EP1778206A4 - Kleinmolekül-inhibitoren aus angehörigen der antioptotischen bcl-2-familie und verwendungen damit - Google Patents

Kleinmolekül-inhibitoren aus angehörigen der antioptotischen bcl-2-familie und verwendungen damit

Info

Publication number
EP1778206A4
EP1778206A4 EP05806407A EP05806407A EP1778206A4 EP 1778206 A4 EP1778206 A4 EP 1778206A4 EP 05806407 A EP05806407 A EP 05806407A EP 05806407 A EP05806407 A EP 05806407A EP 1778206 A4 EP1778206 A4 EP 1778206A4
Authority
EP
European Patent Office
Prior art keywords
bcl
family members
small molecular
corresponding uses
molecular inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP05806407A
Other languages
English (en)
French (fr)
Other versions
EP1778206A2 (de
Inventor
Shaomeng Wang
Guoping Wang
Guozhi Tang
Renxiao Wang
Zaneta Nikolovska-Coleska
Dajon Wang
Liang Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan System
University of Michigan Ann Arbor
Original Assignee
University of Michigan System
University of Michigan Ann Arbor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan System, University of Michigan Ann Arbor filed Critical University of Michigan System
Priority claimed from PCT/US2005/029634 external-priority patent/WO2006023778A2/en
Publication of EP1778206A2 publication Critical patent/EP1778206A2/de
Publication of EP1778206A4 publication Critical patent/EP1778206A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP05806407A 2004-08-20 2005-08-22 Kleinmolekül-inhibitoren aus angehörigen der antioptotischen bcl-2-familie und verwendungen damit Withdrawn EP1778206A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60341104P 2004-08-20 2004-08-20
PCT/US2005/029634 WO2006023778A2 (en) 2004-08-20 2005-08-22 Small molecule inhibitors of anti-apoptotic bcl-2 family members and the uses thereof

Publications (2)

Publication Number Publication Date
EP1778206A2 EP1778206A2 (de) 2007-05-02
EP1778206A4 true EP1778206A4 (de) 2009-08-05

Family

ID=37897167

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05806407A Withdrawn EP1778206A4 (de) 2004-08-20 2005-08-22 Kleinmolekül-inhibitoren aus angehörigen der antioptotischen bcl-2-familie und verwendungen damit

Country Status (4)

Country Link
EP (1) EP1778206A4 (de)
CN (1) CN101039662A (de)
MX (1) MX2007002104A (de)
ZA (1) ZA200702257B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2376480T3 (en) * 2008-12-05 2016-09-12 Abbvie Inc Sulfonamide derivatives AS BCL-2-selective apoptosis inducing agents for the treatment of cancer and immune diseases
CA2772989A1 (en) * 2009-09-10 2011-03-17 Novartis Ag Sulfonamides as inhibitors of bcl-2 family proteins for the treatment of cancer
EP2668180B1 (de) * 2011-01-25 2018-08-01 The Regents of The University of Michigan Bcl-2-/bcl-xl-hemmer zur verwendung in der behandlung von krebs
BR112014015308A8 (pt) * 2011-12-23 2017-06-13 Novartis Ag compostos para inibição da interação de bcl2 com contrapartes de ligação
WO2013096051A1 (en) * 2011-12-23 2013-06-27 Novartis Ag Compounds for inhibiting the interaction of bcl2 with binding partners
EP2794591A1 (de) * 2011-12-23 2014-10-29 Novartis AG Verbindungen zur hemmung der interaktion von bcl2 mit bindungspartnern
FR3008977A1 (fr) * 2013-07-23 2015-01-30 Servier Lab Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008976A1 (fr) * 2013-07-23 2015-01-30 Servier Lab "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
CN109803645B (zh) * 2017-04-10 2022-03-25 师健友 一种用于治疗肿瘤疾病以及具有抗菌、抗病毒和抗炎作用的药物
CN109776414B (zh) * 2019-01-02 2022-04-22 山东大学 一种Bcl-2蛋白抑制剂及其制备方法和应用
CN111393366B (zh) * 2020-06-05 2020-09-01 北京华氏开元医药科技有限公司 四氢异喹啉类衍生物、制备方法、药物组合物及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2686123A (en) * 1951-07-19 1954-08-10 Us Agriculture Stabilization of dehydrated vegetable material
US6114397A (en) * 1990-07-12 2000-09-05 The United States Of America As Represented By The Department Of Health And Human Services Gossypol for the treatment of cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2686123A (en) * 1951-07-19 1954-08-10 Us Agriculture Stabilization of dehydrated vegetable material
US6114397A (en) * 1990-07-12 2000-09-05 The United States Of America As Represented By The Department Of Health And Human Services Gossypol for the treatment of cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AMOLAK CHAND JAIN ET AL: "SYNTHESIS OF SOME NATURALLY OCCURRING ACETYLCHROMENES", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 52, no. 4, 1 January 1979 (1979-01-01), pages 1203/1204, XP001068520, ISSN: 0009-2673 *
G. SCHILL, E. LOGEMANN: "4,6-Di-n-alkylpyrogallol-trimethyläther. Modellreaktionen zu gezielten Catenan-Synthesen", CHEMISCHE BERICHTE, vol. 106, 1973, pages 2910 - 2917, XP002533464 *
M. C. SUTTER: "The pharmacology of isolated veins", BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, vol. 24, no. 3, 1965, pages 742 - 751, XP009118730 *

Also Published As

Publication number Publication date
ZA200702257B (en) 2009-06-24
EP1778206A2 (de) 2007-05-02
MX2007002104A (es) 2007-10-10
CN101039662A (zh) 2007-09-19

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Inventor name: XU, LIANG

Inventor name: WANG, DAJON

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