CL2024001035A1 - Procedimiento para preparar 7-cloro-6-fluoro-1-(2-isopropil-4-metilpiridin-3-il)pirido[2,3-d]pirimidino-2,4(1h,3h)-diona - Google Patents
Procedimiento para preparar 7-cloro-6-fluoro-1-(2-isopropil-4-metilpiridin-3-il)pirido[2,3-d]pirimidino-2,4(1h,3h)-dionaInfo
- Publication number
- CL2024001035A1 CL2024001035A1 CL2024001035A CL2024001035A CL2024001035A1 CL 2024001035 A1 CL2024001035 A1 CL 2024001035A1 CL 2024001035 A CL2024001035 A CL 2024001035A CL 2024001035 A CL2024001035 A CL 2024001035A CL 2024001035 A1 CL2024001035 A1 CL 2024001035A1
- Authority
- CL
- Chile
- Prior art keywords
- compound
- isopropyl
- methylpyridin
- fluoro
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se proporciona en el presente documento un procedimiento para preparar el compuesto A que comprende (a) mezclar 2-isopropil-4-metilpiridin-3-amina (Compuesto B), o una sal de la misma, una primera base, y un compuesto reactivo que comprende fosgeno o un equivalente de fosgeno en un disolvente orgánico para formar 3-isocianato-2-isopropil-4-metilpiridina (Compuesto C); (b) mezclar el Compuesto C y 2,6-dicloro-5-fluoronicotinamida (Compuesto D) para formar 2,6-dicloro-5-fluoro-N-((2-isopropi1-4-metilpiridin-3-il)carbamoil)nicotinamida (Compuesto E); y (c) mezclar el Compuesto E y una segunda base para formar una mezcla de producto que comprende el Compuesto A y la segunda base. También se proporciona en el presente documento un procedimiento para sintetizar AMG 510 (sotorasib) que comprende el uso del Compuesto A preparado según los procedimientos dados a conocer
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063116703P | 2020-11-20 | 2020-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2024001035A1 true CL2024001035A1 (es) | 2024-10-18 |
Family
ID=79024258
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2023001439A CL2023001439A1 (es) | 2020-11-20 | 2023-05-18 | Procedimiento para preparar 7-cloro-6-fluoro-1-(2-isopropil-4-metilpiridin-3-il)pirido[2,3-d]pirimidino-2,4(1h,3h)-diona |
| CL2024001035A CL2024001035A1 (es) | 2020-11-20 | 2024-04-08 | Procedimiento para preparar 7-cloro-6-fluoro-1-(2-isopropil-4-metilpiridin-3-il)pirido[2,3-d]pirimidino-2,4(1h,3h)-diona |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2023001439A CL2023001439A1 (es) | 2020-11-20 | 2023-05-18 | Procedimiento para preparar 7-cloro-6-fluoro-1-(2-isopropil-4-metilpiridin-3-il)pirido[2,3-d]pirimidino-2,4(1h,3h)-diona |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20240025896A1 (es) |
| EP (2) | EP4700026A2 (es) |
| JP (1) | JP7815242B2 (es) |
| KR (1) | KR20230110575A (es) |
| CN (1) | CN116507624A (es) |
| AR (1) | AR124105A1 (es) |
| AU (1) | AU2021382674A1 (es) |
| CA (1) | CA3201663A1 (es) |
| CL (2) | CL2023001439A1 (es) |
| DK (1) | DK4247813T3 (es) |
| ES (1) | ES3063947T3 (es) |
| IL (1) | IL302821A (es) |
| LT (1) | LT4247813T (es) |
| MX (1) | MX2023005823A (es) |
| PL (1) | PL4247813T3 (es) |
| PT (1) | PT4247813T (es) |
| SI (1) | SI4247813T1 (es) |
| TW (1) | TWI902975B (es) |
| WO (1) | WO2022109242A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7516029B2 (ja) | 2018-11-16 | 2024-07-16 | アムジエン・インコーポレーテツド | Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法 |
| JP7837865B2 (ja) | 2019-11-14 | 2026-03-31 | アムジエン・インコーポレーテツド | Ｋｒａｓ ｇ１２ｃ阻害剤化合物の改良合成法 |
| JP2023501528A (ja) | 2019-11-14 | 2023-01-18 | アムジエン・インコーポレーテツド | Ｋｒａｓ ｇ１２ｃ阻害剤化合物の改善された合成 |
| CA3201663A1 (en) * | 2020-11-20 | 2022-05-27 | Amgen Inc. | Process for preparing 7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1h,3h)-dione |
| KR20240156373A (ko) | 2022-03-07 | 2024-10-29 | 암젠 인크 | 4-메틸-2-프로판-2-일-피리딘-3-카르보니트릴의 제조 방법 |
| CN115466259B (zh) * | 2022-08-16 | 2023-12-05 | 山东大学 | 一种kras g12c抑制剂索托拉西布的制备方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2729662B1 (fr) | 1995-01-24 | 1997-06-27 | Poudres & Explosifs Ste Nale | Procede de synthese de carbodiimides substitues |
| CA2538866A1 (en) | 2003-09-23 | 2005-03-31 | Fermion Oy | Preparation of quetiapine |
| EP1685102A4 (en) | 2003-11-12 | 2008-08-20 | Lg Life Sciences Ltd | melanocortin |
| SG10201912805SA (en) | 2014-12-19 | 2020-02-27 | Aragon Pharmaceuticals Inc | Process for the preparation of a diarylthiohydantoin compound |
| CN110366550A (zh) | 2016-12-22 | 2019-10-22 | 美国安进公司 | 作为用于治疗肺癌、胰腺癌或结直肠癌的KRAS G12C抑制剂的苯并异噻唑、异噻唑并[3,4-b]吡啶、喹唑啉、酞嗪、吡啶并[2,3-d]哒嗪和吡啶并[2,3-d]嘧啶衍生物 |
| AU2018273356B2 (en) | 2017-05-22 | 2021-09-16 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
| AU2018329920B2 (en) | 2017-09-08 | 2022-12-01 | Amgen Inc. | Inhibitors of KRAS G12C and methods of using the same |
| EP3788053B1 (en) | 2018-05-04 | 2024-07-10 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| CA3098574A1 (en) | 2018-05-04 | 2019-11-07 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| MA52564A (fr) | 2018-05-10 | 2021-03-17 | Amgen Inc | Inhibiteurs de kras g12c pour le traitement du cancer |
| US11096939B2 (en) | 2018-06-01 | 2021-08-24 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
| MX2020012204A (es) | 2018-06-11 | 2021-03-31 | Amgen Inc | Inhibidores de kras g12c para tratar el cáncer. |
| US11285156B2 (en) | 2018-06-12 | 2022-03-29 | Amgen Inc. | Substituted piperazines as KRAS G12C inhibitors |
| JP7516029B2 (ja) * | 2018-11-16 | 2024-07-16 | アムジエン・インコーポレーテツド | Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法 |
| WO2020123395A1 (en) * | 2018-12-10 | 2020-06-18 | Ideaya Biosciences, Inc. | 2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors |
| JP2023501528A (ja) | 2019-11-14 | 2023-01-18 | アムジエン・インコーポレーテツド | Ｋｒａｓ ｇ１２ｃ阻害剤化合物の改善された合成 |
| JP7837865B2 (ja) | 2019-11-14 | 2026-03-31 | アムジエン・インコーポレーテツド | Ｋｒａｓ ｇ１２ｃ阻害剤化合物の改良合成法 |
| CN111377918B (zh) * | 2019-11-29 | 2021-03-02 | 苏州信诺维医药科技有限公司 | 一种kras抑制剂化合物 |
| DK4225755T3 (da) | 2020-10-07 | 2026-04-07 | Amgen Inc | Fremgangsmåde til racemisering og isolering af atropisomerer af 7-chlor-6-fluor-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2,4(1 h,3 h)-dion |
| CA3201663A1 (en) * | 2020-11-20 | 2022-05-27 | Amgen Inc. | Process for preparing 7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1h,3h)-dione |
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2021
- 2021-11-19 CA CA3201663A patent/CA3201663A1/en active Pending
- 2021-11-19 IL IL302821A patent/IL302821A/en unknown
- 2021-11-19 PT PT218273092T patent/PT4247813T/pt unknown
- 2021-11-19 PL PL21827309.2T patent/PL4247813T3/pl unknown
- 2021-11-19 JP JP2023529991A patent/JP7815242B2/ja active Active
- 2021-11-19 EP EP25213851.6A patent/EP4700026A2/en active Pending
- 2021-11-19 AU AU2021382674A patent/AU2021382674A1/en active Pending
- 2021-11-19 WO PCT/US2021/060048 patent/WO2022109242A1/en not_active Ceased
- 2021-11-19 SI SI202130405T patent/SI4247813T1/sl unknown
- 2021-11-19 MX MX2023005823A patent/MX2023005823A/es unknown
- 2021-11-19 ES ES21827309T patent/ES3063947T3/es active Active
- 2021-11-19 EP EP21827309.2A patent/EP4247813B1/en active Active
- 2021-11-19 KR KR1020237020849A patent/KR20230110575A/ko active Pending
- 2021-11-19 CN CN202180077757.9A patent/CN116507624A/zh active Pending
- 2021-11-19 TW TW110143100A patent/TWI902975B/zh active
- 2021-11-19 AR ARP210103204A patent/AR124105A1/es unknown
- 2021-11-19 LT LTEPPCT/US2021/060048T patent/LT4247813T/lt unknown
- 2021-11-19 DK DK21827309.2T patent/DK4247813T3/da active
- 2021-11-19 US US18/253,285 patent/US20240025896A1/en active Pending
-
2023
- 2023-05-18 CL CL2023001439A patent/CL2023001439A1/es unknown
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2024
- 2024-04-08 CL CL2024001035A patent/CL2024001035A1/es unknown
- 2024-12-19 US US18/987,521 patent/US12441729B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022109242A1 (en) | 2022-05-27 |
| CN116507624A (zh) | 2023-07-28 |
| PT4247813T (pt) | 2026-03-05 |
| US20240025896A1 (en) | 2024-01-25 |
| SI4247813T1 (sl) | 2026-04-30 |
| JP2023550386A (ja) | 2023-12-01 |
| DK4247813T3 (da) | 2026-03-09 |
| IL302821A (en) | 2023-07-01 |
| US12441729B2 (en) | 2025-10-14 |
| EP4247813A1 (en) | 2023-09-27 |
| JP7815242B2 (ja) | 2026-02-17 |
| AR124105A1 (es) | 2023-02-15 |
| TWI902975B (zh) | 2025-11-01 |
| CA3201663A1 (en) | 2022-05-27 |
| MX2023005823A (es) | 2023-05-31 |
| AU2021382674A1 (en) | 2023-06-22 |
| AU2021382674A9 (en) | 2024-04-18 |
| CL2023001439A1 (es) | 2023-10-30 |
| EP4700026A2 (en) | 2026-02-25 |
| TW202237598A (zh) | 2022-10-01 |
| ES3063947T3 (en) | 2026-04-21 |
| US20250129072A1 (en) | 2025-04-24 |
| LT4247813T (lt) | 2026-03-25 |
| KR20230110575A (ko) | 2023-07-24 |
| EP4247813B1 (en) | 2025-12-24 |
| PL4247813T3 (pl) | 2026-04-27 |
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