CL2020002805A1 - Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad (divisional 201302526) - Google Patents
Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad (divisional 201302526)Info
- Publication number
- CL2020002805A1 CL2020002805A1 CL2020002805A CL2020002805A CL2020002805A1 CL 2020002805 A1 CL2020002805 A1 CL 2020002805A1 CL 2020002805 A CL2020002805 A CL 2020002805A CL 2020002805 A CL2020002805 A CL 2020002805A CL 2020002805 A1 CL2020002805 A1 CL 2020002805A1
- Authority
- CL
- Chile
- Prior art keywords
- modulator
- identify
- biological system
- divisional
- disease process
- Prior art date
Links
Classifications
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
- G16B5/20—Probabilistic models
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Physiology (AREA)
- Genetics & Genomics (AREA)
- Probability & Statistics with Applications (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Mobile Radio Communication Systems (AREA)
- Medical Treatment And Welfare Office Work (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Abstract
Un método para proporcionar un modelo para un sistema biológico para su uso en un método de plataforma, que comprende: establecer un modelo para un sistema biológico, usando células asociadas con el sistema biológico, para representar un aspecto característico del sistema biológico, donde el modelo para el sistema biológico es útil para generar conjuntos de datos usados en el método de plataforma; proporcionando así un modelo para un sistema biológico para uso en un método de plataforma.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161448587P | 2011-03-02 | 2011-03-02 | |
| US201261593848P | 2012-02-01 | 2012-02-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2020002805A1 true CL2020002805A1 (es) | 2021-04-30 |
Family
ID=46758320
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013002526A CL2013002526A1 (es) | 2011-03-02 | 2013-09-02 | Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad. |
| CL2020002805A CL2020002805A1 (es) | 2011-03-02 | 2020-10-28 | Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad (divisional 201302526) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013002526A CL2013002526A1 (es) | 2011-03-02 | 2013-09-02 | Método para identificar un modulador de un sistema biológico; método para identificar un modulador de un proceso de enfermedad. |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9886545B2 (es) |
| EP (1) | EP2680925B1 (es) |
| JP (2) | JP6105491B2 (es) |
| KR (1) | KR102071081B1 (es) |
| CN (2) | CN107273712B (es) |
| AU (2) | AU2012223136B2 (es) |
| BR (1) | BR112013022208A2 (es) |
| CA (1) | CA2828972C (es) |
| CL (2) | CL2013002526A1 (es) |
| CO (1) | CO6801640A2 (es) |
| EA (1) | EA201391245A1 (es) |
| ES (1) | ES2777894T3 (es) |
| IL (2) | IL228096B (es) |
| MX (1) | MX358408B (es) |
| MY (2) | MY181093A (es) |
| PE (2) | PE20180776A1 (es) |
| PH (3) | PH12013501802B1 (es) |
| SG (2) | SG10201601224WA (es) |
| WO (1) | WO2012119129A1 (es) |
| ZA (1) | ZA201306453B (es) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2661168T3 (es) | 2003-07-12 | 2018-03-27 | Accelerate Diagnostics, Inc. | Biodetección sensible y rápida |
| US20120077206A1 (en) | 2003-07-12 | 2012-03-29 | Accelr8 Technology Corporation | Rapid Microbial Detection and Antimicrobial Susceptibility Testing |
| US9434937B2 (en) | 2011-03-07 | 2016-09-06 | Accelerate Diagnostics, Inc. | Rapid cell purification systems |
| US10254204B2 (en) | 2011-03-07 | 2019-04-09 | Accelerate Diagnostics, Inc. | Membrane-assisted purification |
| AU2013230045A1 (en) * | 2012-03-05 | 2014-09-11 | Berg Llc | Compositions and methods for diagnosis and treatment of pervasive developmental disorder |
| US9744155B2 (en) | 2012-03-28 | 2017-08-29 | Ixcela, Inc. | IPA as a therapeutic agent, as a protective agent, and as a biomarker of disease risk |
| MX357392B (es) * | 2012-04-02 | 2018-07-06 | Berg Llc | Ensayos basados en interrogatorios celulares y uso de los mismos. |
| EA201492178A1 (ru) | 2012-05-22 | 2015-12-30 | Берг Ллк | Основанные на клетках перекрестные анализы для идентификации маркеров индуцированной лекарственными средствами токсичности |
| WO2014071316A1 (en) * | 2012-11-02 | 2014-05-08 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | In silico identification of cancer molecular signaling pathways and drug candidates |
| US20150302167A1 (en) * | 2012-11-09 | 2015-10-22 | Cellworks Group, Inc. | System and method for development of therapeutic solutions |
| US9677109B2 (en) | 2013-03-15 | 2017-06-13 | Accelerate Diagnostics, Inc. | Rapid determination of microbial growth and antimicrobial susceptibility |
| JP6216044B2 (ja) * | 2013-05-28 | 2017-10-18 | ファイヴ3 ゲノミクス,エルエルシー | Paradigm薬剤反応ネットワーク |
| US20150019189A1 (en) * | 2013-07-01 | 2015-01-15 | Counterpoint Health Solutions, Inc. | Systems biology approach to therapy |
| JP6518269B2 (ja) * | 2014-05-28 | 2019-05-22 | ヴィート エンフェー | 異なる生体試料の混合物中に含まれる化学化合物を相対的に定量する方法 |
| CN114203296B (zh) * | 2014-09-11 | 2025-10-17 | 布普格生物制药公司 | 基于患者数据的用于健康护理诊断和治疗的贝叶斯因果关系网络模型 |
| EP3206032B1 (en) * | 2014-10-10 | 2019-02-27 | Akira Matsumori | Method for detecting cardiac failure patient, method for discrimination of cardiac disease, test reagent for cardiac failure, test kit for cardiac failure, device for detecting cardiac failure, and program for detecting cardiac failure |
| US10539566B2 (en) | 2014-12-08 | 2020-01-21 | Berg Llc | Use of markers including filamin A in the diagnosis and treatment of prostate cancer |
| US10023895B2 (en) | 2015-03-30 | 2018-07-17 | Accelerate Diagnostics, Inc. | Instrument and system for rapid microogranism identification and antimicrobial agent susceptibility testing |
| US10253355B2 (en) | 2015-03-30 | 2019-04-09 | Accelerate Diagnostics, Inc. | Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing |
| CN106250717B (zh) * | 2015-06-04 | 2019-03-12 | 徐勇 | 急性髓性白血病的miRNA与转录因子的系统及其构建方法和应用 |
| KR101881398B1 (ko) * | 2016-04-07 | 2018-07-24 | 한국과학기술원 | 생물학적 시스템 정보 처리 장치 및 방법 |
| US20200185063A1 (en) | 2016-06-05 | 2020-06-11 | Berg Llc | Systems and methods for patient stratification and identification of potential biomarkers |
| US10282588B2 (en) * | 2016-06-09 | 2019-05-07 | Siemens Healthcare Gmbh | Image-based tumor phenotyping with machine learning from synthetic data |
| WO2018090054A1 (en) | 2016-11-14 | 2018-05-17 | Berg Llc | Methods for treating parkinson's disease |
| WO2018094204A1 (en) * | 2016-11-17 | 2018-05-24 | Arivale, Inc. | Determining relationships between risks for biological conditions and dynamic analytes |
| CA3057420C (en) * | 2017-05-12 | 2023-08-01 | Laboratory Corporation Of America Holdings | Systems and methods for biomarker identificaton |
| JP7257405B2 (ja) | 2017-10-02 | 2023-04-13 | コーニンクレッカ フィリップス エヌ ヴェ | 免疫細胞型及び免疫応答の機能状況の決定 |
| CN109086570B (zh) * | 2018-06-29 | 2020-09-04 | 迈凯基因科技有限公司 | 一种多数据库依次交互方法及装置 |
| US12051496B2 (en) * | 2018-06-29 | 2024-07-30 | The Jackson Laboratory | Methods and apparatus for identifying alternative splicing events |
| US11041847B1 (en) | 2019-01-25 | 2021-06-22 | Ixcela, Inc. | Detection and modification of gut microbial population |
| EP3935581A4 (en) | 2019-03-04 | 2022-11-30 | Iocurrents, Inc. | DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING |
| WO2021005729A1 (ja) * | 2019-07-09 | 2021-01-14 | 株式会社島津製作所 | iPS細胞の分化効率予測モデルの構築方法及びiPS細胞の分化効率予測方法 |
| WO2021050760A1 (en) * | 2019-09-11 | 2021-03-18 | Recursion Pharmaceuticals, Inc. | Systems and methods for pairwise inference of drug-gene interaction networks |
| JP7735624B2 (ja) * | 2020-08-31 | 2025-09-09 | 武田薬品工業株式会社 | 推論装置、推論方法、推論プログラム、モデル生成方法、推論サービス提供システム、推論サービス提供方法及び推論サービス提供プログラム |
| CN112151109B (zh) * | 2020-09-09 | 2023-08-25 | 中国科学院大连化学物理研究所 | 用于评价生物分子交联质谱鉴定随机性的半监督学习方法 |
| CN112466403B (zh) * | 2020-12-31 | 2022-06-14 | 广州基迪奥生物科技有限公司 | 一种细胞通讯分析方法及系统 |
| KR102556312B1 (ko) | 2021-04-12 | 2023-07-19 | 서울대학교병원 | 세뇨관 배양부 및 간질 배양부를 포함하는 신장 모사 장기 칩 |
| US20220399092A1 (en) * | 2021-06-10 | 2022-12-15 | Rajant Health Inc. | Ai-enabled health platform |
| CN114038504A (zh) * | 2021-11-30 | 2022-02-11 | 周建伟 | 一种识别驱动肿瘤转移关键异质性分子的预测系统 |
| WO2023102204A1 (en) * | 2021-12-03 | 2023-06-08 | The Trustees Of Indiana University | Biomarker for type 1 diabetes |
| CN115346687B (zh) * | 2022-08-08 | 2025-07-04 | 之江实验室 | 一种采用非线性动态分析辅助神经网络用于评估药物引起的心脏毒性的方法 |
| CN115775594A (zh) * | 2022-12-12 | 2023-03-10 | 南京医基云医疗数据研究院有限公司 | 生物组学调控关系分析方法及装置、电子设备、介质 |
| CN116046877B (zh) * | 2023-04-03 | 2024-03-15 | 深圳先进技术研究院 | 疾病模型代谢分析方法、包埋模具及喷涂装置 |
| WO2025259359A1 (en) * | 2024-06-12 | 2025-12-18 | CytoVale Inc. | Systems and methods for sepsis determination |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| DE3689123T2 (de) | 1985-11-01 | 1994-03-03 | Xoma Corp | Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung. |
| US4868103A (en) | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US6121424A (en) | 1991-11-25 | 2000-09-19 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US4904582A (en) | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
| US4843155A (en) | 1987-11-19 | 1989-06-27 | Piotr Chomczynski | Product and process for isolating RNA |
| EP0436597B1 (en) | 1988-09-02 | 1997-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| DK0585287T3 (da) | 1990-07-10 | 2000-04-17 | Cambridge Antibody Tech | Fremgangsmåde til fremstilling af specifikke bindingsparelementer |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| CA2095633C (en) | 1990-12-03 | 2003-02-04 | Lisa J. Garrard | Enrichment method for variant proteins with altered binding properties |
| EP1820858B1 (en) | 1991-03-01 | 2009-08-12 | Dyax Corporation | Chimeric protein comprising micro-protein having two or more disulfide bonds and embodiments thereof |
| ATE414768T1 (de) | 1991-04-10 | 2008-12-15 | Scripps Research Inst | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| US5621083A (en) | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
| CA2124087C (en) | 1991-11-22 | 2002-10-01 | James L. Winkler | Combinatorial strategies for polymer synthesis |
| EP0552108B1 (en) | 1992-01-17 | 1999-11-10 | Lakowicz, Joseph R. | Energy transfer phase-modulation fluoro-immunoassay |
| US5918200A (en) | 1992-08-31 | 1999-06-29 | Yamatake-Honeywell Co., Ltd. | State estimating apparatus |
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| DE69433811T2 (de) | 1993-01-07 | 2005-06-23 | Sequenom, Inc., San Diego | Dns - sequenzierung durch massenspektronomie |
| CA2158642A1 (en) | 1993-03-19 | 1994-09-29 | Hubert Koster | Dna sequencing by mass spectrometry via exonuclease degradation |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
| DE69829402T2 (de) | 1997-10-31 | 2006-04-13 | Affymetrix, Inc. (a Delaware Corp.), Santa Clara | Expressionsprofile in adulten und fötalen organen |
| US6020135A (en) | 1998-03-27 | 2000-02-01 | Affymetrix, Inc. | P53-regulated genes |
| EP1077724A2 (en) * | 1998-04-17 | 2001-02-28 | The University Of Vermont | Methods and products related to metabolic interactions in disease |
| US6763307B2 (en) | 2000-03-06 | 2004-07-13 | Bioseek, Inc. | Patient classification |
| US20030124548A1 (en) | 2001-03-13 | 2003-07-03 | Christos Hatzis | Method for association of genomic and proteomic pathways associated with physiological or pathophysiological processes |
| US8000949B2 (en) | 2001-06-18 | 2011-08-16 | Genego, Inc. | Methods for identification of novel protein drug targets and biomarkers utilizing functional networks |
| US7393656B2 (en) | 2001-07-10 | 2008-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for risk stratification |
| US7415359B2 (en) | 2001-11-02 | 2008-08-19 | Gene Network Sciences, Inc. | Methods and systems for the identification of components of mammalian biochemical networks as targets for therapeutic agents |
| AU2002304965A1 (en) | 2002-05-24 | 2003-12-12 | Zensun (Shanghai) Sci-Tech.Ltd | Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy |
| US7512497B2 (en) | 2002-08-29 | 2009-03-31 | Gene Network Sciences, Inc. | Systems and methods for inferring biological networks |
| CN1714371A (zh) * | 2002-11-19 | 2005-12-28 | Gni美国公司 | 根据时间序列基因表达数据的基因网络的非线性模拟 |
| JP4288345B2 (ja) | 2003-06-19 | 2009-07-01 | 独立行政法人産業技術総合研究所 | 新規てんかんモデル動物 |
| EP1512970A1 (en) * | 2003-09-05 | 2005-03-09 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Method for determining the impact of a multicomponent mixture on the biological profile of a disease |
| WO2005035780A1 (ja) * | 2003-10-14 | 2005-04-21 | Cellfree Sciences Co.,Ltd. | 指標物質の新規スクリーニング方法 |
| WO2005107412A2 (en) | 2004-04-30 | 2005-11-17 | Rosetta Inpharmatics Llc | Systems and methods for reconstruction gene networks in segregating populations |
| EP1607898A3 (en) | 2004-05-18 | 2006-03-29 | Neal E. Solomon | A bioinformatics system for functional proteomics modelling |
| US20100316629A1 (en) | 2004-09-01 | 2010-12-16 | Shaughnessy Jr John D | Use of gene expression profiling to predict survival in cancer patient |
| AU2006206159A1 (en) | 2005-01-24 | 2006-07-27 | Massachusetts Institute Of Technology | Method for modeling cell signaling systems by means of bayesian networks |
| EP1866818A1 (en) | 2005-03-31 | 2007-12-19 | Koninklijke Philips Electronics N.V. | System and method for collecting evidence pertaining to relationships between biomolecules and diseases |
| EP1887351A4 (en) | 2005-05-31 | 2009-04-08 | Jcl Bioassay Corp | SCREENING PROCEDURE FOR CERTAIN PROTEINS IN THE FULL PROTEAM ANALYSIS |
| US20090035312A1 (en) | 2005-09-30 | 2009-02-05 | Universiteit Maastricht | Tumor angiogenesis associated genes and a method for their identification |
| US8138123B2 (en) * | 2006-01-27 | 2012-03-20 | Takeda Pharmaceutical Company Limited | Gene expressing analysis tool |
| WO2008060620A2 (en) | 2006-11-15 | 2008-05-22 | Gene Network Sciences, Inc. | Systems and methods for modeling and analyzing networks |
| CN101105841B (zh) * | 2007-02-12 | 2011-06-15 | 浙江大学 | 由大规模基因芯片表达谱数据构建基因调控亚网络的方法 |
| US8140270B2 (en) * | 2007-03-22 | 2012-03-20 | National Center For Genome Resources | Methods and systems for medical sequencing analysis |
| CA2684665A1 (en) | 2007-05-16 | 2009-02-12 | Edsa Micro Corporation | Real-time predictive systems for intelligent energy monitoring and management of electrical power networks |
| JP2009050171A (ja) | 2007-08-23 | 2009-03-12 | Toyobo Co Ltd | 表面プラズモン共鳴による基板上におけるリン酸化の検出方法 |
| US7895146B2 (en) * | 2007-12-03 | 2011-02-22 | Microsoft Corporation | Time modulated generative probabilistic models for automated causal discovery that monitors times of packets |
| EP3369827B1 (en) * | 2008-03-12 | 2020-12-23 | The Rockefeller University | Methods and compositions for translational profiling and molecular phenotyping |
| WO2010019952A2 (en) | 2008-08-15 | 2010-02-18 | Merrimack Pharmaceuticals, Inc. | Methods, systems and products for predicting response of tumor cells to a therapeutic agent and treating a patient according to the predicted response |
| CN102481271A (zh) | 2009-05-11 | 2012-05-30 | 博格生物系统有限责任公司 | 利用表观代谢转变剂、多维细胞内分子或环境影响剂治疗代谢障碍的方法 |
| US20130023574A1 (en) | 2010-03-31 | 2013-01-24 | National University Corporation Kumamoto University | Method for generating data set for integrated proteomics, integrated proteomics method using data set for integrated proteomics that is generated by the generation method, and method for identifying causative substance using same |
| MX357392B (es) * | 2012-04-02 | 2018-07-06 | Berg Llc | Ensayos basados en interrogatorios celulares y uso de los mismos. |
| US20150019189A1 (en) * | 2013-07-01 | 2015-01-15 | Counterpoint Health Solutions, Inc. | Systems biology approach to therapy |
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