CL2020002805A1 - Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad (divisional 201302526) - Google Patents

Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad (divisional 201302526)

Info

Publication number
CL2020002805A1
CL2020002805A1 CL2020002805A CL2020002805A CL2020002805A1 CL 2020002805 A1 CL2020002805 A1 CL 2020002805A1 CL 2020002805 A CL2020002805 A CL 2020002805A CL 2020002805 A CL2020002805 A CL 2020002805A CL 2020002805 A1 CL2020002805 A1 CL 2020002805A1
Authority
CL
Chile
Prior art keywords
modulator
identify
biological system
divisional
disease process
Prior art date
Application number
CL2020002805A
Other languages
English (en)
Inventor
Niven Rajin Narain
Rangaprasad Sarangarajan
Vivek K Vishnudas
Original Assignee
Berg Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berg Llc filed Critical Berg Llc
Publication of CL2020002805A1 publication Critical patent/CL2020002805A1/es

Links

Classifications

    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/20Probabilistic models
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Physiology (AREA)
  • Genetics & Genomics (AREA)
  • Probability & Statistics with Applications (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

Un método para proporcionar un modelo para un sistema biológico para su uso en un método de plataforma, que comprende: establecer un modelo para un sistema biológico, usando células asociadas con el sistema biológico, para representar un aspecto característico del sistema biológico, donde el modelo para el sistema biológico es útil para generar conjuntos de datos usados en el método de plataforma; proporcionando así un modelo para un sistema biológico para uso en un método de plataforma.
CL2020002805A 2011-03-02 2020-10-28 Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad (divisional 201302526) CL2020002805A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161448587P 2011-03-02 2011-03-02
US201261593848P 2012-02-01 2012-02-01

Publications (1)

Publication Number Publication Date
CL2020002805A1 true CL2020002805A1 (es) 2021-04-30

Family

ID=46758320

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2013002526A CL2013002526A1 (es) 2011-03-02 2013-09-02 Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad.
CL2020002805A CL2020002805A1 (es) 2011-03-02 2020-10-28 Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad (divisional 201302526)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2013002526A CL2013002526A1 (es) 2011-03-02 2013-09-02 Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad.

Country Status (20)

Country Link
US (3) US9886545B2 (es)
EP (1) EP2680925B1 (es)
JP (2) JP6105491B2 (es)
KR (1) KR102071081B1 (es)
CN (2) CN107273712B (es)
AU (2) AU2012223136B2 (es)
BR (1) BR112013022208A2 (es)
CA (1) CA2828972C (es)
CL (2) CL2013002526A1 (es)
CO (1) CO6801640A2 (es)
EA (1) EA201391245A1 (es)
ES (1) ES2777894T3 (es)
IL (2) IL228096B (es)
MX (1) MX358408B (es)
MY (2) MY181093A (es)
PE (2) PE20180776A1 (es)
PH (3) PH12013501802B1 (es)
SG (2) SG10201601224WA (es)
WO (1) WO2012119129A1 (es)
ZA (1) ZA201306453B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2661168T3 (es) 2003-07-12 2018-03-27 Accelerate Diagnostics, Inc. Biodetección sensible y rápida
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US9434937B2 (en) 2011-03-07 2016-09-06 Accelerate Diagnostics, Inc. Rapid cell purification systems
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
AU2013230045A1 (en) * 2012-03-05 2014-09-11 Berg Llc Compositions and methods for diagnosis and treatment of pervasive developmental disorder
US9744155B2 (en) 2012-03-28 2017-08-29 Ixcela, Inc. IPA as a therapeutic agent, as a protective agent, and as a biomarker of disease risk
MX357392B (es) * 2012-04-02 2018-07-06 Berg Llc Ensayos basados en interrogatorios celulares y uso de los mismos.
EA201492178A1 (ru) 2012-05-22 2015-12-30 Берг Ллк Основанные на клетках перекрестные анализы для идентификации маркеров индуцированной лекарственными средствами токсичности
WO2014071316A1 (en) * 2012-11-02 2014-05-08 H. Lee Moffitt Cancer Center And Research Institute, Inc. In silico identification of cancer molecular signaling pathways and drug candidates
US20150302167A1 (en) * 2012-11-09 2015-10-22 Cellworks Group, Inc. System and method for development of therapeutic solutions
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
JP6216044B2 (ja) * 2013-05-28 2017-10-18 ファイヴ3 ゲノミクス,エルエルシー Paradigm薬剤反応ネットワーク
US20150019189A1 (en) * 2013-07-01 2015-01-15 Counterpoint Health Solutions, Inc. Systems biology approach to therapy
JP6518269B2 (ja) * 2014-05-28 2019-05-22 ヴィート エンフェー 異なる生体試料の混合物中に含まれる化学化合物を相対的に定量する方法
CN114203296B (zh) * 2014-09-11 2025-10-17 布普格生物制药公司 基于患者数据的用于健康护理诊断和治疗的贝叶斯因果关系网络模型
EP3206032B1 (en) * 2014-10-10 2019-02-27 Akira Matsumori Method for detecting cardiac failure patient, method for discrimination of cardiac disease, test reagent for cardiac failure, test kit for cardiac failure, device for detecting cardiac failure, and program for detecting cardiac failure
US10539566B2 (en) 2014-12-08 2020-01-21 Berg Llc Use of markers including filamin A in the diagnosis and treatment of prostate cancer
US10023895B2 (en) 2015-03-30 2018-07-17 Accelerate Diagnostics, Inc. Instrument and system for rapid microogranism identification and antimicrobial agent susceptibility testing
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
CN106250717B (zh) * 2015-06-04 2019-03-12 徐勇 急性髓性白血病的miRNA与转录因子的系统及其构建方法和应用
KR101881398B1 (ko) * 2016-04-07 2018-07-24 한국과학기술원 생물학적 시스템 정보 처리 장치 및 방법
US20200185063A1 (en) 2016-06-05 2020-06-11 Berg Llc Systems and methods for patient stratification and identification of potential biomarkers
US10282588B2 (en) * 2016-06-09 2019-05-07 Siemens Healthcare Gmbh Image-based tumor phenotyping with machine learning from synthetic data
WO2018090054A1 (en) 2016-11-14 2018-05-17 Berg Llc Methods for treating parkinson's disease
WO2018094204A1 (en) * 2016-11-17 2018-05-24 Arivale, Inc. Determining relationships between risks for biological conditions and dynamic analytes
CA3057420C (en) * 2017-05-12 2023-08-01 Laboratory Corporation Of America Holdings Systems and methods for biomarker identificaton
JP7257405B2 (ja) 2017-10-02 2023-04-13 コーニンクレッカ フィリップス エヌ ヴェ 免疫細胞型及び免疫応答の機能状況の決定
CN109086570B (zh) * 2018-06-29 2020-09-04 迈凯基因科技有限公司 一种多数据库依次交互方法及装置
US12051496B2 (en) * 2018-06-29 2024-07-30 The Jackson Laboratory Methods and apparatus for identifying alternative splicing events
US11041847B1 (en) 2019-01-25 2021-06-22 Ixcela, Inc. Detection and modification of gut microbial population
EP3935581A4 (en) 2019-03-04 2022-11-30 Iocurrents, Inc. DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING
WO2021005729A1 (ja) * 2019-07-09 2021-01-14 株式会社島津製作所 iPS細胞の分化効率予測モデルの構築方法及びiPS細胞の分化効率予測方法
WO2021050760A1 (en) * 2019-09-11 2021-03-18 Recursion Pharmaceuticals, Inc. Systems and methods for pairwise inference of drug-gene interaction networks
JP7735624B2 (ja) * 2020-08-31 2025-09-09 武田薬品工業株式会社 推論装置、推論方法、推論プログラム、モデル生成方法、推論サービス提供システム、推論サービス提供方法及び推論サービス提供プログラム
CN112151109B (zh) * 2020-09-09 2023-08-25 中国科学院大连化学物理研究所 用于评价生物分子交联质谱鉴定随机性的半监督学习方法
CN112466403B (zh) * 2020-12-31 2022-06-14 广州基迪奥生物科技有限公司 一种细胞通讯分析方法及系统
KR102556312B1 (ko) 2021-04-12 2023-07-19 서울대학교병원 세뇨관 배양부 및 간질 배양부를 포함하는 신장 모사 장기 칩
US20220399092A1 (en) * 2021-06-10 2022-12-15 Rajant Health Inc. Ai-enabled health platform
CN114038504A (zh) * 2021-11-30 2022-02-11 周建伟 一种识别驱动肿瘤转移关键异质性分子的预测系统
WO2023102204A1 (en) * 2021-12-03 2023-06-08 The Trustees Of Indiana University Biomarker for type 1 diabetes
CN115346687B (zh) * 2022-08-08 2025-07-04 之江实验室 一种采用非线性动态分析辅助神经网络用于评估药物引起的心脏毒性的方法
CN115775594A (zh) * 2022-12-12 2023-03-10 南京医基云医疗数据研究院有限公司 生物组学调控关系分析方法及装置、电子设备、介质
CN116046877B (zh) * 2023-04-03 2024-03-15 深圳先进技术研究院 疾病模型代谢分析方法、包埋模具及喷涂装置
WO2025259359A1 (en) * 2024-06-12 2025-12-18 CytoVale Inc. Systems and methods for sepsis determination

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
DE3689123T2 (de) 1985-11-01 1994-03-03 Xoma Corp Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung.
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US6121424A (en) 1991-11-25 2000-09-19 Enzon, Inc. Multivalent antigen-binding proteins
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
US4843155A (en) 1987-11-19 1989-06-27 Piotr Chomczynski Product and process for isolating RNA
EP0436597B1 (en) 1988-09-02 1997-04-02 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
DK0585287T3 (da) 1990-07-10 2000-04-17 Cambridge Antibody Tech Fremgangsmåde til fremstilling af specifikke bindingsparelementer
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ATE158021T1 (de) 1990-08-29 1997-09-15 Genpharm Int Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
CA2095633C (en) 1990-12-03 2003-02-04 Lisa J. Garrard Enrichment method for variant proteins with altered binding properties
EP1820858B1 (en) 1991-03-01 2009-08-12 Dyax Corporation Chimeric protein comprising micro-protein having two or more disulfide bonds and embodiments thereof
ATE414768T1 (de) 1991-04-10 2008-12-15 Scripps Research Inst Bibliotheken heterodimerer rezeptoren mittels phagemiden
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
US5621083A (en) 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
CA2124087C (en) 1991-11-22 2002-10-01 James L. Winkler Combinatorial strategies for polymer synthesis
EP0552108B1 (en) 1992-01-17 1999-11-10 Lakowicz, Joseph R. Energy transfer phase-modulation fluoro-immunoassay
US5918200A (en) 1992-08-31 1999-06-29 Yamatake-Honeywell Co., Ltd. State estimating apparatus
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
DE69433811T2 (de) 1993-01-07 2005-06-23 Sequenom, Inc., San Diego Dns - sequenzierung durch massenspektronomie
CA2158642A1 (en) 1993-03-19 1994-09-29 Hubert Koster Dna sequencing by mass spectrometry via exonuclease degradation
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
DE69829402T2 (de) 1997-10-31 2006-04-13 Affymetrix, Inc. (a Delaware Corp.), Santa Clara Expressionsprofile in adulten und fötalen organen
US6020135A (en) 1998-03-27 2000-02-01 Affymetrix, Inc. P53-regulated genes
EP1077724A2 (en) * 1998-04-17 2001-02-28 The University Of Vermont Methods and products related to metabolic interactions in disease
US6763307B2 (en) 2000-03-06 2004-07-13 Bioseek, Inc. Patient classification
US20030124548A1 (en) 2001-03-13 2003-07-03 Christos Hatzis Method for association of genomic and proteomic pathways associated with physiological or pathophysiological processes
US8000949B2 (en) 2001-06-18 2011-08-16 Genego, Inc. Methods for identification of novel protein drug targets and biomarkers utilizing functional networks
US7393656B2 (en) 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
US7415359B2 (en) 2001-11-02 2008-08-19 Gene Network Sciences, Inc. Methods and systems for the identification of components of mammalian biochemical networks as targets for therapeutic agents
AU2002304965A1 (en) 2002-05-24 2003-12-12 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
US7512497B2 (en) 2002-08-29 2009-03-31 Gene Network Sciences, Inc. Systems and methods for inferring biological networks
CN1714371A (zh) * 2002-11-19 2005-12-28 Gni美国公司 根据时间序列基因表达数据的基因网络的非线性模拟
JP4288345B2 (ja) 2003-06-19 2009-07-01 独立行政法人産業技術総合研究所 新規てんかんモデル動物
EP1512970A1 (en) * 2003-09-05 2005-03-09 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Method for determining the impact of a multicomponent mixture on the biological profile of a disease
WO2005035780A1 (ja) * 2003-10-14 2005-04-21 Cellfree Sciences Co.,Ltd. 指標物質の新規スクリーニング方法
WO2005107412A2 (en) 2004-04-30 2005-11-17 Rosetta Inpharmatics Llc Systems and methods for reconstruction gene networks in segregating populations
EP1607898A3 (en) 2004-05-18 2006-03-29 Neal E. Solomon A bioinformatics system for functional proteomics modelling
US20100316629A1 (en) 2004-09-01 2010-12-16 Shaughnessy Jr John D Use of gene expression profiling to predict survival in cancer patient
AU2006206159A1 (en) 2005-01-24 2006-07-27 Massachusetts Institute Of Technology Method for modeling cell signaling systems by means of bayesian networks
EP1866818A1 (en) 2005-03-31 2007-12-19 Koninklijke Philips Electronics N.V. System and method for collecting evidence pertaining to relationships between biomolecules and diseases
EP1887351A4 (en) 2005-05-31 2009-04-08 Jcl Bioassay Corp SCREENING PROCEDURE FOR CERTAIN PROTEINS IN THE FULL PROTEAM ANALYSIS
US20090035312A1 (en) 2005-09-30 2009-02-05 Universiteit Maastricht Tumor angiogenesis associated genes and a method for their identification
US8138123B2 (en) * 2006-01-27 2012-03-20 Takeda Pharmaceutical Company Limited Gene expressing analysis tool
WO2008060620A2 (en) 2006-11-15 2008-05-22 Gene Network Sciences, Inc. Systems and methods for modeling and analyzing networks
CN101105841B (zh) * 2007-02-12 2011-06-15 浙江大学 由大规模基因芯片表达谱数据构建基因调控亚网络的方法
US8140270B2 (en) * 2007-03-22 2012-03-20 National Center For Genome Resources Methods and systems for medical sequencing analysis
CA2684665A1 (en) 2007-05-16 2009-02-12 Edsa Micro Corporation Real-time predictive systems for intelligent energy monitoring and management of electrical power networks
JP2009050171A (ja) 2007-08-23 2009-03-12 Toyobo Co Ltd 表面プラズモン共鳴による基板上におけるリン酸化の検出方法
US7895146B2 (en) * 2007-12-03 2011-02-22 Microsoft Corporation Time modulated generative probabilistic models for automated causal discovery that monitors times of packets
EP3369827B1 (en) * 2008-03-12 2020-12-23 The Rockefeller University Methods and compositions for translational profiling and molecular phenotyping
WO2010019952A2 (en) 2008-08-15 2010-02-18 Merrimack Pharmaceuticals, Inc. Methods, systems and products for predicting response of tumor cells to a therapeutic agent and treating a patient according to the predicted response
CN102481271A (zh) 2009-05-11 2012-05-30 博格生物系统有限责任公司 利用表观代谢转变剂、多维细胞内分子或环境影响剂治疗代谢障碍的方法
US20130023574A1 (en) 2010-03-31 2013-01-24 National University Corporation Kumamoto University Method for generating data set for integrated proteomics, integrated proteomics method using data set for integrated proteomics that is generated by the generation method, and method for identifying causative substance using same
MX357392B (es) * 2012-04-02 2018-07-06 Berg Llc Ensayos basados en interrogatorios celulares y uso de los mismos.
US20150019189A1 (en) * 2013-07-01 2015-01-15 Counterpoint Health Solutions, Inc. Systems biology approach to therapy

Also Published As

Publication number Publication date
CO6801640A2 (es) 2013-11-29
NZ712105A (en) 2017-05-26
BR112013022208A2 (pt) 2022-03-08
EP2680925A1 (en) 2014-01-08
ZA201306453B (en) 2021-05-26
CA2828972A1 (en) 2012-09-07
US11456054B2 (en) 2022-09-27
WO2012119129A1 (en) 2012-09-07
US20240062844A1 (en) 2024-02-22
PE20180776A1 (es) 2018-05-07
IL257824A (en) 2018-04-30
US20120258874A1 (en) 2012-10-11
PH12017502073A1 (en) 2019-01-14
CN103501859B (zh) 2017-08-25
US9886545B2 (en) 2018-02-06
PH12013501802B1 (en) 2018-06-27
AU2012223136A1 (en) 2013-09-19
PH12013501802A1 (en) 2013-11-18
CA2828972C (en) 2021-09-07
CL2013002526A1 (es) 2014-04-25
MX358408B (es) 2018-08-20
AU2017202977B2 (en) 2019-09-19
CN103501859A (zh) 2014-01-08
SG193006A1 (en) 2013-10-30
IL228096A0 (en) 2013-09-30
EP2680925B1 (en) 2019-11-20
IL228096B (en) 2018-03-29
US20180260515A1 (en) 2018-09-13
JP2017148046A (ja) 2017-08-31
AU2017202977A1 (en) 2017-05-25
MY164530A (en) 2017-12-29
CN107273712A (zh) 2017-10-20
KR102071081B1 (ko) 2020-01-29
JP6105491B2 (ja) 2017-03-29
JP2014512520A (ja) 2014-05-22
PE20140627A1 (es) 2014-05-30
MX2013010068A (es) 2013-11-01
ES2777894T3 (es) 2020-08-06
EP2680925A4 (en) 2014-12-31
MY181093A (en) 2020-12-17
EA201391245A1 (ru) 2014-05-30
NZ614891A (en) 2016-01-29
PH12017502072A1 (en) 2019-01-14
CN107273712B (zh) 2021-12-03
SG10201601224WA (en) 2016-03-30
AU2012223136B2 (en) 2017-05-25
KR20140013006A (ko) 2014-02-04

Similar Documents

Publication Publication Date Title
CL2020002805A1 (es) Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad (divisional 201302526)
MX357392B (es) Ensayos basados en interrogatorios celulares y uso de los mismos.
AR090903A1 (es) Anticuerpos e inmunoconjugados anti-pmel17
BR112013011083A2 (pt) processo e sistema para treinamento pessoal automatizado
BR112015030918A2 (pt) método para produção de células progenitoras renais, e fármacos contendo células progenitoras renais
MX2016008251A (es) Medios para cultivo celular.
BR112013025777A2 (pt) imidazopiridazinas como inibidores da quinase akt
CL2015003599A1 (es) Solucion que contiene theralosa y dextrano para transplantar celulas de mamiferos
AR088322A1 (es) Anticuerpos anti-htra1 y metodos de uso
MX376437B (es) Uso de hígado descelularizado por perfusión para recelularización de células de islote.
PE20151652A1 (es) Proceso e intermedios para preparar un medicamento
BR112015021189A2 (pt) métodos de banco de células de alta densidade
AR090319A1 (es) Biorrefineria integrada
AR081151A1 (es) Metodo para producir bacterias pertenecientes al genero bifidobacterium
AR079704A1 (es) Anticuerpos anti-bv8 y sus usos
IN2012DE00401A (es)
AR085824A1 (es) Anticuerpo anti-receptor il-3 humano
CL2016000746A1 (es) Un método para producir un l-aminoácido usando una bacteria de la familia de las enterobacteriaceae teniendo atenuada la expresión de un gen que codifica un transportador de fosfato
BR112014006911A2 (pt) aditivos de perda de fluido e métodos de produção e uso dos mesmos
BR112016006383A8 (pt) métodos para extração de uma proteína solúvel, produção de uma composição e produção de um suporte sólido ou semissólido
EA201791659A1 (ru) Компьютеризированный способ создания модели процесса ферментации
BR112014005383C8 (pt) complexo bis-iminopiridina de lantanídeos, sistema catalítico compreendendo o dito complexo bis-iminopiridina e processo para a (co)polimerização de dienos conjugados
AR086030A1 (es) Metodos y dispositivos para amplificar acidos nucleicos
AR104564A1 (es) Método y sistema para análisis de producción usando análisis de datos
CL2012002361A1 (es) Método para mejorar rasgos relacionados con el rendimiento en plantas que comprende modular la expresión en una planta de una molécula de ácido nucleico, vector que comprende, y método de producción dichas plantas transgénicas.