CL2021000033A1 - Nuevos compuestos - Google Patents

Nuevos compuestos

Info

Publication number
CL2021000033A1
CL2021000033A1 CL2021000033A CL2021000033A CL2021000033A1 CL 2021000033 A1 CL2021000033 A1 CL 2021000033A1 CL 2021000033 A CL2021000033 A CL 2021000033A CL 2021000033 A CL2021000033 A CL 2021000033A CL 2021000033 A1 CL2021000033 A1 CL 2021000033A1
Authority
CL
Chile
Prior art keywords
new compounds
diseases
new
human
pharmaceuticals
Prior art date
Application number
CL2021000033A
Other languages
English (en)
Inventor
Michael Joseph Bishop
Vincent J Colandrea
Yuehu Li
Eugene L Stewart
Iulia Strambeanu
Katherine Louisa Widdowson
James Walter Janetka
Laurel Kathryn Mcgrane
Original Assignee
Glaxosmithkline Ip Dev Ltd
Fimbrion Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip Dev Ltd, Fimbrion Therapeutics Inc filed Critical Glaxosmithkline Ip Dev Ltd
Publication of CL2021000033A1 publication Critical patent/CL2021000033A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/04—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with air or molecular oxygen
    • C07D301/08—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with air or molecular oxygen in the gaseous phase
    • C07D301/10—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with air or molecular oxygen in the gaseous phase with catalysts containing silver or gold
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describen en la presente memoria nuevos compuestos y composiciones de C-manósido y su aplicación como productos farmacéuticos para el tratamiento de enfermedades humanas. También se proporcionan métodos para inhibir la actividad de FimH en un sujeto humano con el fin de tratar enfermedades, tales como infección del tracto urinario.
CL2021000033A 2018-07-10 2021-01-07 Nuevos compuestos CL2021000033A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862695993P 2018-07-10 2018-07-10
US201862755588P 2018-11-05 2018-11-05

Publications (1)

Publication Number Publication Date
CL2021000033A1 true CL2021000033A1 (es) 2021-07-30

Family

ID=67957191

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021000033A CL2021000033A1 (es) 2018-07-10 2021-01-07 Nuevos compuestos

Country Status (27)

Country Link
US (3) US11111262B2 (es)
EP (1) EP3820856B9 (es)
JP (2) JP7309862B2 (es)
KR (1) KR20210031682A (es)
CN (1) CN112334455B (es)
AU (1) AU2019301946B2 (es)
BR (1) BR112021000370A2 (es)
CA (1) CA3105940A1 (es)
CL (1) CL2021000033A1 (es)
CY (1) CY1125704T1 (es)
DK (1) DK3820856T3 (es)
ES (1) ES2928634T3 (es)
HR (1) HRP20221381T1 (es)
HU (1) HUE060140T2 (es)
IL (1) IL279993B2 (es)
LT (1) LT3820856T (es)
MX (1) MX2021000340A (es)
MY (1) MY201687A (es)
PH (1) PH12020551905A1 (es)
PL (1) PL3820856T3 (es)
PT (1) PT3820856T (es)
RS (1) RS63712B1 (es)
SG (1) SG11202011066XA (es)
SM (1) SMT202200435T1 (es)
TW (1) TWI821328B (es)
UY (1) UY38293A (es)
WO (1) WO2020012336A1 (es)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11560388B2 (en) 2019-03-19 2023-01-24 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic aza-benzothiophene and aza-benzofuran compounds
US11964977B2 (en) 2020-05-29 2024-04-23 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic heterocyclic compounds
US11999742B2 (en) 2021-11-01 2024-06-04 Boehringer Ingelheim Vetmedica Gmbh Substituted pyrrolo[1,2-b]pyridazines as anthelmintics
US12269822B2 (en) 2018-07-09 2025-04-08 Boehringer Ingelheim Animal Health USA Inc. Anthelminthic heterocyclic compounds

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS63712B1 (sr) * 2018-07-10 2022-11-30 Glaxosmithkline Ip Dev Ltd Jedinjenja c-manozida korisna za tretman infekcija urinarnog trakta
CA3138394A1 (en) 2019-05-07 2020-11-12 Glaxosmithkline Intellectual Property Development Limited Novel compounds
WO2021197363A1 (zh) * 2020-03-31 2021-10-07 苏州大学 2-炔基甘露糖衍生物及其应用
WO2026077990A1 (en) 2024-10-09 2026-04-16 Glaxosmithkline Intellectual Property Development Limited Novel use

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US5122602A (en) 1989-02-13 1992-06-16 Miles Inc. Chromogenic merocyanine enzyme substrates
US6420127B1 (en) 1994-11-18 2002-07-16 Washington University Compounds and pharmaceutical compositions for the treatment and prophylaxis of bacterial infections
AU704114B2 (en) 1993-11-18 1999-04-15 Siga Technologies, Inc. Compounds and pharmaceutical compositions for the treatment and prophylaxis of bacterial infections
DE60006390T2 (de) 1999-06-28 2004-05-13 Lear Corp., Southfield Verfahren zum formen eines blasgeformten kunststoffteils mit filmscharnier
WO2001010386A2 (en) 1999-08-11 2001-02-15 Washington University Anti-bacterial compounds directed against pilus biogenesis, adhesion and activity; co-crystals of pilus subunits and methods of use thereof
WO2001095876A1 (en) 2000-06-09 2001-12-20 Baylor College Of Medicine The combination of antimicrobial agents and bacterial interference to coat medical devices
EP1679299A1 (en) 2003-10-08 2006-07-12 Innovaprotean, S.L. Compounds for the treatment of diseases associated with the formation of amyloid fibrils
EP1755619A2 (en) 2004-03-23 2007-02-28 VIB vzw Anti-adhesive compounds to prevent and treat bacterial infections
SE528382C2 (sv) 2004-10-05 2006-10-31 Probi Ab Probiotiska lactobacillusstammar för förbättrad vaginal hälsa
FR2876798A1 (fr) 2004-10-14 2006-04-21 Univ Clermont Auvergne Diagnostic et traitement de la maladie de crohn
WO2011050323A1 (en) 2009-10-22 2011-04-28 The Washington University Compounds and methods for treating bacterial infections
NZ616764A (en) 2009-12-14 2014-11-28 Univ Basel Mannose derivatives as antagonists of bacterial adhesion
EP2672820B1 (en) 2011-02-07 2019-04-17 The Washington University Mannoside compounds and methods of use thereof
WO2012164074A1 (en) 2011-06-03 2012-12-06 University Of Basel Mannose phosphate derivatives as antagonists of bacterial adhesion
WO2013134415A1 (en) 2012-03-07 2013-09-12 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
EP2690105A1 (en) 2012-07-24 2014-01-29 Centre National De La Recherche Scientifique Mannose derivatives, a process for preparing the same and their uses as a drug
US20150197536A1 (en) 2012-07-28 2015-07-16 The Regents Of The University Of Colorado, A Body Corporate Compounds reducing the production of sorbitol in the eye and methods of using the same
WO2014055474A1 (en) 2012-10-04 2014-04-10 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
EP3388441A1 (en) 2012-12-18 2018-10-17 Vertex Pharmaceuticals Incorporated Mannose derivatives for treating bacterial infections
MX2015012472A (es) 2013-03-12 2016-02-10 Vertex Pharma Derivados de manosa para el tratamiento de infecciones bacterianas.
CN105682665A (zh) * 2013-05-30 2016-06-15 华盛顿大学 用于治疗细菌性感染的化合物和方法
WO2017021549A1 (en) 2015-08-05 2017-02-09 Enterome Mannose derivatives useful for treating pathologies associated with adherent e. coli
JP2019508504A (ja) * 2016-03-11 2019-03-28 フィンブリオン セラピューティックス， インコーポレイテッドＦｉｍｂｒｉｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 疾病の処置に有用なｃ−グリコシド化合物
AU2017238392A1 (en) 2016-03-23 2018-09-27 Fimbrion Therapeutics, Inc. Mannose-derived antagonists of FimH useful for treating disease
WO2019076931A1 (en) 2017-10-16 2019-04-25 Enterome NEW TOOLS FOR EVALUATING THE THERAPEUTIC EFFECTIVENESS OF FIMH BLOCKERS
RS63712B1 (sr) 2018-07-10 2022-11-30 Glaxosmithkline Ip Dev Ltd Jedinjenja c-manozida korisna za tretman infekcija urinarnog trakta
CN109818150A (zh) 2019-03-12 2019-05-28 信利半导体有限公司 一种液晶天线及其制作方法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12269822B2 (en) 2018-07-09 2025-04-08 Boehringer Ingelheim Animal Health USA Inc. Anthelminthic heterocyclic compounds
US11560388B2 (en) 2019-03-19 2023-01-24 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic aza-benzothiophene and aza-benzofuran compounds
US11964977B2 (en) 2020-05-29 2024-04-23 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic heterocyclic compounds
US12312356B2 (en) 2020-05-29 2025-05-27 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic heterocyclic compounds
US11999742B2 (en) 2021-11-01 2024-06-04 Boehringer Ingelheim Vetmedica Gmbh Substituted pyrrolo[1,2-b]pyridazines as anthelmintics
US12503474B2 (en) 2021-11-01 2025-12-23 Boehringer Ingelheim Vetmedica Gmbh Substituted pyrrolo[1,2-b]pyridazines as anthelmintics

Also Published As

Publication number Publication date
BR112021000370A2 (pt) 2021-04-06
US20230287028A1 (en) 2023-09-14
CY1125704T1 (el) 2026-02-25
TW202019893A (zh) 2020-06-01
PH12020551905A1 (en) 2021-06-21
JP2022191325A (ja) 2022-12-27
IL279993A (en) 2021-03-01
US20210395287A1 (en) 2021-12-23
US20210017212A1 (en) 2021-01-21
KR20210031682A (ko) 2021-03-22
US11697665B2 (en) 2023-07-11
PL3820856T3 (pl) 2022-12-19
TWI821328B (zh) 2023-11-11
AU2019301946A1 (en) 2020-11-26
EP3820856B1 (en) 2022-08-31
HUE060140T2 (hu) 2023-02-28
LT3820856T (lt) 2022-11-10
IL279993B1 (en) 2023-09-01
UY38293A (es) 2020-05-29
WO2020012336A1 (en) 2020-01-16
DK3820856T3 (da) 2022-10-24
US11111262B2 (en) 2021-09-07
CN112334455B (zh) 2022-07-01
AU2019301946B2 (en) 2022-03-31
HRP20221381T1 (hr) 2023-01-06
EP3820856B9 (en) 2023-07-12
EP3820856A1 (en) 2021-05-19
MX2021000340A (es) 2021-03-25
PT3820856T (pt) 2022-10-17
JP2022511594A (ja) 2022-02-01
RS63712B1 (sr) 2022-11-30
JP7483820B2 (ja) 2024-05-15
JP7309862B2 (ja) 2023-07-18
CN112334455A (zh) 2021-02-05
ES2928634T3 (es) 2022-11-21
IL279993B2 (en) 2024-01-01
MY201687A (en) 2024-03-13
US12552824B2 (en) 2026-02-17
SMT202200435T1 (it) 2023-01-13
SG11202011066XA (en) 2021-01-28
CA3105940A1 (en) 2020-01-16

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