CN102007101A - 作为抗菌剂的四氢-异喹啉ppat抑制剂 - Google Patents

作为抗菌剂的四氢-异喹啉ppat抑制剂 Download PDF

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Publication number
CN102007101A
CN102007101A CN2008801260189A CN200880126018A CN102007101A CN 102007101 A CN102007101 A CN 102007101A CN 2008801260189 A CN2008801260189 A CN 2008801260189A CN 200880126018 A CN200880126018 A CN 200880126018A CN 102007101 A CN102007101 A CN 102007101A
Authority
CN
China
Prior art keywords
compound
independently
alkyl
aryl
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2008801260189A
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English (en)
Chinese (zh)
Inventor
R·弗里切特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biota Scientific Management Pty Ltd
Original Assignee
Biota Scientific Management Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biota Scientific Management Pty Ltd filed Critical Biota Scientific Management Pty Ltd
Publication of CN102007101A publication Critical patent/CN102007101A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN2008801260189A 2007-11-30 2008-11-26 作为抗菌剂的四氢-异喹啉ppat抑制剂 Pending CN102007101A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99152507P 2007-11-30 2007-11-30
US60/991,525 2007-11-30
PCT/US2008/084948 WO2009073545A2 (fr) 2007-11-30 2008-11-26 Inhibiteurs tétrahydro-isoquinolino de ppat utilisés en tant qu'agents antibactériens

Publications (1)

Publication Number Publication Date
CN102007101A true CN102007101A (zh) 2011-04-06

Family

ID=40718459

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801260189A Pending CN102007101A (zh) 2007-11-30 2008-11-26 作为抗菌剂的四氢-异喹啉ppat抑制剂

Country Status (6)

Country Link
EP (1) EP2225207A2 (fr)
JP (1) JP2011518109A (fr)
CN (1) CN102007101A (fr)
AU (1) AU2008334075A1 (fr)
CA (1) CA2707445A1 (fr)
WO (1) WO2009073545A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113461699A (zh) * 2021-04-14 2021-10-01 宁波大学 一种四环吡咯生物碱类化合物及其制备方法和用途

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009073534A2 (fr) 2007-11-30 2009-06-11 Maxthera Inc. Inhibiteurs de ppat bicycliques utilisés en tant qu'agents antibactériens
FR2986002B1 (fr) 2012-01-24 2014-02-21 Servier Lab Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN102603755B (zh) * 2012-02-08 2015-09-09 中国人民解放军第二军医大学 一类具有协同氟康唑抗耐药真菌作用的化合物
FR3008975A1 (fr) * 2013-07-23 2015-01-30 Servier Lab Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008977A1 (fr) 2013-07-23 2015-01-30 Servier Lab Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008976A1 (fr) 2013-07-23 2015-01-30 Servier Lab "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
JP6633618B2 (ja) 2014-08-21 2020-01-22 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 強力なｒｏｃｋ阻害剤としてのタイドバックのベンズアミド誘導体
WO2017025509A1 (fr) * 2015-08-12 2017-02-16 Syngenta Participations Ag Dérivés hétérobicycliques microbiocides
MX2021004566A (es) 2018-10-22 2021-06-08 C4X Discovery Ltd Compuestos terapeuticos.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2365401A1 (fr) * 1999-03-11 2000-10-05 Neurogen Corporation Pyridines 2,4-disubstituees fusionnees avec un aryle: ligands du recepteur nk-3
US20050070570A1 (en) * 2003-06-18 2005-03-31 4Sc Ag Novel potassium channels modulators
EP1637529A1 (fr) * 2004-09-20 2006-03-22 4Sc Ag Nouveaux analogues de piperidin-4-yl-thiazole-carboxamide en tant qu'inhibiteurs de proliferation de lymphocytes T er leurs utilisations
EP1994017A2 (fr) * 2006-03-15 2008-11-26 4Sc Ag Nouveaux inhibiteurs hétérocycliques de nf/kb

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113461699A (zh) * 2021-04-14 2021-10-01 宁波大学 一种四环吡咯生物碱类化合物及其制备方法和用途

Also Published As

Publication number Publication date
WO2009073545A3 (fr) 2009-09-11
AU2008334075A1 (en) 2009-06-11
JP2011518109A (ja) 2011-06-23
CA2707445A1 (fr) 2009-06-11
WO2009073545A2 (fr) 2009-06-11
EP2225207A2 (fr) 2010-09-08

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Legal Events

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20110406