CN1037272A - 促旋酶抑制剂的肌内注射剂 - Google Patents

促旋酶抑制剂的肌内注射剂 Download PDF

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Publication number: CN1037272A
Authority: CN; China
Prior art keywords: acid; lecithin; intramuscular injection; ciprofloxacin; methyl
Prior art date: 1988-04-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CN89102284A

Other languages

English (en)

Chinese (zh)

Inventor

诺伯特·波林格尔

彼得·塞诺

沃尔弗勒姆·霍夫曼

迪特尔·比尔曼

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer AG

Original Assignee

Bayer AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-15

Filing date

1989-04-15

Publication date

1989-11-22

1989-04-15 Application filed by Bayer AG filed Critical Bayer AG

1989-11-22 Publication of CN1037272A publication Critical patent/CN1037272A/zh

Status Pending legal-status Critical Current

Links

239000002271 gyrase inhibitor Substances 0.000 title claims abstract description 15
238000010255 intramuscular injection Methods 0.000 title claims description 32
239000007927 intramuscular injection Substances 0.000 title claims description 32
239000003795 chemical substances by application Substances 0.000 title claims description 16
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 104
150000001875 compounds Chemical class 0.000 claims abstract description 53
-1  hydrochlorate Chemical compound 0.000 claims abstract description 29
150000003839 salts Chemical class 0.000 claims abstract description 20
239000004094 surface-active agent Substances 0.000 claims abstract description 11
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims abstract description 4
239000002552 dosage form Substances 0.000 claims abstract 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 119
238000000034 method Methods 0.000 claims description 53
239000000725 suspension Substances 0.000 claims description 41
238000002360 preparation method Methods 0.000 claims description 35
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 28
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 23
239000002253 acid Substances 0.000 claims description 21
239000000787 lecithin Substances 0.000 claims description 21
235000010445 lecithin Nutrition 0.000 claims description 21
229940067606 lecithin Drugs 0.000 claims description 21
229910052739 hydrogen Inorganic materials 0.000 claims description 15
239000001257 hydrogen Substances 0.000 claims description 14
235000014655 lactic acid Nutrition 0.000 claims description 14
239000004310 lactic acid Substances 0.000 claims description 14
JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 12
239000003921 oil Substances 0.000 claims description 12
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150000002431 hydrogen Chemical class 0.000 claims description 11
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical class OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 10
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Quinoline Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CN89102284A 1988-04-15 1989-04-15 促旋酶抑制剂的肌内注射剂 Pending CN1037272A (zh)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE3812508		1988-04-15
DEP3812508.0		1988-04-15
DE3902079A DE3902079A1 (de)	1988-04-15	1989-01-25	I.m. injektionsformen von gyrase-inhibitoren
DEP3902079.7		1989-01-25

Publications (1)

Publication Number	Publication Date
CN1037272A true CN1037272A (zh)	1989-11-22

Family

ID=25866993

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CN89102284A Pending CN1037272A (zh)	1988-04-15	1989-04-15	促旋酶抑制剂的肌内注射剂

Country Status (15)

Country	Link
US (1)	US5023257A (2)
EP (1)	EP0337231B1 (2)
JP (1)	JPH01316321A (2)
KR (1)	KR900015736A (2)
CN (1)	CN1037272A (2)
AU (1)	AU610380B2 (2)
CA (1)	CA1336822C (2)
DE (2)	DE3902079A1 (2)
DK (1)	DK169772B1 (2)
ES (1)	ES2038359T3 (2)
GR (1)	GR3005415T3 (2)
HU (1)	HUT54048A (2)
IE (1)	IE60407B1 (2)
IL (1)	IL89928A (2)
NZ (1)	NZ228708A (2)

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FR2665635A1 (fr) *	1990-08-10	1992-02-14	Merck Sharp & Dohme	Composition pharmaceutique fluide a base d'un complexe metallique et son procede de preparation.
US5420124A (en) *	1994-01-12	1995-05-30	Kim; Young S.	Stable, painless piroxicam potassium injectable composition
DE69620136T2 (de) *	1995-06-06	2002-08-01	Bayer Ag	Antibakterielle präparate für die ohren ohne irritierende, sensibilisierende und ototoxische wirkungen
US5843930A (en) *	1995-06-06	1998-12-01	Bayer Corporation	Method of treating otitis with ciprofloxacin-hydrocortisone suspension
CZ293747B6 (cs) *	1995-12-21	2004-07-14	Pfizer Inc.	Vodný farmaceutický roztok vhodný pro injekční podávání hostiteli a jeho použití
IN186245B (2)	1997-09-19	2001-07-14	Ranbaxy Lab Ltd
ID21415A (id)	1997-12-05	1999-06-10	Upjohn Co	Senyawa-senyawa antibiotik magnesium quinolon
WO2001052846A1 (en) *	2000-01-18	2001-07-26	Vertex Pharmaceuticals Incorporated	Gyrase inhibitors and uses thereof
US20030170858A1 (en) *	2001-01-16	2003-09-11	Paul Charifson	Gyrase inhibitors and uses thereof
NZ534746A (en) *	2002-03-12	2006-06-30	Bristol Myers Squibb Co	Palatable oral suspension and method
CN100410249C (zh)	2003-09-10	2008-08-13	杏林制药株式会社	7-(4-取代-3-环丙基氨基甲基-1-吡咯烷基)喹诺酮羧酸衍生物
US20070196398A1 (en) *	2006-02-17	2007-08-23	Murthy Yerramilli V S	Fluoroquinolone fatty acid salt compositions
CA2688008A1 (en)	2007-05-24	2008-11-27	Kyorin Pharmaceutical Co., Ltd.	Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
CN102716072B (zh) *	2012-06-13	2014-06-18	广州南新制药有限公司	一种乳酸环丙沙星氯化钠注射液的制备方法
JP6523245B2 (ja) *	2013-03-15	2019-05-29	アイリスインターナショナル，インコーポレイテッド	血液試料における粒子分析のためのシース液システム及び方法
US9279750B2 (en)	2013-03-15	2016-03-08	Iris International, Inc.	Method and composition for staining and sample processing
US9393243B1 (en)	2015-07-14	2016-07-19	Nilesh Parikh	Topical Ciprofloxacin compositions
ITUB20155193A1 (it) *	2015-11-03	2017-05-03	Italfarmaco Spa	Sospensioni orali di Givinostat fisicamente e chimicamente stabili

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DE3033157A1 (de) *	1980-09-03	1982-04-01	Bayer Ag, 5090 Leverkusen	7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4620007A (en) *	1980-09-03	1986-10-28	Bayer Aktiengesellschaft	6-fluoro-7-chloro-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
US4670444B1 (en) *	1980-09-03	1999-02-09	Bayer Ag	and-naphthyridine-3-carboxylic acids and antibacte7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-rial agents containing these compounds
DE3306771A1 (de) *	1983-02-25	1984-08-30	Bayer Ag, 5090 Leverkusen	Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3306772A1 (de) *	1983-02-25	1984-08-30	Bayer Ag, 5090 Leverkusen	Chinolonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
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US4780468A (en) *	1987-08-07	1988-10-25	Warner-Lambert Company	8-trifluoromethyl quinolones as antibacterial agents
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1989
- 1989-01-25 DE DE3902079A patent/DE3902079A1/de not_active Withdrawn
- 1989-04-03 DE DE8989105795T patent/DE58901663D1/de not_active Expired - Lifetime
- 1989-04-03 EP EP89105795A patent/EP0337231B1/de not_active Expired - Lifetime
- 1989-04-03 ES ES89105795T patent/ES2038359T3/es not_active Expired - Lifetime
- 1989-04-12 JP JP1090887A patent/JPH01316321A/ja active Pending
- 1989-04-12 NZ NZ228708A patent/NZ228708A/en unknown
- 1989-04-12 AU AU32753/89A patent/AU610380B2/en not_active Ceased
- 1989-04-12 IL IL89928A patent/IL89928A/xx not_active IP Right Cessation
- 1989-04-13 CA CA000596557A patent/CA1336822C/en not_active Expired - Fee Related
- 1989-04-14 HU HU891867A patent/HUT54048A/hu unknown
- 1989-04-14 DK DK181389A patent/DK169772B1/da not_active IP Right Cessation
- 1989-04-14 KR KR1019890004958A patent/KR900015736A/ko not_active Ceased
- 1989-04-14 IE IE120189A patent/IE60407B1/en not_active IP Right Cessation
- 1989-04-15 CN CN89102284A patent/CN1037272A/zh active Pending
1990
- 1990-07-06 US US07/549,664 patent/US5023257A/en not_active Expired - Fee Related
1992
- 1992-08-11 GR GR920401742T patent/GR3005415T3/el unknown

Also Published As

Publication number	Publication date
HUT54048A (en)	1991-01-28
IL89928A0 (en)	1989-12-15
GR3005415T3 (2)	1993-05-24
EP0337231B1 (de)	1992-06-17
DK169772B1 (da)	1995-02-27
JPH01316321A (ja)	1989-12-21
EP0337231A3 (en)	1990-01-17
US5023257A (en)	1991-06-11
IL89928A (en)	1993-05-13
CA1336822C (en)	1995-08-29
ES2038359T3 (es)	1995-04-01
DK181389A (da)	1989-10-31
IE891201L (en)	1989-10-15
AU3275389A (en)	1989-10-19
IE60407B1 (en)	1994-07-13
NZ228708A (en)	1992-06-25
DK181389D0 (da)	1989-04-14
AU610380B2 (en)	1991-05-16
KR900015736A (ko)	1990-11-10
EP0337231A2 (de)	1989-10-18
DE3902079A1 (de)	1989-10-26
DE58901663D1 (de)	1992-07-23

Legal Events

Date	Code	Title
1989-11-22	C06	Publication
1989-11-22	PB01	Publication
1991-07-17	C10	Entry into substantive examination
1991-07-17	SE01	Entry into force of request for substantive examination
1996-09-25	C01	Deemed withdrawal of patent application (patent law 1993)
1996-09-25	WD01	Invention patent application deemed withdrawn after publication

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