CN102215867B - 疾病治疗用组合物 - Google Patents

疾病治疗用组合物 Download PDF

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Publication number
CN102215867B
CN102215867B CN200980143326.7A CN200980143326A CN102215867B CN 102215867 B CN102215867 B CN 102215867B CN 200980143326 A CN200980143326 A CN 200980143326A CN 102215867 B CN102215867 B CN 102215867B
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CN
China
Prior art keywords
humanization
antibodies
patient
applications
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200980143326.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN102215867A (zh
Inventor
弗兰克·奥斯特罗斯
西尔克·艾格纳
克里斯托夫·尤尔克
安德里亚·瓦滕贝格-德曼特
阿纳托利·鲁德涅夫
迈克尔·索尔丹
克里斯托夫·布鲁切尔
本杰明·德尔肯
尚塔尔·祖伯
格雷戈尔·舒尔茨
尼古拉斯·蔡洛特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ogyne Co ltd
Original Assignee
Biotest AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0817809A external-priority patent/GB0817809D0/en
Priority claimed from GB0817810A external-priority patent/GB0817810D0/en
Priority claimed from GB0817811A external-priority patent/GB0817811D0/en
Priority claimed from PCT/EP2009/052810 external-priority patent/WO2009112502A1/en
Priority claimed from PCT/EP2009/052809 external-priority patent/WO2009121690A1/en
Priority claimed from PCT/EP2009/052811 external-priority patent/WO2009124815A1/en
Application filed by Biotest AG filed Critical Biotest AG
Publication of CN102215867A publication Critical patent/CN102215867A/zh
Application granted granted Critical
Publication of CN102215867B publication Critical patent/CN102215867B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN200980143326.7A 2008-09-29 2009-08-31 疾病治疗用组合物 Expired - Fee Related CN102215867B (zh)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
GB0817809A GB0817809D0 (en) 2008-09-29 2008-09-29 Agent for treating disease
GB0817809.7 2008-09-29
GB0817810.5 2008-09-29
GB0817811.3 2008-09-29
GB0817810A GB0817810D0 (en) 2008-09-29 2008-09-29 Agent for treating disease
GB0817811A GB0817811D0 (en) 2008-09-29 2008-09-29 Agent for treating disease
EPPCT/EP2009/052811 2009-03-10
EPPCT/EP2009/052809 2009-03-10
EPPCT/EP2009/052810 2009-03-10
PCT/EP2009/052810 WO2009112502A1 (en) 2008-03-13 2009-03-10 Agent for treating disease
PCT/EP2009/052809 WO2009121690A1 (en) 2008-03-13 2009-03-10 Agent for treating disease
PCT/EP2009/052811 WO2009124815A1 (en) 2008-03-13 2009-03-10 Agent for treating disease
PCT/EP2009/061210 WO2010034590A1 (en) 2008-09-29 2009-08-31 Composition for treating disease

Publications (2)

Publication Number Publication Date
CN102215867A CN102215867A (zh) 2011-10-12
CN102215867B true CN102215867B (zh) 2017-04-19

Family

ID=41138980

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980143326.7A Expired - Fee Related CN102215867B (zh) 2008-09-29 2009-08-31 疾病治疗用组合物

Country Status (16)

Country Link
US (1) US20110229465A1 (2)
JP (2) JP2012504110A (2)
KR (1) KR20110061630A (2)
CN (1) CN102215867B (2)
AU (1) AU2009296078B2 (2)
BR (1) BRPI0919489A2 (2)
CA (1) CA2738598C (2)
CR (1) CR20110226A (2)
DK (1) DK2341937T3 (2)
ES (1) ES2528419T3 (2)
IL (1) IL211904A (2)
MX (1) MX2011003335A (2)
PT (1) PT2341937E (2)
RU (1) RU2531548C2 (2)
SG (1) SG194362A1 (2)
WO (1) WO2010034590A1 (2)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1460088A1 (en) 2003-03-21 2004-09-22 Biotest AG Humanized anti-CD4 antibody with immunosuppressive properties
BRPI0909048A2 (pt) * 2008-03-13 2015-11-24 Biotest Ag composição farmacêutica, e, método de tratamento de uma doença autoimune
ES2610327T3 (es) * 2008-03-13 2017-04-27 Biotest Ag Régimen de dosificación de anticuerpos anti-CD4 para el tratamiento de enfermedades autoinmunitarias
HUE028962T2 (en) * 2008-03-13 2017-01-30 Biotest Ag Active ingredient for treating disease
GB0920944D0 (en) 2009-11-30 2010-01-13 Biotest Ag Agents for treating disease
EP3019193B1 (en) * 2013-07-10 2019-09-25 The U.S.A. as represented by the Secretary, Department of Health and Human Services Apoptotic cell-mediated induction of antigen specific regulatory t-cells for the therapy of autoimmune diseases in animals and humans
GB202017681D0 (en) * 2020-11-09 2020-12-23 T Balance Therapeutics Gmbh Anti-CD4 antibody or fragment thereof for medical use
DE102020129648A1 (de) * 2020-11-10 2022-05-12 Leopold MTX GmbH Pharmazeutische zusammensetzung

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WO2004083247A1 (en) * 2003-03-21 2004-09-30 Biotest Ag Humanized anti-cd4 antibody with immunosuppressive properties
CN101031305A (zh) * 2004-09-29 2007-09-05 兴和株式会社 类风湿性关节炎的预防和/或治疗药物

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CN101031305A (zh) * 2004-09-29 2007-09-05 兴和株式会社 类风湿性关节炎的预防和/或治疗药物

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Also Published As

Publication number Publication date
PT2341937E (pt) 2015-02-18
SG194362A1 (en) 2013-11-29
KR20110061630A (ko) 2011-06-09
ES2528419T3 (es) 2015-02-09
RU2011117293A (ru) 2012-11-10
IL211904A (en) 2016-03-31
MX2011003335A (es) 2011-04-27
IL211904A0 (en) 2011-06-30
AU2009296078A1 (en) 2010-04-01
RU2531548C2 (ru) 2014-10-20
CA2738598C (en) 2017-11-21
BRPI0919489A2 (pt) 2015-12-01
CR20110226A (es) 2011-12-05
HK1154797A1 (en) 2012-05-04
JP6154847B2 (ja) 2017-06-28
WO2010034590A1 (en) 2010-04-01
US20110229465A1 (en) 2011-09-22
CA2738598A1 (en) 2010-04-01
JP2012504110A (ja) 2012-02-16
JP2015172060A (ja) 2015-10-01
AU2009296078B2 (en) 2015-08-20
CN102215867A (zh) 2011-10-12
DK2341937T3 (en) 2015-02-09

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SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
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Effective date of registration: 20191015

Address after: Frankfurt, Germany

Patentee after: Ogyne Co.,Ltd.

Address before: Dreiser, Germany

Patentee before: Biotest Ag

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20170419

CF01 Termination of patent right due to non-payment of annual fee