CL2020002199A1 - Compuesto de anillo de metillactama y uso farmacéutico del mismo. - Google Patents
Compuesto de anillo de metillactama y uso farmacéutico del mismo.Info
- Publication number
- CL2020002199A1 CL2020002199A1 CL2020002199A CL2020002199A CL2020002199A1 CL 2020002199 A1 CL2020002199 A1 CL 2020002199A1 CL 2020002199 A CL2020002199 A CL 2020002199A CL 2020002199 A CL2020002199 A CL 2020002199A CL 2020002199 A1 CL2020002199 A1 CL 2020002199A1
- Authority
- CL
- Chile
- Prior art keywords
- methylactam
- pharmaceutical use
- ring compound
- pharmaceutically acceptable
- acceptable salt
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 108091006277 SLC5A1 Proteins 0.000 abstract 1
- 102000058090 Sodium-Glucose Transporter 1 Human genes 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un objetivo de la presente invención es proporcionar un compuesto de anillo de metillactama que tiene una actividad inhibidora de SGLT1 y es útil para un fármaco, o una sal farmacéuticamente aceptable del mismo, una composición farmacéutica que lo comprende, y uso farmacéutico del mismo; se proporciona un compuesto de la Fórmula [I]: o una sal farmacéuticamente aceptable del mismo, una composición farmacéutica que lo comprende, y uso farmacéutico del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018036307 | 2018-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2020002199A1 true CL2020002199A1 (es) | 2020-12-18 |
Family
ID=67806229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2020002199A CL2020002199A1 (es) | 2018-03-01 | 2020-08-26 | Compuesto de anillo de metillactama y uso farmacéutico del mismo. |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US11014910B2 (es) |
| EP (1) | EP3760624A4 (es) |
| JP (3) | JP7206132B2 (es) |
| KR (1) | KR102795351B1 (es) |
| CN (1) | CN111757877B (es) |
| AR (1) | AR114418A1 (es) |
| AU (1) | AU2019227770B2 (es) |
| BR (1) | BR112020016788A2 (es) |
| CA (1) | CA3087859A1 (es) |
| CL (1) | CL2020002199A1 (es) |
| IL (1) | IL276311B2 (es) |
| MA (1) | MA52427A (es) |
| MX (1) | MX2020009070A (es) |
| MY (1) | MY205197A (es) |
| PE (1) | PE20210123A1 (es) |
| PH (1) | PH12020551340A1 (es) |
| SA (1) | SA520420037B1 (es) |
| SG (1) | SG11202007120UA (es) |
| TW (1) | TWI805699B (es) |
| WO (1) | WO2019168096A1 (es) |
| ZA (1) | ZA202004600B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI805699B (zh) * | 2018-03-01 | 2023-06-21 | 日商日本煙草產業股份有限公司 | 甲基內醯胺環化合物及其用途 |
| MX2020010433A (es) | 2018-04-04 | 2020-10-28 | Japan Tobacco Inc | Compuestos de pirazol sustituidos con heteroarilo y uso farmaceutico de los mismos. |
| US20230210831A1 (en) * | 2019-09-04 | 2023-07-06 | Japan Tobacco Inc. | Chronic kidney disease treatment or prevention method |
| AU2020341926B2 (en) * | 2019-09-04 | 2026-02-26 | Shionogi & Co., Ltd. | Therapeutic or prophylactic method for diabetes using combination medicine |
| CN115209919B (zh) * | 2020-03-19 | 2024-12-31 | 日本烟草产业株式会社 | 慢性心衰的治疗或预防方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3657282A (en) * | 1969-01-23 | 1972-04-18 | Merck & Co Inc | Carboxyepoxyethyl-1-phosphonic acid and derivatives |
| FR2665898B1 (fr) | 1990-08-20 | 1994-03-11 | Sanofi | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| JPH04247081A (ja) | 1991-02-01 | 1992-09-03 | Takeda Chem Ind Ltd | ５員複素環酸アミド類 |
| FR2692575B1 (fr) | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| DE602004028800D1 (en) | 2003-02-07 | 2010-10-07 | Daiichi Sankyo Co Ltd | Pyrazolderivat |
| AU2004200420A1 (en) | 2003-03-11 | 2004-09-30 | Astellas Pharma Inc. | Inhibitor of cyclooxygenase |
| JP2006182648A (ja) | 2003-04-08 | 2006-07-13 | Dai Ichi Seiyaku Co Ltd | ７員複素環誘導体 |
| WO2004110351A2 (en) | 2003-05-14 | 2004-12-23 | Anadys Pharmaceuticals, Inc. | Heterocyclic compounds for treating hepatitis c virus |
| TW200526588A (en) | 2003-11-17 | 2005-08-16 | Smithkline Beecham Corp | Chemical compounds |
| TW200526641A (en) | 2003-12-26 | 2005-08-16 | Daiichi Seiyaku Co | Amidopyrazole derivatives |
| JP2008505905A (ja) | 2004-07-07 | 2008-02-28 | メルク エンド カムパニー インコーポレーテッド | ピラゾールアミド誘導体、こうした化合物を含有する組成物および使用方法 |
| CA2586358C (en) | 2004-11-16 | 2015-11-24 | Gw Pharma Limited | Use of tetrahydrocannabivarin (thcv) as neutral antagonist of the cb1 cannabinoid receptor |
| JP2008007405A (ja) | 2004-12-07 | 2008-01-17 | Takeda Chem Ind Ltd | カルボキサミド誘導体 |
| JP4137956B2 (ja) | 2005-06-08 | 2008-08-20 | 日本たばこ産業株式会社 | 複素環化合物 |
| AU2006255944B2 (en) | 2005-06-08 | 2010-03-04 | Japan Tobacco Inc. | Heterocyclic compound |
| ZA200800142B (en) * | 2005-06-08 | 2009-05-27 | Japan Tobacco Inc | Heterocyclic compound |
| WO2007034279A2 (en) * | 2005-09-19 | 2007-03-29 | Pfizer Products Inc. | C3a antagonists and pharmaceutical compositions thereof |
| WO2007098826A2 (en) | 2006-01-18 | 2007-09-07 | Siena Biotech S.P.A. | Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof |
| KR20090007606A (ko) * | 2006-04-27 | 2009-01-19 | 솔베이 파머슈티컬스 게엠베하 | ＣＢｘ 칸나비노이드 수용체 조절제들 및 칼륨 채널 조절제들을 포함하는 약학적 조성물들 |
| US20080027014A1 (en) | 2006-07-28 | 2008-01-31 | Tanabe Seiyaku Co., Ltd. | Novel SGLT inhibitors |
| EP2121619A2 (en) | 2006-11-24 | 2009-11-25 | AC Immune S.A. | Compounds for the treatment of diseases associated with amyloid or amyloid-like proteins |
| EP2102165A2 (en) | 2006-11-24 | 2009-09-23 | AC Immune S.A. | N-(methyl)-1h-pyrazol-3-amine, n-(methyl)-pyridin-2-amine and n-(methyl)-thiazol-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins, like e.g. alzheimer's |
| CL2008000119A1 (es) | 2007-01-16 | 2008-05-16 | Wyeth Corp | Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia. |
| CN101652377A (zh) * | 2007-04-02 | 2010-02-17 | 泰拉科斯有限公司 | 苄基化糖苷衍生物及其用法 |
| WO2009091813A1 (en) | 2008-01-14 | 2009-07-23 | Wyeth | Compounds useful as alpha7 nicotinic acetylcholine receptor agonists |
| TW201006832A (en) | 2008-07-15 | 2010-02-16 | Novartis Ag | Organic compounds |
| EP2560966B1 (en) | 2010-03-30 | 2021-01-06 | Verseon International Corporation | Multisubstituted aromatic compounds as inhibitors of thrombin |
| AR087701A1 (es) * | 2011-08-31 | 2014-04-09 | Japan Tobacco Inc | Derivados de pirazol con actividad inhibidora de sglt1 |
| MY193765A (en) * | 2015-02-16 | 2022-10-27 | Univ Queensland | Sulfonylureas and related compounds and use of same |
| US11858922B2 (en) * | 2016-02-16 | 2024-01-02 | The University Of Queensland | Sulfonylureas and related compounds and use of same |
| TWI805699B (zh) * | 2018-03-01 | 2023-06-21 | 日商日本煙草產業股份有限公司 | 甲基內醯胺環化合物及其用途 |
| MX2020010433A (es) | 2018-04-04 | 2020-10-28 | Japan Tobacco Inc | Compuestos de pirazol sustituidos con heteroarilo y uso farmaceutico de los mismos. |
-
2019
- 2019-02-27 TW TW108106807A patent/TWI805699B/zh active
- 2019-02-28 MX MX2020009070A patent/MX2020009070A/es unknown
- 2019-02-28 AU AU2019227770A patent/AU2019227770B2/en active Active
- 2019-02-28 BR BR112020016788-6A patent/BR112020016788A2/pt unknown
- 2019-02-28 KR KR1020207025856A patent/KR102795351B1/ko active Active
- 2019-02-28 IL IL276311A patent/IL276311B2/en unknown
- 2019-02-28 WO PCT/JP2019/007799 patent/WO2019168096A1/ja not_active Ceased
- 2019-02-28 CN CN201980016238.4A patent/CN111757877B/zh active Active
- 2019-02-28 MA MA052427A patent/MA52427A/fr unknown
- 2019-02-28 EP EP19760111.5A patent/EP3760624A4/en active Pending
- 2019-02-28 US US16/289,500 patent/US11014910B2/en active Active
- 2019-02-28 PE PE2020001287A patent/PE20210123A1/es unknown
- 2019-02-28 MY MYPI2020003891A patent/MY205197A/en unknown
- 2019-02-28 JP JP2019035140A patent/JP7206132B2/ja active Active
- 2019-02-28 AR ARP190100503A patent/AR114418A1/es unknown
- 2019-02-28 SG SG11202007120UA patent/SG11202007120UA/en unknown
- 2019-02-28 CA CA3087859A patent/CA3087859A1/en active Pending
-
2020
- 2020-07-24 ZA ZA2020/04600A patent/ZA202004600B/en unknown
- 2020-08-24 SA SA520420037A patent/SA520420037B1/ar unknown
- 2020-08-26 CL CL2020002199A patent/CL2020002199A1/es unknown
- 2020-08-27 PH PH12020551340A patent/PH12020551340A1/en unknown
-
2021
- 2021-04-16 US US17/233,273 patent/US20220064148A1/en not_active Abandoned
-
2023
- 2023-01-04 JP JP2023000037A patent/JP2023026566A/ja active Pending
- 2023-06-28 US US18/343,415 patent/US20240174646A1/en not_active Abandoned
-
2024
- 2024-12-09 JP JP2024214451A patent/JP2025026615A/ja active Pending
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