CL2020003257A1 - Compuestos antagonistas de pcsk9. - Google Patents

Compuestos antagonistas de pcsk9.

Info

Publication number
CL2020003257A1
CL2020003257A1 CL2020003257A CL2020003257A CL2020003257A1 CL 2020003257 A1 CL2020003257 A1 CL 2020003257A1 CL 2020003257 A CL2020003257 A CL 2020003257A CL 2020003257 A CL2020003257 A CL 2020003257A CL 2020003257 A1 CL2020003257 A1 CL 2020003257A1
Authority
CL
Chile
Prior art keywords
antagonist compounds
pcsk9 antagonist
pcsk9
compounds
macroclyclic
Prior art date
Application number
CL2020003257A
Other languages
English (en)
Inventor
Chengwei Wu
Elisabetta Bianchi
Harold B Wood
Hubert B Josien
Thomas Joseph Tucker
Angela Dawn Kerekes
Ling Tong
Abbas M Walji
Anikumar G Nair
Fa-Xiang Ding
Danila Branca
Yusheng Xiong
Sookhee Nicole Ha
Jian Liu
Sobhana Babu Boga
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of CL2020003257A1 publication Critical patent/CL2020003257A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6454—Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21061—Kexin (3.4.21.61), i.e. proprotein convertase subtilisin/kexin type 9
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMPUESTOS MACROCLÍCLICOS, ANTAONISTAS DE PCSK9; UNA COMPOSICION FARMACEUTICA; Y SU USO PARA EL TRATAMIENTO DE LA HIPERCOLESTEROLEMIA.
CL2020003257A 2018-06-21 2020-12-16 Compuestos antagonistas de pcsk9. CL2020003257A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862687913P 2018-06-21 2018-06-21

Publications (1)

Publication Number Publication Date
CL2020003257A1 true CL2020003257A1 (es) 2021-07-23

Family

ID=67263083

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2020003257A CL2020003257A1 (es) 2018-06-21 2020-12-16 Compuestos antagonistas de pcsk9.
CL2022000027A CL2022000027A1 (es) 2018-06-21 2022-01-05 Compuestos antagonistas de pcsk9. (divisional de solicitud 202003257).

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2022000027A CL2022000027A1 (es) 2018-06-21 2022-01-05 Compuestos antagonistas de pcsk9. (divisional de solicitud 202003257).

Country Status (38)

Country Link
US (3) US11427616B2 (es)
EP (2) EP4660303A3 (es)
JP (3) JP7112531B2 (es)
KR (2) KR20250161677A (es)
CN (2) CN121130044A (es)
AR (1) AR115597A1 (es)
AU (2) AU2019290163C1 (es)
BR (1) BR112020025274A8 (es)
CA (1) CA3102629A1 (es)
CL (2) CL2020003257A1 (es)
CO (1) CO2021000456A2 (es)
CR (1) CR20210031A (es)
DK (1) DK3810626T3 (es)
DO (1) DOP2020000250A (es)
EA (1) EA202190086A1 (es)
EC (1) ECSP21003643A (es)
ES (1) ES3047399T3 (es)
FI (1) FI3810626T3 (es)
GE (2) GEAP202215540A (es)
HR (1) HRP20251302T1 (es)
HU (1) HUE073367T2 (es)
IL (2) IL279363B2 (es)
JO (1) JOP20190150A1 (es)
LT (1) LT3810626T (es)
MA (1) MA52967B1 (es)
MD (1) MD3810626T2 (es)
MX (1) MX2020013726A (es)
NI (1) NI202000101A (es)
PE (1) PE20211584A1 (es)
PH (1) PH12020552187A1 (es)
PL (1) PL3810626T3 (es)
PT (1) PT3810626T (es)
RS (1) RS67338B1 (es)
SG (1) SG11202012451WA (es)
SI (1) SI3810626T1 (es)
TW (1) TWI840376B (es)
UA (1) UA129467C2 (es)
WO (1) WO2019246349A1 (es)

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TW202542176A (zh) 2023-12-15 2025-11-01 美商默沙東有限責任公司 用於治療動脈粥樣硬化及發炎病症之環狀肽IL-1β捕捉劑
WO2025242221A1 (zh) * 2024-05-24 2025-11-27 上海翰森生物医药科技有限公司 新型修饰侧链、其制备方法和应用
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WO2026019622A1 (en) * 2024-07-15 2026-01-22 Merck Sharp & Dohme Llc Crystal forms of a cyclictetrapeptide and processes for preparing
WO2026032253A1 (zh) * 2024-08-06 2026-02-12 石药集团中奇制药技术（石家庄）有限公司 环肽类似物及其制备方法和用途
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US20250206781A1 (en) 2025-06-26
DK3810626T3 (da) 2025-08-18
MA52967B1 (fr) 2025-09-30
KR20250161677A (ko) 2025-11-17
RS67338B1 (sr) 2025-11-28
US11427616B2 (en) 2022-08-30
GEP20237506B (en) 2023-05-25
GEAP202215540A (en) 2022-12-12
AR115597A1 (es) 2021-02-03
MD3810626T2 (ro) 2025-12-31
IL279363A (en) 2021-01-31
US20190389909A1 (en) 2019-12-26
JP7112531B2 (ja) 2022-08-03
ES3047399T3 (en) 2025-12-03
SG11202012451WA (en) 2021-01-28
KR20210024035A (ko) 2021-03-04
AU2019290163A1 (en) 2021-01-07
CA3102629A1 (en) 2019-12-26
HUE073367T2 (hu) 2026-01-28
EP4660303A3 (en) 2026-02-25
AU2022259744B2 (en) 2024-07-11
US20230159592A1 (en) 2023-05-25
FI3810626T3 (fi) 2025-10-21
PL3810626T3 (pl) 2025-12-22
CR20210031A (es) 2021-02-11
AU2019290163B2 (en) 2022-08-04
MA52967A (fr) 2021-04-28
EP3810626A1 (en) 2021-04-28
AU2022259744A1 (en) 2022-12-01
IL279363B2 (en) 2025-12-01
IL279363B1 (en) 2025-08-01
PT3810626T (pt) 2025-10-15
DOP2020000250A (es) 2021-02-28
CL2022000027A1 (es) 2022-08-19
HRP20251302T1 (hr) 2025-12-19
BR112020025274A2 (pt) 2021-03-09
NI202000101A (es) 2021-05-28
ECSP21003643A (es) 2021-02-26
IL321719A (en) 2025-08-01
CN121130044A (zh) 2025-12-16
KR102884527B1 (ko) 2025-11-13
US12209145B2 (en) 2025-01-28
JP2021522311A (ja) 2021-08-30
JOP20190150A1 (ar) 2019-12-21
EP3810626B1 (en) 2025-07-23
PE20211584A1 (es) 2021-08-18
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MX2020013726A (es) 2021-03-02
CO2021000456A2 (es) 2021-01-29
EA202190086A1 (ru) 2021-05-18
CN112313243B (zh) 2025-09-02
WO2019246349A1 (en) 2019-12-26
TW202019950A (zh) 2020-06-01
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CN112313243A (zh) 2021-02-02
TWI840376B (zh) 2024-05-01
EP4660303A2 (en) 2025-12-10
JP2022141879A (ja) 2022-09-29
LT3810626T (lt) 2025-11-10
PH12020552187A1 (en) 2021-07-26
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