CL2022003054A1 - Síntesis de intermedios de vinil ciclobutilo - Google Patents
Síntesis de intermedios de vinil ciclobutiloInfo
- Publication number
- CL2022003054A1 CL2022003054A1 CL2022003054A CL2022003054A CL2022003054A1 CL 2022003054 A1 CL2022003054 A1 CL 2022003054A1 CL 2022003054 A CL2022003054 A CL 2022003054A CL 2022003054 A CL2022003054 A CL 2022003054A CL 2022003054 A1 CL2022003054 A1 CL 2022003054A1
- Authority
- CL
- Chile
- Prior art keywords
- intermediates
- cyclobutyl
- vinyl
- synthesis
- compound
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- -1 vinyl cyclobutyl Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 230000002194 synthesizing effect Effects 0.000 abstract 3
- 239000012453 solvate Substances 0.000 abstract 2
- SFHYNDMGZXWXBU-LIMNOBDPSA-N 6-amino-2-[[(e)-(3-formylphenyl)methylideneamino]carbamoylamino]-1,3-dioxobenzo[de]isoquinoline-5,8-disulfonic acid Chemical compound O=C1C(C2=3)=CC(S(O)(=O)=O)=CC=3C(N)=C(S(O)(=O)=O)C=C2C(=O)N1NC(=O)N\N=C\C1=CC=CC(C=O)=C1 SFHYNDMGZXWXBU-LIMNOBDPSA-N 0.000 abstract 1
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 abstract 1
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/62—Use of additives, e.g. for stabilisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/23—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
En la presente se proporcionan procesos para sintetizar intermedios útiles en la preparación de inhibidores de Mcl-1. En particular, en la presente se proporcionan procesos para sintetizar el compuesto F, o una sal del mismo, en donde R1 y OGP2 se describen en la presente. El compuesto F puede ser útil para sintetizar el compuesto A1, o una sal o solvato del mismo, y el compuesto A2, o una sal o solvato del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063020877P | 2020-05-06 | 2020-05-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2022003054A1 true CL2022003054A1 (es) | 2023-06-30 |
Family
ID=76197567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2022003054A CL2022003054A1 (es) | 2020-05-06 | 2022-11-04 | Síntesis de intermedios de vinil ciclobutilo |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US12623993B2 (es) |
| EP (1) | EP4146634A1 (es) |
| JP (2) | JP7494318B2 (es) |
| KR (1) | KR20230006552A (es) |
| CN (1) | CN115485267A (es) |
| AR (1) | AR122000A1 (es) |
| AU (1) | AU2021268617B2 (es) |
| BR (1) | BR112022022471A2 (es) |
| CA (1) | CA3181213A1 (es) |
| CL (1) | CL2022003054A1 (es) |
| CO (1) | CO2022015976A2 (es) |
| CR (1) | CR20220622A (es) |
| IL (1) | IL297523A (es) |
| JO (1) | JOP20220297A1 (es) |
| MX (1) | MX2022013870A (es) |
| PE (1) | PE20230465A1 (es) |
| TW (1) | TWI867217B (es) |
| UY (1) | UY39200A (es) |
| WO (1) | WO2021226009A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230006550A (ko) * | 2020-05-06 | 2023-01-10 | 암젠 인크 | 비닐 보호된 알코올 중간체의 합성 |
| BR112023010228A2 (pt) * | 2020-11-25 | 2023-10-17 | Amgen Inc | Alquenilação enantiosseletiva de aldeídos |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3474B1 (ar) | 2014-08-29 | 2020-07-05 | Amgen Inc | مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1 |
| WO2017147410A1 (en) * | 2016-02-25 | 2017-08-31 | Amgen Inc. | Compounds that inhibit mcl-1 protein |
| JP6453507B2 (ja) * | 2017-03-30 | 2019-01-16 | アムジエン・インコーポレーテツド | Ｍｃｌ−１タンパク質を阻害する化合物 |
| TWI778443B (zh) * | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1抑制劑 |
| PT4065567T (pt) | 2019-11-26 | 2024-11-08 | Gilead Sciences Inc | Processos e intermediários para a preparação de inibidores de mcl1 |
-
2021
- 2021-04-29 TW TW110115527A patent/TWI867217B/zh active
- 2021-05-04 KR KR1020227042181A patent/KR20230006552A/ko active Pending
- 2021-05-04 AU AU2021268617A patent/AU2021268617B2/en active Active
- 2021-05-04 AR ARP210101208A patent/AR122000A1/es not_active Application Discontinuation
- 2021-05-04 EP EP21729090.7A patent/EP4146634A1/en active Pending
- 2021-05-04 US US17/920,084 patent/US12623993B2/en active Active
- 2021-05-04 BR BR112022022471A patent/BR112022022471A2/pt unknown
- 2021-05-04 CA CA3181213A patent/CA3181213A1/en active Pending
- 2021-05-04 MX MX2022013870A patent/MX2022013870A/es unknown
- 2021-05-04 JP JP2022566645A patent/JP7494318B2/ja active Active
- 2021-05-04 WO PCT/US2021/030548 patent/WO2021226009A1/en not_active Ceased
- 2021-05-04 CN CN202180032530.2A patent/CN115485267A/zh active Pending
- 2021-05-04 CR CR20220622A patent/CR20220622A/es unknown
- 2021-05-04 IL IL297523A patent/IL297523A/en unknown
- 2021-05-04 PE PE2022002563A patent/PE20230465A1/es unknown
- 2021-05-06 UY UY0001039200A patent/UY39200A/es not_active Application Discontinuation
-
2022
- 2022-11-02 JO JOJO/P/2022/0297A patent/JOP20220297A1/ar unknown
- 2022-11-04 CL CL2022003054A patent/CL2022003054A1/es unknown
- 2022-11-08 CO CONC2022/0015976A patent/CO2022015976A2/es unknown
-
2024
- 2024-03-05 JP JP2024032723A patent/JP7781199B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JOP20220297A1 (ar) | 2022-11-02 |
| WO2021226009A1 (en) | 2021-11-11 |
| CO2022015976A2 (es) | 2022-12-09 |
| CN115485267A (zh) | 2022-12-16 |
| JP2023524259A (ja) | 2023-06-09 |
| UY39200A (es) | 2021-11-30 |
| AR122000A1 (es) | 2022-08-03 |
| IL297523A (en) | 2022-12-01 |
| US12623993B2 (en) | 2026-05-12 |
| PE20230465A1 (es) | 2023-03-14 |
| TW202208342A (zh) | 2022-03-01 |
| US20230183164A1 (en) | 2023-06-15 |
| EP4146634A1 (en) | 2023-03-15 |
| BR112022022471A2 (pt) | 2022-12-13 |
| AU2021268617A1 (en) | 2022-12-15 |
| AU2021268617B2 (en) | 2024-06-13 |
| TWI867217B (zh) | 2024-12-21 |
| MX2022013870A (es) | 2022-11-30 |
| CR20220622A (es) | 2023-01-24 |
| KR20230006552A (ko) | 2023-01-10 |
| JP7781199B2 (ja) | 2025-12-05 |
| JP2024095652A (ja) | 2024-07-10 |
| JP7494318B2 (ja) | 2024-06-03 |
| CA3181213A1 (en) | 2021-11-11 |
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