CL2020002805A1 - Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad (divisional 201302526) - Google Patents

Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad (divisional 201302526)

Info

Publication number
CL2020002805A1
CL2020002805A1 CL2020002805A CL2020002805A CL2020002805A1 CL 2020002805 A1 CL2020002805 A1 CL 2020002805A1 CL 2020002805 A CL2020002805 A CL 2020002805A CL 2020002805 A CL2020002805 A CL 2020002805A CL 2020002805 A1 CL2020002805 A1 CL 2020002805A1
Authority
CL
Chile
Prior art keywords
modulator
identify
biological system
divisional
disease process
Prior art date
Application number
CL2020002805A
Other languages
English (en)
Inventor
Niven Rajin Narain
Rangaprasad Sarangarajan
Vivek K Vishnudas
Original Assignee
Berg Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berg Llc filed Critical Berg Llc
Publication of CL2020002805A1 publication Critical patent/CL2020002805A1/es

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/20—Probabilistic models
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Physiology (AREA)
  • Genetics & Genomics (AREA)
  • Probability & Statistics with Applications (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

Un método para proporcionar un modelo para un sistema biológico para su uso en un método de plataforma, que comprende: establecer un modelo para un sistema biológico, usando células asociadas con el sistema biológico, para representar un aspecto característico del sistema biológico, donde el modelo para el sistema biológico es útil para generar conjuntos de datos usados en el método de plataforma; proporcionando así un modelo para un sistema biológico para uso en un método de plataforma.
CL2020002805A 2011-03-02 2020-10-28 Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad (divisional 201302526) CL2020002805A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161448587P 2011-03-02 2011-03-02
US201261593848P 2012-02-01 2012-02-01

Publications (1)

Publication Number Publication Date
CL2020002805A1 true CL2020002805A1 (es) 2021-04-30

Family

ID=46758320

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2013002526A CL2013002526A1 (es) 2011-03-02 2013-09-02 Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad.
CL2020002805A CL2020002805A1 (es) 2011-03-02 2020-10-28 Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad (divisional 201302526)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2013002526A CL2013002526A1 (es) 2011-03-02 2013-09-02 Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad.

Country Status (20)

Country Link
US (3) US9886545B2 (es)
EP (1) EP2680925B1 (es)
JP (2) JP6105491B2 (es)
KR (1) KR102071081B1 (es)
CN (2) CN107273712B (es)
AU (2) AU2012223136B2 (es)
BR (1) BR112013022208A2 (es)
CA (1) CA2828972C (es)
CL (2) CL2013002526A1 (es)
CO (1) CO6801640A2 (es)
EA (1) EA201391245A1 (es)
ES (1) ES2777894T3 (es)
IL (2) IL228096B (es)
MX (1) MX358408B (es)
MY (2) MY164530A (es)
PE (2) PE20180776A1 (es)
PH (3) PH12013501802B1 (es)
SG (2) SG193006A1 (es)
WO (1) WO2012119129A1 (es)
ZA (1) ZA201306453B (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4773348B2 (ja) 2003-07-12 2011-09-14 アクセラー８ テクノロジー コーポレイション 高感度かつ迅速なバイオ検出法
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
US9434937B2 (en) 2011-03-07 2016-09-06 Accelerate Diagnostics, Inc. Rapid cell purification systems
AU2013230045A1 (en) * 2012-03-05 2014-09-11 Berg Llc Compositions and methods for diagnosis and treatment of pervasive developmental disorder
US9744155B2 (en) 2012-03-28 2017-08-29 Ixcela, Inc. IPA as a therapeutic agent, as a protective agent, and as a biomarker of disease risk
AU2012376214B2 (en) 2012-04-02 2019-02-14 Berg Llc Interrogatory cell-based assays and uses thereof
MX2014013875A (es) 2012-05-22 2015-06-04 Berg Llc Ensayo basado en celulas interrogadoras para identificar marcadores de toxicidad inducida por medicamentos.
US20150302140A1 (en) * 2012-11-02 2015-10-22 H. Lee Moffit Cancer Center And Research Institute, Inc. In silico identification of cancer molecular signaling pathways and drug candidates
US20150302167A1 (en) * 2012-11-09 2015-10-22 Cellworks Group, Inc. System and method for development of therapeutic solutions
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
CA2920608C (en) * 2013-05-28 2018-07-24 Five3 Genomics, Llc Paradigm drug response networks
EP3017300A4 (en) * 2013-07-01 2017-03-08 Ixcela, Inc. Systems biology approach to therapy
JP6518269B2 (ja) * 2014-05-28 2019-05-22 ヴィート エンフェー 異なる生体試料の混合物中に含まれる化学化合物を相対的に定量する方法
SG10201902151UA (en) * 2014-09-11 2019-04-29 Berg Llc Bayesian causal relationship network models for healthcare diagnosis and treatment based on patient data
CN106716135B (zh) 2014-10-10 2019-03-15 松森昭 用于检测心力衰竭的装置及储存介质
EP3230314B1 (en) 2014-12-08 2023-05-03 Berg LLC Use of markers including filamin a in the diagnosis and treatment of prostate cancer
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
AU2016243656A1 (en) 2015-03-30 2017-11-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
CN106250717B (zh) * 2015-06-04 2019-03-12 徐勇 急性髓性白血病的miRNA与转录因子的系统及其构建方法和应用
KR101881398B1 (ko) * 2016-04-07 2018-07-24 한국과학기술원 생물학적 시스템 정보 처리 장치 및 방법
JP7042755B2 (ja) 2016-06-05 2022-03-28 バーグ エルエルシー 患者層別化及び潜在的バイオマーカー同定のためのシステム及び方法
US10282588B2 (en) * 2016-06-09 2019-05-07 Siemens Healthcare Gmbh Image-based tumor phenotyping with machine learning from synthetic data
EP3538095A4 (en) 2016-11-14 2020-06-17 Berg LLC Methods for treating parkinson's disease
WO2018094204A1 (en) * 2016-11-17 2018-05-24 Arivale, Inc. Determining relationships between risks for biological conditions and dynamic analytes
WO2018209165A1 (en) * 2017-05-12 2018-11-15 Laboratory Corporation Of America Holdings Systems and methods for biomarker identificaton
US12487233B2 (en) 2017-10-02 2025-12-02 Koninklijke Philips N.V. Determining functional status of immune cells types and immune response
CN109086570B (zh) * 2018-06-29 2020-09-04 迈凯基因科技有限公司 一种多数据库依次交互方法及装置
CN112639986B (zh) * 2018-06-29 2025-03-07 杰克逊实验室 用于标识选择性剪接事件的方法和装置
US11041847B1 (en) 2019-01-25 2021-06-22 Ixcela, Inc. Detection and modification of gut microbial population
EP3935581A4 (en) 2019-03-04 2022-11-30 Iocurrents, Inc. DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING
JP7185243B2 (ja) * 2019-07-09 2022-12-07 株式会社島津製作所 ｉＰＳ細胞の分化効率予測モデルの構築方法及びｉＰＳ細胞の分化効率予測方法
US20210071256A1 (en) * 2019-09-11 2021-03-11 Recursion Pharmaceuticals, Inc. Systems and methods for pairwise inference of drug-gene interaction networks
WO2022045334A1 (ja) * 2020-08-31 2022-03-03 武田薬品工業株式会社 推論装置、推論方法、推論プログラム、モデル生成方法、推論サービス提供システム、推論サービス提供方法及び推論サービス提供プログラム
CN112151109B (zh) * 2020-09-09 2023-08-25 中国科学院大连化学物理研究所 用于评价生物分子交联质谱鉴定随机性的半监督学习方法
CN112466403B (zh) * 2020-12-31 2022-06-14 广州基迪奥生物科技有限公司 一种细胞通讯分析方法及系统
KR102556312B1 (ko) 2021-04-12 2023-07-19 서울대학교병원 세뇨관 배양부 및 간질 배양부를 포함하는 신장 모사 장기 칩
US20220399092A1 (en) * 2021-06-10 2022-12-15 Rajant Health Inc. Ai-enabled health platform
US20220399129A1 (en) * 2021-06-15 2022-12-15 Flagship Pioneering Innovations Vi, Llc Systems and methods for terraforming
CN114038504A (zh) * 2021-11-30 2022-02-11 周建伟 一种识别驱动肿瘤转移关键异质性分子的预测系统
WO2023102204A1 (en) * 2021-12-03 2023-06-08 The Trustees Of Indiana University Biomarker for type 1 diabetes
CN115346687B (zh) * 2022-08-08 2025-07-04 之江实验室 一种采用非线性动态分析辅助神经网络用于评估药物引起的心脏毒性的方法
CN115775594A (zh) * 2022-12-12 2023-03-10 南京医基云医疗数据研究院有限公司 生物组学调控关系分析方法及装置、电子设备、介质
CN116046877B (zh) * 2023-04-03 2024-03-15 深圳先进技术研究院 疾病模型代谢分析方法、包埋模具及喷涂装置
WO2025259359A1 (en) * 2024-06-12 2025-12-18 CytoVale Inc. Systems and methods for sepsis determination

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
EP0247091B1 (en) 1985-11-01 1993-09-29 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
US4843155A (en) 1987-11-19 1989-06-27 Piotr Chomczynski Product and process for isolating RNA
EP0768377A1 (en) 1988-09-02 1997-04-16 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
CA2109602C (en) 1990-07-10 2002-10-01 Gregory P. Winter Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
AU8507191A (en) 1990-08-29 1992-03-30 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
ES2113940T3 (es) 1990-12-03 1998-05-16 Genentech Inc Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas.
DE69233769D1 (de) 1991-03-01 2009-09-24 Dyax Corp Chimäres Protein mit Mikroprotein mit zwei oder mehr Disulfidbindungen und Ausgestaltungen davon
AU662148B2 (en) 1991-04-10 1995-08-24 Scripps Research Institute, The Heterodimeric receptor libraries using phagemids
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
US5621083A (en) 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US5677195A (en) 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
US6027725A (en) 1991-11-25 2000-02-22 Enzon, Inc. Multivalent antigen-binding proteins
CA2087413A1 (en) 1992-01-17 1993-07-18 Joseph R. Lakowicz Fluorescent energy transfer immunoassay
US5918200A (en) * 1992-08-31 1999-06-29 Yamatake-Honeywell Co., Ltd. State estimating apparatus
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
CA2153387A1 (en) 1993-01-07 1994-07-21 Hubert Koester Dna sequencing by mass spectrometry
CA2158642A1 (en) 1993-03-19 1994-09-29 Hubert Koster Dna sequencing by mass spectrometry via exonuclease degradation
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
EP0880598A4 (en) 1996-01-23 2005-02-23 Affymetrix Inc RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM
AU1287799A (en) 1997-10-31 1999-05-24 Affymetrix, Inc. Expression profiles in adult and fetal organs
US6020135A (en) 1998-03-27 2000-02-01 Affymetrix, Inc. P53-regulated genes
EP1077724A2 (en) * 1998-04-17 2001-02-28 The University Of Vermont Methods and products related to metabolic interactions in disease
US6763307B2 (en) 2000-03-06 2004-07-13 Bioseek, Inc. Patient classification
EP1380001A2 (en) 2001-03-13 2004-01-14 Ashni Naturaceuticals, Inc. Method for association of genomic and proteomic pathways associated with physiological or pathophysiological processes
US8000949B2 (en) 2001-06-18 2011-08-16 Genego, Inc. Methods for identification of novel protein drug targets and biomarkers utilizing functional networks
US7393656B2 (en) 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
US7415359B2 (en) 2001-11-02 2008-08-19 Gene Network Sciences, Inc. Methods and systems for the identification of components of mammalian biochemical networks as targets for therapeutic agents
AU2002304965A1 (en) 2002-05-24 2003-12-12 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
ATE398808T1 (de) 2002-08-29 2008-07-15 Gene Network Sciences Inc Systeme und verfahren zum schliessen auf biologische netzwerke
CN1714371A (zh) * 2002-11-19 2005-12-28 Gni美国公司 根据时间序列基因表达数据的基因网络的非线性模拟
JP4288345B2 (ja) 2003-06-19 2009-07-01 独立行政法人産業技術総合研究所 新規てんかんモデル動物
EP1512970A1 (en) * 2003-09-05 2005-03-09 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Method for determining the impact of a multicomponent mixture on the biological profile of a disease
US20070134734A1 (en) 2003-10-14 2007-06-14 Cellfree Sciences Co., Ltd. Novel screening method of indicator substance
WO2005107412A2 (en) * 2004-04-30 2005-11-17 Rosetta Inpharmatics Llc Systems and methods for reconstruction gene networks in segregating populations
EP1607898A3 (en) 2004-05-18 2006-03-29 Neal E. Solomon A bioinformatics system for functional proteomics modelling
US20100316629A1 (en) 2004-09-01 2010-12-16 Shaughnessy Jr John D Use of gene expression profiling to predict survival in cancer patient
CN101194260A (zh) * 2005-01-24 2008-06-04 利兰·斯坦福青年大学托管委员会 使用贝叶斯网络建立细胞信号传导系统模型的方法
US20080195570A1 (en) 2005-03-31 2008-08-14 Koninklijke Philips Electronics, N.V. System and Method for Collecting Evidence Pertaining to Relationships Between Biomolecules and Diseases
US20090132171A1 (en) 2005-05-31 2009-05-21 Jcl Bioassay Corporation Screening Method for Specific Protein in Proteome Comprehensive Analysis
EP2332984A3 (en) 2005-09-30 2011-10-12 Universiteit Maastricht Tumor angiogenesis associated genes and a method for their identification
JPWO2007086515A1 (ja) * 2006-01-27 2009-06-25 武田薬品工業株式会社 遺伝子発現解析ツール
WO2008060620A2 (en) 2006-11-15 2008-05-22 Gene Network Sciences, Inc. Systems and methods for modeling and analyzing networks
CN101105841B (zh) * 2007-02-12 2011-06-15 浙江大学 由大规模基因芯片表达谱数据构建基因调控亚网络的方法
US8140270B2 (en) * 2007-03-22 2012-03-20 National Center For Genome Resources Methods and systems for medical sequencing analysis
EP2147387A4 (en) * 2007-05-16 2012-05-02 Edsa Micro Corp REAL-TIME FORECASTING SYSTEMS FOR INTELLIGENT ENERGY MONITORING AND MANAGEMENT OF ELECTRICITY NETWORKS
JP2009050171A (ja) 2007-08-23 2009-03-12 Toyobo Co Ltd 表面プラズモン共鳴による基板上におけるリン酸化の検出方法
US7895146B2 (en) * 2007-12-03 2011-02-22 Microsoft Corporation Time modulated generative probabilistic models for automated causal discovery that monitors times of packets
WO2009114185A2 (en) * 2008-03-12 2009-09-17 The Rockefeller University Methods and compositions for translational profiling and molecular phenotyping
WO2010019952A2 (en) 2008-08-15 2010-02-18 Merrimack Pharmaceuticals, Inc. Methods, systems and products for predicting response of tumor cells to a therapeutic agent and treating a patient according to the predicted response
EA023913B1 (ru) 2009-05-11 2016-07-29 БЕРГ ФАРМА ЭлЭлСи Способы лечения метаболических нарушений, использующие эпиметаболические переключатели, многоаспектные внутриклеточные молекулы или факторы влияния
EP2600154A4 (en) 2010-03-31 2014-06-11 Univ Kumamoto Nat Univ Corp METHOD FOR GENERATING A DATA SET FOR INTEGRATED PROTEOMICS, METHOD FOR INTEGRATED PROTEOMICS WITH THE DATA PROTEOM FOR INTEGRATED PROTEOMICS PRODUCED IN THIS PRODUCTION PROCESS, AND METHOD FOR IDENTIFYING A DISEASE SUBSTANCE THEREWITH
AU2012376214B2 (en) 2012-04-02 2019-02-14 Berg Llc Interrogatory cell-based assays and uses thereof
EP3017300A4 (en) * 2013-07-01 2017-03-08 Ixcela, Inc. Systems biology approach to therapy

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