CR20210178A - OLIGONUCLEÓTIDOS PARA MODULAR LA EXPRESIÓN DE TAU (Divisional 2021-0058) - Google Patents

OLIGONUCLEÓTIDOS PARA MODULAR LA EXPRESIÓN DE TAU (Divisional 2021-0058)

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Publication number
CR20210178A
CR20210178A CR20210178A CR20210178A CR20210178A CR 20210178 A CR20210178 A CR 20210178A CR 20210178 A CR20210178 A CR 20210178A CR 20210178 A CR20210178 A CR 20210178A CR 20210178 A CR20210178 A CR 20210178A
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Costa Rica
Prior art keywords
oligonucleotides
present
tau expression
modulating tau
relates
Prior art date
Application number
CR20210178A
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English (en)
Inventor
Marianne L Jensen
Peter Hagedorn
Richard E Olson
Anja Mølhart Høg
Original Assignee
Hoffmann La Roche
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Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20210178A publication Critical patent/CR20210178A/es

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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12Y301/26—Endoribonucleases producing 5'-phosphomonoesters (3.1.26)
    • C12Y301/26004—Ribonuclease H (3.1.26.4)
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Abstract

La presente invención se refiere a oligonucleótidos antisentido que pueden modular la expresión de Tau en una célula diana. Los oligonucleótidos se hibridan a mARN de MAPT. La presente invención, además, se refiere a conjugados del oligonucleótido y composiciones farmacéuticas y métodos para el tratamiento de taupatías, enfermedad de Alzheimer, demencia frontotemporal (FTD), FTDP-17, parálisis supranuclear progresiva (PSP), encefalopatía traumática crónica (CTE), degeneración ganglionar corticobasal (CBD), epilepsia, síndrome de Dravet, depresión, trastornos convulsivos y trastornos motores
CR20210178A 2018-07-03 2019-07-03 OLIGONUCLEÓTIDOS PARA MODULAR LA EXPRESIÓN DE TAU (Divisional 2021-0058) CR20210178A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862693851P 2018-07-03 2018-07-03
US201862726005P 2018-08-31 2018-08-31
PCT/EP2019/067799 WO2020007892A1 (en) 2018-07-03 2019-07-03 Oligonucleotides for modulating tau expression

Publications (1)

Publication Number Publication Date
CR20210178A true CR20210178A (es) 2021-05-11

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CR20210179A CR20210179A (es) 2018-07-03 2019-07-03 OLIGONUCLEÓTIDOS PARA MODULAR LA EXPRESIÓN DE TAU (Divisional 2021-0058)
CR20210178A CR20210178A (es) 2018-07-03 2019-07-03 OLIGONUCLEÓTIDOS PARA MODULAR LA EXPRESIÓN DE TAU (Divisional 2021-0058)
CR20210058A CR20210058A (es) 2018-07-03 2019-07-03 Oligonucleótidos para modular la expresión de tau

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CR20210058A CR20210058A (es) 2018-07-03 2019-07-03 Oligonucleótidos para modular la expresión de tau

Country Status (19)

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US (5) US11279929B2 (es)
EP (1) EP3818159A1 (es)
JP (3) JP7102557B2 (es)
KR (3) KR20240157136A (es)
CN (2) CN120137967A (es)
AU (2) AU2019297391B2 (es)
BR (1) BR112020026973A2 (es)
CA (2) CA3103054C (es)
CL (6) CL2020003457A1 (es)
CR (3) CR20210179A (es)
IL (1) IL279056A (es)
MX (3) MX2020013366A (es)
MY (1) MY206038A (es)
PE (2) PE20210346A1 (es)
PH (1) PH12020552276A1 (es)
RU (1) RU2768285C1 (es)
SG (1) SG11202012759XA (es)
TW (2) TWI862501B (es)
WO (1) WO2020007892A1 (es)

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