CL2021001072A1 - Oligonucleótidos para modular la expresión de tau (divisional solicitud no. 202003457) - Google Patents

Oligonucleótidos para modular la expresión de tau (divisional solicitud no. 202003457)

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Publication number
CL2021001072A1
CL2021001072A1 CL2021001072A CL2021001072A CL2021001072A1 CL 2021001072 A1 CL2021001072 A1 CL 2021001072A1 CL 2021001072 A CL2021001072 A CL 2021001072A CL 2021001072 A CL2021001072 A CL 2021001072A CL 2021001072 A1 CL2021001072 A1 CL 2021001072A1
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Chile
Prior art keywords
oligonucleotides
tau
modulate
expression
divisional application
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CL2021001072A
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English (en)
Inventor
Peter Hagedorn
Richard E Olson
Anja Mølhart Høg
Marianne L Jensen
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Hoffmann La Roche
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Publication of CL2021001072A1 publication Critical patent/CL2021001072A1/es

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Abstract

La presente invención se refiere a oligonucleótidos antisentido que pueden modular la expresión de Tau en una célula diana. Los oligonucleótidos se hibridan a mARN de MAPT. La presente invención, además, se refiere a conjugados del oligonucleótido y composiciones farmacéuticas y métodos para el tratamiento de taupatías, enfermedad de Alzheimer, demencia frontotemporal (FTD), FTDP-17, parálisis supranuclear progresiva (PSP), encefalopatía traumática crónica (CTE), degeneración ganglionar corticobasal (CBD), epilepsia, síndrome de Dravet, depresión, trastornos convulsivos y trastornos motores.
CL2021001072A 2018-07-03 2021-04-26 Oligonucleótidos para modular la expresión de tau (divisional solicitud no. 202003457) CL2021001072A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862693851P 2018-07-03 2018-07-03
US201862726005P 2018-08-31 2018-08-31
CL2020003457A CL2020003457A1 (es) 2018-07-03 2020-12-31 Oligonucleótidos para modular la expresión de tau

Publications (1)

Publication Number Publication Date
CL2021001072A1 true CL2021001072A1 (es) 2021-10-15

Family

ID=67439176

Family Applications (6)

Application Number Title Priority Date Filing Date
CL2020003457A CL2020003457A1 (es) 2018-07-03 2020-12-31 Oligonucleótidos para modular la expresión de tau
CL2021001071A CL2021001071A1 (es) 2018-07-03 2021-04-26 Oligonucleótidos para modular la expresión de tau (divisional solicitud no. 202003457)
CL2021001072A CL2021001072A1 (es) 2018-07-03 2021-04-26 Oligonucleótidos para modular la expresión de tau (divisional solicitud no. 202003457)
CL2024001779A CL2024001779A1 (es) 2018-07-03 2024-06-13 Oligonucleótidos para modular la expresión de tau
CL2024001778A CL2024001778A1 (es) 2018-07-03 2024-06-13 Oligonucleótidos para modular la expresión de tau
CL2024003932A CL2024003932A1 (es) 2018-07-03 2024-12-18 Oligonucleótido antisentido de 19 a 30 nucleótidos de longitud; conjugado; composición farmacéutica; y su uso.

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CL2020003457A CL2020003457A1 (es) 2018-07-03 2020-12-31 Oligonucleótidos para modular la expresión de tau
CL2021001071A CL2021001071A1 (es) 2018-07-03 2021-04-26 Oligonucleótidos para modular la expresión de tau (divisional solicitud no. 202003457)

Family Applications After (3)

Application Number Title Priority Date Filing Date
CL2024001779A CL2024001779A1 (es) 2018-07-03 2024-06-13 Oligonucleótidos para modular la expresión de tau
CL2024001778A CL2024001778A1 (es) 2018-07-03 2024-06-13 Oligonucleótidos para modular la expresión de tau
CL2024003932A CL2024003932A1 (es) 2018-07-03 2024-12-18 Oligonucleótido antisentido de 19 a 30 nucleótidos de longitud; conjugado; composición farmacéutica; y su uso.

Country Status (19)

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US (5) US11279929B2 (es)
EP (1) EP3818159A1 (es)
JP (3) JP7102557B2 (es)
KR (3) KR102723469B1 (es)
CN (2) CN112567033A (es)
AU (2) AU2019297391B2 (es)
BR (1) BR112020026973A2 (es)
CA (2) CA3247235A1 (es)
CL (6) CL2020003457A1 (es)
CR (3) CR20210179A (es)
IL (1) IL279056A (es)
MX (3) MX2020013366A (es)
MY (1) MY206038A (es)
PE (2) PE20210346A1 (es)
PH (1) PH12020552276A1 (es)
RU (1) RU2768285C1 (es)
SG (1) SG11202012759XA (es)
TW (2) TW202519658A (es)
WO (1) WO2020007892A1 (es)

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