CN102574785A - 四取代的杂芳基化合物和它们作为mdm2和/或mdm4调节剂的用途 - Google Patents

四取代的杂芳基化合物和它们作为mdm2和/或mdm4调节剂的用途 Download PDF

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CN102574785A
CN102574785A CN2010800482502A CN201080048250A CN102574785A CN 102574785 A CN102574785 A CN 102574785A CN 2010800482502 A CN2010800482502 A CN 2010800482502A CN 201080048250 A CN201080048250 A CN 201080048250A CN 102574785 A CN102574785 A CN 102574785A
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alkyl
amino
carbonyl
phenyl
chloro
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G·博尔德
P·菲雷
F·热西耶
J·卡伦
J·赫尔戈维奇李斯特万
K·马苏亚
A·沃佩尔
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Novartis AG
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CN2010800482502A 2009-08-26 2010-08-24 四取代的杂芳基化合物和它们作为mdm2和/或mdm4调节剂的用途 Pending CN102574785A (zh)

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US23710709P 2009-08-26 2009-08-26
US61/237,107 2009-08-26
PCT/EP2010/062300 WO2011023677A1 (en) 2009-08-26 2010-08-24 Tetra-substituted heteroaryl compounds and their use as mdm2 and/or mdm4 modulators

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US (1) US20120149661A1 (2)
EP (1) EP2470502A1 (2)
JP (1) JP2013503129A (2)
KR (1) KR20120050492A (2)
CN (1) CN102574785A (2)
AU (1) AU2010288534A1 (2)
BR (1) BR112012008075A2 (2)
CA (1) CA2771936A1 (2)
EA (1) EA201200321A1 (2)
IN (1) IN2012DN01693A (2)
MX (1) MX2012002420A (2)
WO (1) WO2011023677A1 (2)

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DK2118123T3 (en) 2007-01-31 2016-01-25 Dana Farber Cancer Inst Inc Stabilized p53 peptides and uses thereof
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
PE20121172A1 (es) 2009-10-14 2012-09-05 Merck Sharp & Dohme Piperidinas sustituidas con actividad en la hdm2
JO2998B1 (ar) 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
ES2711526T3 (es) 2010-08-13 2019-05-06 Aileron Therapeutics Inc Macrociclos peptidomiméticos
US9376425B2 (en) 2011-09-27 2016-06-28 Amgen, Inc. Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer
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