CN101664112B - Production method of colistin sulfate microcapsule for feed - Google Patents
Production method of colistin sulfate microcapsule for feed Download PDFInfo
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- CN101664112B CN101664112B CN2009100348860A CN200910034886A CN101664112B CN 101664112 B CN101664112 B CN 101664112B CN 2009100348860 A CN2009100348860 A CN 2009100348860A CN 200910034886 A CN200910034886 A CN 200910034886A CN 101664112 B CN101664112 B CN 101664112B
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- colistin
- colistin sulfate
- feed
- microcapsules
- sulfate
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Abstract
The invention relates to a method for producing colistin sulfate microcapsules for feed, which comprises the following process steps: firstly, preparing a mixed solution of colistin sulfate and a capsule wall material; secondly, carrying out spray drying; thirdly, adding a proper amount of anti-sticking agent and auxiliary materials for mixing. The advantages are that: the colistin sulfate is wrapped by the high molecular substance, so that the colistin sulfate is isolated from the external environment, the effective titer of the colistin is protected, and when the colistin is mixed with the feed, the vitamins and alkaline trace elements in the feed are also protected from reacting with the strong-acid colistin through the isolation of the high molecular film. After entering the intestinal tract, the polymer film is gradually dissolved, and colistin molecules are gradually released to exert the drug effect. Improves the bioavailability of colistin sulfate, prolongs the action time of the medicine, reduces the times of medicine taking, reduces the medicine taking cost of farmers and improves the economic benefit.
Description
Technical field
What the present invention relates to is a kind of production method of feed colistin sulfate microcapsules.Belong to feed and field of feed additive technology.
Background technology:
Colistine sulfate has another name called colistin sulfate, Ke Lisiting (Colistin), polymyxin e (Polymyxin E), colistin etc., white or near-white powder, odorless, bitter have draw moist, soluble in water, be slightly soluble in methyl alcohol, ethanol, be dissolved in acetone, ether etc., the aqueous solution is highly acid.Colistine sulfate is produced by poly-viscosity bacillus, and Gram-negative bacteria is had stronger antibacterial action, is used to prevent and treat the intestines problem that Gram-negative bacteria causes, as feed addictive, and obvious growth promoting function is arranged.But colistine sulfate is highly acid, and has many alkaline matters in the feed, as vitamin, trace element etc., easily reacts with colistine sulfate, makes the colistine sulfate decline of tiring, bioavailability decline.The hydrone of reaction generation can make the feed water content improve in addition, and feed easily takes place rotten, the period of storage shortening.
Summary of the invention:
The objective of the invention is to defective at above-mentioned existence; a kind of production method of improved feed colistin sulfate microcapsules is proposed; with polymer substance colistine sulfate is wrapped up; colistine sulfate and external environment are isolated; both protected effectively tiring of colistin; when colistin mixes with feed, also protected in the feed vitamin and alkaline trace element not suffer a loss by the isolation of polymeric membrane.
Technical solution of the present invention: a kind of production method of feed colistin sulfate microcapsules is characterized in that this method comprises following processing step:
One, the preparation of capsule core material and capsule material mixed solution: 1) get colistine sulfate and carboxylic propyl methocel and dolomol earlier, cross 60 mesh sieves respectively; 2) with colistine sulfate: the carboxylic propyl methocel: dolomol is with weight ratio=(15-20): (10-13): (8-12) mix; 3) add the water that accounts for gross weight 60%～67%, mix again, make colistine sulfate and capsule material mixed solution;
Two, put and carry out spray-drying in the spraying apparatus: above-mentioned mixed solution is put carried out spray-drying in the spraying apparatus, the drying process with atomizing condition is as follows: liquid supply speed: 10mlmin-1; EAT: 105 ℃; 70 ℃ of leaving air temps, atomization gas flow velocity 300Lh-1, dry back moisture 6%; Obtain the colistine sulfate micro-capsule of almost spherical, the micro-capsule diameter is 50～400 μ m;
Three, will account for the colistine sulfate micro-capsule of gross weight 35%, and add the supplementary product starch account for the dolomol of gross weight 5% and to account for gross weight 60% again and mix, obtain final colistine sulfate micro-capsule.
Advantage of the present invention: colistine sulfate is wrapped up with polymer substance; colistine sulfate and external environment are isolated; both protected effectively tiring of colistin; when colistin mixes with feed, vitamin and alkalescence trace element in the feed have also been protected by the isolation of polymeric membrane.Polymeric membrane dissolves gradually after entering enteron aisle, and the colistin molecule also progressively discharges, the performance drug effect.Improved the colistine sulfate bioavilability, medicine prolongs action time, reduces the medication number of times, reduces raiser's drug cost, increases economic efficiency.
Description of drawings
Accompanying drawing 1 is technological process of production figure of the present invention.
Accompanying drawing 2 is that colistine sulfate microcapsule formulation and common pulvis are stored the back contrast of 16 weeks, colistin relative surplus wherein tire (percentage) exceed 35% correlation curve schematic diagram.
The specific embodiment:
Embodiment 1
Get colistine sulfate, HPMC and dolomol, cross 60 mesh sieves respectively, colistine sulfate with 15kg adds 10kgHPMC, the 8kg dolomol mixes, adding water 67kg mixes, make colistine sulfate and capsule material mixed solution, colistine sulfate and capsule material mixed solution are put spraying apparatus carry out spray-drying, promptly obtain the colistine sulfate micro-capsule.Again above-mentioned micro-capsule 35kg is added 60 order dolomol 5kg and starch 60kg, mix, obtain final finished.The drying process with atomizing condition is as follows: liquid supply speed: 10mlmin-1; EAT: 105 ℃; 70 ℃ of leaving air temps, atomization gas flow velocity 300Lh-1, dry back moisture 6%.
Colistine sulfate with 16kg adds 10kgHPMC, 9kg dolomol, crossing 60 mesh sieves mixes, adding water 65% mixes, make colistine sulfate and capsule material mixed solution, colistine sulfate and capsule material mixed solution are put spraying apparatus carry out spray-drying, promptly obtain the colistine sulfate micro-capsule.Again above-mentioned micro-capsule 35kg is added 60 order dolomol 5kg and starch 60kg, mix, obtain final finished.The drying process with atomizing condition is as follows: liquid supply speed: 10mlmin-1; EAT: 105 ℃; 70 ℃ of leaving air temps, atomization gas flow velocity 300Lh-1, dry back moisture 6%.
Embodiment 3
Colistine sulfate with 18kg adds 11kgHPMC, 8kg dolomol, crossing 60 mesh sieves mixes, adding water 63 mixes, make colistine sulfate and capsule material mixed solution, colistine sulfate and capsule material mixed solution are put spraying apparatus carry out spray-drying, promptly obtain the colistine sulfate micro-capsule.Again above-mentioned micro-capsule 35kg is added 60 order dolomol 5kg and starch 60kg, mix, obtain final finished.The drying process with atomizing condition is as follows: liquid supply speed: 10mlmin-1; EAT: 105 ℃; 70 ℃ of leaving air temps, atomization gas flow velocity 300Lh-1, dry back moisture 6%.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100348860A CN101664112B (en) | 2009-09-11 | 2009-09-11 | Production method of colistin sulfate microcapsule for feed |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100348860A CN101664112B (en) | 2009-09-11 | 2009-09-11 | Production method of colistin sulfate microcapsule for feed |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101664112A CN101664112A (en) | 2010-03-10 |
| CN101664112B true CN101664112B (en) | 2011-09-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009100348860A Expired - Fee Related CN101664112B (en) | 2009-09-11 | 2009-09-11 | Production method of colistin sulfate microcapsule for feed |
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| CN (1) | CN101664112B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104397361A (en) * | 2014-12-12 | 2015-03-11 | 无锡正大畜禽有限公司 | A kind of preparation method of nanoscale colistin sulfate premix for feed |
| CN104721809A (en) * | 2015-03-12 | 2015-06-24 | 内蒙古金河动物药业有限公司 | Pharmaceutical composition containing colistin sulfate and preparation method of pharmaceutical composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1090459C (en) * | 1994-06-29 | 2002-09-11 | 明治制果株式会社 | Stable compositions containing colistin sulfate |
| CN1562347A (en) * | 2004-04-14 | 2005-01-12 | 山东鲁抗动物药业有限公司 | Method for preparing granule of colistin sulphuric acid |
| WO2008015203A2 (en) * | 2006-08-04 | 2008-02-07 | Eurhema S.R.L. | Compositions of microparticles and granules for oral controlled release of substances for veterinary use |
-
2009
- 2009-09-11 CN CN2009100348860A patent/CN101664112B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1090459C (en) * | 1994-06-29 | 2002-09-11 | 明治制果株式会社 | Stable compositions containing colistin sulfate |
| CN1562347A (en) * | 2004-04-14 | 2005-01-12 | 山东鲁抗动物药业有限公司 | Method for preparing granule of colistin sulphuric acid |
| WO2008015203A2 (en) * | 2006-08-04 | 2008-02-07 | Eurhema S.R.L. | Compositions of microparticles and granules for oral controlled release of substances for veterinary use |
Non-Patent Citations (2)
| Title |
|---|
| 佚名.硫酸粘菌素.《当代禽畜养殖业》.2002,(第7期),29. * |
| 张蓓 等.硫酸多粘菌素E脂质体的制备及含量和包封率的测定.《药物分析杂志》.2005,(第8期),920-922. * |
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| CN101664112A (en) | 2010-03-10 |
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Granted publication date: 20110921 Termination date: 20120911 |