CL2022001384A1 - Formulaciones de moduladores de canales iónicos y métodos de preparación y su uso - Google Patents

Formulaciones de moduladores de canales iónicos y métodos de preparación y su uso

Info

Publication number
CL2022001384A1
CL2022001384A1 CL2022001384A CL2022001384A CL2022001384A1 CL 2022001384 A1 CL2022001384 A1 CL 2022001384A1 CL 2022001384 A CL2022001384 A CL 2022001384A CL 2022001384 A CL2022001384 A CL 2022001384A CL 2022001384 A1 CL2022001384 A1 CL 2022001384A1
Authority
CL
Chile
Prior art keywords
preparation
methods
ion channel
channel modulator
modulator formulations
Prior art date
Application number
CL2022001384A
Other languages
English (en)
Inventor
Martinez Botella Gabriel
Loya Carlos
J Lunsmann Walter
Makhija Garad Sapna
Reed David
Mark Griffin Andrew
Kristopher Mathieu Kahlig Michael
Edward Marron Brian
Original Assignee
Praxis Prec Medicines Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Praxis Prec Medicines Inc filed Critical Praxis Prec Medicines Inc
Publication of CL2022001384A1 publication Critical patent/CL2022001384A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

FORMULACIONES DE MODULADORES DE CANALES IÓNICOS Y MÉTODOS DE PREPARACIÓN Y SU USO
CL2022001384A 2019-11-27 2022-05-26 Formulaciones de moduladores de canales iónicos y métodos de preparación y su uso CL2022001384A1 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962941322P 2019-11-27 2019-11-27
US201962941319P 2019-11-27 2019-11-27
US202063001906P 2020-03-30 2020-03-30
US202063001801P 2020-03-30 2020-03-30
US202063028229P 2020-05-21 2020-05-21
US202063082857P 2020-09-24 2020-09-24
US202063082864P 2020-09-24 2020-09-24

Publications (1)

Publication Number Publication Date
CL2022001384A1 true CL2022001384A1 (es) 2023-03-10

Family

ID=76130400

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2022001384A CL2022001384A1 (es) 2019-11-27 2022-05-26 Formulaciones de moduladores de canales iónicos y métodos de preparación y su uso
CL2024003707A CL2024003707A1 (es) 2019-11-27 2024-12-02 Método de síntesis de relutrigina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2024003707A CL2024003707A1 (es) 2019-11-27 2024-12-02 Método de síntesis de relutrigina.

Country Status (17)

Country Link
US (1) US12552797B2 (es)
EP (2) EP4065114B1 (es)
JP (1) JP7822621B2 (es)
KR (1) KR20220121238A (es)
CN (1) CN115038442A (es)
AU (1) AU2020392128A1 (es)
BR (1) BR112022010329A2 (es)
CA (1) CA3163091A1 (es)
CL (2) CL2022001384A1 (es)
CO (1) CO2022008769A2 (es)
EC (1) ECSP22049650A (es)
ES (1) ES3056108T3 (es)
IL (1) IL293264A (es)
MX (1) MX2022006452A (es)
PE (1) PE20221280A1 (es)
SA (1) SA522432737B1 (es)
WO (1) WO2021108625A1 (es)

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PE20221280A1 (es) 2019-11-27 2022-09-05 Praxis Prec Medicines Inc Formulaciones de moduladores de canales ionicos y metodos de preparacion y uso de moduladores de canales ionicos
GB2597320A (en) * 2020-07-20 2022-01-26 Gw Res Ltd Use of cannabidiol in the treatment of seizures associated with rare epilepsy syndromes related to genetic abnormalities
KR20250005348A (ko) * 2022-04-26 2025-01-09 프락시스 프리시젼 메디신즈, 인크. 신경 장애의 치료
WO2025259553A1 (en) * 2024-06-09 2025-12-18 Praxis Precision Medicines, Inc. Methods of treatment of neurological disorders
CN121550436A (zh) * 2026-01-23 2026-02-24 四川大学华西医院 新靶点在结节性硬化症相关癫痫中的应用、组合物及联合用药方式

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Also Published As

Publication number Publication date
IL293264A (en) 2022-07-01
JP2023504038A (ja) 2023-02-01
AU2020392128A1 (en) 2022-06-09
MX2022006452A (es) 2022-07-11
EP4065114C0 (en) 2025-11-05
JP7822621B2 (ja) 2026-03-03
KR20220121238A (ko) 2022-08-31
SA522432737B1 (ar) 2024-01-03
CL2024003707A1 (es) 2025-04-21
ECSP22049650A (es) 2022-07-29
EP4065114A1 (en) 2022-10-05
PE20221280A1 (es) 2022-09-05
EP4671248A3 (en) 2026-04-01
WO2021108625A1 (en) 2021-06-03
CA3163091A1 (en) 2021-06-03
CO2022008769A2 (es) 2022-07-19
BR112022010329A2 (pt) 2022-08-16
CN115038442A (zh) 2022-09-09
EP4065114A4 (en) 2023-12-20
EP4065114B1 (en) 2025-11-05
US20230348466A1 (en) 2023-11-02
ES3056108T3 (en) 2026-02-18
EP4671248A2 (en) 2025-12-31
US12552797B2 (en) 2026-02-17

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