CL2020002317A1 - Compuesto inhibidor de tirosina quinasa c-abl: modalidades y métodos de fabricación y uso - Google Patents

Compuesto inhibidor de tirosina quinasa c-abl: modalidades y métodos de fabricación y uso

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Publication number
CL2020002317A1
CL2020002317A1 CL2020002317A CL2020002317A CL2020002317A1 CL 2020002317 A1 CL2020002317 A1 CL 2020002317A1 CL 2020002317 A CL2020002317 A CL 2020002317A CL 2020002317 A CL2020002317 A CL 2020002317A CL 2020002317 A1 CL2020002317 A1 CL 2020002317A1
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CL
Chile
Prior art keywords
abl
tyrosine kinase
compound
modalities
manufacture
Prior art date
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CL2020002317A
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English (en)
Inventor
Noel T Southall
Edith Beni Von Bernhardi Montgomery Rommy
Christopher R Dextras
Andres E Dulcey
Juan J Marugan
Zanlungo Matsuhiro Silvana
Daniel C Talley
Marc Ferrer
Xin Hu
Alvarez Alejandra
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Us Health
Univ Pontificia Catolica Chile
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Publication of CL2020002317A1 publication Critical patent/CL2020002317A1/es

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    • C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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Abstract

En el presente documento, se divulgan modalidades de un compuesto que inhibe la tirosina quinasa c-Abl (también denominada en el presente documento “c-Abl”). Las modalidades de compuesto descritas en el presente documento corresponden a novedosos inhibidores de la tirosina quinasa c-Abl, que se pueden unir a un sitio alostérico en c-Abl e inhibir su actividad a través de diferentes vías. Las modalidades de compuesto son capaces de pasar a través de la barrera hematoencefálica, por lo que permiten inhibir la actividad de la tirosina quinasa c-Abl y su efecto sobre vías y/o proteínas cerebrales. Las modalidades de compuesto descritas en el presente documento corresponden a efectivos agentes terapéuticos para tratar enfermedades en las que existe actividad de la tirosina quinasa c-Abl, como distintos tipos de cáncer, enfermedades de las neuronas motrices y enfermedades neurodegenerativas. Además, en el presente documento se divulgan modalidades de métodos de fabricación y uso de las modalidades de compuesto inhibidor de c-Abl.
CL2020002317A 2018-03-09 2020-09-07 Compuesto inhibidor de tirosina quinasa c-abl: modalidades y métodos de fabricación y uso CL2020002317A1 (es)

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