CN101039662A - 抗－细胞凋亡bcl－2家族成员的小分子抑制剂及其应用 - Google Patents

抗－细胞凋亡bcl－2家族成员的小分子抑制剂及其应用 Download PDF

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Publication number
CN101039662A
CN101039662A CNA2005800347571A CN200580034757A CN101039662A CN 101039662 A CN101039662 A CN 101039662A CN A2005800347571 A CNA2005800347571 A CN A2005800347571A CN 200580034757 A CN200580034757 A CN 200580034757A CN 101039662 A CN101039662 A CN 101039662A
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China
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nmr
ppm
300mhz
cocd
apoptosis
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Pending
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CNA2005800347571A
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English (en)
Chinese (zh)
Inventor
S·王
G·王
G·唐
R·王
Z·尼克罗夫斯卡－科勒斯卡
D·王
L·许
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University of Michigan Ann Arbor
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University of Michigan Ann Arbor
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Publication of CN101039662A publication Critical patent/CN101039662A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2005800347571A 2004-08-20 2005-08-22 抗－细胞凋亡bcl－2家族成员的小分子抑制剂及其应用 Pending CN101039662A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60341104P 2004-08-20 2004-08-20
US60/603,411 2004-08-20
US11/209,998 2005-08-22

Publications (1)

Publication Number Publication Date
CN101039662A true CN101039662A (zh) 2007-09-19

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CNA2005800347571A Pending CN101039662A (zh) 2004-08-20 2005-08-22 抗－细胞凋亡bcl－2家族成员的小分子抑制剂及其应用

Country Status (4)

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EP (1) EP1778206A4 (de)
CN (1) CN101039662A (de)
MX (1) MX2007002104A (de)
ZA (1) ZA200702257B (de)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102498111A (zh) * 2009-09-10 2012-06-13 诺瓦提斯公司 作为Bcl-2家族蛋白抑制剂用于癌症的治疗的磺酰胺化合物
CN103562202A (zh) * 2011-01-25 2014-02-05 密执安大学评议会 Bcl-2/bcl-xl抑制剂和使用它们的治疗方法
CN104125954A (zh) * 2011-12-23 2014-10-29 诺华股份有限公司 用于抑制bcl2与结合配偶体相互作用的化合物
CN104136428A (zh) * 2011-12-23 2014-11-05 诺华股份有限公司 用于抑制bcl2与结合配偶体相互作用的化合物
CN104136429A (zh) * 2011-12-23 2014-11-05 诺华股份有限公司 用于抑制bcl2与结合配偶体相互作用的化合物
CN105579450A (zh) * 2013-07-23 2016-05-11 法国施维雅药厂 新的吲嗪化合物、其制备方法和包含它们的药物组合物
CN106008322B (zh) * 2008-12-05 2018-09-04 Abbvie 公司 作为用于治疗癌症和免疫疾病的bcl-2-选择性诱发细胞凋亡药剂的磺酰胺衍生物
CN109456324A (zh) * 2013-07-23 2019-03-12 法国施维雅药厂 新的异吲哚啉或异喹啉化合物、其制备方法以及含有它们的药用组合物
CN109776414A (zh) * 2019-01-02 2019-05-21 山东大学 一种Bcl-2蛋白抑制剂及其制备方法和应用
CN109803645A (zh) * 2017-04-10 2019-05-24 师健友 一种用于治疗肿瘤疾病以及具有抗菌、抗病毒和抗炎作用的药物
CN111393366A (zh) * 2020-06-05 2020-07-10 北京华氏开元医药科技有限公司 四氢异喹啉类衍生物、制备方法、药物组合物及应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2686123A (en) * 1951-07-19 1954-08-10 Us Agriculture Stabilization of dehydrated vegetable material
US5385936A (en) * 1990-07-12 1995-01-31 The United States Of America As Represented By The Secretary Of The Department Of The Health And Human Services Gossypol acetic acid for the treatment of cancer

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106008322B (zh) * 2008-12-05 2018-09-04 Abbvie 公司 作为用于治疗癌症和免疫疾病的bcl-2-选择性诱发细胞凋亡药剂的磺酰胺衍生物
CN102498111A (zh) * 2009-09-10 2012-06-13 诺瓦提斯公司 作为Bcl-2家族蛋白抑制剂用于癌症的治疗的磺酰胺化合物
CN103562202A (zh) * 2011-01-25 2014-02-05 密执安大学评议会 Bcl-2/bcl-xl抑制剂和使用它们的治疗方法
CN103562202B (zh) * 2011-01-25 2016-09-14 密执安大学评议会 Bcl-2/bcl-xl抑制剂和使用它们的治疗方法
CN104136429A (zh) * 2011-12-23 2014-11-05 诺华股份有限公司 用于抑制bcl2与结合配偶体相互作用的化合物
CN104136428A (zh) * 2011-12-23 2014-11-05 诺华股份有限公司 用于抑制bcl2与结合配偶体相互作用的化合物
CN104125954A (zh) * 2011-12-23 2014-10-29 诺华股份有限公司 用于抑制bcl2与结合配偶体相互作用的化合物
CN105579450A (zh) * 2013-07-23 2016-05-11 法国施维雅药厂 新的吲嗪化合物、其制备方法和包含它们的药物组合物
CN105579450B (zh) * 2013-07-23 2017-12-12 法国施维雅药厂 新的吲嗪化合物、其制备方法和包含它们的药物组合物
CN109456324A (zh) * 2013-07-23 2019-03-12 法国施维雅药厂 新的异吲哚啉或异喹啉化合物、其制备方法以及含有它们的药用组合物
CN109456324B (zh) * 2013-07-23 2022-04-22 法国施维雅药厂 新的异吲哚啉或异喹啉化合物、其制备方法以及含有它们的药用组合物
CN109803645A (zh) * 2017-04-10 2019-05-24 师健友 一种用于治疗肿瘤疾病以及具有抗菌、抗病毒和抗炎作用的药物
CN109803645B (zh) * 2017-04-10 2022-03-25 师健友 一种用于治疗肿瘤疾病以及具有抗菌、抗病毒和抗炎作用的药物
CN109776414A (zh) * 2019-01-02 2019-05-21 山东大学 一种Bcl-2蛋白抑制剂及其制备方法和应用
CN109776414B (zh) * 2019-01-02 2022-04-22 山东大学 一种Bcl-2蛋白抑制剂及其制备方法和应用
CN111393366A (zh) * 2020-06-05 2020-07-10 北京华氏开元医药科技有限公司 四氢异喹啉类衍生物、制备方法、药物组合物及应用
CN111393366B (zh) * 2020-06-05 2020-09-01 北京华氏开元医药科技有限公司 四氢异喹啉类衍生物、制备方法、药物组合物及应用

Also Published As

Publication number Publication date
EP1778206A4 (de) 2009-08-05
ZA200702257B (en) 2009-06-24
EP1778206A2 (de) 2007-05-02
MX2007002104A (es) 2007-10-10

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Open date: 20070919