EA201200321A1 - Тетразамещенные гетероарильные соединения и их применение в качестве модуляторов mdm2 и/или mdm4 - Google Patents

Тетразамещенные гетероарильные соединения и их применение в качестве модуляторов mdm2 и/или mdm4

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Publication number
EA201200321A1
EA201200321A1 EA201200321A EA201200321A EA201200321A1 EA 201200321 A1 EA201200321 A1 EA 201200321A1 EA 201200321 A EA201200321 A EA 201200321A EA 201200321 A EA201200321 A EA 201200321A EA 201200321 A1 EA201200321 A1 EA 201200321A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
mdm4
mdm2
tetra
substituted
Prior art date
Application number
EA201200321A
Other languages
English (en)
Russian (ru)
Inventor
Гуидо Больд
Паскаль Фюре
Франсуа Жессье
Йёрг Каллен
Йоанна Хергових-Лиштван
Кейичи Масуя
Андреа Фаупель
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201200321A1 publication Critical patent/EA201200321A1/ru

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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EA201200321A 2009-08-26 2010-08-24 Тетразамещенные гетероарильные соединения и их применение в качестве модуляторов mdm2 и/или mdm4 EA201200321A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23710709P 2009-08-26 2009-08-26
PCT/EP2010/062300 WO2011023677A1 (en) 2009-08-26 2010-08-24 Tetra-substituted heteroaryl compounds and their use as mdm2 and/or mdm4 modulators

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EA201200321A1 true EA201200321A1 (ru) 2012-09-28

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US (1) US20120149661A1 (2)
EP (1) EP2470502A1 (2)
JP (1) JP2013503129A (2)
KR (1) KR20120050492A (2)
CN (1) CN102574785A (2)
AU (1) AU2010288534A1 (2)
BR (1) BR112012008075A2 (2)
CA (1) CA2771936A1 (2)
EA (1) EA201200321A1 (2)
IN (1) IN2012DN01693A (2)
MX (1) MX2012002420A (2)
WO (1) WO2011023677A1 (2)

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US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
PE20121172A1 (es) 2009-10-14 2012-09-05 Merck Sharp & Dohme Piperidinas sustituidas con actividad en la hdm2
JO2998B1 (ar) 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
ES2711526T3 (es) 2010-08-13 2019-05-06 Aileron Therapeutics Inc Macrociclos peptidomiméticos
US9376425B2 (en) 2011-09-27 2016-06-28 Amgen, Inc. Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
US8987274B2 (en) 2011-10-28 2015-03-24 Merck Sharp & Dohme Corp Macrocycles that increase p53 activity and the uses thereof
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