CL2020002914A1 - Métodos y composiciones para tratar el cáncer - Google Patents
Métodos y composiciones para tratar el cáncerInfo
- Publication number
- CL2020002914A1 CL2020002914A1 CL2020002914A CL2020002914A CL2020002914A1 CL 2020002914 A1 CL2020002914 A1 CL 2020002914A1 CL 2020002914 A CL2020002914 A CL 2020002914A CL 2020002914 A CL2020002914 A CL 2020002914A CL 2020002914 A1 CL2020002914 A1 CL 2020002914A1
- Authority
- CL
- Chile
- Prior art keywords
- compositions
- methods
- treating cancer
- cancer
- treatment
- Prior art date
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0636—T lymphocytes
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Abstract
Se proporcionan en el presente documento, en algunas realizaciones, métodos y composiciones (por ejemplo, composiciones de células) para el tratamiento del cáncer.
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| US201862773658P | 2018-11-30 | 2018-11-30 | |
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Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210137085A (ko) | 2019-03-05 | 2021-11-17 | 엔카르타, 인크. | Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도 |
| US20220249558A1 (en) | 2019-04-30 | 2022-08-11 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| KR20220009446A (ko) * | 2019-05-15 | 2022-01-24 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 비-소세포 폐암의 치료를 위한 방법 및 조성물 |
| BR112021026382A2 (pt) | 2019-06-27 | 2022-02-08 | Crispr Therapeutics Ag | Uso de células t de receptor de antígenos quimérico e inibidores de células nk para tratamento de câncer |
| CN114729325A (zh) | 2019-09-06 | 2022-07-08 | 克里斯珀医疗股份公司 | 在培养物中具有改善的持久性的基因工程化t细胞 |
| KR20220101128A (ko) * | 2019-11-13 | 2022-07-19 | 크리스퍼 테라퓨틱스 아게 | Cd70을 표적화하는 유전자 조작된 t 세포를 사용하는 cd70+ 고형 종양 치료법 |
| IL292329A (en) | 2019-11-13 | 2022-06-01 | Crispr Therapeutics Ag | Manufacturing process for making t cells expressing chimeric antigen receptors |
| TW202132560A (zh) | 2019-11-13 | 2021-09-01 | 瑞士商Crispr治療公司 | 製備car-t細胞之方法 |
| IL292467A (en) * | 2019-11-13 | 2022-06-01 | Crispr Therapeutics Ag | Treatment of hematopoietic cell cancers using genetically engineered t cells targeting cd70 |
| MX2022005821A (es) | 2019-11-13 | 2022-08-16 | Crispr Therapeutics Ag | Terapia del carcinoma de celulas renales (rcc) usando linfocitos t modificados por ingenieria genetica dirigidos a cd70. |
| CN113087805A (zh) * | 2019-12-31 | 2021-07-09 | 华东师范大学 | 一种共表达免疫调节分子的嵌合抗原受体t细胞的制备及其应用 |
| CN115348868A (zh) * | 2020-01-17 | 2022-11-15 | 克里斯珀医疗股份公司 | 表达bcma特异性嵌合抗原受体的基因工程化t细胞及其在癌症疗法中的用途 |
| WO2021161197A1 (en) | 2020-02-11 | 2021-08-19 | Crispr Therapeutics Ag | Anti-idiotype antibodies targeting anti-cd19 chimeric antigen receptor |
| WO2021202770A2 (en) * | 2020-03-31 | 2021-10-07 | Fred Hutchinson Cancer Research Center | Human anti-cd33 antibodies and uses thereof |
| GB202005184D0 (en) * | 2020-04-08 | 2020-05-20 | Autolus Ltd | Method |
| TW202208412A (zh) | 2020-05-06 | 2022-03-01 | 瑞士商Crispr治療公司 | 對酪胺酸蛋白激酶樣7(ptk7)特異的經掩蔽的嵌合抗原受體和表現其的免疫細胞 |
| WO2021234662A1 (en) | 2020-05-21 | 2021-11-25 | Crispr Therapeutics Ag | Genetically engineered car t cells that secrete interleukin-12 and therapeutic uses thereof |
| WO2021245603A1 (en) | 2020-06-04 | 2021-12-09 | Crispr Therapeutics Ag | Anti-cd70 antibodies and uses thereof |
| AU2021286655A1 (en) * | 2020-06-12 | 2023-01-05 | Nkarta, Inc. | Genetically modified natural killer cells for CD70-directed cancer immunotherapy |
| WO2021260657A1 (en) | 2020-06-26 | 2021-12-30 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| US11795238B2 (en) | 2020-08-04 | 2023-10-24 | Crispr Therapeutics Ag | Anti-idiotype antibodies targeting anti-CD70 chimeric antigen receptor |
| WO2022043861A1 (en) | 2020-08-25 | 2022-03-03 | Crispr Therapeutics Ag | Anti-idiotype antibodies targeting anti-bcma chimeric antigen receptor |
| CN116648507A (zh) * | 2020-08-28 | 2023-08-25 | 基因泰克公司 | 宿主细胞蛋白的CRISPR/Cas9多重敲除 |
| CN114164231B (zh) * | 2020-09-10 | 2024-05-17 | 上海邦耀生物科技有限公司 | 对细胞中的靶位点进行基因编辑的方法 |
| JP2023542348A (ja) * | 2020-09-23 | 2023-10-06 | クリスパー セラピューティクス アクチェンゲゼルシャフト | Regnase-1及び/又はTGFBRIIを破壊した遺伝子操作されたT細胞は機能性及び持続性を改善させた |
| AU2021366431A1 (en) | 2020-10-20 | 2023-05-18 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| EP4232465A4 (en) * | 2020-10-26 | 2024-10-23 | Memorial Sloan Kettering Cancer Center | Cells with cd70 knockout and uses for immunotherapy |
| TW202237827A (zh) | 2020-12-03 | 2022-10-01 | 美商世紀治療股份有限公司 | 經基因工程改造之細胞及其用途 |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| CN116635064A (zh) | 2020-12-18 | 2023-08-22 | 世纪治疗股份有限公司 | 具有适应性受体特异性的嵌合抗原受体系统 |
| US20220193134A1 (en) | 2020-12-23 | 2022-06-23 | Crispr Therapeutics Ag | Co-use of lenalidomide with car-t cells |
| US20220202859A1 (en) | 2020-12-23 | 2022-06-30 | Crispr Therapeutics Ag | Cancer treatment using cd38 inhibitor and/or lenalidomide and t-cells expressing a chimeric antigen receptor |
| US12553030B2 (en) | 2021-03-09 | 2026-02-17 | Crispr Therapeutics Ag | Genetically engineered T cells with PTPN2 knockout have improved functionality and anti-tumor activity |
| WO2022215978A1 (ko) * | 2021-04-05 | 2022-10-13 | 주식회사 셀렌진 | Pdcd-1 유전자에 상보적인 가이드 rna 및 이의 용도 |
| WO2022238962A1 (en) | 2021-05-12 | 2022-11-17 | Crispr Therapeutics Ag | Genetically engineered immune cells targeting cd70 for use in treating hematopoietic malignancies |
| US20220378829A1 (en) | 2021-05-12 | 2022-12-01 | Crispr Therapeutics Ag | Genetically engineered immune cells targeting cd70 for use in treating solid tumors |
| EP4376873A1 (en) | 2021-07-26 | 2024-06-05 | CRISPR Therapeutics AG | Methods for manufacturing genetically engineered car-t cells |
| WO2023042079A1 (en) | 2021-09-14 | 2023-03-23 | Crispr Therapeutics Ag | Genetically engineered immune cells having a disrupted cd83 gene |
| WO2023084399A1 (en) | 2021-11-09 | 2023-05-19 | Crispr Therapeutics Ag | Genetically engineered immune cells expressing masked chimeric antigen receptors specific to protein tyrosine kinase 7 |
| WO2023100153A1 (en) | 2021-12-03 | 2023-06-08 | Crispr Therapeutics Ag | Use of anti-cd70 antibodies for identifying subjects susceptible for treatment with nk cell-based anti-cd70 therapy |
| WO2023111913A1 (en) | 2021-12-15 | 2023-06-22 | Crispr Therapeutics Ag | Engineered anti-liv1 cell with regnase-1 and/or tgfbrii disruption |
| WO2023119201A2 (en) | 2021-12-22 | 2023-06-29 | Crispr Therapeutics Ag | Genetically engineered t cells with disrupted casitas b-lineage lymphoma proto-oncogene-b (cblb) and uses thereof |
| WO2023123195A1 (zh) * | 2021-12-30 | 2023-07-06 | 深圳市先康达生命科学有限公司 | 一种目的基因可调控的工程化免疫细胞及其制备方法和应用 |
| CN114369622A (zh) * | 2021-12-31 | 2022-04-19 | 西安桑尼赛尔生物医药有限公司 | 同时靶向cd7和cd19的双特异通用型car-t细胞及其制备方法 |
| EP4507706A1 (en) * | 2022-04-15 | 2025-02-19 | The General Hospital Corporation | Cd70 binding car-t cells comprising cd33 binding t-cell engaging antibody molecules |
| WO2023205148A1 (en) | 2022-04-19 | 2023-10-26 | Intellia Therapeutics, Inc. | Chimeric antigen receptor compositions and uses |
| EP4540288A1 (en) | 2022-06-20 | 2025-04-23 | CRISPR Therapeutics AG | Cd117-targeting nanoparticles for use in drug delivery |
| EP4540287A1 (en) | 2022-06-20 | 2025-04-23 | CRISPR Therapeutics AG | Chimeric antigen receptor specific to cd117 |
| WO2024023804A2 (en) | 2022-07-29 | 2024-02-01 | Crispr Therapeutics Ag | Genetically engineered immune cells having disrupted transporter associated with antigen processing binding protein (tapbp) gene |
| WO2024023801A2 (en) | 2022-07-29 | 2024-02-01 | Crispr Therapeutics Ag | Genetically engineered immune cells having disrupted transporter associated with antigen processing-1 (tap-1) gene |
| WO2024023802A2 (en) | 2022-07-29 | 2024-02-01 | Crispr Therapeutics Ag | Genetically engineered immune cells having disrupted transporter associated with antigen processing-2 (tap-2) gene |
| WO2024192108A1 (en) | 2023-03-14 | 2024-09-19 | Evolveimmune Therapeutics, Inc. | Genetically modified car t cells and methods of making and using the same |
| WO2024220768A1 (en) * | 2023-04-21 | 2024-10-24 | Cold Spring Harbor Laboratory | Metabolic switches for anti-tumor immunity |
| CN121195068A (zh) * | 2023-05-26 | 2025-12-23 | 爱迪塔斯医药公司 | 靶向cd70表达的crispr相关方法和组合物 |
| TW202515994A (zh) * | 2023-08-14 | 2025-04-16 | 美商英特利亞醫療公司 | 用於對cd70進行基因修飾之組合物及方法 |
| WO2025093707A1 (en) | 2023-10-31 | 2025-05-08 | Université de Lausanne | Method for suppressing car-t cells unresponsiveness for improving cancer immunotherapy |
| WO2025126049A2 (en) | 2023-12-11 | 2025-06-19 | Crispr Therapeutics Ag | Multiplex gene editing |
| CN117844811A (zh) * | 2024-03-08 | 2024-04-09 | 上海恒润达生生物科技股份有限公司 | 靶向敲除CD70基因的sgRNA组合物及其应用 |
Family Cites Families (140)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| GB9710807D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| KR20090016772A (ko) | 1999-08-17 | 2009-02-17 | 바이오겐 아이덱 엠에이 인코포레이티드 | Baff 수용체(bcma), 면역조절제 |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| AU4328801A (en) | 2000-02-24 | 2001-09-03 | Xcyte Therapies Inc | Simultaneous stimulation and concentration of cells |
| JP2002060786A (ja) | 2000-08-23 | 2002-02-26 | Kao Corp | 硬質表面用殺菌防汚剤 |
| CA2425862C (en) | 2000-11-07 | 2013-01-22 | City Of Hope | Cd19-specific redirected immune cells |
| WO2002066516A2 (en) | 2001-02-20 | 2002-08-29 | Zymogenetics, Inc. | Antibodies that bind both bcma and taci |
| WO2003016496A2 (en) | 2001-08-20 | 2003-02-27 | The Scripps Research Institute | Zinc finger binding domains for cnn |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| US20080025989A1 (en) | 2003-02-20 | 2008-01-31 | Seattle Genetics, Inc. | Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
| ATE472338T1 (de) | 2003-02-20 | 2010-07-15 | Seattle Genetics Inc | Anti-cd70 antikörper-arzneimittelkonjugate und ihre verwendung zur behandlung von krebs |
| EP1460088A1 (en) | 2003-03-21 | 2004-09-22 | Biotest AG | Humanized anti-CD4 antibody with immunosuppressive properties |
| DE10328289B3 (de) | 2003-06-23 | 2005-01-05 | Enginion Ag | Arbeitsmedium für Dampfkreisprozesse |
| US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| US7435596B2 (en) | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
| US7972854B2 (en) | 2004-02-05 | 2011-07-05 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| WO2006044643A2 (en) | 2004-10-15 | 2006-04-27 | Seattle Genetics, Inc. | Anti-cd70 antibody and its use for the treatment and prevention of cancer and immune disorders |
| US8337838B2 (en) | 2004-10-15 | 2012-12-25 | Seattle Genetics, Inc. | Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders |
| US7641903B2 (en) | 2004-10-15 | 2010-01-05 | Seattle Genetics, Inc. | Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders |
| US20120294863A1 (en) | 2004-10-15 | 2012-11-22 | Seattle Genetics, Inc. | Anti-CD70 Antibody and Its Use for the Treatment and Prevention of Cancer and Immune Disorders |
| WO2006060878A1 (en) | 2004-12-10 | 2006-06-15 | Peter Maccallum Cancer Institute | Methods and compositions for adoptive immunotherapy |
| CN101203241B (zh) | 2005-04-19 | 2012-02-22 | 西雅图基因公司 | 人源化抗-cd70结合物和其应用 |
| NZ596992A (en) | 2005-06-30 | 2013-07-26 | Abbott Lab | Il-12/p40 binding proteins |
| KR20080056167A (ko) | 2005-09-26 | 2008-06-20 | 메다렉스, 인코포레이티드 | 씨디70에 대한 인간 모노크로날 항체 |
| JP2010513306A (ja) * | 2006-12-14 | 2010-04-30 | メダレックス インコーポレーティッド | Cd70に結合するヒト抗体およびその使用 |
| DK2141997T3 (da) | 2007-03-30 | 2013-02-11 | Sloan Kettering Inst Cancer | Konstitutiv ekspression af co-stimulatoriske ligander på adoptivt overførte t-lymfocytter |
| EP2198055A4 (en) | 2007-09-07 | 2012-04-18 | Cisthera Inc | HUMANIZED PAI-1 ANTIBODIES |
| KR101674097B1 (ko) | 2008-04-11 | 2016-11-08 | 시애틀 지네틱스, 인크. | 췌장, 난소 및 다른 암의 검출 및 치료 |
| JP5425775B2 (ja) | 2008-06-30 | 2014-02-26 | 協和発酵キリン株式会社 | 抗cd27抗体 |
| WO2011059836A2 (en) | 2009-10-29 | 2011-05-19 | Trustees Of Dartmouth College | T cell receptor-deficient t cell compositions |
| US8956828B2 (en) | 2009-11-10 | 2015-02-17 | Sangamo Biosciences, Inc. | Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases |
| EP3456826B1 (en) | 2009-12-10 | 2023-06-28 | Regents of the University of Minnesota | Tal effector-mediated dna modification |
| CA2785964C (en) | 2009-12-29 | 2021-03-30 | Kyowa Hakko Kirin Co., Ltd. | Anti-cd27 antibody |
| CA3253628A1 (en) | 2010-03-05 | 2025-11-29 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
| MX339621B (es) | 2010-04-13 | 2016-06-02 | Celldex Therapeutics Inc * | Anticuerpos que se unen a cd27 humano y uso de los mismos. |
| US20120213771A1 (en) | 2010-04-13 | 2012-08-23 | Celldex Therapeutics Inc. | Antibodies that bind human cd27 and uses thereof |
| CA2804550C (en) | 2010-07-09 | 2021-01-05 | Bionovion Holding B.V. | Agonistic antibody to cd27 |
| AU2011319727B2 (en) | 2010-10-27 | 2016-06-30 | Baylor College Of Medicine | Chimeric CD27 receptors for redirecting T cells to CD70-positive malignancies |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| EP2686347B1 (en) | 2011-03-16 | 2018-05-02 | argenx BVBA | Antibodies to cd70 |
| SG194176A1 (en) | 2011-05-27 | 2013-12-30 | Glaxo Group Ltd | Bcma (cd269/tnfrsf17) -binding proteins |
| US9382319B2 (en) | 2011-09-26 | 2016-07-05 | Jn Biosciences Llc | Hybrid constant regions |
| AR088693A1 (es) | 2011-11-11 | 2014-06-25 | Rinat Neuroscience Corp | Anticuerpos especificos para trop-2 y sus usos |
| WO2013074916A1 (en) | 2011-11-18 | 2013-05-23 | Board Of Regents, The University Of Texas System | Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla |
| KR20130060720A (ko) | 2011-11-30 | 2013-06-10 | 한국전자통신연구원 | 목적 기반 시맨틱 서비스 디스커버리를 위한 서비스 목적 해석 장치 및 방법 |
| NZ629697A (en) | 2012-03-15 | 2017-01-27 | Janssen Biotech Inc | Human anti-cd27 antibodies, methods and uses |
| EA201990959A1 (ru) | 2012-04-11 | 2020-02-10 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток |
| SG10201806573TA (en) | 2012-05-25 | 2018-09-27 | Cellectis | Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy |
| EP2914628A1 (en) | 2012-11-01 | 2015-09-09 | Max-Delbrück-Centrum für Molekulare Medizin | An antibody that binds cd269 (bcma) suitable for use in the treatment of plasma cell diseases such as multiple myeloma and autoimmune diseases |
| ES2667420T3 (es) | 2013-02-05 | 2018-05-10 | Engmab Sàrl | Anticuerpos biespecíficos contra cd3epsilon y bcma |
| WO2014158821A1 (en) | 2013-03-12 | 2014-10-02 | Imaginab, Inc. | Antigen binding constructs to cd70 |
| MX385713B (es) | 2013-03-13 | 2025-03-18 | Seagen Inc | Ciclodextrina y formulaciones de conjugados anticuerpo-fármaco. |
| WO2014140374A2 (en) | 2013-03-15 | 2014-09-18 | Novo Nordisk A/S | Monovalent cd27 antibodies |
| WO2014153470A2 (en) | 2013-03-21 | 2014-09-25 | Sangamo Biosciences, Inc. | Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases |
| JP2016522679A (ja) | 2013-04-04 | 2016-08-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | CRISPR/Cas系を用いたゲノム編集の治療的使用 |
| US9890393B2 (en) | 2013-05-29 | 2018-02-13 | Cellectis | Methods for engineering T cells for immunotherapy by using RNA-guided CAS nuclease system |
| ES2883131T3 (es) | 2013-05-29 | 2021-12-07 | Cellectis | Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN |
| JP2016536021A (ja) | 2013-11-07 | 2016-11-24 | エディタス・メディシン,インコーポレイテッド | CRISPR関連方法および支配gRNAのある組成物 |
| SG11201603484PA (en) | 2013-11-21 | 2016-05-30 | Ucl Business Plc | Cell |
| KR20200032763A (ko) | 2014-02-04 | 2020-03-26 | 카이트 파마 인코포레이티드 | B 세포 악성종양 및 다른 암을 치료하는데 유용한 자가 t 세포 및 그의 조성물의 생산 방법 |
| US10836998B2 (en) | 2014-02-14 | 2020-11-17 | Cellectis | Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells |
| EP3114217A4 (en) | 2014-03-07 | 2017-09-20 | Bellicum Pharmaceuticals, Inc. | Caspase polypeptides having modified activity and uses thereof |
| WO2015136001A1 (en) | 2014-03-11 | 2015-09-17 | Cellectis | Method for generating t-cells compatible for allogenic transplantation |
| JP2017513818A (ja) | 2014-03-15 | 2017-06-01 | ノバルティス アーゲー | キメラ抗原受容体を使用する癌の処置 |
| AU2015248956B2 (en) | 2014-04-14 | 2020-06-25 | Cellectis | BCMA (CD269) specific chimeric antigen receptors for cancer immunotherapy |
| US20170175128A1 (en) * | 2014-04-18 | 2017-06-22 | Editas Medicine, Inc. | Crispr-cas-related methods, compositions and components for cancer immunotherapy |
| CN106459924A (zh) | 2014-04-23 | 2017-02-22 | 得克萨斯州大学系统董事会 | 用于疗法中的嵌合抗原受体(car)及其制备方法 |
| EP3149044B1 (en) | 2014-06-02 | 2020-10-21 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Chimeric antigen receptors targeting cd-19 |
| EP3152319A4 (en) | 2014-06-05 | 2017-12-27 | Sangamo BioSciences, Inc. | Methods and compositions for nuclease design |
| US10174095B2 (en) | 2014-07-21 | 2019-01-08 | Novartis Ag | Nucleic acid encoding a humanized anti-BCMA chimeric antigen receptor |
| MX2017001079A (es) | 2014-07-24 | 2017-09-12 | Bluebird Bio Inc | Receptores de antígeno quiméricos de antígeno de maduración de células b (bcma). |
| BR112017001818A2 (pt) | 2014-07-29 | 2017-11-21 | Pfizer | receptores antigênicos quiméricos específicos para egfrviii para imunoterapia de câncer |
| SG11201701111SA (en) | 2014-08-12 | 2017-03-30 | Anthrogenesis Corp | Car-t lymphocytes engineered to home to lymph node b cell zone, skin, or gastrointestinal tract |
| GB201418965D0 (es) | 2014-10-24 | 2014-12-10 | Ospedale San Raffaele And Fond Telethon | |
| AU2015339743C1 (en) | 2014-10-31 | 2021-04-22 | The Trustees Of The University Of Pennsylvania | Altering gene expression in modified T cells and uses thereof |
| US12180263B2 (en) | 2014-11-06 | 2024-12-31 | President And Fellows Of Harvard College | Cells lacking B2M surface expression and methods for allogeneic administration of such cells |
| US10900034B2 (en) | 2014-12-03 | 2021-01-26 | Agilent Technologies, Inc. | Guide RNA with chemical modifications |
| EP4310097A3 (en) | 2014-12-05 | 2024-04-03 | Memorial Sloan Kettering Cancer Center | Chimeric antigen receptors targeting b-cell maturation antigen and uses thereof |
| EP3597663B1 (en) * | 2014-12-08 | 2022-04-06 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Anti-cd70 chimeric antigen receptors |
| SMT201900596T1 (it) | 2014-12-12 | 2019-11-13 | Bluebird Bio Inc | Recettori chimerici di antigene per bcma |
| IL320860A (en) | 2014-12-19 | 2025-07-01 | Dana Farber Cancer Inst Inc | Chimeric antigen receptors and methods of using them |
| US20180002435A1 (en) | 2015-01-26 | 2018-01-04 | Cellectis | mAb-DRIVEN CHIMERIC ANTIGEN RECEPTOR SYSTEMS FOR SORTING/DEPLETING ENGINEERED IMMUNE CELLS |
| GB201504840D0 (en) | 2015-03-23 | 2015-05-06 | Ucl Business Plc | Chimeric antigen receptor |
| CN115537396A (zh) | 2015-03-27 | 2022-12-30 | 哈佛学院校长同事会 | 经过修饰的t细胞及其制备和使用方法 |
| KR102888521B1 (ko) | 2015-04-06 | 2025-11-19 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna |
| US20190031759A1 (en) | 2015-04-30 | 2019-01-31 | Technion Research & Development Foundation Limited | Chimeric antigen receptors and methods of their use |
| CN107921148A (zh) | 2015-05-08 | 2018-04-17 | 哈佛学院校长同事会 | 通用供体干细胞和相关方法 |
| MX2017014822A (es) | 2015-05-18 | 2018-04-30 | Tcr2 Therapeutics Inc | Composiciones y métodos para la reprogramación del tcr con proteínas de fusión. |
| CN104910278B (zh) | 2015-05-27 | 2018-05-25 | 上海吉凯基因科技有限公司 | 一种用于制备cart细胞的具有高效转染能力和生物学活性的慢病毒 |
| IL295616A (en) | 2015-07-31 | 2022-10-01 | Us Health | Adapted cells and treatment methods |
| EP3355937A4 (en) | 2015-09-28 | 2019-04-17 | Regents of the University of Minnesota | CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS AS THERAPEUTIC INTERVENTIONS AT AUTO AND ALLO IMMUNITY |
| DK3359184T3 (da) | 2015-10-05 | 2020-06-15 | Prec Biosciences Inc | Genetisk modificerede celler, der omfatter et modificeret gen fra konstant alfaregion i human t-cellereceptor |
| GB201518136D0 (en) | 2015-10-14 | 2015-11-25 | Glaxosmithkline Ip Dev Ltd | Novel chimeric antigen receptors |
| WO2017070429A1 (en) | 2015-10-22 | 2017-04-27 | Regents Of The University Of Minnesota | Methods involving editing polynucleotides that encode t cell receptor |
| WO2017075537A1 (en) | 2015-10-30 | 2017-05-04 | Aleta Biotherapeutics Inc. | Compositions and methods for treatment of cancer |
| AU2016353067B2 (en) | 2015-11-13 | 2023-10-05 | Sanford Research | Anti-BCMA polypeptides and proteins |
| IL259576B (en) | 2015-12-04 | 2022-09-01 | Novartis Ag | grna molecule containing tracr and crrna, pharmaceutical composition containing it and method for preparing cells for immunotherapy |
| US11052111B2 (en) | 2015-12-08 | 2021-07-06 | Chimera Bioengineering, Inc. | Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses |
| WO2017106528A2 (en) | 2015-12-18 | 2017-06-22 | Sangamo Biosciences, Inc. | Targeted disruption of the t cell receptor |
| MX2018007519A (es) | 2015-12-18 | 2019-09-04 | Sangamo Therapeutics Inc | Alteracion dirigida del receptor celular del complejo mayor de histocompatibilidad (mhc). |
| ES2901000T3 (es) | 2015-12-23 | 2022-03-21 | Prec Biosciences Inc | Meganucleasas de ingeniería con secuencias de reconocimiento encontradas en el gen de la microglobulina beta-2 humana |
| ITUB20160112A1 (it) | 2016-01-28 | 2016-04-28 | Serteaweb Srl | Processo di allarme e sistema televisivo relativo ad un tale processo di allarme |
| US20190194338A1 (en) | 2016-02-17 | 2019-06-27 | Seattle Genetics, Inc. | Bcma antibodies and use of same to treat cancer and immunological disorders |
| WO2017149515A1 (en) | 2016-03-04 | 2017-09-08 | Novartis Ag | Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore |
| RU2018135819A (ru) | 2016-03-11 | 2020-04-13 | Блубёрд Био, Инк. | Иммунные эффекторные клетки с отредактированным геномом |
| PT3436079T (pt) | 2016-04-01 | 2021-10-06 | Kite Pharma Inc | Recetores de antigénios quiméricos e de células t e métodos de uso |
| EP3988111A1 (en) | 2016-04-01 | 2022-04-27 | Innovative Cellular Therapeutics Holdings, Ltd. | Use of chimeric antigen receptor modified cells to treat cancer |
| CA3020330A1 (en) | 2016-04-07 | 2017-10-12 | Bluebird Bio, Inc. | Chimeric antigen receptor t cell compositions |
| CN109311963A (zh) | 2016-04-14 | 2019-02-05 | 蓝鸟生物公司 | 救助嵌合抗原受体系统 |
| JP2019514870A (ja) * | 2016-04-22 | 2019-06-06 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | B細胞悪性腫瘍の処置のための方法及びワクチン組成物 |
| US11141471B2 (en) | 2016-04-25 | 2021-10-12 | Regen BioPharma, Inc. | Universal donor checkpoint inhibitor silenced/gene edited cord blood killer cells |
| US10875919B2 (en) | 2016-04-26 | 2020-12-29 | Alector Llc | Chimeric receptors and methods of use thereof |
| US11596699B2 (en) | 2016-04-29 | 2023-03-07 | CureVac SE | RNA encoding an antibody |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| CA3022611A1 (en) | 2016-05-06 | 2017-11-09 | Juno Therapeutics, Inc. | Genetically engineered cells and methods of making the same |
| EP3464375A2 (en) | 2016-06-02 | 2019-04-10 | Novartis AG | Therapeutic regimens for chimeric antigen receptor (car)- expressing cells |
| SG10202012157QA (en) | 2016-06-07 | 2021-01-28 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Chimeric antigen receptor and car-t cells that bind bcma |
| JP7114490B2 (ja) | 2016-06-24 | 2022-08-08 | アイセル・ジーン・セラピューティクス・エルエルシー | キメラ抗体受容体(CARs)の構成およびその使用方法 |
| WO2018068257A1 (zh) | 2016-10-13 | 2018-04-19 | 北京艺妙神州医疗科技有限公司 | 通用型car-t细胞及其制备方法和用途 |
| CN106544321B (zh) | 2016-10-13 | 2019-01-29 | 北京艺妙神州医疗科技有限公司 | 通用型car-t细胞及其制备方法和用途 |
| WO2018073391A1 (en) | 2016-10-19 | 2018-04-26 | Cellectis | Targeted gene insertion for improved immune cells therapy |
| WO2018073393A2 (en) * | 2016-10-19 | 2018-04-26 | Cellectis | Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy |
| US12459975B2 (en) | 2017-01-10 | 2025-11-04 | The General Hospital Corporation | Modified T cells and methods of their use |
| IL270415B2 (en) * | 2017-05-12 | 2024-08-01 | Crispr Therapeutics Ag | Materials and methods for cell engineering and their uses in immuno-oncology |
| WO2019119036A1 (en) * | 2017-12-19 | 2019-06-27 | Benitec Biopharma Limited | Cd70 deficient cells, and methods and reagents for producing same |
| IL276396B2 (en) | 2018-02-01 | 2026-01-01 | Pfizer | Chimeric antigen receptors against CD70 |
| US11957695B2 (en) * | 2018-04-26 | 2024-04-16 | The Broad Institute, Inc. | Methods and compositions targeting glucocorticoid signaling for modulating immune responses |
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