CN102271683B - 恶性血液病的治疗 - Google Patents

恶性血液病的治疗 Download PDF

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Publication number
CN102271683B
CN102271683B CN200980154097.9A CN200980154097A CN102271683B CN 102271683 B CN102271683 B CN 102271683B CN 200980154097 A CN200980154097 A CN 200980154097A CN 102271683 B CN102271683 B CN 102271683B
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compound
cells
cell
treatment
formula
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Expired - Fee Related
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CN200980154097.9A
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Chinese (zh)
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CN102271683A (zh
Inventor
M·W·加勒廷
R·G·尤里奇
N·吉斯
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Gilead Calistoga LLC
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Gidded Calistoga Co
Gilead Calistoga LLC
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Priority to CN201410246030.0A priority Critical patent/CN104042618B/zh
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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  • Rheumatology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN200980154097.9A 2008-11-13 2009-11-13 恶性血液病的治疗 Expired - Fee Related CN102271683B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410246030.0A CN104042618B (zh) 2008-11-13 2009-11-13 恶性血液病的治疗

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US11443408P 2008-11-13 2008-11-13
US61/114,434 2008-11-13
US14284509P 2009-01-06 2009-01-06
US61/142,845 2009-01-06
US15505709P 2009-02-24 2009-02-24
US61/155,057 2009-02-24
US18076809P 2009-05-22 2009-05-22
US61/180,768 2009-05-22
US23127809P 2009-08-04 2009-08-04
US61/231,278 2009-08-04
US24519609P 2009-09-23 2009-09-23
US61/245,196 2009-09-23
PCT/US2009/064471 WO2010057048A1 (en) 2008-11-13 2009-11-13 Therapies for hematologic malignancies

Related Child Applications (1)

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CN201410246030.0A Division CN104042618B (zh) 2008-11-13 2009-11-13 恶性血液病的治疗

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CN102271683A CN102271683A (zh) 2011-12-07
CN102271683B true CN102271683B (zh) 2014-07-09

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CN200980154097.9A Expired - Fee Related CN102271683B (zh) 2008-11-13 2009-11-13 恶性血液病的治疗
CN201410246030.0A Expired - Fee Related CN104042618B (zh) 2008-11-13 2009-11-13 恶性血液病的治疗

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US (5) US20100202963A1 (2)
EP (2) EP2355828B1 (2)
JP (3) JP5794919B2 (2)
KR (3) KR20160091440A (2)
CN (2) CN102271683B (2)
AU (6) AU2009313878B2 (2)
CA (3) CA2743642C (2)
ES (1) ES2674719T3 (2)
IL (1) IL212851A0 (2)
NZ (3) NZ631024A (2)
PT (1) PT2355828T (2)
SG (2) SG10201703911XA (2)
WO (1) WO2010057048A1 (2)

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