CN100334071C - 外消旋西酞普兰二醇和 /或 s －或 r－西酞普兰二醇的制备方法及这些二醇在制备外消旋西酞普兰二醇、 r －西酞普兰和 /或 s －西酞普兰中的用途 - Google Patents

外消旋西酞普兰二醇和 /或 s －或 r－西酞普兰二醇的制备方法及这些二醇在制备外消旋西酞普兰二醇、 r －西酞普兰和 /或 s －西酞普兰中的用途 Download PDF

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Publication number
CN100334071C
CN100334071C CNB200380107283XA CN200380107283A CN100334071C CN 100334071 C CN100334071 C CN 100334071C CN B200380107283X A CNB200380107283X A CN B200380107283XA CN 200380107283 A CN200380107283 A CN 200380107283A CN 100334071 C CN100334071 C CN 100334071C
Authority
CN
China
Prior art keywords
citalopram
citalopram diol
acid addition
free base
diol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB200380107283XA
Other languages
English (en)
Chinese (zh)
Other versions
CN1729164A (zh
Inventor
H·彼得森
R·丹塞尔
B·克里斯蒂安森
R·E·洪布尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of CN1729164A publication Critical patent/CN1729164A/zh
Application granted granted Critical
Publication of CN100334071C publication Critical patent/CN100334071C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB200380107283XA 2002-12-23 2003-12-18 外消旋西酞普兰二醇和 /或 s －或 r－西酞普兰二醇的制备方法及这些二醇在制备外消旋西酞普兰二醇、 r －西酞普兰和 /或 s －西酞普兰中的用途 Expired - Lifetime CN100334071C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200202004 2002-12-23
DKPA200202004 2002-12-23

Publications (2)

Publication Number Publication Date
CN1729164A CN1729164A (zh) 2006-02-01
CN100334071C true CN100334071C (zh) 2007-08-29

Family

ID=35423357

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB200380107283XA Expired - Lifetime CN100334071C (zh) 2002-12-23 2003-12-18 外消旋西酞普兰二醇和 /或 s －或 r－西酞普兰二醇的制备方法及这些二醇在制备外消旋西酞普兰二醇、 r －西酞普兰和 /或 s －西酞普兰中的用途

Country Status (17)

Country Link
KR (1) KR101076640B1 (sr)
CN (1) CN100334071C (sr)
AR (1) AR042655A1 (sr)
BR (1) BR0317629A (sr)
DK (1) DK1581483T3 (sr)
EA (1) EA009061B1 (sr)
ES (1) ES2385975T3 (sr)
ME (1) MEP5708A (sr)
MY (1) MY142404A (sr)
PE (1) PE20050065A1 (sr)
PT (1) PT1581483E (sr)
RS (1) RS52152B (sr)
SI (1) SI1581483T1 (sr)
TW (1) TWI331605B (sr)
UA (1) UA84859C2 (sr)
UY (1) UY28146A1 (sr)
ZA (1) ZA200504715B (sr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA95199U (uk) 2014-07-09 2014-12-10 Дозатор з точним дозуванням для сипучих продуктів
CN110590602B (zh) * 2019-09-25 2022-04-05 浙江海森药业股份有限公司 外消旋西酞普兰二醇的拆分精制方法
CN114763329A (zh) * 2021-01-14 2022-07-19 浙江华海药业股份有限公司 一种西酞普兰关键中间体的纯化方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0347066A1 (en) * 1988-06-14 1989-12-20 H. Lundbeck A/S New enantiomers and their isolation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0347066A1 (en) * 1988-06-14 1989-12-20 H. Lundbeck A/S New enantiomers and their isolation

Also Published As

Publication number Publication date
EA009061B1 (ru) 2007-10-26
EA200501042A1 (ru) 2005-12-29
ZA200504715B (en) 2006-08-30
RS20050488A (sr) 2007-06-04
MY142404A (en) 2010-11-30
KR20050093801A (ko) 2005-09-23
AR042655A1 (es) 2005-06-29
TWI331605B (en) 2010-10-11
UY28146A1 (es) 2004-07-30
RS52152B (sr) 2012-08-31
CN1729164A (zh) 2006-02-01
UA84859C2 (ru) 2008-12-10
TW200512202A (en) 2005-04-01
BR0317629A (pt) 2005-11-29
DK1581483T3 (da) 2012-07-23
ME00034B (me) 2010-02-10
SI1581483T1 (sl) 2012-09-28
KR101076640B1 (ko) 2011-10-27
PE20050065A1 (es) 2005-02-18
MEP5708A (xx) 2010-02-10
ES2385975T3 (es) 2012-08-06
PT1581483E (pt) 2012-07-24

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