹽類
CN106536498A (zh) * 2014-06-24 2017-03-22 堪萨斯大学 作为hsp90抑制剂和hsp70诱导剂的具有经修饰醚基的联苯酰胺
HUE052588T2 (hu) * 2014-09-30 2021-05-28 Jiangsu Hengrui Medicine Co Az L-prolin/nátrium-glukóz kotranszporter 2 gátló kristály komplexének kristálya
IL276583B2 (en) 2018-02-07 2025-03-01 Reata Pharmaceuticals Inc Crystal structures of proline and a novobiocin analog

Also Published As

Publication number Publication date
JP2026012851A (ja) 2026-01-27
SG11202007530XA (en) 2020-09-29
AR114245A1 (es) 2020-08-12
JP2021512910A (ja) 2021-05-20
CA3090646A1 (en) 2019-08-15
AU2022283638B2 (en) 2024-07-25
CN112020506A (zh) 2020-12-01
IL276583B2 (en) 2025-03-01
US20240043465A1 (en) 2024-02-08
US11401294B2 (en) 2022-08-02
CN118894894A (zh) 2024-11-05
KR102718111B1 (ko) 2024-10-17
IL276583A (en) 2020-09-30
IL276583B1 (en) 2024-11-01
JP2024001167A (ja) 2024-01-09
PE20211446A1 (es) 2021-08-05
CA3090646C (en) 2024-02-27
TWI868593B (zh) 2025-01-01
TW202510893A (zh) 2025-03-16
WO2019156907A1 (en) 2019-08-15
TWI797249B (zh) 2023-04-01
EA202091885A1 (ru) 2021-01-15
CA3226385A1 (en) 2019-08-15
IL315865A (en) 2024-11-01
EP3749675A1 (en) 2020-12-16
AU2019217821B2 (en) 2022-09-08
CN112020506B (zh) 2024-10-11
US10717755B2 (en) 2020-07-21
AU2022283638A1 (en) 2023-02-02
US20190241599A1 (en) 2019-08-08
MX2020008326A (es) 2020-09-28
BR112020016205A2 (pt) 2020-12-15
KR20240155354A (ko) 2024-10-28
MY209803A (en) 2025-08-05
TW201945381A (zh) 2019-12-01
EP3749675B1 (en) 2025-12-31
CO2020009761A2 (es) 2020-10-30
AU2019217821A1 (en) 2020-09-24
MX2022012856A (es) 2022-11-30
NZ767558A (en) 2024-11-29
KR20200141985A (ko) 2020-12-21
TW202323267A (zh) 2023-06-16
CL2022003784A1 (es) 2023-06-09
AU2024227646A1 (en) 2024-11-14
US20200347088A1 (en) 2020-11-05

Similar Documents

Publication Publication Date Title
CL2022003784A1 (es) Formas co-cristalinas de un análogo de novobiocina y prolina
NZ629778A (en) C-terminal hsp90 inhibitors
CL2022003510A1 (es) Inhibidores de cisteína proteasas y sus métodos de uso
MX2019008846A (es) N-[4-fluoro-5-[[(2s,4s)-2-metil-4-[(5-metil-1,2,4-oxadiazol-3-il) metoxi]-1-piperidil]metil]tiazol-2-il] acetamida como inhibidor de oga.
CO2020003432A2 (es) Molécula de unión al antígeno multiespecífica que tiene actividad de sustitución de la función de cofactor del factor viii de coagulación de sangre (fviii) y formulación farmacéutica que contiene tal molécula como ingrediente activo
CL2021002959A1 (es) Nuevas formas sólidas de ácido (2s,3s,4s,5r,6s)-3,4,5-trihidroxi-6-(((4ar,10ar)-7- hidroxi-1-propil-1,2,3,4,4a,5,10,10a- octahidrobenzo[g]quinolin-6-il)oxi)tetrahidro2h-piran-2-carboxílico.
CL2018002367A1 (es) Compuestos de bifenil amidas con grupos éteres modificados derivados de n-((2-(ciclohexiloxi o 2h-piran-2-iloxi)-3’-fluoro-[1,1’-bifenil]-2-il)-etil)-acetamida y 2-oxo-2h-cromen-3il-acetamida sustituidos; composiciones farmacológicas; inhibidores de hsp90 e inductores de hsp70, útiles para tratar trastornos neurológicos, asociados a las complicaciones de la diabetes, tales como neuropatía, nefropatía, retinopatía y vasculopatía. modificados como inhibidores de hsp90 e inductores de hsp70(div n° 3276-16)
CL2011001263A1 (es) Compuestos derivados de pirimidinonas opcionalmente sustituidas; composicion farmaceutica que los comprende; y su uso como inhibidores de fosfodiesterasa 1 (pde1) para el tratamiento de enfermedades que involucran trastornos de la trayectoria intracelular del receptor de dopamina d1 como parkinson, alzheimer, depresion, enfermedad bipolar, hipertension, glaucoma.
SV2009003305A (es) Derivados de ester y amida de indazolilo para el tratamiento de enfermedades mediadas por un receptor de glucocorticoides
CL2008002268A1 (es) Compuestos derivados de amidas, moduladores del receptor taar1; proceso de obtencion; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como depresion, ansiedad, estres, entre otros.
MX377532B (es) Sales y formas sólidas de un antibiótico de monobactam.
BR112015019412A2 (pt) inibidores de bace1
EA201001586A1 (ru) Соединения и композиции в качестве ингибиторов itpkb
CL2012000013A1 (es) Compuestos derivados de 4-{3-[3-(4-trifluorometil-fenil)ureido]-5-fluoro-bencilamino}-1h-pirazol-3-carboxamida; procedimiento de preparacion; composicion farmaceutica que los comprende; compuestos intermediarios; y su uso como moduladores de la actividad de las proteinas quinasa para el tratamiento del cancer.
MX2019003310A (es) Inhibidores de dopamina-b-hidroxilasa.
BR112022021976A2 (pt) Composto, e, composição farmacêutica compreendendo um composto
BR112022005881A2 (pt) Compostos de benzoxazinona como inibidores duplos de klk5/7
CL2020001461A1 (es) Inhibidores de dopamina–b–hidroxilasa.
CL2012000097A1 (es) Compuestos derivados de 3-fenoximetilpirrolidina, inhibidores de la recaptacion de serotonina-norepinefrina; procedimiento de preparacion; compuestos intermediarios; composicion farmaceutica que lo comprende; y su uso en el tratamiento de trastornos del dolor, depresion, entre otros.
EA202190899A1 (ru) АРИЛСУЛЬФОНИЛПИРРОЛКАРБОКСАМИДНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ АКТИВАТОРОВ КАЛИЕВЫХ КАНАЛОВ Kv3
MA46778A1 (fr) Composition intranasale comprenant de la bétahistine
CL2008003780A1 (es) Compuestos derivados de azetidinas; procedimiento de preparacion; compuestos intermediarios; composicion farmaceutica; y uso para el tratamiento o la prevencion de trastornos psiquiatricos, dependencia o deshabituacion a una sustancia, trastornos cognitivos, enfermedades neurodegenerativas, entre otras.
EP3991727A4 (en) Composition for treating degenerative brain diseases, containing 2-pentylfuran as active ingredient
CL2020001928A1 (es) Formas cristalinas del antagonista del receptor cxcr7 ácido (3s,4s)-1-ciclopropilmetil-4-{[5-(2,4-difluoro-fenil)-isoxazol-3-carbonil]-amino}-piperidin-3-carboxílico (1-pirimidin-2-il-ciclopropil)-amida.
CO2020001375A2 (es) Derivado de adamantilmetilamina y uso del mismo como producto farmacéutico