CN101048402B - 咔唑衍生物、其溶剂合物或其药学上允许的盐 - Google Patents

咔唑衍生物、其溶剂合物或其药学上允许的盐 Download PDF

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Publication number
CN101048402B
CN101048402B CN2005800370489A CN200580037048A CN101048402B CN 101048402 B CN101048402 B CN 101048402B CN 2005800370489 A CN2005800370489 A CN 2005800370489A CN 200580037048 A CN200580037048 A CN 200580037048A CN 101048402 B CN101048402 B CN 101048402B
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China
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methoxy
methyl
benzyl
group
yloxy
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Expired - Fee Related
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CN2005800370489A
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Chinese (zh)
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CN101048402A (zh
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村田正和
丝数义彦
中尾龙
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Zeria Pharmaceutical Co Ltd
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Zeria Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2005800370489A 2004-10-29 2005-10-28 咔唑衍生物、其溶剂合物或其药学上允许的盐 Expired - Fee Related CN101048402B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004316872 2004-10-29
JP316872/2004 2004-10-29
PCT/JP2005/020250 WO2006046779A1 (ja) 2004-10-29 2005-10-28 カルバゾール誘導体、その溶媒和物、又は薬学的に許容されるその塩

Publications (2)

Publication Number Publication Date
CN101048402A CN101048402A (zh) 2007-10-03
CN101048402B true CN101048402B (zh) 2011-11-09

Family

ID=36227999

Family Applications (1)

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CN2005800370489A Expired - Fee Related CN101048402B (zh) 2004-10-29 2005-10-28 咔唑衍生物、其溶剂合物或其药学上允许的盐

Country Status (16)

Country Link
US (1) US8329913B2 (2)
EP (1) EP1852433B1 (2)
JP (1) JP3997491B2 (2)
KR (1) KR101223820B1 (2)
CN (1) CN101048402B (2)
AT (1) ATE534646T1 (2)
AU (1) AU2005297800B2 (2)
CA (1) CA2585642C (2)
CY (1) CY1112649T1 (2)
DK (1) DK1852433T3 (2)
ES (1) ES2378177T3 (2)
PL (1) PL1852433T3 (2)
PT (1) PT1852433E (2)
SI (1) SI1852433T1 (2)
TW (1) TW200635922A (2)
WO (1) WO2006046779A1 (2)

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AU2008279447A1 (en) 2007-07-19 2009-01-29 Metabolex, Inc. N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders
WO2011003043A1 (en) 2009-07-01 2011-01-06 The Penn State Research Foundation Blood pump with expandable cannula
US8410127B2 (en) 2009-10-01 2013-04-02 Metabolex, Inc. Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
CN109674753A (zh) 2010-06-23 2019-04-26 希玛贝治疗股份有限公司 固态分散体
CN102382037B (zh) * 2010-09-03 2016-01-20 中国医学科学院药物研究所 苯丙酸类化合物及其制法和药物用途
US8485961B2 (en) 2011-01-05 2013-07-16 Thoratec Corporation Impeller housing for percutaneous heart pump
US8597170B2 (en) 2011-01-05 2013-12-03 Thoratec Corporation Catheter pump
US8591393B2 (en) 2011-01-06 2013-11-26 Thoratec Corporation Catheter pump
WO2012094641A2 (en) 2011-01-06 2012-07-12 Thoratec Corporation Percutaneous heart pump
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DE102013008159A1 (de) 2012-05-14 2013-11-14 Thoratec Corporation Mantelsystem für Katheterpumpe
US9446179B2 (en) 2012-05-14 2016-09-20 Thoratec Corporation Distal bearing support
US8721517B2 (en) 2012-05-14 2014-05-13 Thoratec Corporation Impeller for catheter pump
US9327067B2 (en) 2012-05-14 2016-05-03 Thoratec Corporation Impeller for catheter pump
US9872947B2 (en) 2012-05-14 2018-01-23 Tc1 Llc Sheath system for catheter pump
US9358329B2 (en) 2012-07-03 2016-06-07 Thoratec Corporation Catheter pump
US9421311B2 (en) 2012-07-03 2016-08-23 Thoratec Corporation Motor assembly for catheter pump
EP4186557A1 (en) 2012-07-03 2023-05-31 Tc1 Llc Motor assembly for catheter pump
US11077294B2 (en) 2013-03-13 2021-08-03 Tc1 Llc Sheath assembly for catheter pump
EP3834876B1 (en) 2013-03-13 2022-09-14 Tc1 Llc Fluid handling system
US11033728B2 (en) 2013-03-13 2021-06-15 Tc1 Llc Fluid handling system
US9308302B2 (en) 2013-03-15 2016-04-12 Thoratec Corporation Catheter pump assembly including a stator
EP2968742B1 (en) 2013-03-15 2020-12-02 Tc1 Llc Catheter pump assembly including a stator
US10363349B2 (en) 2014-04-15 2019-07-30 Tc1 Llp Heart pump providing adjustable outflow
US10029037B2 (en) 2014-04-15 2018-07-24 Tc1 Llc Sensors for catheter pumps
US10583232B2 (en) 2014-04-15 2020-03-10 Tc1 Llc Catheter pump with off-set motor position
EP4417244A3 (en) 2014-04-15 2024-10-16 Tc1 Llc Catheter pump introducer system
EP3131599B1 (en) 2014-04-15 2019-02-20 Tc1 Llc Catheter pump with access ports
EP3583973A1 (en) 2014-08-18 2019-12-25 Tc1 Llc Guide features for percutaneous catheter pump
EP3247420B1 (en) 2015-01-22 2019-10-02 Tc1 Llc Reduced rotational mass motor assembly for catheter pump
WO2016118784A1 (en) 2015-01-22 2016-07-28 Thoratec Corporation Attachment mechanisms for motor of catheter pump
US9675739B2 (en) 2015-01-22 2017-06-13 Tc1 Llc Motor assembly with heat exchanger for catheter pump
US9907890B2 (en) 2015-04-16 2018-03-06 Tc1 Llc Catheter pump with positioning brace
EP3487550B1 (en) 2016-07-21 2022-09-28 Tc1 Llc Gas-filled chamber for catheter pump motor assembly
EP3804804A1 (en) 2016-07-21 2021-04-14 Tc1 Llc Fluid seals for catheter pump motor assembly
AU2017305392A1 (en) 2016-08-03 2019-02-21 Cymabay Therapeutics, Inc. Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
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WO2021120134A1 (zh) 2019-12-19 2021-06-24 弈柯莱生物科技(上海)股份有限公司 一种氟乙酸脱卤酶突变体及其应用
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WO2004024939A2 (en) * 2002-09-13 2004-03-25 Georgetown University Ligands for the peroxisome proliferator-activated receptor, and methods of use thereof
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Also Published As

Publication number Publication date
PL1852433T3 (pl) 2012-05-31
KR20070072554A (ko) 2007-07-04
US8329913B2 (en) 2012-12-11
ATE534646T1 (de) 2011-12-15
TW200635922A (en) 2006-10-16
CA2585642C (en) 2013-04-02
KR101223820B1 (ko) 2013-01-17
WO2006046779A1 (ja) 2006-05-04
ES2378177T3 (es) 2012-04-09
AU2005297800B2 (en) 2011-02-03
DK1852433T3 (da) 2012-01-30
EP1852433B1 (en) 2011-11-23
CY1112649T1 (el) 2016-02-10
JP3997491B2 (ja) 2007-10-24
AU2005297800A1 (en) 2006-05-04
US20100286210A1 (en) 2010-11-11
EP1852433A1 (en) 2007-11-07
EP1852433A4 (en) 2010-07-21
CA2585642A1 (en) 2006-05-04
SI1852433T1 (sl) 2012-06-29
CN101048402A (zh) 2007-10-03
PT1852433E (pt) 2012-02-08
JPWO2006046779A1 (ja) 2008-05-22
TWI359148B (2) 2012-03-01

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